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Medical Forum / General / Alternative / December 2008Garlic Derived Diabetes Treatment
Injection-free treatment for diabetes patients? 19 November 2008 A compound found in garlic is the basis of a potential orally- available drug candidate for types 1 and 2 diabetes. "Diabetes incidence is increasing worldwide, and there is a continuing need to develop effective treatments"Diabetes incidence is increasing worldwide, and there is a continuing need to develop effective treatments. Exisiting treatments involve either injection with insulin (primarily for sufferers of type 1 diabetes), or treatment with drugs (for type 2 diabetes). However, says Hiromu Sakurai, of the Suzuka University of Medical Science, Japan, neither method is ideal, as they involve frequent injections, and the drugs have undesirable side- effects. In earlier work, Sakurai's group had shown that a complex of vanadium and allixin, a compound found in garlic, lowered blood glucose levels in mouse models of both types 1 and 2 diabetes and that the effect was maintained for type 2 model mice given the complex orally. In its latest study the team found that the orally administered complex also lowered glucose levels in type 1 model mice, offering hope for an injection-free treatment for people with type 1 diabetes. The vanadyl complex of garlic-compound allixin lowers blood glucose in diabetes models The new study looked primarily at how the allixin complex works. By examining the effects of the complex on genes affected by diabetes, the researchers found that it activates not only the insulin signalling cascade, which regulates glucose metabolism, but also an enzyme that helps cells to absorb glucose. John McNeill is a professor emeritus in the division of pharmacology and toxicology at the University of British Columbia, Vancouver, Canada. He says that although other vanadium compounds have shown promise for the treatment of diabetes, this investigation is extensive and 'adds significant information to our understanding of how vanadium compounds can affect both carbohydrate and lipid metabolism.' "Allixin and similar complexes could be good candidates for treating both type 1 and type 2 diabetes" The researchers say that the allixin and similar complexes could be good candidates for treating both type 1 and type 2 diabetes. Future work, says Sakurai, will be aimed towards clinical trials of their complexes in human diabetes patients. David Barden ------------------- Garlic chemical tablet treats diabetes I and II 19 November 2008 A drug based on a chemical found in garlic can treat diabetes types I and II when taken as a tablet, a study in the new Royal Society of Chemistry journal Metallomics says. When Hiromu Sakurai and colleagues from the Suzuka University of Medical Science, Japan, gave the drug orally to type I diabetic mice, they found it reduced blood glucose levels. The drug is based on vanadium and allaxin, a compound found in garlic, and its action described in an Advance Article from Metallomics available free online from today. The first issue of the new journal will be published in 2009. In previous work they had discovered the vanadium-allaxin compound treated both diabetes types when injected, but this new study shows the drug has promise as an oral treatment for the disease. Type I diabetes (insulin dependent) is currently treated with daily injections of insulin, while type II (non-insulin dependent) is treated with drugs bearing undesirable side-effects - the authors note neither treatment is ideal. The researchers aim to test the drug in humans in future work. ReferencesMakoto Hiromura, Metallomics, 2009, DOI: 10.1039/b815384c Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > A compound found in garlic is the basis of a potential orally- > available drug candidate for types 1 and 2 diabetes. A variety of anti-oxidants and anti-inflammatories are helpful in a wide range of diseases. Avoiding exposure to persistent pollutant may be helpful also. See www.newscientist.com/article/mg19926731.900-could-the-diabetes-epidemic-be-down- to-pollution.html?full=true Ironman, Good Post! Every now-and-then you post a winner. My only objection to the actual research is they settled for garlic derivatives instead of settling on the real deal, whole raw garlic. Why go second rate? Paul On Nov 19, 9:34 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > Injection-free treatment for diabetes patients? > [quoted text clipped - 84 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Ironman, Good Post! << As if you'd know .. You posting to my threads .. denigrates my threads .. Understand .. ? Good .