Pathophysiology. 2006 Jun 14; [Epub ahead of print] Links

Oxidative stress in Alzheimer's disease.

Chauhan V, Chauhan A.

NYS Institute for Basic Research in Developmental Disabilities, 1050
Forest Hill Road, Staten Island, NY 10314, USA.

Oxidative damage is a major feature in the pathophysiology of
Alzheimer's disease (AD). In this review, we discuss free
radical-mediated damage to the biochemical components involved in the
pathology and clinical symptoms of AD. We explain how amyloid
beta-protein (Abeta), microtubule-associated protein tau, presenilins,
apolipoprotein E, mitochondria and proteases play a role in increasing
oxidative stress in AD. Abeta not only can induce oxidative stress, but
its generation is also increased as a result of oxidative stress.
Finally, a hypothetical model linking oxidative stress with
beta-amyloid and neurofibrillary tangle pathology in AD is proposed.

PMID: 16781128 [PubMed - as supplied by publisher]

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