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Medical Forum / Diseases and Disorders / Alzheimer's / March 2006Iron chelation in Alzheimer's disease
Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease. Reznichenko L, Amit T, Zheng H, Avramovich-Tirosh Y, Youdim MB, Weinreb O, Mandel S J Neurochem. 2006 Mar 15; Brain iron dysregulation and its association with amyloid precursor protein (APP) plaque formation are implicated in Alzheimer's disease (AD) pathology and so iron chelation could be considered a rational therapeutic strategy for AD. Here we analyzed the effect of the main polyphenol constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), which possesses metal-chelating and radical-scavenging properties, on the regulation of the iron metabolism-related proteins APP and transferrin receptor (TfR). EGCG exhibited potent iron-chelating activity comparable to that of the prototype iron chelator desferrioxamine, and dose dependently (1-10 microm) increased TfR protein and mRNA levels in human SH-SY5Y neuroblastoma cells. Both the immature and full-length cellular holo-APP were significantly reduced by EGCG, as shown by two-dimensional gel electrophoresis, without altering APP mRNA levels, suggesting a post-transcriptional action. Indeed, EGCG suppressed the translation of a luciferase reporter gene fused to the APP mRNA 5'-untranslated region, encompassing the APP iron-responsive element. The finding that Fe(2)SO(4) reversed the action of EGCG on APP and TfR proteins reinforces the likelihood that these effects are mediated through modulation of the intracellular iron pool. Furthermore, EGCG reduced toxic beta-amyloid peptide generation in Chinese hamster ovary cells overexpressing the APP 'Swedish' mutation. Thus, the natural non-toxic brain-permeable EGCG may provide a potential therapeutic approach for AD and other iron-associated disorders. . Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Reduction of iron-regulated amyloid precursor protein and beta-amyloid > peptide by (-)-epigallocatechin-3-gallate in cell cultures: [quoted text clipped - 41 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking My mom had chelation and now has AD, I'm not convinced the chelation was any good. >>My mom had chelation and now has AD, I'm not convinced the chelation was any good.<< Did she have .. iron .. chelation .. ? Most people go after OTHER metals .. and the chelation practitioners I have spoken to .. REPLACE .. the iron which they believe they have mistakenly .. removed .. Now it is a matter of whether they went after the .. iron .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > ... > Most people go after OTHER metals .. and the chelation practitioners I > have spoken to .. REPLACE .. the iron which they believe they have > mistakenly .. removed .. > ... I've responded to your postings over in the alt.support.cancer.prostate group. I'll add here that the alternative medicine practitioners I've met know about as much about blood chemistry, cell biology and physiology as the hamsters in the study you cited above. Most of them wouldn't have any idea whether people have too much or too little of some metal in their bodies, don't have any capability to perform medical tests to find out, and are completely clueless when it comes to understanding the role of metals in body chemistry. The ones I've met perform "chelation" by doing something that someone (often a quack) told them to do. They don't know if the procedure they performed actually did anything or not, and have no way of finding out. Iron, for example, is a required nutrient. It is a vital element in hemoglobin and in oxidative phosphorylation of ADP. Without it, people will die. The same is true of magnesium, calcium, copper, cobalt, molybdenum, zinc, and some other metals. What sense does it make to cut back one's iron intake or to undergo iron chelation without at least knowing if you have too much of it in your body? Alan >> ... >> Most people go after OTHER metals .. and the chelation practitioners I [quoted text clipped - 30 lines] > > Alan That's our iron troll. He is just a wacko who trolls all the newsgroups having anything to do with health. I heard that for many years iron deficiency was very rare because people used iron frying pans.  SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') > ... > That's our iron troll. > He is just a wacko who trolls all the newsgroups having anything to do with health. I'm a sucker for all kinds of trolls. My wife used to pull me away from the front door when she found me in deep discussion with crackpots, missionaries, traveling salesmen, or anyone else with a spiel and a tin cup. I should have learned my lesson but I'm incorrigible. > I heard that for many years iron deficiency was very rare because people used iron > frying pans. I've heard that too, though nowadays I think it would be teflon deficiency that is very rare. Regards, Alan >> ... >> That's our iron troll. [quoted text clipped - 8 lines] > > I should have learned my lesson but I'm incorrigible. LOL.... I have often done the same....:-) >> I heard that for many years iron deficiency was very rare because people >> used iron frying pans. > > I've heard that too, though nowadays I think it would be teflon > deficiency that is very rare. LOL! Would you believe that people who use induction cooking ranges are now looking for old iron frying pans? Apparently induction only works with ferrous metals, and cast iron conducts the best and cooks the best. I had a collection of them, all the sizes. Had scoured flea markets for years till I got a whole set of Griswolds with the large logo on the back. The newer ones won't do, they aren't smooth enough and seasoning them takes forever. Anyway I shipped half the collection off to my daughter who just put in an induction cooktop in her gorgeous new ultramodern kitchen. Our pesky iron troll ought to go into a frenzy hearing this..... SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') > I'm a sucker for all kinds of trolls. > > I should have learned my lesson but I'm incorrigible. if you keep replying to mr iron justice and the other trolls here, you WILL be killfiled by most of the folks in this group. with me you have ONE more chance. one more reply to a troll, and you'll be in my killfile just like them. >>What sense does it make to cut back one's iron intake or to undergo iron chelation without at least knowing if you have too much of it in your body? << Your body stores seven months worth of iron and then ATTEMPTS to downregulate the absorption of iron to just .. top up .. the seven months worth of iron. This process is unsatisfactory. The body .. as studies .. show .. CANNOT .. control the absorption of .. meat / blood iron and this iron bypasses the .. control .. and .. "tends to accumulate in the body" .. So as long as you have eaten meat .. the body has stored this iron away .. You therefore KNOW you have elevated iron levels .. It is IMPOSSIBLE .. not to .. Simple facts .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking i > Your body stores seven months worth of iron and then ATTEMPTS to > downregulate the absorption of iron to just .. top up .. the seven > months worth of iron. Tom and everyone, There is a condition called hemachromatosis, too much iron in the blood. Usually due to a sick liver. People shouldn't need chelation 1) if they have normal iron levels, 2) if they have normal LFT's, 3) if they are asymtomatic. My mom had to go to Ottawa for her chelation as there are no reputable MD's in NNY that would do it. That tells me alot! I believe SOME holistic med may work, but in todays market, they are full of fillers and not much of the effective substance. The good old 'snake oil' cart is what comes to my mind. Sorry. >>The good old 'snake oil' cart is what comes to my mind. Sorry.<< Soooooo .. the whole .. gist of your .. 'comments' .. IS .. "I don't believe in it .. " .. That is very good and very .. helpful .. Next time stay off the thread unless you have a more .. current .. article .. OK .. ? Great .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Next time stay off the thread unless you have a more .. current .. > article .. [quoted text clipped - 8 lines] > Jesus Was A Vegetarian! > http://jesuswasavegetarian.7h.com Don't start throwing stones Tom. I don't know what Jesus ate, but I know what he said about throwing stones. You've made some statements that I'd question too. For example: "Your body stores seven months worth of iron and then ATTEMPTS to downregulate the absorption of iron to just .. top up .. the seven months worth of iron." Can you give me the source for that? And even if true, how does it signify that a person gets too much iron? We know for example that very small blood losses can result in iron deficiency anemia. [Sorry Evelyn. Somebody pull me away from this door. :)] Alan >> Next time stay off the thread unless you have a more .. current .. >> article .. [quoted text clipped - 28 lines] > > Alan I know, I know.... sometimes it is just too tempting. SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') As much fun as it is, Alan, you're wasting your time on this one. I've asked Tom to support his claims more than once, and never once has he done so. Max. > As much fun as it is, Alan, you're wasting your time on this one. I've > asked Tom to support his claims more than once, and never once has he > done so. > > Max. Because he can't. He's a certifiable wacko who lives in my killfile, and I will warrant many other people have him in theirs too. SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') >Because he can't. He's a certifiable wacko who lives in my killfile, and I >will warrant many other people have him in theirs too. > > Yep. :-) I am wondering what happened to the girl whos dad i believe was in a home and her mom at