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Medical Forum / Diseases and Disorders / Alzheimer's / April 2005Cognition / oxidative stress
Neurology. 2005 Apr 12;64(7):1152-6. Links Evidence of increased oxidative damage in subjects with mild cognitive impairment. Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfield DA, Markesbery WR. Department of Anatomy, University of Kentucky, Lexington 40536-0230, USA. Jnkell0@pop.uky.edu OBJECTIVE: To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS: The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD. RESULTS: Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined. CONCLUSION: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease. PMID: 15824339 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://herbivore.7h.com Mult Scler. 2005 Apr;11(2):191-7. Related Articles, Links Pattern of neuropsychological impairment in the early phase of relapsing-remitting multiple sclerosis. Olivares T, Nieto A, Sanchez MP, Wollmann T, Hernandez MA, Barroso J. Facultad de Psicologia, Universidad de La Laguna, La Laguna 38205, Tenerife, Islas Canarias, Spain. To investigate the neuropsychological profile in the first few years post-onset of relapsing-remitting multiple sclerosis (MS) we carried out a comprehensive neuropsychological evaluation of 33 patients characterized by very short evolution of this disease, minimal levels of neurological disability and preserved general cognition. Thirty-three individually pair-matched controls were also evaluated. Patients performed as well as controls on many of the cognitive exploration measures. Nevertheless, the group of patients evinced a general slowness that affected motor execution and cognitive processing. Memory functions were characterized by preservation of working memory, retrieval or storage of information and a deficit at the acquisition phase in (verbal and visual) supraspan tasks. In addition, significant correlations were observed between some measures of information processing speed and memory. These results highlight the importance of studying cognitive deficits not only in the different subtypes of MS but also in different phases of the disease. PMID: 15794394 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEADPEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking There's no mention whatsoever of oxidative stress here, Tom. If you're hallucinating again, you must have forgotten your meds. > Mult Scler. 2005 Apr;11(2):191-7. Related Articles, Links > [quoted text clipped - 35 lines] > DEADPEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking Yes, and this is also understood to be the mechanism for cognitive damage from statin drugs (Lipitor, Crestor, Zocor, Pravachol, Lescol, Mevacor, and Baycol). Statin drugs depelete body of CoQ10, an antioxidant that is normally manufactured in the body, but statins interrupt that process. > Neurology. 2005 Apr 12;64(7):1152-6. Links > [quoted text clipped - 34 lines] > Jesus Was A Vegetarian! > http://herbivore.7h.com > Yes, and this is also understood to be the mechanism for cognitive damage > from statin drugs (Lipitor, Crestor, Zocor, Pravachol, Lescol, Mevacor, and > Baycol). Understood mechanism for cognitive damage? Maybe it's the milk they are drinking? Here's the proven understood mechanism. The milk causes your lungs to glue together and causes depletion of oxygen and in so doing your body is forced into making ROS causing the damage. That's been understood for many years now. > Statin drugs depelete body of CoQ10, an antioxidant that is normally > manufactured in the body, but statins interrupt that process. Everybody knows that. There's a million people with muscle damage and renal failure and cognitive damage. >> Yes, and this is also understood to be the mechanism for cognitive damage >> from statin drugs (Lipitor, Crestor, Zocor, Pravachol, Lescol, Mevacor, [quoted text clipped - 14 lines] > renal > failure and cognitive damage. Actually, there is measurable evidence of cognitive damage after only 6 months of statin use. See Dr. Muldoon's studies. Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. Am J Med. 2004 Dec 1;117(11):823-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15589485 Effects of lovastatin on cognitive function and psychological well-being. Am J Med. 2000 May;108(7):538-46. