Medical Forum / Diseases and Disorders / Alzheimer's / April 2005
Popular Alzheimer's Drug Found to Be All But Worthless in Independent Study
|
|
Thread rating:  |
Tim Campbell - 11 Apr 2005 06:19 GMT A new independent study, conducted at the University of Birmingham, UK,
reveals that a popular prescription drug for Alzheimer's disease, Aricept, offers no real benefit to Alzheimer's patients compared to placebo. And yet, the drug has been approved and heavily marketed based on findings from drug trials funded by its maker who claims the drug benefits Alzheimer's patients in scientifically proven ways. As it turns out, the drug does seem to help Alzheimer's patients score
slightly higher on cognitive tests, but it has no real benefit in delaying the institutionalization of Alzheimer's patients.
In the study, 42% of candidates taking the drug ended up in institutions within 3 years, compared to 44% who ended up in institutions after taking placebo.
The author of this study, Richard Gray, said, "Doctors and health care
funders need to question whether it would be better to invest in more doctors and nurses and more social support rather than spending huge sums of money prescribing these expensive drugs."
The findings presented here certainly don't surprise me. When independent studies are conducted on high-profit, brand-name prescription drugs, they typically come to a very different conclusion than the one offered by the manufacturer of that drug.
As we know, drug trials are frequently distorted and selected to show only the positive results. These findings are then forwarded to the FDA, where the drugs are approved for widespread use.
But during this process, studies showing negative effects of the drug are ignored or buried and are almost never made public unless they have
to be revealed in lawsuits. What we see in this case is a very expensive Alzheimer's drug that, from a scientific standpoint, has little or no benefit to patients, but yet is right now being marketed and prescribed
as something that offers a tremendous benefit to patients.
If you look at the marketing materials offered by the manufacturer of Aricept, you will find a large number of statements that imply this drug enhances the quality of life of Alzheimer's patients (and especially boosts their mental performance in significant ways).
But as this independent study seems to indicate, those claims are distorted, or, you could say they are accurate but they are highly selective statements, designed to get physicians and patients to focus on the few things the drug does improve, while ignoring the overall quality of life to the patient (which is not improved by the drug).
All of this is yet more evidence that prescription drugs largely do not
work. They are over-hyped, over-sold, and approved for widespread use under rather dubious conditions. In an astounding number of cases, when
FDA-approved prescription drugs are held up to the scrutiny of independent tests, they are found to be all but worthless.
As Americans, we are being sold empty promises in the form of extremely
expensive prescription drugs marketed by companies that seem to be far more interested in profits than in improving the quality of life of people around the world.
Alzheimer's drugs in particular are extremely profitable due to the growing epidemic of Alzheimer's in the United States and around the world. In the decades ahead, Alzheimer's disease is expected to skyrocket, creating potentially a multi-billion dollar market for prescription drugs to treat the symptoms of the disease. You can bet that more and more of these prescription drugs will be approved and marketed with dubious claims that exaggerate the benefits of the drug and minimize the drug's risks.
If you really want to prevent Alzheimer's, you can do that by making lifestyle changes. You can change your diet, give yourself outstanding nutrition (see related ebook on nutrition) (search this site for "Alzheimer's" to learn more), and avoid the "metabolic disruptors" that
disrupt normal nervous system function in the human body.
Those include ingredients such as MSG, aspartame, and artificial colors. You can also engage in mentally challenging activities such as doing crossword puzzles, playing card games with friends, giving speeches, or playing strategy games. Learning a new language also engages the brain and helps prevent Alzheimer's.
Sitting in front of the TV, on the other hand, promotes the onset of Alzheimer's. http://www.newstarget.com/001692.html
Dennis P. Harris - 11 Apr 2005 08:10 GMT > A new independent study, conducted at the University of Birmingham, UK, > > reveals that a popular prescription drug for Alzheimer's disease, > Aricept, offers no real benefit to Alzheimer's patients compared to > placebo. cite this "study", please. who published it? was it in a refereed journal? are you a doctor or just a crank?
there are many folks here who can tell you that when their LO stopped using aricept, the LO presented with far more impairment.
Mary_Gordon@tvo.org - 11 Apr 2005 11:32 GMT The study came out in summer of 2004, so this isn't breaking news.
http://www.alzheimersissues.com/ms/news/519718/main.html
If you do a google on it, you'll find lots of controversy around the findings. Their main argument seemed to be one of cost benefit - i.e. the tiny differences aren't worth the cost of the drug. Personally, I wish it had been around during my MIL's journey, because when you've got no hope, anything that does SOMETHING, however incrememental, is better than nothing.