home.She did not get along with her mom and just didn't seem to be able to handle her criticism .Hope someone remembers her.I have often wondered about her and would like to know hows shes doing.Barb >I am wondering what happened to the girl whos dad i believe was in a > home and her mom at home.She did not get along with her mom and just > didn't seem to be able to handle her criticism .Hope someone remembers > her.I have often wondered about her and would like to know hows shes > doing.Barb I have often wondered that too, Barb. She got angry with someone here (it was unwarranted) and left a while ago. She was having such difficulty with her family situation. Both parents were alcoholics, and her sister was using the parents money for whatever she wanted without keeping track. When we told her that it could cause problems with medicaid and nursing home admission later on, she got upset. She herself was on meds for her own problems, and it was just such a sad scenario. I wish she would come around and let us know how she is. SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') Evelyn,Thank you and lets just pray everything is ok.Barb >>"Your body stores seven months worth of iron and then ATTEMPTS to downregulate the absorption of iron to just .. top up .. the seven months worth of iron." Can you give me the source for that? http://www.ajcn.org/cgi/content/abstract/72/4/982 >>And even if true, how does it signify that a person gets too much iron? << They have NO 'standard' that has shown .. reliability .. They have used the 'standards' .. and have given people iron until it killed them .. Soooooo .. one has to logically assume the iron is .. there .. DUE TO the FACT you KNOW you ate meat and you KNOW it was uncontrolled ... Plus the fact soooo .. mannnnyyyyy .. researchers are beginning to talk about the iron in the brain .. KNOWN to be there by MRI .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >>And even if true, how does it signify that a person gets too much iron? << They have NO 'standard' that has shown .. reliability .. << <<snip>> However, traditional indices of iron that are currently utilized may not reflect iron stores accurately <<snip>> Semin Dial. 2006 Mar-Apr;19(2):146-51. Links Managing erythropoietin hyporesponsiveness. Kwack C, Balakrishnan VS. Division of Nephrology, Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts. ABSTRACT The anemia of chronic kidney disease is associated with cardiovascular disease, decreased quality of life, and mortality. The introduction of recombinant human erythropoietin (rHuEPO) has transformed the management of this condition. However, a significant proportion of patients fail to respond to even high doses of rHuEPO. Several factors have been implicated in the hyporesponsiveness to rHuEPO. Iron deficiency, whether absolute or functional, is considered the most important, and maintenance of adequate iron stores reduces rHuEPO requirements among patients on hemodialysis. However, traditional indices of iron that are currently utilized may not reflect iron stores accurately, and there is also increasing concern regarding the potential long-term toxicity of parenteral iron therapy. Infection and inflammation also influence the response to rHuEPO, both by disruption of iron metabolism and by eliciting the release of cytokines that inhibit erythropoiesis. Oxidative stress may contribute to rHuEPO hyporesponsiveness directly by promoting lipid peroxidation in cell membranes, leading to increased erythrocyte fragility and reduced life span and also through its strong association with inflammation. Severe hyperparathyroidism can lead to a reduced number of erythroid progenitor cells. Inadequate dialysis dose, aluminum overload, nutritional factors such as deficiencies of carnitine, vitamin B(12), folic acid, and vitamin C can also reduce the efficacy of rHuEPO therapy. Hyporesponsiveness to rHuEPO presents a challenge to both diagnosis and management in an era where optimizing response to rHuEPO is critical both in limiting the burgeoning costs of anemia management and improving clinical outcomes in the dialysis population. PMID: 16551293 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > [Sorry Evelyn. Somebody pull me away from this door. :)] > > TOO BLEEPING LATE! PLONK! you're in my killfile like the rest of the trolls. >> [Sorry Evelyn. Somebody pull me away from this door. :)] >> > TOO BLEEPING LATE! PLONK! you're in my killfile like the rest > of the trolls. I know Dennis won't see this but, by golly, it's going to be hard for me to sleep at night knowing that Dennis won't be seeing my messages. Maybe if I send him a dozen roses he'll relent? Alan >>> [Sorry Evelyn. Somebody pull me away from this door. :)] >>> [quoted text clipped - 8 lines] > > Alan You could try. I know that many people (like myself) periodically clear out the entire block sender list and see how long it takes me to plonk the