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Ironman: Nine times out of ten your posts denigrate yourself. > Ironman, Good Post! << > [quoted text clipped - 14 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk >Ironman: Nine times out of ten your posts denigrate yourself. << Like I said .. pautry .. YOU would .. know .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Jesus Was A Vegetarian! So was Hitler.........................what's your point ? >> Jesus Was A Vegetarian! > > So was Hitler.........................what's your point ? Ma, you're really magnetized for notorious usenet trolls, huh? Susan Hi Susan, H2S is a small signal molecule.It escaped science like NO.I posted this one before : http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17951430 Hydrogen sulfide mediates the vasoactivity of garlic The consumption of garlic is inversely correlated with the progression of cardiovascular disease, although the responsible mechanisms remain unclear. Here we show that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H2S), an endogenous cardioprotective vascular cell signaling molecule. This H2S production, measured in real time by a novel polarographic H2S sensor, is supported by glucose-maintained cytosolic glutathione levels and is to a large extent reliant on reduced thiols in or on the RBC membrane. H2S production from organic polysulfides is facilitated by allyl substituents and by increasing numbers of tethering sulfur atoms. Allyl-substituted polysulfides undergo nucleophilic substitution at the ? carbon of the allyl substituent, thereby forming a hydropolysulfide (RSnH), a key intermediate during the formation of H2S. Organic polysulfides (R-Sn-R'; n > 2) also undergo nucleophilic substitution at a sulfur atom, yielding RSnH and H2S. Intact aorta rings, under physiologically relevant oxygen levels, also metabolize garlic-derived organic polysulfides to liberate H2S. The vasoactivity of garlic compounds is synchronous with H2S production, and their potency to mediate relaxation increases with H2S yield, strongly supporting our hypothesis that H2S mediates the vasoactivity of garlic. Our results also suggest that the capacity to produce H2S can be used to standardize garlic dietary supplements. hth Gys > x-no-archive: yes > [quoted text clipped - 5 lines] > > Susan Hey - I was a bum magnet in me yoot. But I've gone high tech now. > Hey - I was a bum magnet in me yoot. > > But I've gone high tech now. Old habits die hard, huh? Susan > x-no-archive: yes > [quoted text clipped - 5 lines] > > Susan Getting married can definitely kill them for some. I'm an................................avoider. But still amoral, so that counts. D On Nov 19, 4:47 pm, High Miles <2Blue...@comcast.net> wrote:Jesus Was A Vegetarian! what's your point ? << Some people would like to know that. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >> Jesus Was A Vegetarian! > > So was Hitler.........................what's your point ? He's one of our worst trolls. Definitely for the kf.  Signature-- Best Regards, Evelyn (Our) enemies are not man. They are intolerance, fanaticism, dictatorship, cupidity, hatred and discrimination, which lie within the heart of man." -- Thich Nhat Hanh Garlic Compound Effective Against Killer MRSA ‘Superbugs’ – New Evidence next article 23.12.2003 Garlic bulb A compound extracted from garlic is effective against even the most antibiotic-resistant strains of MRSA, the killer ‘hospital superbug’, and can cure patients with MRSA-infected wounds within weeks, according to new research by microbiologist Dr Ron Cutler of the University of East London (UEL). In a paper to be published in the New Year, Dr Cutler, an expert in the antimicrobial properties of plant extracts, claims that allicin - a compound that occurs naturally in garlic – kills not only established varieties of MRSA, but also destroys the new generation of ‘super-superbugs’ that have evolved resistance to Vancomycin and Glycopeptides, the powerful antibiotics widely considered to be the last line of defence against MRSA. MRSA (Methicillin-resistant Staphylococcus aureus) now causes an estimated 2,000 deaths in UK hospitals each year mainly through secondary infection of surgical wounds. Though MRSA organisms can live harmlessly in humans and are carried in the nasal passages and on the skin, they can