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Medical Forum / Diseases and Disorders / Alzheimer's / April 2005

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Popular Alzheimer's Drug Found to Be All But Worthless in Independent Study

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Tim Campbell - 11 Apr 2005 06:19 GMT
A new independent study, conducted at the University of Birmingham, UK,

reveals that a popular prescription drug for Alzheimer's disease,
Aricept, offers no real benefit to Alzheimer's patients compared to
placebo.
And yet, the drug has been approved and heavily marketed based on
findings from drug trials funded by its maker who claims the drug
benefits Alzheimer's patients in scientifically proven ways.
As it turns out, the drug does seem to help Alzheimer's patients score

slightly higher on cognitive tests, but it has no real benefit in
delaying the institutionalization of Alzheimer's patients.

In the study, 42% of candidates taking the drug ended up in
institutions
within 3 years, compared to 44% who ended up in institutions after
taking placebo.

The author of this study, Richard Gray, said, "Doctors and health care

funders need to question whether it would be better to invest in more
doctors and nurses and more social support rather than spending huge
sums of money prescribing these expensive drugs."

The findings presented here certainly don't surprise me. When
independent studies are conducted on high-profit, brand-name
prescription drugs, they typically come to a very different conclusion
than the one offered by the manufacturer of that drug.

As we know, drug trials are frequently distorted and selected to show
only the positive results. These findings are then forwarded to the
FDA,
where the drugs are approved for widespread use.

But during this process, studies showing negative effects of the drug
are ignored or buried and are almost never made public unless they have

to be revealed in lawsuits. What we see in this case is a very
expensive
Alzheimer's drug that, from a scientific standpoint, has little or no
benefit to patients, but yet is right now being marketed and prescribed

as something that offers a tremendous benefit to patients.

If you look at the marketing materials offered by the manufacturer of
Aricept, you will find a large number of statements that imply this
drug
enhances the quality of life of Alzheimer's patients (and especially
boosts their mental performance in significant ways).

But as this independent study seems to indicate, those claims are
distorted, or, you could say they are accurate but they are highly
selective statements, designed to get physicians and patients to focus
on the few things the drug does improve, while ignoring the overall
quality of life to the patient (which is not improved by the drug).

All of this is yet more evidence that prescription drugs largely do not

work. They are over-hyped, over-sold, and approved for widespread use
under rather dubious conditions. In an astounding number of cases, when

FDA-approved prescription drugs are held up to the scrutiny of
independent tests, they are found to be all but worthless.

As Americans, we are being sold empty promises in the form of extremely

expensive prescription drugs marketed by companies that seem to be far
more interested in profits than in improving the quality of life of
people around the world.

Alzheimer's drugs in particular are extremely profitable due to the
growing epidemic of Alzheimer's in the United States and around the
world. In the decades ahead, Alzheimer's disease is expected to
skyrocket, creating potentially a multi-billion dollar market for
prescription drugs to treat the symptoms of the disease.
You can bet that more and more of these prescription drugs will be
approved and marketed with dubious claims that exaggerate the benefits
of the drug and minimize the drug's risks.

If you really want to prevent Alzheimer's, you can do that by making
lifestyle changes. You can change your diet, give yourself outstanding
nutrition (see related ebook on nutrition) (search this site for
"Alzheimer's" to learn more), and avoid the "metabolic disruptors" that

disrupt normal nervous system function in the human body.

Those include ingredients such as MSG, aspartame, and artificial
colors. You can also engage in mentally challenging activities such as
doing crossword puzzles, playing card games with friends, giving
speeches, or playing strategy games. Learning a new language also
engages the brain and helps prevent Alzheimer's.

Sitting in front of the TV, on the other hand, promotes the onset of
Alzheimer's.
http://www.newstarget.com/001692.html
Dennis P. Harris - 11 Apr 2005 08:10 GMT
> A new independent study, conducted at the University of Birmingham, UK,
>
> reveals that a popular prescription drug for Alzheimer's disease,
> Aricept, offers no real benefit to Alzheimer's patients compared to
> placebo.

cite this "study", please.  who published it?  was it in a
refereed journal?  are you a doctor or just a crank?

there are many folks here who can tell you that when their LO
stopped using aricept, the LO presented with far more impairment.
Mary_Gordon@tvo.org - 11 Apr 2005 11:32 GMT
The study came out in summer of 2004, so this isn't breaking news.

http://www.alzheimersissues.com/ms/news/519718/main.html

If you do a google on it, you'll find lots of controversy around the
findings. Their main argument seemed to be one of cost benefit - i.e.
the tiny differences aren't worth the cost of the drug. Personally, I
wish it had been around during my MIL's journey, because when you've
got no hope, anything that does SOMETHING, however incrememental, is
better than nothing.