offenders all over again :-) I just have to prove to myself that it is always the same people..... Not much hope for improvement for the really problematic ones, but somehow I don't think Dennis includes you in that lot. SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') > >>The good > old 'snake oil' cart is what comes to my mind. [quoted text clipped - 11 lines] > > NO NOT OK!! Who do you think YOU are?? Why don't you stay off instead of trying to push your whacked out ideas on here! Not everyone thinks like you, not everyone is going to believe like you, DEAL!! or shut up and DON"T ever tell me to stay off a thread because you don't like what I have written! See the thread .. ? Iron chelation in alzheimers .. Did I .. write .. the article .. ? Did I have ANYTHING to .. do .. WITH .. the article .. ? No .. I simply placed a medical study .. current .. medical study .. And .. YOU .. come onto the thread .. With .. ? And now you whine like some little .. It is a current medical study of the targeting of iron in alzheimers disease .. and .. leave it at that .. What .. IS .. your .. 'problem' .. Eh .. Whacked out ideas .. See the thread .. ? THEIR .. 'whacked out ideas' .. Get it .. straight .. lefty .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking NO NOT OK!! Who do you think YOU are?? Why don't you stay off instead of trying to push your whacked out ideas on here! Not everyone thinks like you, not everyone is going to believe like you, DEAL!! or shut up and DON"T ever tell me to stay off a thread because you don't like what I have written! >> >>The good >> old 'snake oil' cart is what comes to my mind. [quoted text clipped - 15 lines] >DON"T ever tell me >to stay off a thread because you don't like what I have >written! Here's a suggestion..walk out of your house, turn around and look at it. If its made of bricks, go talk to them, if not, find a brick wall nearby and talk to that. That will be as constructive as you talking to this loon. SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com >This process is unsatisfactory. The body .. as studies .. show .. >CANNOT .. control the absorption of .. meat / blood iron and this iron >bypasses the .. control .. and .. "tends to accumulate in the body" .. > >So as long as you have eaten meat .. the body has stored this iron away Not everyone has that disease of haemochromatosis. Most don't have it. >>Not everyone has that disease of haemochromatosis. Most don't have it. << Well unless you have CONTRADICTING studies that support YOUR stance .. then one must go with the studies which seem to NOT .. support .. your .. stupidity .. Most DO have it .. In this study of .. elderly .. anyhow .. <<snip>> The likely liability in iron nutriture in free-living, elderly white Americans eating a Western diet is HIGH iron stores, NOT iron deficiency <<snip>> Am J Clin Nutr 2001 Mar;73(3):638-46 Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores. Fleming DJ, Jacques PF, Tucker KL, Massaro JM, D'Agostino RB Sr, Wilson PW, Wood RJ Mineral Bioavailability Laboratory and the Epidemiology Program, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. BACKGROUND: Although iron deficiency occurs commonly in vulnerable groups of women of reproductive age, infants, and children, less is known about the iron nutriture of the elderly. OBJECTIVE: Our objective was to evaluate the iron status of a noninstitutionalized, elderly US population, with a particular focus on 2 concerns unique to the elderly: 1) potential confounding effects of chronic disease on iron measures and 2) increased occurrence of elevated iron stores. DESIGN: Multiple iron measures, including serum ferritin (SF), transferrin saturation, mean cell volume, and hemoglobin, were used to evaluate the prevalence of iron deficiency (ID), iron deficiency anemia (IDA), and other measures of iron nutriture in 1016 elderly white Americans aged 67-96 y from the Framingham Heart Study. "Diseased" subjects were defined as those with possible pathologically altered iron measures due to inflammation, infection, elevated liver enzymes, hereditary hemochromatosis, or cancer. The effect of altered iron status on various prevalence estimates was assessed. RESULTS: The elderly subjects had a low prevalence of ID (2.7%), IDA (1.2%), and depleted iron stores (3%; SF < 12 microg/L). In contrast, 12.9% had elevated iron stores (SF > 300 microg/L in men and SF > 200 microg/L in women), of which only 1% was attributable to chronic disease. The prevalence of ID, IDA, and depleted iron stores was unaffected by the presence of chronic disease. CONCLUSIONS: The Framingham Heart Study cohort is an iron-replete elderly population with a high prevalence of elevated iron stores in contrast with a low prevalence of iron deficiency, with insignificant effects of chronic disease on these iron status estimates. The likely liability in iron nutriture in free-living, elderly white Americans eating a Western diet is high iron stores, not iron deficiency. PMID: 11237943, UI: 21133919 __________________________________ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >depleted iron stores (3%; SF < 12 microg/L). In contrast, 12.9% had >elevated iron stores (SF > 300 microg/L in men and SF > 200 microg/L 12 % is the most of them?? My god. Is really 12% a majority of that group?? What about the 85% that was seemingly normal here? Is that a minority group? >>high prevalence of elevated iron stores<< The marker .. is ..300/200 for iron stores .. considered .. 