Neurobiol Aging. 2005 Apr 30; [Epub ahead of print] Related Articles,
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Blueberry supplemented diet reverses age-related decline in hippocampal
HSP70 neuroprotection.

Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA.

Neuroscience Laboratory, USDA-ARS Human Nutrition Research Center on
Aging at Tufts University, 711 Washington St., Boston, MA 02111, USA;
Department of Psychology, Simmons College, 300 The Fenway, Boston, MA
02115-5898, USA.

Dietary supplementation with antioxidant rich foods can decrease the
level of oxidative stress in brain regions and can ameliorate
age-related deficits in neuronal and behavioral functions. We examined
whether short-term supplementation with blueberries might enhance the
brain's ability to generate a heat shock protein 70 (HSP70) mediated
neuroprotective response to stress. Hippocampal (HC) regions from young
and old rats fed either a control or a supplemented diet for 10 weeks
were subjected to an in vitro inflammatory challenge (LPS) and then
examined for levels of HSP70 at various times post LPS (30, 90 and
240min). While baseline levels of HSP70 did not differ among the
various groups compared to young control diet rats, increases in HSP70
protein levels in response to an in vitro LPS challenge were
significantly less in old as compared to young control diet rats at the
30, 90 and 240min time points. However, it appeared that the blueberry
diet completely restored the HSP70 response to LPS in the old rats at
the 90 and 240min times. This suggests that a short-term blueberry (BB)
intervention may result in improved HSP70-mediated protection against a
number of neurodegenerative processes in the brain. Results are
discussed in terms of the multiplicity of the effects of the BB
supplementation which appear to range from
antioxidant/anti-inflammatory activity to signaling.

PMID: 15869824 [PubMed - as supplied by publisher]

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