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=10806282 BTW, CoQ10 affects quite a bit of the body, and a deficiency caused by statin drugs can impact the body in many ways. See the presentations from last weekend below: Programme of the 4th Conference of the International Coenzyme Q10 Association Beverly Hilton, Los Angeles, April 14-17 2005 Thursday, April 14th 14.00 - 19.00 Registration 19.00 Welcome reception Friday, April 15th 8.30 - 8.50: Introductory remarks: Bioenergetics and Biosynthesis Chairpersons: G. Lenaz and E. Cadenas 8.50 G. Lenaz The existence of supercomplexes of the mitochondrial respiratory chain: the role of Coenzyme Q diffusion and implications in human pathology 9.10 G. Dallner Regulation of coenzyme Q synthesis by endogenous modified intermediates 9.30 C. Clarke Genetic and Physical Evidence for a Coenzyme Q Biosynthetic Complex 9.50 J. Olsson Reduction of coenzyme Q10 by thioredoxin reductase. A reaction dependent on the selenium concentration. 10.10 - 10.30 Discussion 10.30 - 10.50 Coffee break 10.50 P. Navas Q biosynthesis during development and aging 11.10 M. Kawamukai Prenyl diphosphate synthases from higher eukaryotes 11.30 - 11.40 Discussion Non mitochondrial electron transport and antioxidant aspects Chairpersons: T. Kishi and L. Packer 11.40 T. Kishi Extra-mitochndrial CoQ redox cycle and cellular defense mechanism 12.00 J. Villalba Interference of cell cycle checkpoint by quinone reductase inhibitors. 12.20 J. Morrè CoQ/CoQH2 ratios from plasma membrane electron transport ceramide and shingosine-1-phosphate levels during GL arrest and apoptosis. 12.40 - 13.00 Discussion 13.00 - 14.30 Lunch Plasma and tissue concentrations Chairpersons: GP Littarru and T. Menke 14.30 M. Miles Serum levels in children, adults and in metabolic syndrome 14.50 P. Palan Serum levels in pregnancy and menopause 15.10 T. Menke Measurement of CoQ10 in plasma and blood cells in childhood: Age related reference values, disease related changes and comparison of values in plasma and blood cells after oral supplementation 15.30 Lili Miles CoQ10 content of skeletal muscle 15.50 RB. Singh Effect of oral coenzymeQ10 dosages on serum Q10 and MDA levels among healthy men. 16.10 - 16.30 Discussion 16.30 - 16.50 Coffee break Effect of CoQ10 in gene expression Chairpersons: C. Clarke and G. Dallner 16.50 D. Groneberg Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells 17.10 H. Nohl Ubiquinol and the papeverine derivative caroverin prevent the expression of tumor-promoting factors involved in coloncarcinogenesis induced by dietary-fat nutrition 17.30 -17.50 Discussion 17.50 - 18.30 Poster Session - R. Kalpravidh (beta-thalassemia), De Luca-Korkina (Coenzyme Q10 treatment in burns) 18.30 - 19.30 Meeting of participants involved in the Q-Symbio trial Saturday, April 16th Neuromuscular and neurodegenerative diseases Chairpersons: C. Shults and A. Naini 8.30 F. Beal Preclinical Studies of CoQ in Neurodegenerative Diseases and Clinical Trials 8.50 Geng Li Volume MRI Study: The effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia 9.10 R. Artuch Familiar cerebellar ataxia caused by primary coenzyme Q10 deficiency 9.30 C. Shults Clinical Trials of Coenzyme Q10 in Neurological Diseases 9.50 Y. Yamamoto Redox status of CoQ in neurodegenerative syndromes 10.10-10.30 Discussion 10.30 -10.50 Coffee break Role in aging mechanisms Chairpersons: P. Navas and R. Sohal 10.50 R. Sohal Effects of coenzyme Q intake on the aging process 11.10 J. Quiles Coenzyme Q supplementation in aging 11.30 S. Hekimi Multiple ubiquinone-dependent processes as revealed by clk-1 mutants 11.50 C. Santos Ocana Yeast YML125C, a Q-dependent PM reductase and aging control 12.10 -12.30 Discussion 12.30 - 14.30 Lunch break Cardiovascular diseases Chairpersons: SA. Mortensen and R. Belardinelli 14.30 B. Golomb Clinical follow-up after stopping statin treatment 14.50 P. Langsjoen Adverse consequences of HMG-CoA reductase inhibitors in clinical cardiology and their response to supplemental CoQ10 15.10 M. Silver Lipitor/CoQ10/Diastolic Dysfunction study 15.30 H. Mabuchi Reduction of Serum Ubiquinol-10 and Ubiquinone-10 Levels by Atorvastatin in Hypercholesterolemic Patients 15.50 K. Adarsh Atorvastatin alone/in combination with coenzyme Q10 in 103 cases of heart failure (HF) due to ischemic cardiomyopathy (ICM). 