cause fatal infection in immune-suppressed patients, the elderly, the young and those with surgical implants. Doctors have become increasingly alarmed over the past few months by the emergence in UK hospitals of new generations of resistant strains of MRSA known as VISAs, and GISAs (Vancomycin or Glycopeptide resistant Staphylococcus aureus). MRSA has also become endemic in many hospitals, especially in London and the South-East, prompting the NHS to review its hygiene procedures. Dr Cutler, recently proved that allicin destroys the MRSA microbe in laboratory trials, has now teamed up with a new company, Allicin International, to develop topical treatments to prevent MRSA infection. The group have developed a nasal cream, oral capsules and soaps that have proved effective against both MRSA and GISA. In partnership with colleagues in the NHS, Dr Cutler is now embarking on a major clinical trial involving around two hundred volunteers, including patients at several hospitals in London and the South East. Dr Cutler said: "The trials we have conducted so far show that this formulation is highly effective against MRSA, and it could save many lives. This finding is backed up by initial findings a number of recent case studies. We have been trying to set up a clinical trial for many months now, and at last we have secured funding from sources including Allicin International. “MRSA is causing a genuine crisis in our hospital system in Britain and worldwide. Antibiotics are increasingly ineffective, but we do have a powerful natural ally. Plant compounds have evolved over millions of years as chemical defence agents against infection. Garlic has been used in medicine for centuries, and it should be no surprise that it is effective against this very modern infection.” The research on the laboratory effects of allicin on GISA was presented in part at the Institute of Biomedical Scientists congress in Birmingham, October 2003, and is being prepared for publication in the Journal of Biomedical Science, to appear in the New Year. A full clinical study involving the use of allicin to reduce nasal carriage in healthy volunteers, including in hospitals in London and South East England, is underway and initial results are due to be published in summer 2004. Case Study: Deborah’s story Deborah Brown (34), a probation service officer who lives in Rainham, Kent, contracted MRSA after a major spinal operation in November 2000. The painful wounds on her spine failed to heal despite constant applications of both oral antibiotics and creams, which also failed to reduce the levels of MRSA in her tissue. In December 2002, Deborah’s mother Pauline contacted Dr Cutler after seeing an item on TV about MRSA and received a course of Allimax cream and capsules by post. Within two months, the MRSA had mostly cleared from Deborah’s tissues and the wounds had begun to heal, allowing an operation to remove her spinal supports to be carried out in June 2003. Deborah said: “The effect of the treatment was dramatic - I am making a good recovery now – but it was really awful at the time. Having weeping wounds on my back that never healed for two years was incredibly painful, and I became increasingly depressed as the MRSA didn’t respond to repeated courses of antibiotics. If my case helps to show that allicin works against MRSA then I am glad that something good might come of it.” Patrick Wilson | Source: alphagalileo Further information: www.uel.ac.uk http://www.innovations-report.com/html/reports/medicine_health/report-24405.html On Nov 20, 4:53 am, "Evelyn" <evelyn.r...@gmail.com> wrote: snip << Ruut .. You've been told to stay off my threads .. You should maybe cut back on the eating .. Stuffing your gob does not a diet make .. Understand how that works you fat .. fkg .. cow .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > >> Jesus Was A Vegetarian! > [quoted text clipped - 9 lines] > cupidity, hatred and discrimination, which lie within the heart of man." -- > Thich Nhat Hanh Ruut.. Stuffing your gob does not a diet make .. << ANZHP symposium: Obesity - should there be a law against it? (Edited by Roger Magnusson (Coordinator)) http://www.anzhealthpolicy.com/articles/theme-series.asp?series=1743-... Editorial Obesity: should there be a law against it? Introduction to a symposium Roger S Magnusson Faculty of Law, University of Sydney, Sydney, Australia Australia and New Zealand Health Policy 2008, 5:9doi: 10.1186/1743-8462-5-9 Published: 5 June 2008 Abstract The rapid rise in rates of