Mary G
Tim Campbell - 13 Apr 2005 15:37 GMT > cite this "study", please. who published it? was it in a > refereed journal? are you a doctor or just a crank? Take the first line of the post and do a search on it...One can always do this to track down the source of any post...
Dennis P. Harris - 14 Apr 2005 02:15 GMT > > cite this "study", please. who published it? was it in a > > refereed journal? are you a doctor or just a crank? > > Take the first line of the post and do a search on it...One can always > do this to track down the source of any post... nope. not good enough. if you want folks to believe you, you have to cite where the "paper" was PUBLISHED in a peer reviewed journal.
you're just another crank that's in my killfile now. PLONK.
Partran - 19 Apr 2005 00:03 GMT > > > cite this "study", please. who published it? was it in a > > > refereed journal? are you a doctor or just a crank? [quoted text clipped - 7 lines] > > you're just another crank that's in my killfile now. PLONK. The article later sited from http://www.newstarget.com/001692.html fails to state where the article can be found published, therefore I can't see the study itself.
I don't doubt their findings were properly reported by the media, but their methods and such were not made public. Also, we aren't privy to whether or not the study was looking at the group the FDA has approved the drug for or for more severe cases. Recall that Aricept is only FDA approved for treatment of mild to moderate Alzheimers.
While it may be something to keep an eye out for, with the bredth of positive anecdotal evidence and without the study itself, I'll have to take this news story with a grain of salt. It may very well have been shown to be ineffective, but that may be for special populations, or patients with early onset AD, or any other number of mitigating factors.
-Nathan (Pharmacy student)
Tumbleweed - 11 Apr 2005 08:17 GMT <snip>
> The findings presented here certainly don't surprise me. When > independent studies are conducted on high-profit, brand-name > prescription drugs, they typically come to a very different conclusion > than the one offered by the manufacturer of that drug. It surprises the hell out of me, my dad showed a large and immediate decline with a few days of stopping, a significant improvement when he started again, and an even worse decline when he finally stopped. These declines were within days first time, and weeks second.
 Signature Tumbleweed
email replies not necessary but to contact use; tumbleweednews at hotmail dot com
Anthony Shipley - 11 Apr 2005 10:45 GMT >It surprises the hell out of me, my dad showed a large and immediate decline >with a few days of stopping, a significant improvement when he started >again, and an even worse decline when he finally stopped. These declines >were within days first time, and weeks second. After tests indicating a deterioration during the period of taking Aricept, I was taken off that. Because the government sponsors most of the cost, they won't continue treatment unless there are signs of improvement.
I'm now on Ritenal. At first, the side-effects were almost entirely gone--but sadly--some, at least, seem to be creeping back. Even so, I feel much better without the Aricept. I still get very sleepy but don't know if it's the Prozac or not (anti-depressants always had that side-effect).
- Mind control is being able to make all the voices in your head take turns.
Mod as a hooter!
pitirish - 12 Apr 2005 04:41 GMT Hi Tumbleweed,
Would you please briefly discuss the conditions under which your dad had to stop taking Aricept? My wife has been on 10mgs per day for years. If there are steps I can take now to prevent her from reaching a point or developing a symptom which would cause her doctor to stop her Aricept, I'd like to prepare for the possibility now.
Thank you for the response.
go'l.
> It surprises the hell out of me, my dad showed a large and immediate > decline with a few days of stopping, a significant improvement when he > started again, and an even worse decline when he finally stopped. These > declines were within days first time, and weeks second. Tumbleweed - 12 Apr 2005 07:52 GMT The first was money ..the doctor felt it wasnt doing any good and stopped it on the grounds it was needless expenditure. The decline was so marked that within a week my mother was at the doctors crying hysterically, and he was restarted. The second time was when he was switched to memantine. At that time memantine was new in the UK and he was part of a trial. In order to be on the trial he couldnt be on anything else. We felt it was worth the risk, but maybe 12 or so weeks later he was in care due to the fact that my mother coudnt cope with him any more. Nowadays aricept and memantine together are usally recommended. FWIW I do think that second time round he would have had to be placed in care within a few months anyway but there was still a notable deterioration.