16.10 - 16.30 Discussion 16.30 - 16.50 Coffee break Chairpersons: P. Langsjoen and B. Golomb 16.50 SA. Mortensen Q-Symbio study status 17.10 F. Rosenfeldt Metabolic, Physical and Mental preoperative approach to surgery 17.30 R. Stocker Plasma CoQ10 concentration and cardiovascular disease outcome 17.50 R. Belardinelli High-dose coenzymeQ10 improves the contractile response to dobutamine of dysfunctional myocardium in patients with ischemic cardiomyopathy 18.10 - 18.30 Discussion 18.30 - 19.30 Poster session 20.00 Social dinner Sunday, April 17th Various clinical fields Chairperson: Udo Hoppe and F. Beal 8.40 E. Teran Preeclampsia and CoQ10 9.00 A. Mancini CoQ10 levels in sperm cells and seminal plasma: physiopathological implications 9.20 G. Balercia Treatment of idiopathic asthenozoospermia with coenzyme Q10 9.40 Y. Ashida (Shiseido) CoQ10 intake elevates the epidermal CoQ10 level in adult hairless mice 10.00 T. Blatt (Beiersdorf) Stimulation of the Skin`s Energy Metabolism Provides Multiple Benefits 10.20-10.40 Discussion 10.40 -11.00 Coffee break 11.00 O. Gabrielli CoQ10 trial in Down syndrome 11.40 L. Korkina Coenzyme Q in treatment of the alkali-injured rabbit cornea 12.0 J. Feher CoQ10 in combination with acetyl-L-carnitine and omega -3 improves age-related macular degeneration 12.20 Discussion and conclusions 13.00 Lunch >>> Yes, and this is also understood to be the mechanism for cognitive >>> damage [quoted text clipped - 36 lines] > > Beverly Hilton, Los Angeles, April 14-17 2005 I was taking 150 mg of coenzyme Q-10 per day while I was taking lipitor, and I still had horrible side effects of muscle pain and extreme muscle weakness. It may have some effect on memory, but it certainly isn't the cause of alzheimers. My mother in law never took a statin drug and she is dying this moment at 84 of the disease. My father is 92 and he is doing fine, been on statin drugs for years. I have seen your posts before regarding statin drugs. Are you a troll?  SignatureBest Regards, Evelyn (to reply personally, remove 'sox') > I was taking 150 mg of coenzyme Q-10 per day while I was taking lipitor, and > I still had horrible side effects of muscle pain and extreme muscle [quoted text clipped - 7 lines] > I have seen your posts before regarding statin drugs. > Are you a troll? Sharon isn't a troll, she's a necessary counterbalance to all the well heeled drug peddlers out there. The information she presents is always useful, even if her assertions are sometimes a tad broad. Susan > x-no-archive: yes > Sharon isn't a troll, she's a necessary counterbalance to all the well > heeled drug peddlers out there. [quoted text clipped - 3 lines] > > Susan Hi Susan, I do respect your opinion (as you already know) and was planning to write to you again about your regimen for alternative cholesterol control. Please post it again, and if you would prefer, you could write me again personally with it. Be sure to remove "sox" from my address. After we last spoke, my doctor pursuaded me to give the Lipitor a second shot. It worked, (got down to under 200) but the cost in quality of life, was too high! Been off it for a week and I already feel better! SignatureBest Regards, Evelyn (to reply personally, remove 'sox') > x-no-archive: yes > > > I was taking 150 mg of coenzyme Q-10 per day while I was taking lipitor, and > > I still had horrible side effects of muscle pain and extreme muscle > > weakness. > > [quoted text clipped - 10 lines] > > The information she presents is always useful, even if her assertions > are sometimes a tad broad. > > Susan I can attest that Sharon Hope is not a troll. Nor am I. And though I have had cognitive damage from statins, including short term memory loss, working memory loss (what you need to learn), aphasia (loss of language, word loss, vocabularly loss, confusion of words, spelling and syntax difficulties, forgetting what you want to say by the time you get to the end of the sentence, inability to follow a conversation; loss of memory of things one used to do for years for example driving a car or knitting, spatial loss, becoming lost in one's own neighbourhood, forgetting if one ate, or how to get dressed--on and on. I have partly recovered so I can tell people: statin cognitive damage is real. It is not Alzheimerer's although often misdiagnosed