Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase
Activities

Hye Kyung Kim1, Mija Kim2, Sunki Kim3, Mujo Kim4, and Joo Ho Chung5

1Department of Food and Biotechnology, Hanseo University, Seosan
356-706, Korea
2Graduate School of Obesity Science, Dongduk Womens University, Seoul
136-714, Korea
3Doosan Biotechnology, BU, Sooji, Yonginsi, Kyunggido, 449-844, Korea
4Pharma Foods International, Minami-ku, Kyoto 601-8357, Japan
5Department of Pharmacology, College of Medicine, Kyung Hee University,
Seoul 130-701, Korea

The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase
activity was examined in scopolamine-treated mice. Chronic
administration of TP significantly reversed scopolamine-induced
retention deficits in both step-through passive avoidance and
spontaneous alternation behavior tasks. Furthermore, TP exhibited a
dramatic inhibitory effect on acetylcholinesterase activity. This
finding suggests that TP might be useful in the treatment of
Alzheimers disease.

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