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Medical Forum / Diseases and Disorders / Alzheimer's / March 2005

Experience with Seroquel (Quetiapine)

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Dr Drool - 21 Mar 2005 07:48 GMT
Hi group,

My father (who lives in the UK) has had AD for about 3 years and has
recently started taking the anti-psychotic Seroquel (active ingredient
Quetiapine) at 25 mg a day.

This worked fine for several weeks but in the last few days he has
become very restless again, and my Mum (who is his main carer) is
worried that his agitated activity will lead to another stroke.

Does anyone have experience of this drug, that we can add to the
advice of our doctor.

MikeC
Boydette - 21 Mar 2005 09:45 GMT
Hi Mike I take this drug on a daily basis for the mania of Bipolar
disorder...I cant imagine why a doc would give this to an elderly person
unless they are phycotic (sp?) it is an anti psychotic drug....tell me
more and I will try to help.....b

Experience with Seroquel (Quetiapine)  

Group: alt.support.alzheimers Date: Mon, Mar 21, 2005, 6:48am (CST+6)
From: f@ke.com (Dr Drool)
Hi group,
My father (who lives in the UK) has had AD for about 3 years and has
recently started taking the anti-psychotic Seroquel (active ingredient
Quetiapine) at 25 mg a day.
This worked fine for several weeks but in the last few days he has
become very restless again, and my Mum (who is his main carer) is
worried that his agitated activity will lead to another stroke.
Does anyone have experience of this drug, that we can add to the advice
of our doctor.
MikeC  
Evelyn Ruut - 21 Mar 2005 12:48 GMT
Hi Mike I take this drug on a daily basis for the mania of Bipolar
disorder...I cant imagine why a doc would give this to an elderly person
unless they are phycotic (sp?) it is an anti psychotic drug....tell me
more and I will try to help.....b

Hi Boydette and Mike,

They often give Alzheimer patients who are agitated due to delusions, some
kind of anti-psychotic medication.   My mother in law got extremely upset by
certain delusions that had her restless and agitated, and our doctor also
put her on an anti-psychotic as well as the anti-depressant she was taking
all along.

It worked well, but there were some side effects to deal with.   Even with
the side effects it made living with her more bearable, and frankly, if I
had to do it over again we'd probably make the same choices, as the
medication helped enormously.

Mike, if I were you I'd ask the doctor if he could increase the dosage or
provide a stronger drug, if it has stopped working.   Alzheimers disease is
horrible enough to have to deal with, without delusions and agitation.

Signature

Regards,
Evelyn

(to reply to me personally, remove 'sox")

Glenfiddich - 21 Mar 2005 16:44 GMT
>Hi Mike I take this drug on a daily basis for the mania of Bipolar
>disorder...I cant imagine why a doc would give this to an elderly person
[quoted text clipped - 13 lines]
>had to do it over again we'd probably make the same choices, as the
>medication helped enormously.

Sorry to butt in, but I want to stress for the benefit of a few that
it "made living with her more bearable" not only for you but FOR HER,
too.

And THAT is the whole point of the treatment.
It's solely to help the patient - any benefit to the caregiver
is just a nice bonus.

Thanks for letting me vent on this sore point.
Evelyn Ruut - 21 Mar 2005 18:37 GMT
>>Hi Mike I take this drug on a daily basis for the mania of Bipolar
>>disorder...I cant imagine why a doc would give this to an elderly person
[quoted text clipped - 24 lines]
>
> Thanks for letting me vent on this sore point.

Thank YOU for clarifying it!   I should have done so myself.   I was
miserable seeing how stressed out she was.   The delusions were very
disturbing to her, and that is why it was also disturbing to us.   Our only
wish was for her to be at peace and comfortable.  The anti-psychotic meds
helped us both that way.

Signature

Regards,
Evelyn

(to reply to me personally, remove 'sox")

MikeC - 21 Mar 2005 21:08 GMT
Thanks to all for your comments.

After considering the issue further I have to be honest and say that
both my mum and I think about the benefits of anti-psychotics to us
(the carers) as well as to my father (the patient), though we will try
to keep the dose to the minimum required to make life tolerable for
him.

I suspect though that many AD patients are drugged more for the
benefit of the carers, especially in care homes.

Best wishes to all

MikeC
Evelyn Ruut - 21 Mar 2005 23:27 GMT
> Thanks to all for your comments.
>
[quoted text clipped - 10 lines]
>
> MikeC

Mike, in our experience the need for the drugs took a curve.   In the
beginning she was fine with just her antidepressant medication, and the
doctor increased the dosage over time... then when the delusions came, we
started with one risperdol per day.   After that it continued to build up,
and at one point she was receiving two risperdol tablets a day, one in the
morning and one in the evening.   Later in her illness she became a bit more
calm and the delusions were less compelling.   At that point we tapered off
to only one per day.

Now that she is in the nursing home, their philosophy is to manage with as
little medication as possible towards "controlling" the patient.   They feel
that they want the patients to have as much of their abilities as possible
and the anti-psychotics tend to make them too docile and tending to fall
more often and such.   So I don't think she is even still receiving the
risperdol anymore at all, though she is still on her Aricept and her Zoloft.

In any case she was happier and calmer and more "normal" while on the
risperdol than without.   You could actually reason with her and she did
well.   Every person is different and your loved one may not fit that same
mold at all.  Play it by ear, as they say :-)
Signature

Regards,
Evelyn

(to reply to me personally, remove 'sox")

Stephen - 22 Mar 2005 00:56 GMT
>Thanks to all for your comments.
>
[quoted text clipped - 10 lines]
>
>MikeC

Hi, Mike. My mom is also on an anti-psychotic, Risperdol (SP?), due to extreme
agitation and delusions that developed last year. They have helped immensely and
the only side effect that she experiences is that she is a little less steady on
her feet. Not to the point of falling, but she moves more slowly. She is being
cared for at home by my father and I am there daily to visit and check on her.
Without the medication, life was miserable for her and us. She still has
delusions and occasionally gets agitated, but nothing like it was a few months
ago. We want her to be happy, but the benefit is that she is more docile and my
father can enjoy his remaining years just a bit now, too.
-steve
fowlermain@yahoo.com - 26 Mar 2005 05:38 GMT
My mother has had varying doses of Quetiapine (Seroquel) for at least a
couple of years.  It was first prescribed for anxiety (obsessing) about
carpal tunnel syndrome -- her reaction was far beyond what was
warranted by the actual physical condition.

We've also used it to reduce other obsessive behaviors -- eye rubbing,
picking at skin, etc.  Her present dose is 25 mg in am, and 50 mg in
pm, but she had been on a higher amount without problems.  We adjust
the dose as needed.  We are always balancing the benefits of reducing
anxiety and harmful behaviors, vs. sedation.

Overall, I'd say Seroquel has given her a much better quality of life
than she would have had without it.  The only problem we encountered
was when I questioned whether it was helping with her anxiety about
carpal tunnel sydrome, and the neurologist told me to withhold it for a
day or so and we'd be able to tell.  This was when the drug was very
new.  Two days after stopping it, we saw no change, and figured that it
wasn't helping -- but all hell broke loose around days 6-7, and we
immediately restarted Seroquel, with a rapid return to the way she had
been before it was stopped.
 
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