overweight and obesity among adults and children in Australia and New Zealand has intensified debate about the most effective policies for obesity prevention. Law has much to contribute to this policy discussion, although its role is often misunderstood. The articles in this symposium follow on from a conference hosted in September 2006 by the Centre for Health Governance, Law & Ethics in the Faculty of Law, University of Sydney, titled: Obesity: should there be a law against it? In different ways, these articles provide a variety of perspectives on regulatory responses to obesity, including theoretical justifications for a legal approach, conceptual models that assist in making sense of law's role, as well as specific legal strategies for obesity prevention in various settings. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Understand how that works you fat .. fkg .. cow .. ? > [quoted text clipped - 26 lines] > > - Show quoted text - morbidly obese << More money for more .. foooood .. eh .. Ruut .. --------------- Pay the obese to take a walk: Now the nanny state offers rewards just for losing weight in £30m health drive By Daniel Martin 11th November 2008 Exercise routine: The daily walk to school may earn points Overweight parents will be paid to walk their children to school under plans to tackle the obesity epidemic. Those who attend keep-fit classes, weight-loss clubs or even go for a run in the park would also be eligible for rewards. They will collect points on supermarket-style loyalty cards which would be redeemed against healthy food, sports equipment or gym sessions. The scheme is part of a £30million drive to improve health which will begin next year in Manchester, one of England's unhealthiest cities. If successful, it could be rolled out nationwide. However, critics believe that the payments are tantamount to bribery - and that the scheme is open to fraud. Under the proposals, men and women will be invited to join exercise classes or slimming clubs. Points would be given just for turning up, but participants can accrue more depending on how much weight they lose. Walking children to school would count, as would using public transport, because it involves a walk to the bus stop or train station. It is thought machines could be placed in schools and at stations so parents and commuters could swipe their cards, although details have yet to be finalised. Going for a run could also be an earner. Joggers would swipe their cards at machines in parks and collect points given in accordance with the distance run. The launch of 'healthy towns' follows a report warning that nine out of ten British adults will be overweight or obese by the year 2050 (file picture) Buying healthy food from chosen retailers would also earn rewards. These could be redeemed against products and services such as sports equipment, more healthy food and free places on children's activity schemes. Matthew Elliot, of the TaxPayers' Alliance, said: 'This whole scheme is so dubious because there is clearly potential for abuse and fraud. 'It would be so easy for someone to hop out of their car for a second to go and swipe their card, enabling them to claim they had walked to school. 'Healthy people pay quite enough tax already without having to bribe the obese or put cash into the pockets of fraudsters.' 'Carry me! Carry me!' Tam Fry, of the National Obesity Forum, said: 'In many ways this is too little, too late. The Government should have acted years ago. However, you have to start somewhere and these are certainly the right kind of schemes.' Colin Waine from the charity said: 'I support schemes like the one in Manchester but would ask that it be carefully evaluated and only continued if it demonstrates results and changes behaviours.' Other areas involved in the Healthy Towns initiative are Dudley, Halifax, Sheffield, Tower Hamlets in London, Thetford in Norfolk, Middlesbrough, Tewkesbury and Portsmouth. Projects include an award scheme encouraging restaurants and shops along the road to the site of the 2012 Olympics stadium, in East London, to stock more healthy food. In Halifax, social housing tenants will be encouraged to join a grow- your-own fruit and vegetable scheme - and Sheffield will become a 'breastfeeding-friendly city'. Dudley is to turn parks into family health zones, while Middlesbrough has implemented junior trainer plans to encourage children to exercise and urban farming. Tewkesbury is promoting urban gardening and Portsmouth and Thetford are motivating