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Medical Forum / Diseases and Disorders / Alzheimer's / February 2006

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Iron In Elderly Participants Reporting Memory Loss

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ironjustice@aol.com - 18 Feb 2006 16:15 GMT
Quantitative MR Imaging R2 Relaxometry in Elderly Participants
Reporting Memory Loss.
House MJ, St Pierre TG, Foster JK, Martins RN, Clarnette R
AJNR Am J Neuroradiol. 2006 Feb ; 27(2): 430-9

BACKGROUND AND PURPOSE: In Alzheimer disease (AD), elevated brain iron
concentrations in gray matter suggest a disruption in iron homeostasis,
while demyelination processes in white matter increase the water
content. Our aim was to assess whether the transverse proton relaxation
rate, or R(2), an MR imaging parameter affected by changes in brain
iron concentration and water content, was different in elderly
participants with mild to severe levels of cognitive impairment
compared with healthy controls. METHODS: Twelve elderly participants
reporting memory problems and 11 healthy volunteers underwent
single-spin-echo MR imaging in a 1.5T scanner, with subsequent
neuropsychological testing. R(2) data were collected from 14 brain
regions in cortical and subcortical gray and white matter. Those with
memory complaints were separated into 2 further subgroups: MC1 (no
objective cognitive impairment) and MC2 (mild to severe objective
cognitive impairment). RESULTS: Mean brain R(2) values from the 11
controls correlated strongly (r = 0.94, P < .0001) with reference brain
iron concentrations for healthy adults. R(2) values in the MC1 and MC2
subgroups were significantly higher in the right temporal cortex and
significantly lower in the left internal capsule, compared with healthy
controls. R(2) values in the MC2 subgroup were significantly lower in
the left temporal and frontal white matter, compared with healthy
controls. CONCLUSIONS: R(2) differences between both subgroups and the
healthy controls suggest iron has increased in the temporal cortex, and
myelin has been lost from several white matter regions in those with
memory complaints, consistent with incipient AD pathogenesis and
biochemical data.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Alf Christophersen - 24 Feb 2006 17:34 GMT
>BACKGROUND AND PURPOSE: In Alzheimer disease (AD), elevated brain iron
>concentrations in gray matter suggest a disruption in iron homeostasis,
>while demyelination processes in white matter increase the water
>content. Our aim was to assess whether the transverse proton relaxation

Nice to see you are still fighting against body's use of iron in
different systems.

When are we experiencing some articles about the other half part of
the story, the dangerousness of oxygen and why it is dangerous to
mankind to breathe??

There are lot of articles showing dangerousness of oxygen, also
without the assistance of iron, like forming isolevuglandines from
arachidonic acid and EPA and other di-aldehydes made by oxygen attack
on long-chain fatty acids (non-enzymatically and partly also
enzymatically), like isoketals, isoneurals and isofurals (the products
of preferably arachidonic acid, but also EPA and isoneurals from DHA.

These di-ketals are crosslinking agents involved in atherosclerosis
but also most probably in DNA mutations. Free arachidonic acid or
cholesterol bound may form these compounds freely, but unfortunately,
also membrane bound in intact cell membrane layers if exposed to
molecular O2. That's one of the mechanisms why it is so utterly
important to life that O2 is transported in a way it cannot be exposed
to certain components of the cell.
(And of course, if iron is involved, such derangement reactions
accelerate tremendously.)

So, I'm waiting for your references to articles showing the
dangerousness of breathing. I have given you pointers to one class of
such dangerous side effects of breating and eating far too much
polyunsaturated fats. (But, eating too little pufas and too much
monoenes are also dangerous, if you by accident cut the toe when
trying to cut your toe nails without really seeing where the nail is
compared to the scissor :-) Even a tiny scar may do the same as I
experienced about a month ago (I'm using almost exclusively an oil
consisting of 10% omega-3, 20% omega-6, 65% monoenes and 5% saturated
fats, eat almost no meat (too expensive here in Norway, not becayse
I'm vegetarian).
The bleeding stopped after about 12 hours and my bathroom floor was
more or less covered with blood and in the morning part of my bed was
red of blood stain and there are still and forever lot of stains in
the matress :-(
(Just a comment to someone else here who dislikes any kind of PUFA)

Playing games with signalling systems in body may in time turn more or
less fatal. If you need a surgery, it may turn fatal because far too
much bleeding, even nose bleeding may be quite bad experience. I
myself during hospitalisation 3 years ago, after purgating my sinuses,
started to bleed in night furiously, but the nurse didn't call the
doctor, just put in some paper sheets to stop it. In turn it seems
like it did so, but in morning, a five cm coagel of blood fall
backwards from nose down into my throat, blocking my lung. Fortunately
I had already got some air in my lungs so I managed to throw my body
forward and press and it came out. The doctor was rather shocked when
presented the coagel (I had had a little smaller one the night
before). Afterwards I had a count of 10 g/l of rbc against normal
range around 14. And my iron was gone. :-(
Laura(wow) - 24 Feb 2006 18:52 GMT
ROFLMAO.. the dangers of breathing..that is priceless. You just might send
doe-Knob off into another crusade..Thanks for the laugh

Signature

LAURA

> When are we experiencing some articles about the other half part of
> the story, the dangerousness of oxygen and why it is dangerous to
[quoted text clipped - 47 lines]
> before). Afterwards I had a count of 10 g/l of rbc against normal
> range around 14. And my iron was gone. :-(
Alf Christophersen - 25 Feb 2006 01:55 GMT
On Fri, 24 Feb 2006 13:52:17 -0500, "Laura\(wow\)"
<thehappywife@myrealbox.com> wrote:

>ROFLMAO.. the dangers of breathing..that is priceless. You just might send
>doe-Knob off into another crusade..Thanks for the laugh

Thanx for laughing. but for many bacteria, oxygen is extremely fatal.
Fortunately, otherwise we would face botulism far more often.

And yes, oxygen is extremely dangerous for ourselves too :-( But,
nature has developed many strategies to prevent harm done.

But, due to profit needs, our food producers do everything to remove
many of these compounds from our diet. :-(
Sylv - 25 Feb 2006 03:08 GMT
Laura;

>You just might send
>doe-Knob off into another crusade..Thanks for the laugh

Gee, do you think he'd start using the moniker "airjustice?"

LOL!  He IS an airhead, after all!

Sylvia
Alf Christophersen - 25 Feb 2006 04:26 GMT
>Laura;
>
[quoted text clipped - 4 lines]
>
>LOL!  He IS an airhead, after all!

well, it is oxygen that makes iron dangerous. Nothing else.
So, without oxygen at all, iron would do no harm.

So, ironjustice should definitively start a new fight, the fight
against oxygen being present in free form on earth (once upon a time,
at the very beginning, oxygen partial pressure was far below 10(-16)
atmosphere, and the most primitive bacterias still hide in such area
where such low pressure can be measured. Like C. botulinum which dies
if exposed to partial pressures exceeding around 10(-12) atmosphere.
Unfortunately, in babies and under certain conditions in elderly
people, such conditions may be met in intestines and spores of C.
botulinum may start to grow and produce lethal amounts of the poison.
 
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