J Alzheimers Dis. 2005 Nov;8(2):183-200. Links

Iron, neuroinflammation, and Alzheimer's disease.

Ong WY, Farooqui AA.

Department of Anatomy, National University of Singapore, Singapore
119260.

The present article reviews the roles and interactions of iron and
neuroinflammation in Alzheimer's disease. It highlights the importance
of neuroinflammatory changes in the glial scar after neuronal injury,
in promoting iron accumulation, and iron-dependent oxidative damage.
Elevation of iron in Alzheimer's disease not only affects amyloid
precursor protein processing and mitochondrial function but also
induces the aggregation of Abeta peptide and abnormalities in signal
transduction processes associated with oxidative damage. Collective
evidence suggests that although alterations in iron homeostasis may not
be the primary triggering event that starts the pathological cascade of
Alzheimer's disease, it is an important factor involved in
neuroinflammation and progression of this disease.

PMID: 16308487 [PubMed - as supplied by publisher]

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