'normal' .. Fine .. you and the rest of the dckhds can figure .. 200/300 .. to be .. normal .. and I will continue to believe .. 40 to be .. normal .. The marker found in a common everyday vegetarian .. The marker found in a common everyday meat eater is 72 .. and when lowered to the marker found in a vegetarian .. they have a forty percent drop in insulin resistance .. Now unless you have ANOTHER .. reason .. WHY the meat eaters would have a forty percent drop in insulin resistance BY simple lowering of iron levels .. then I will assume this .. decrease in insulin resistence is DUE TO iron reduction .. Insulin resistance is pre-diabetes / metabolic syndrome .. Vegetarian - 35 Meat eaters - 72 <<snip>>lacto-ovo vegetarians had lower body Fe stores, as indicated by a serum ferritin concentration (microg/l) of 35 (95 % CI 21, 49) compared with 72 (95 % CI 45, 100) for meat-eaters<<snip>> Br J Nutr 2001 Oct;86(4):515-9 Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Hua NW, Stoohs RA, Facchini FS Department of Medicine, Division of Nephrology, San Francisco General Hospital, San Francisco, CA, USA. The efficacy of insulin in stimulating whole-body glucose disposal (insulin sensitivity) was quantified using direct methodology in thirty lacto-ovo vegetarians and in thirty meat-eaters. All subjects were adult, lean (BMI <23 kg/m2), healthy and glucose tolerant. Lacto-ovo vegetarians were more insulin sensitive than meat-eaters, with a steady-state plasma glucose (mmol/l) of 4.1 (95 % CI 3.5, 5.0) v. 6.9 (95 % CI 5.2, 7.5; respectively. In addition, lacto-ovo vegetarians had lower lacto-ovo vegetarians had lower body Fe stores, as indicated by a serum ferritin concentration (microg/l) of 35 (95 % CI 21, 49) compared with 72 (95 % CI 45, 100) for meat-eaters To test whether or not Fe status might modulate insulin sensitivity, body Fe was lowered by phlebotomy in six male meat-eaters to levels similar to that seen in vegetarians, with a resultant approximately 40 % enhancement of insulin-mediated glucose disposal Our results demonstrate that lacto-ovo vegetarians are more insulin sensitive and have lower Fe stores than meat-eaters. In addition, it seems that reduced insulin sensitivity in meat-eaters is amenable to improvement by reducing body Fe. The latter finding is in agreement with results from animal studies where, no matter how induced, Fe depletion consistently enhanced glucose disposal. PMID: 11591239, UI: 21475355 -------------------------------------------------------------------------- And the FACT there is POSITIVE .. recovery .. BY .. lowering of iron levels .. MEANS .. cause and effect .. The iron levels .. the iron levels found WELL WITHIN .. your / and others .. 'safe' .. parameters .. 200/300 .. actually seems to be .. dangerous .. unless you and your braindeadcohorts believe insulin resistance to be .. good .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking It seems .. 200 might be considered a .. wee bit .. high .. seeing that .. all the patients WITH metabolic syndrome fall WELL .. within .. below .. the 'marker' .. BELIEVED .. to BE .. 'safe' .. But that is just .. me .. and .. logic .. <<snip>> mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 microg/l <<snip>> Diabetes Care. 2004 Oct;27(10):2422-8. Related Articles, Links Serum ferritin and risk of the metabolic syndrome in U.S. adults. Jehn M, Clark JM, Guallar E. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. OBJECTIVE: We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study of 6,044 adults >20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio. RESULTS: After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 microg/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4%, P = 0.002), postmenopausal women (47.5 vs. 28.2%, P < 0.001), and men (27.3 vs. 13.8%, P < 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI. CONCLUSIONS: Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance. Copyright 2004 American Diabetes Association PMID: 15451911 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >>>high prevalence of >elevated iron stores<< [quoted text clipped - 3 lines] >Fine .. you and the rest of the dckhds can figure .. 200/300 .. to be >.. normal .. and I will continue to believe .. 