Mary G
Tim Campbell - 13 Apr 2005 15:37 GMT
> cite this "study", please.  who published it?  was it in a
> refereed journal?  are you a doctor or just a crank?

Take the first line of the post and do a search on it...One can always
do this to track down the source of any post...
Dennis P. Harris - 14 Apr 2005 02:15 GMT
> > cite this "study", please.  who published it?  was it in a
> > refereed journal?  are you a doctor or just a crank?
>
> Take the first line of the post and do a search on it...One can always
> do this to track down the source of any post...

nope.  not good enough.  if you want folks to believe you, you
have to cite where the "paper" was PUBLISHED in a peer reviewed
journal.

you're just another crank that's in my killfile now.  PLONK.
Partran - 19 Apr 2005 00:03 GMT
> > > cite this "study", please.  who published it?  was it in a
> > > refereed journal?  are you a doctor or just a crank?
[quoted text clipped - 7 lines]
>
> you're just another crank that's in my killfile now.  PLONK.

The article later sited from http://www.newstarget.com/001692.html
fails to state where the article can be found published, therefore I
can't see the study itself.

I don't doubt their findings were properly reported by the media, but
their methods and such were not made public. Also, we aren't privy to
whether or not the study was looking at the group the FDA has approved
the drug for or for more severe cases. Recall that Aricept is only FDA
approved for treatment of mild to moderate Alzheimers.

While it may be something to keep an eye out for, with the bredth of
positive anecdotal evidence and without the study itself, I'll have to
take this news story with a grain of salt. It may very well have been
shown to be ineffective, but that may be for special populations, or
patients with early onset AD, or any other number of mitigating
factors.

-Nathan
(Pharmacy student)
Tumbleweed - 11 Apr 2005 08:17 GMT
<snip>

> The findings presented here certainly don't surprise me. When
> independent studies are conducted on high-profit, brand-name
> prescription drugs, they typically come to a very different conclusion
> than the one offered by the manufacturer of that drug.

It surprises the hell out of me, my dad showed a large and immediate decline
with a few days of stopping, a significant improvement when he started
again, and an even worse decline when he finally stopped. These declines
were within days first time, and weeks second.
Signature

Tumbleweed

email replies not necessary but to contact use;
tumbleweednews at hotmail dot com

Anthony Shipley - 11 Apr 2005 10:45 GMT
>It surprises the hell out of me, my dad showed a large and immediate decline
>with a few days of stopping, a significant improvement when he started
>again, and an even worse decline when he finally stopped. These declines
>were within days first time, and weeks second.
After tests indicating a deterioration during the period of taking Aricept, I
was taken off that. Because the government sponsors most of the cost, they won't
continue treatment unless there are signs of improvement.

I'm now on Ritenal. At first, the side-effects were almost entirely gone--but
sadly--some, at least, seem to be creeping back. Even so, I feel much better
without the Aricept. I still get very sleepy but don't know if it's the Prozac
or not (anti-depressants always had that side-effect).

-
Mind control is being able to make all the voices in your head take turns.

Mod as a hooter!
pitirish - 12 Apr 2005 04:41 GMT
Hi Tumbleweed,

Would you please briefly discuss the conditions under which your dad had to
stop taking Aricept? My wife has been on 10mgs per day for years. If there
are steps I can take now to prevent her from reaching a point or developing
a symptom  which would cause her doctor to stop her Aricept, I'd like to
prepare for the possibility now.

Thank you for the response.

go'l.

> It surprises the hell out of me, my dad showed a large and immediate
> decline with a few days of stopping, a significant improvement when he
> started again, and an even worse decline when he finally stopped. These
> declines were within days first time, and weeks second.
Tumbleweed - 12 Apr 2005 07:52 GMT
The first was money ..the doctor felt it wasnt doing any good and stopped it
on the grounds it was needless expenditure. The decline was so marked that
within a week my mother was at the doctors crying hysterically, and he was
restarted. The second time was when he was switched to memantine. At that
time memantine was new in the UK and he was part of a trial. In order to be
on the trial he couldnt be on anything else. We felt it was worth the risk,
but maybe 12 or so weeks later he was in care due to the fact that my mother
coudnt cope with him any more. Nowadays aricept and memantine together are
usally recommended. FWIW I do think that second time round he would have had
to be placed in care within a few months anyway but there was still a
notable deterioration.