residents to run and cycle. The Department of Health also announced that it had linked up with supermarkets such as Tesco and Asda to run promotions encouraging healthy eating. In the New Year, ITV will start a campaign encouraging viewers to pledge to lose weight. And Pepsi will advertise the benefits of sport. Health Secretary Alan Johnson says obesity is the biggest health challenge we face In the North East, branches of stores such as Spar, Londis and Costcutter will install chiller units and sell discounted fruit and vegetables. But Norman Lamb, the LibDem health spokesman, dismissed the schemes as little more than 'time-wasting gimmicks'. Obesity is thought to represent a serious threat to our health in the future. Experts say that by 2050 at least 60 per cent of the UK population will be obese - so fat their health is in danger. Manchester has the lowest male life expectancy in England, and the fourth lowest for women. The £4.6million loyalty-card scheme, run by a primary care trust, will begin in October. All residents will be eligible. Laura Roberts, chief executive of NHS Manchester, said obesity cost the city more than £166million every year. 'Unfortunately people in Manchester have among the poorest health in the country. 'There are lots of reasons, but the simple, everyday decisions we all make about food and exercise contribute hugely to our biggest health problems, including heart disease and cancer. 'Points4Life is based on tried and tested techniques from some of the world's most successful companies, the difference being that we're not looking for customers to be loyal to a particular store, but to help people make healthier choices.' Health Secretary Alan Johnson said: 'Obesity is the biggest health challenge we face - every year 9,000 people die prematurely and a third of 11 and 12-year-olds are overweight. 'If we don't take action now we will condemn our children to reduced life expectancy. That's why we are aiming to create a lifestyle revolution that will help families to eat well, move more and live longer.' THE 'BREAST IS BEST' PATROL Labour is to recruit breastfeeding 'champions' to teach new mothers of the benefits. Studies have shown that children who were breastfed are much less likely to grow up overweight than those fed on formula milk. Under the scheme, recruits will be sent out to encourage those in deprived areas to take it up. The champions themselves would live in deprived areas, such as council estates, where fewer women tend to breastfeed, although mothers from more affluent parts would also be able to visit them. The scheme is designed to enable new mothers to receive support and advice in their community, rather than having to rely on health visitors. Based in Sheffield, it would also help the city become ' breastfeeding friendly'. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Ruut.. Stuffing your gob does not a diet make .. << > [quoted text clipped - 75 lines] > > - Show quoted text - "As if you'd know .. You posting to my threads .. denigrates my threads .. Understand .. ?" No, but it is clearly understood by *-* ALL *-* who read your childish No, but it is clearly understood by *-* ALL *-* who read your childish responses and rants which denigrates yourself. You are your own worst nightmare and critical error. You do not own threads nor the information you post by way of your own creation. It comes from real researchers who do not live in a fantasy world in a cut and paste universe who are hobbled by obsessive and compulsive personality disorders. Your peace of mind would be much greater if you refused the compulsion to ever touch a search enjine ever again. I'm sorry life has left you so sad and bitter in your old age. On Nov 20, 6:03 pm, anonym...@nowhere.you.know wrote: snip << I'm not sure you really understand how this works there.. whacko .. I gave up reading your crud long ago there .. whacko .. YOU hit the .. road .. Understand there creeeeeeepoo .. ? Do ya .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk I'm sorry life has left you so sad and bitter in your old age. On Nov 22, 10:34 am, anonym...@nowhere.you.know wrote:snip << I'm not sure you really understand how this works there.. whacko .. YOU hit the .. road .. Understand there creeeeeeepoo .. ? Do ya .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Nov 22, 10:34 am, anonym...