40 to be .. normal .. Have you ever been that low in iron any time?? I doubt seriously. Otherwise you would have known how it feel to be anemic. Start sleeping after about listening to a lesson in an auditory for about 30 min, start sleeping, with a terrible headache after 10 minutes sitting in a tram with little air condition etc. I have had such low levels several times due to bleeding, and it is not something I strive for. Please be glad you have at least 100 -200 as a value. On the other hand, above 300 is not good either. Then what you cites is of concern. >>This process is unsatisfactory. The body .. as studies .. show .. >>CANNOT .. control the absorption of .. meat / blood iron and this iron [quoted text clipped - 4 lines] >Not everyone has that disease of haemochromatosis. >Most don't have it. About 99% don't have it. -- David Wright :: alphabeta at prodigy.net These are my opinions only, but they're almost always correct. "If you can't say something nice, then sit next to me." -- Alice Roosevelt Longworth >>>This process is unsatisfactory. The body .. as studies .. show .. >>>CANNOT .. control the absorption of .. meat / blood iron and this iron [quoted text clipped - 6 lines] > > About 99% don't have it. Almost correct. About 99.8% don't "have" it. The defective gene is fairly prevalent in northern european populations (maybe 1 in 10), BUT only something less than 25% of the homozygotes (MUCH less than 25%) have any clinical presentations. However there may be sub-clinical issues, even for heterozygotes, depending on other factors (including inappropriate diet - ie, excessive in iron and nutrients). This area of speculation seems to attract nutters like "ironjustice". There is a great variety of conditions linked to haemochromatosis - many conditions which are common to affluent societies. However, it's really silly to apply logic in the wrong direction from common conditions in affluent regions, to make assumptions about the gene. If they gene isn't there, the reasoning is just plain nuts. Chypho... >>attract nutters like "ironjustice<< Actually .. it seems the thread HAS attracted .. nutters .. And since it was .. ME .. that PLACED the article .. means the article attracted .. YOU .. and the rest of you dckhds .. Doesn't it .. I placed a simple article about how the researchers believe iron targeting may be a possible way to treat alzheimers .. and what happens .. Dckhds .. No medical studies .. just .. "don't target the iron because I said so .." .. Based on .. ? Their extreme intelligence which they have displayed numerous times .. Let them show .. one .. just ONE .. incidence where they were .. right .. before .. anyone .. Heh .. heh .. Pusssssiiiiiiiiiiiieeeeeeeeesssss .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking .. >> About 99% don't have it. > >Almost correct. > >About 99.8% don't "have" it. Depends of your ethnicity :-( Here in Norway there are areas with far higher prevalens. :-( >>> About 99% don't have it. >> [quoted text clipped - 4 lines] > Depends of your ethnicity :-( Here in Norway there are areas with far > higher prevalens. :-( Yes, that is correct. Northern European prevalence. Obvious genetic advantage for surviving long winters with little iron food... Chypho... >>> About 99% don't have it. >> [quoted text clipped - 4 lines] > Depends of your ethnicity :-( Here in Norway there are areas with far > higher prevalens. :-( Of course the much higher prevalence of the (most common) mutation means that the homozygotes are much much more common... Similar thing happened with Australian first fleet arrival. Large number of Irish celts. Chypho... >What sense does it make to cut back one's iron intake or to >undergo iron chelation without at least knowing if you have >too much of it in your body? ironjustice think that the presence of only a single atom of iron in total in body is one far too much. He reminds me about a folklore tale in Norway about the farmer who ride to place in forest to find some more wood for winter and put one piece of wood on the sleigh, murmuring, "if you managed the previous, you'll take the next". When the sleigh was overfilled and no more wood left, he started, but the horse was not able to move the sleigh at all. Then he started to throw away one piece after the other, murmuring for each piece of wood, if you didn't managed to move the previous, neither would you manage to take this one" and then emptied the whole sleigh completely and took the horse home, extremely furious. (Story says nothing about the fate afterwards of the horse) >>Then he started to throw away one piece after the other<< Which one and when should I .. 'throw away' .. first .. ? I'm still loading and haven't thrown one away yet .. Diabetes .. ? Alzheimers .. ? Malaria .. ? Hepatitis .. ? Cancer .. ? Cirrhosis .. ? Osteoporosis .. ? Arthritis .. ? Parkinsons .. ? Multiple sclerosis .. ? Hookworm infection .. ? Which . one .. ? Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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