as such, and although if caught in time one can recover, it can cause permanent damage. I know people who will never recover from frontal lobe damage and damage to the cerrebelum. Alheimer's is a terrible disease. Do not accept this diagnosis without a complete examination of ALL the possibilities. Most of all, do not let anyone with dubious motives imply you or your affected loved one are a "tad broad" or mentally ill. Zee >>>> Yes, and this is also understood to be the mechanism for cognitive >>>> damage [quoted text clipped - 45 lines] > this moment at 84 of the disease. My father is 92 and he is doing fine, > been on statin drugs for years. Evelyn, No, the memory loss from statin drugs is real, and is just as debilitating as Alzheimers, but does not cause death (to my knowledge) - although the muscle damage from statins can cause death by rhabdomyolysis. Alzheimer's is a separate and distinct condition. Never in any of my posts will you see me confuse the two. They are absolutely different. HOWEVER, there are many many MANY primary care physicians who DO confuse the two. Many many statin patients who are suffering cognitive damage from statins, including extreme short-term memory loss and multiple episodes of transient global amnesia, are at first MISDIAGNOSED as having Alzheimer's. In this misdiagnosis, not only is there the additional stress and trauma of being told INCORRECTLY that they have Alzheimers, but the statin drug, which is CAUSING the damage, is continued to be prescribed, so the damage worsens until they get Alzheimers ruled out. I have asked several times, and have read other people ask, and they have always been told that this is a support group for people with, and families of people with MEMORY LOSS, and it does not have to be just Alzheimer's. > I have seen your posts before regarding statin drugs. > Are you a troll? I am the wife (of 38 years) of a man who was twice a corporate CEO, who took Lipitor 10mg/day for 4 years in his mid-50's and is now completely disabled from Lipitor side effects. He has been off the Lipitor for 3 years and has worked weekly with a Cognitive Rehabilitation Therapist, struggling to recover from these adverse effects. His neuromuscular damage is so debilitating that he can hardly walk - a major improvement from the day that he stopped taking the Lipitor. He is in constant excruciating chronic pain. His short term memory is still in the NP-tested "Impaired" range. His business is gone and he is unable to conduct daily activities in any semblance of his pre-Lipitor routine. Since he was afflicted by these horrific side effects and has become so thoroughly disabled and is in so much pain and distress, I have made the discovery that many, many others are similarly affected. Since this is a support group that welcomes families of those with horrific memory loss, and I am one of those, I come to this group for support, as many others do. I also offer my experience and what I have learned up to others who might have been misled into thinking their loved one has Alzheimers, if it is in fact possible or even likely that the damage is actually a side effect of the most-prescribed of all drugs in the world right now, and in history: Statins. So far, the tragedy of Alzheimer's is not yet preventable. Statin Cognitive Damage is absolutely preventable - it only takes an awareness campaign and doctors monitoring for it. So far they do not. There is no reason for people to suffer statin memory loss, but far too many do experience it. I am in contact with 2 women this month alone, whose husbands were tested below the 10 percentile in short-term memory, DUE TO STATINS. I know of 3 families who have lost their homes JUST THIS MONTH due to the economic impact of this disabling condition striking the breadwinner. How many people asked you if there were any chance of statin adverse effects being eliminated as the cause of memory loss in the significant person in your family, prior to a diagnosis of ALZ? Any? Why not? You can read about my husband's case at: http://www.n3inc.com/SmartMoneyReprint_103003Web.pdf You can read about some of his amnesia episodes in "Lipitor, Thief of Memory" at http://www.spacedoc.net/ There are also publication-pending medical studies that contain his case. |
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