 Signature Tumbleweed
email replies not necessary but to contact use; tumbleweednews at hotmail dot com
> Hi Tumbleweed, > [quoted text clipped - 12 lines] >> started again, and an even worse decline when he finally stopped. These >> declines were within days first time, and weeks second. Baird Stafford - 11 Apr 2005 10:50 GMT > A new independent study, conducted at the University of Birmingham, UK, > [quoted text clipped - 8 lines] > slightly higher on cognitive tests, but it has no real benefit in > delaying the institutionalization of Alzheimer's patients. <snip>
I want to see more than one study on this, please (and please tell me where I can get a copy of this particular study, at that). All too often, sensational single studies are not repeatable under laboratory control.
> If you really want to prevent Alzheimer's, you can do that by making > lifestyle changes. You can change your diet, give yourself outstanding [quoted text clipped - 4 lines] > Those include ingredients such as MSG, aspartame, and artificial > colors. Please cite reputable studies that confirm these claims.
> You can also engage in mentally challenging activities such as > doing crossword puzzles, playing card games with friends, giving > speeches, or playing strategy games. Learning a new language also > engages the brain and helps prevent Alzheimer's. To the best of my knowledge, none of these things have been proven to *prevent* Alzheimer's in controlled, double-blind studies. The most that has yet been claimed for such activities is that they may slow down the progress of the disease.
> Sitting in front of the TV, on the other hand, promotes the onset of > Alzheimer's. Again, not proven - along with electrical power lines, radar, microwaves or any other modern development.
Incidentally, if TV promotes the onset of the disease, what on *earth* does sitting in front of computer monitors for countless hours each day do?
Blessed be, Baird
 Signature Modkin of soc.religion.paganism Modstaff of alt.religion.wicca.moderated Newstaff, Inc. at newstaff.com
Stephen - 11 Apr 2005 12:59 GMT >Incidentally, if TV promotes the onset of the disease, what on *earth* >does sitting in front of computer monitors for countless hours each day >do? > >Blessed be, >Baird Well, then, I'm in trouble. :-) For the record, my mom is at late/middle stages. She recognizes familiar people, but doesn't relate that recognition to specific familiarity, i.e., I am her best friend and not her son. She is not on Aricept, but on Reminyl. She is also on Riserdal for delusions and Paxil for depression. The combination of these drugs is a blessing. I don't expect any of them to do more than make life with her bearable and to keep her calm and happier. -steve
Evelyn Ruut - 11 Apr 2005 13:14 GMT > A new independent study, conducted at the University of Birmingham, UK, > [quoted text clipped - 91 lines] > Alzheimer's. > http://www.newstarget.com/001692.html I disagree completely with all the above.
I am sorry to tell you this, but there was VAST NOTICEABLE difference when my mother in law gave up Aricept, and we couldn't WAIT to get her back on it, in which the problems almost immediately reversed, and she was better (though she still had alzheimers)
In her case it definitely helped her.
 Signature Best Regards, Evelyn
(to reply personally, remove 'sox')
Karen - 12 Apr 2005 04:29 GMT Sorry, but I've seen the improvement Aricept made with my MIL. And been told by healthcare workers that they have seen patients experience severe quality of life issue when it's stopped. Not just cognitive issues but simple things like continence, swallowing and other body functions.
I've often wondered if people that have Alzheimer's watch more TV because it's a non-demanding activity they feel comfortable with and if people that do mentally stimulating activities do them because they can. I am certain Alzheimer's has an onset much earlier than we currently acknowledge. Haven't seen any data on that opinion, just my MIL and a few others (not a statistical universe).
Hubby's neurologist says MSG and aspartame are the main causes of migraines and I believe it. The first NutraSweet gumballs I tried gave me a ripping headache and MSG has always produced a reaction too. But as far as causing Alzheimer's? They need to get in line behind the kajillion other things we eat, breath and drink that are also unhealthy. How many people ever read the hazard notice for the toner used in their office copier? And how many people didn't grow up with a strange old lady or man down the street that seemed unbalanced but nobody knew what to do with them? IMO, Alzheimer's and dementia are old problems we've just become better at diagnosing.
Sorry, I'm not up to hyperventilating over this one.
Karen
> A new independent study, conducted at the University of Birmingham, UK, > [quoted text clipped - 91 lines] > Alzheimer's. > http://www.newstarget.com/001692.html
|
|
|