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Medical Forum / Diseases and Disorders / Alzheimer's / July 2005Curcumin breaks up AD plaque
This recent article from Japan shows that AD plaque can be broken up by using the spice Curcumin. Curcumin is extracted from Turmeric and is generally considered to be safe as it has been in customary use for centuries in India. (Disclosure of interest by myself who is in care of LO who has dementia: curcumin can be obtained here at my site: www.turmericextract.com) "... we examined the effects of curcumin (Cur) and rosmarinic acid (RA) on the formation, extension, and destabilization of fAbeta(1-40) and fAbeta(1-42) at pH 7.5 at 37 degrees C in vitro. ... Cur and RA dose-dependently inhibited fAbeta formation from Abeta(1-40) and Abeta(1-42), as well as their extension. In addition, they dose-dependently destabilized preformed fAbetas. ... Although the mechanism by which Cur and RA inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro remains unclear, they could be a key molecule for the development of therapeutics for AD." J Neurosci Res. 2004 Mar 15;75(6):742-50. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Notes: Abeta = waxy starch used by brain to repair brain cells. fAbeta = Abeta in toxic fibril form where it has become oxidized and has begun to bind together with other fibrils of the same matter. > This recent article from Japan shows that AD plaque can be broken up by > using the spice Curcumin. Curcumin is extracted from Turmeric and is [quoted text clipped - 22 lines] > fAbeta = Abeta in toxic fibril form where it has become oxidized and has > begun to bind together with other fibrils of the same matter. So, how do you get the Curcumin into the brain? Or was this by any chance an experiment in a petri dish? ...oh yes, so it was. No doubt a thousand other chemicals could be shown in a petri dish to have one effect or another on plaques. Getting them into the brain, (and then showing they are safe in the brain), is another matter entirely.  SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com > > [quoted text clipped - 33 lines] >brain), is another matter entirely. > You're right, this experiment was in a dish but others are in mice and rats and the curcumin, in metabolic form, does get in. The reason why it gets in is because its a fat-soluble food (it won't dissolve in water and blood is basically water) and although the brain has a "Blood-Brain-Barrier" around it, the BBB is a layer of fat and only accepts fat-soluble substances. Curcumin therefore can enter. This explanation probably is not entirely accurate but it will serve for this purpose. In any case, its an emipirical question and has never been in question. As to safety of Curcumin in the brain, it is important to be careful that one is not turning the brain into a chemlab, but Indians and others consume Turmeric at a huge rate and the amount of Turmeric extract (Curcumin) that they consume per day is estimated to be 80-200mg. Indians use Turmeric and Curcumin as an alternative to refrigeration to preserve food in a tropical climate. The Medscape article on Curcumin concludes: "... appears generally safe." IMO, dissolve the Turmeric Extract into a spoonful of pure DHA (the most important Omega-3 fatty acid, taken from fish oil or from wherever the fish get it, eg algae) or fish oil itself and take it that way. Abeta (the pristine form of waxy starch in the brain) loves fish oil (see Koudinov's reasearch) and combines with it to patch up brain cells and their synapses. The DHA will be protected from oxidation on the way into the body and brain by the Curcumin, and the Curcumin will be combined suitably with an oil-fat to help escort it across the BBB. I'm sure Dr Harmon has quoted Koudinov's articles somewhere as he/she has quoted everyone else at some time :) >>>This recent article from Japan shows that AD plaque can be broken up by >>>using the spice Curcumin. Curcumin is extracted from Turmeric and is [quoted text clipped - 57 lines] > quoted Koudinov's articles somewhere as he/she has quoted everyone else at > some time :) Dr. Harmon is a troll, who has mostly been killfiled by everyone here. He floods this newsgroup with enormous messages and responds to no one. SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') > I'm sure Dr > Harmon has quoted Koudinov's articles somewhere as he/she has quoted > everyone else at some time :) "dr. harmon" is a quack. quack. quack. quack. and a spammer. if you keep up with this nonsense, you'll get killfiled by everyone in the group just like he has been. you'd have to eat so much turmeric that you'd be permanently jaundiced before you'd get a high enough curcumin level to make the slightest difference. > > [quoted text clipped - 13 lines] > > Yes, you would have to eat a lot of turmeric but not turmeric extract (curcumin). Its about a 20:1 ratio of dry turmeric root to pure curcumin so you just eat 1 gm (1 level teaspoon) of curcumin per day. It has no unpleasant flavor, nor odour and goes well, colorwise, with apricot or mandarin yoghurt. I don't know about Dr Harman being a quack - he's just quoting Pubmed (National Library of Medicine) articles on an industrial scale ... I use Outlook Express and added Dr. Harman to my blocked sender's list. Really cleaned up this newsgroup to the more relevant postings from real people with real concerns..... As for the turmeric ...what the heck it's cheap enough. The thing that I take that seems to make the biggest difference mentally and physically for me is Acetyl L-Carnitine. I couldn't believe the energy I have from taking this supplement. It works best with coenzyme Q10. I had lost my sense of taste last year after a cold so after several months of taste loss I decided that I was going to have to go to a doctor or try a natural remedy. I did some research on the internet and started taking Alpha Lipoic Acid and now I can even taste lettuce! I've read that a change in taste can precede dementia so I thought I would share this. I'll admit I strongly believe in supplements. These things aren't cheap but then neither is going to the doctor. My mother who has dementia has vitamin B12 shots once a month for a deficiency and all the family has noticed a difference when she has these shots. She seems a little better mentally. I know nothing can reverse this awful disease as of yet. So I figure I have nothing to lose by taking these supplements especially when I can tell they're helping me now..... >> I'm sure Dr >> Harmon has quoted Koudinov's articles somewhere as he/she has quoted [quoted text clipped - 7 lines] > jaundiced before you'd get a high enough curcumin level to make > the slightest difference. June, That's interesting. Which one (out of CoQ10, ala and acetyl-l-carnitine) gave you the taste back and which the energy? Was there any effect on short-term memory? I take about 200 to 300 mg of Alpha Lipoic Acid a day for my sense of taste. I take 500mg of the Acetyl L-Carnitine for energy. Both of these work along with Co Q10 (75mg The Andrew Lessman formula) I do not have a short term memory problem so I can't answer you on that one. I have noticed that I can find the word I'm trying to say maybe a wee bit quicker with Acetyl L-Carnitine and I feel sharper mentally but that could be because I feel more energetic. I do take a good multi-vitamin everyday as well. I take other supplements including calcium and lutein. If I could only take one pill a day it would be The Acetyl L-Carnitine. I take care of a 4 year old grandson and I need the extra energy. I always look for supplements in capsule form so the body can absorb them. I've been a strong believer in nutritional supplements for many, many years. I retired in '98 and I feel better these days than at any other time in my life! > June, > > That's interesting. Which one (out of CoQ10, ala and acetyl-l-carnitine) > gave you the taste back and which the energy? Was there any effect on > short-term memory? > I've read that a change in taste can precede > dementia so I thought I would share this. it can also signal serious liver problems, either cancer or cirrhosis. when food tastes metallic, it's an indication of liver failure, according to the oncologist who told me. Good point I would advise anybody who has had this happen to see a doctor. But a loss of the sense of smell and taste runs in my family. Both of my brothers have this same problem. >> I've read that a change in taste can precede >> dementia so I thought I would share this. > > it can also signal serious liver problems, either cancer or > cirrhosis. when food tastes metallic, it's an indication of > liver failure, according to the oncologist who told me. |
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