Medical Forum / Diseases and Disorders / Alzheimer's / March 2005
Experience with Seroquel (Quetiapine)
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Dr Drool - 21 Mar 2005 07:48 GMT Hi group,
My father (who lives in the UK) has had AD for about 3 years and has recently started taking the anti-psychotic Seroquel (active ingredient Quetiapine) at 25 mg a day.
This worked fine for several weeks but in the last few days he has become very restless again, and my Mum (who is his main carer) is worried that his agitated activity will lead to another stroke.
Does anyone have experience of this drug, that we can add to the advice of our doctor.
MikeC
Boydette - 21 Mar 2005 09:45 GMT Hi Mike I take this drug on a daily basis for the mania of Bipolar disorder...I cant imagine why a doc would give this to an elderly person unless they are phycotic (sp?) it is an anti psychotic drug....tell me more and I will try to help.....b Experience with Seroquel (Quetiapine) Group: alt.support.alzheimers Date: Mon, Mar 21, 2005, 6:48am (CST+6) From: f@ke.com (Dr Drool) Hi group, My father (who lives in the UK) has had AD for about 3 years and has recently started taking the anti-psychotic Seroquel (active ingredient Quetiapine) at 25 mg a day. This worked fine for several weeks but in the last few days he has become very restless again, and my Mum (who is his main carer) is worried that his agitated activity will lead to another stroke. Does anyone have experience of this drug, that we can add to the advice of our doctor. MikeC
Evelyn Ruut - 21 Mar 2005 12:48 GMT Hi Mike I take this drug on a daily basis for the mania of Bipolar disorder...I cant imagine why a doc would give this to an elderly person unless they are phycotic (sp?) it is an anti psychotic drug....tell me more and I will try to help.....b
Hi Boydette and Mike,
They often give Alzheimer patients who are agitated due to delusions, some kind of anti-psychotic medication. My mother in law got extremely upset by certain delusions that had her restless and agitated, and our doctor also put her on an anti-psychotic as well as the anti-depressant she was taking all along.
It worked well, but there were some side effects to deal with. Even with the side effects it made living with her more bearable, and frankly, if I had to do it over again we'd probably make the same choices, as the medication helped enormously.
Mike, if I were you I'd ask the doctor if he could increase the dosage or provide a stronger drug, if it has stopped working. Alzheimers disease is horrible enough to have to deal with, without delusions and agitation.
 Signature Regards, Evelyn
(to reply to me personally, remove 'sox")
Glenfiddich - 21 Mar 2005 16:44 GMT >Hi Mike I take this drug on a daily basis for the mania of Bipolar >disorder...I cant imagine why a doc would give this to an elderly person [quoted text clipped - 13 lines] >had to do it over again we'd probably make the same choices, as the >medication helped enormously. Sorry to butt in, but I want to stress for the benefit of a few that it "made living with her more bearable" not only for you but FOR HER, too.
And THAT is the whole point of the treatment. It's solely to help the patient - any benefit to the caregiver is just a nice bonus.
Thanks for letting me vent on this sore point.
Evelyn Ruut - 21 Mar 2005 18:37 GMT >>Hi Mike I take this drug on a daily basis for the mania of Bipolar >>disorder...I cant imagine why a doc would give this to an elderly person [quoted text clipped - 24 lines] > > Thanks for letting me vent on this sore point. Thank YOU for clarifying it! I should have done so myself. I was miserable seeing how stressed out she was. The delusions were very disturbing to her, and that is why it was also disturbing to us. Our only wish was for her to be at peace and comfortable. The anti-psychotic meds helped us both that way.
 Signature Regards, Evelyn
(to reply to me personally, remove 'sox")
MikeC - 21 Mar 2005 21:08 GMT Thanks to all for your comments.
After considering the issue further I have to be honest and say that both my mum and I think about the benefits of anti-psychotics to us (the carers) as well as to my father (the patient), though we will try to keep the dose to the minimum required to make life tolerable for him.
I suspect though that many AD patients are drugged more for the benefit of the carers, especially in care homes.
Best wishes to all
MikeC
Evelyn Ruut - 21 Mar 2005 23:27 GMT > Thanks to all for your comments. > [quoted text clipped - 10 lines] > > MikeC Mike, in our experience the need for the drugs took a curve. In the beginning she was fine with just her antidepressant medication, and the doctor increased the dosage over time... then when the delusions came, we started with one risperdol per day. After that it continued to build up, and at one point she was receiving two risperdol tablets a day, one in the morning and one in the evening. Later in her illness she became a bit more calm and the delusions were less compelling. At that point we tapered off to only one per day.
Now that she is in the nursing home, their philosophy is to manage with as little medication as possible towards "controlling" the patient. They feel that they want the patients to have as much of their abilities as possible and the anti-psychotics tend to make them too docile and tending to fall more often and such. So I don't think she is even still receiving the risperdol anymore at all, though she is still on her Aricept and her Zoloft.
In any case she was happier and calmer and more "normal" while on the risperdol than without. You could actually reason with her and she did well. Every person is different and your loved one may not fit that same mold at all. Play it by ear, as they say :-)
 Signature Regards, Evelyn
(to reply to me personally, remove 'sox")
Stephen - 22 Mar 2005 00:56 GMT >Thanks to all for your comments. > [quoted text clipped - 10 lines] > >MikeC Hi, Mike. My mom is also on an anti-psychotic, Risperdol (SP?), due to extreme agitation and delusions that developed last year. They have helped immensely and the only side effect that she experiences is that she is a little less steady on her feet. Not to the point of falling, but she moves more slowly. She is being cared for at home by my father and I am there daily to visit and check on her. Without the medication, life was miserable for her and us. She still has delusions and occasionally gets agitated, but nothing like it was a few months ago. We want her to be happy, but the benefit is that she is more docile and my father can enjoy his remaining years just a bit now, too. -steve
fowlermain@yahoo.com - 26 Mar 2005 05:38 GMT My mother has had varying doses of Quetiapine (Seroquel) for at least a couple of years. It was first prescribed for anxiety (obsessing) about carpal tunnel syndrome -- her reaction was far beyond what was warranted by the actual physical condition.
We've also used it to reduce other obsessive behaviors -- eye rubbing, picking at skin, etc. Her present dose is 25 mg in am, and 50 mg in pm, but she had been on a higher amount without problems. We adjust the dose as needed. We are always balancing the benefits of reducing anxiety and harmful behaviors, vs. sedation.
Overall, I'd say Seroquel has given her a much better quality of life than she would have had without it. The only problem we encountered was when I questioned whether it was helping with her anxiety about carpal tunnel sydrome, and the neurologist told me to withhold it for a day or so and we'd be able to tell. This was when the drug was very new. Two days after stopping it, we saw no change, and figured that it wasn't helping -- but all hell broke loose around days 6-7, and we immediately restarted Seroquel, with a rapid return to the way she had been before it was stopped.
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