Signature

Tumbleweed

email replies not necessary but to contact use;
tumbleweednews at hotmail dot com

> Hi Tumbleweed,
>
[quoted text clipped - 12 lines]
>> started again, and an even worse decline when he finally stopped. These
>> declines were within days first time, and weeks second.
Baird Stafford - 11 Apr 2005 10:50 GMT
> A new independent study, conducted at the University of Birmingham, UK,
>
[quoted text clipped - 8 lines]
> slightly higher on cognitive tests, but it has no real benefit in
> delaying the institutionalization of Alzheimer's patients.

<snip>

I want to see more than one study on this, please (and please tell me
where I can get a copy of this particular study, at that).  All too
often, sensational single studies are not repeatable under laboratory
control.

> If you really want to prevent Alzheimer's, you can do that by making
> lifestyle changes. You can change your diet, give yourself outstanding
[quoted text clipped - 4 lines]
>  Those include ingredients such as MSG, aspartame, and artificial
> colors.

Please cite reputable studies that confirm these claims.

> You can also engage in mentally challenging activities such as
> doing crossword puzzles, playing card games with friends, giving
> speeches, or playing strategy games. Learning a new language also
> engages the brain and helps prevent Alzheimer's.

To the best of my knowledge, none of these things have been proven to
*prevent* Alzheimer's in controlled, double-blind studies.  The most
that has yet been claimed for such activities is that they may slow down
the progress of the disease.

>  Sitting in front of the TV, on the other hand, promotes the onset of
> Alzheimer's.

Again, not proven - along with electrical power lines, radar, microwaves
or any other modern development.

Incidentally, if TV promotes the onset of the disease, what on *earth*
does sitting in front of computer monitors for countless hours each day
do?

Blessed be,
Baird

Signature

Modkin of soc.religion.paganism
Modstaff of alt.religion.wicca.moderated
Newstaff, Inc. at newstaff.com

Stephen - 11 Apr 2005 12:59 GMT
>Incidentally, if TV promotes the onset of the disease, what on *earth*
>does sitting in front of computer monitors for countless hours each day
>do?
>
>Blessed be,
>Baird

Well, then, I'm in trouble. :-) For the record, my mom is at late/middle stages.
She recognizes familiar people, but doesn't relate that recognition to specific
familiarity, i.e., I am her best friend and not her son. She is not on Aricept,
but on Reminyl. She is also on Riserdal for delusions and Paxil for depression.
The combination of these drugs is a blessing. I don't expect any of them to do
more than make life with her bearable and to keep her calm and happier.
-steve
Evelyn Ruut - 11 Apr 2005 13:14 GMT
> A new independent study, conducted at the University of Birmingham, UK,
>
[quoted text clipped - 91 lines]
> Alzheimer's.
> http://www.newstarget.com/001692.html

I disagree completely with all the above.

I am sorry to tell you this, but there was VAST NOTICEABLE difference when
my mother in law gave up Aricept, and we couldn't WAIT to get her back on
it, in which the problems almost immediately reversed, and she was better
(though she still had alzheimers)

In her case it definitely helped her.

Signature

Best Regards,
Evelyn

(to reply personally, remove 'sox')

Karen - 12 Apr 2005 04:29 GMT
Sorry, but I've seen the improvement Aricept made with my MIL.  And been
told by healthcare workers that they have seen patients experience severe
quality of life issue when it's stopped.  Not just cognitive issues but
simple things like continence, swallowing and other body functions.

I've often wondered if people that have Alzheimer's watch more TV because
it's a non-demanding activity they feel comfortable with and if people that
do mentally stimulating activities do them because they can.  I am certain
Alzheimer's has an onset much earlier than we currently acknowledge.
Haven't seen any data on that opinion, just my MIL and a few others (not a
statistical universe).

Hubby's neurologist says MSG and aspartame are the main causes of migraines
and I believe it.  The first NutraSweet gumballs I tried gave me a ripping
headache and MSG has always produced a reaction too.  But as far as causing
Alzheimer's?  They need to get in line behind the kajillion other things we
eat, breath and drink that are also unhealthy.  How many people ever read
the hazard notice for the toner used in their office copier?  And how many
people didn't grow up with a strange old lady or man down the street that
seemed unbalanced but nobody knew what to do with them?  IMO, Alzheimer's
and dementia are old problems we've just become better at diagnosing.

Sorry, I'm not up to hyperventilating over this one.

Karen

> A new independent study, conducted at the University of Birmingham, UK,
>
[quoted text clipped - 91 lines]
> Alzheimer's.
> http://www.newstarget.com/001692.html
 
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