Neuroprotective effects of iron chelator Desferal on dopaminergic
neurons in the substantia nigra of rats with iron-overload.
Jiang H, Luan Z, Wang J, Xie J
Neurochem Int. 2006 Jun 24;

The aim of the present study was to investigate whether the iron
chelator Desferal prevents the degeneration of dopaminergic neurons in
the substantia nigra (SN) induced by iron-overload in rats. Using fast
cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry,
Perls' iron staining, and high-performance liquid
chromatography-electrochemical detection, we measured the degeneration
of dopaminergic neurons and increased iron content in the SN of rats
overloaded with iron dextran and assessed the effects of treatment with
Desferal. The results showed that iron dextran overload increased the
iron content in the SN, decreased dopamine release and content, and
reduced the numbers of TH-immunoreactive neurons. Treatment with
Desferal prevented the increased iron content in the SN. As a result,
dopamine release and content remained at almost normal levels, while
the numbers of TH-immunoreactive neurons remained at control values.
This study suggests that the iron chelator Desferal is neuroprotective
against iron-overload, so iron chelators that can cross the blood-brain
barrier may have the potential to treat cases where abnormal iron
accumulation in the brain is associated with the degenerative
processes, as in Parkinson's disease.

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