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MRI of Brain Iron in Neurodegenerative Disease

This study is currently recruiting patients.
Verified by Albany Medical College November 2005

Sponsors and Collaborators: Albany Medical College
Department of Defense
Information provided by: Albany Medical College
ClinicalTrials.gov Identifier: NCT00249080

Purpose

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's
disease, and multiple sclerosis are recognized as a major health
concern at the present time. There is information in magnetic resonance
imaging (MRI) studies regarding the role of brain iron in normal brain
aging that may be enhanced with the use of better scanning equipment
and procedures, and by correlating this information with clinical data.
This research study aims to develop and evaluate a number of techniques
that can potentially improve the effectiveness of three tesla (3T)
magnetic resonance imaging of neurodegenerative brain disorders.
Condition
Normal, Healthy Subject Without Memory Complaint
Neurodegenerative Disease
Mild Cognitive Impairment
Not Pregnant
MR Compatible

MedlinePlus related topics:  Degenerative Nerve Diseases;   Mental
Health;   Neurologic Diseases
Genetics Home Reference related topics:  Degenerative Nerve Diseases

Study Type: Observational
Study Design: Natural History, Longitudinal, Defined Population,
Prospective Study

Official Title: High Field MRI of Brain Iron in Neurodegenerative
Disease

Further study details as provided by Albany Medical College:

Expected Total Enrollment:  100
Study start: June 2005;  Expected completion: December 2006
Last follow-up: December 2006;  Data entry closure: December 2006

Eligibility: A healthy person without memory complaints or someone with
neurodegenerative disease. However, the person should not have metal in
the body (ie, pacemaker, implants, shrapnel, etc.), should not be
pregnant, and should not have claustrophobic anxieties.

Study Procedures: During a regular office visit, a neurologist will
perform a routine physical and neurological examination, including your
medical and family history, to determine your eligibility for this
study. You will then be scheduled for a series of neuropsychological
tests, which take between 1 to 1.5 hours, and an MRI scan, which takes
approximately 1 hour to complete. This is a longitudinal study and you
may be asked to repeat these procedures approximately every six months
for the duration of this 2 year project.

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for
Study:  Both
Accepts Healthy Volunteers

Criteria
Inclusion Criteria:

18 years or older
healthy person without memory complaint OR person diagnosed with a
neurodegenerative disease (ie, Alzheimer's disease, Parkinson's
disease, multiple sclerosis)
Exclusion Criteria:

MR contraindication such as metal in body (ie, pacemaker, implant,
shrapnel, etc)
pregnant
claustrophobic anxieties
Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier
NCT00249080

Earl A Zimmerman, MD      518-262-0800

New York
     Alzheimer's Center of Albany Medical Center, Albany,  New York,
12208,  United States; Recruiting
Earl A Zimmerman, MD,  Sub-Investigator

Study chairs or principal investigators

Earl A Zimmerman, MD,  Study Director,  Albany Medical College
John F Schenck, MD, PhD,  Principal Investigator,  GE Global Research
Center & Neurosciences Advanced Imaging Research Center
More Information

Publications

Schenck JF, Zimmerman EA. High-field magnetic resonance imaging of
brain iron: birth of a biomarker? NMR Biomed. 2004 Nov;17(7):433-45.
Review.

Schenck JF. Magnetic resonance imaging of brain iron. J Neurol Sci.
2003 Mar 15;207(1-2):99-102. Review. No abstract available.

Schenck JF. Safety of strong, static magnetic fields. J Magn Reson
Imaging. 2000 Jul;12(1):2-19. Review.

Study ID Numbers:  AMC-IRB-1599; A-13214
Last Updated:  December 8, 2005
Record first received:  November 3, 2005
ClinicalTrials.gov Identifier:  NCT00249080
Health Authority: United States: Institutional Review Board
ClinicalTrials.gov processed this record on 2006-02-15

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