@nowhere.you.know wrote:snip << > [quoted text clipped - 5 lines] > > Do ya .. ? Or what, rustbucket? Gonna beat him with a malformed ellipsis? Your ISP, telus, doesn't like people who make threats. It says so right in their Acceptable Use Policy. (ko0klinks snipped) Your ISP, telus, doesn't like people who make threats. It says so right in their Acceptable Use Policy.<< Neither do I .. percy .. I notice you didn't say a whole lot about diabetes OR .. garlic .. did ya .. percy .. **I** don't like it when people post off topic on my threads .. Do you understand .. Per .. cey .. boi .. Don't do it again .. per .. cey .. boi .. Understand .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Your ISP, telus, doesn't like people who make threats. It says so right in their Acceptable Use Policy.<< "Neither do I .. percy .. I notice you didn't say a whole lot about diabetes OR .. garlic .. did ya .. percy .. **I** don't like it when people post off topic on my threads .. Do you understand .. Per .. cey .. boi .. Don't do it again .. per .. cey .. boi .. Understand .. ?" No, don't understand anything but that you are a nasty person who can not respond on the merits of the flaws people see in your ideas and mostly misunderstood abstracts. I'm sorry old age finds you a bitter and sad old man. On Nov 25, 8:40 am, anonym...@nowhere.you.know wrote: snip << You were told to stay off my threads .. dioxin boy .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Your ISP, telus, doesn't like people who make threats. It says so right in their Acceptable Use Policy.<< "Neither do I .. percy .. I notice you didn't say a whole lot about diabetes OR .. garlic .. did ya .. percy .. **I** don't like it when people post off topic on my threads .. Do you understand .. Per .. cey .. boi .. Don't do it again .. per .. cey .. boi .. Understand .. ?" No, don't understand anything but that you are a nasty person who can not respond on the merits of the flaws people see in your ideas and mostly misunderstood abstracts. I'm sorry old age finds you a bitter and sad old man. On Nov 27, 7:51 am, anonym...@nowhere.you.know wrote:snip << You were told to stay off my threads .. dioxin boy .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Your ISP, telus, doesn't like people who make threats. It says so right in their Acceptable Use Policy.<< "Neither do I .. percy .. I notice you didn't say a whole lot about diabetes OR .. garlic .. did ya .. percy .. **I** don't like it when people post off topic on my threads .. Do you understand .. Per .. cey .. boi .. Don't do it again .. per .. cey .. boi .. Understand .. ?" No, don't understand anything but that you are a nasty person who can not respond on the merits of the flaws people see in your ideas and mostly misunderstood abstracts. I'm sorry old age finds you a bitter and sad old man. On Nov 29, 6:24 am, anonym...@nowhere.you.know wrote:snip << You were told to stay off my threads .. dioxin boy .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Nov 19, 7:34 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote: A compound found in garlic is the basis of a potential orally- available drug candidate for types 1 and 2 diabetes. << "Garlic oil may suppress Fe-NTA-induced nephrotoxicity" Food Chem Toxicol 1998 Jun;36(6):485-95 Attenuation of iron-nitrilotriacetate (Fe-NTA)-mediated renal oxidative stress, toxicity and hyperproliferative response by the prophylactic treatment of rats with garlic oil. Iqbal M, Athar M Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi, India. Iron nitrilotriacetate (Fe-NTA) is a potent nephrotoxic agent. In this communication we show that Fe-NTA-mediated nephrotoxicity is diminished by 1 wk of oral daily pretreatment of male albino Wistar rats with garlic oil given by gavage at 50 or 100 mg/kg body weight/ ml corn oil. Intraperitoneal Fe-NTA treatment at a dose level of 9 mg Fe/kg body weight/10 ml enhances renal microsomal lipid peroxidation and hydrogen peroxide generation which are accompanied by a decrease in the activities of renal antioxidant enzymes (e.g. catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase), and a depletion in the level of renal glutathione. Parallel to these changes, a sharp increase in blood urea nitrogen and serum creatinine has been observed. In addition, Fe-NTA treatment also enhances renal ornithine decarboxylase (ODC) activity and increases [3H]thymidine incorporation into renal DNA. Prophylactic treatment of animals with garlic oil before the administration of Fe-NTA resulted in the diminution of Fe-NTA mediated injury. The enhancement of renal lipid peroxidation and hydrogen peroxide generation was decreased. In addition, there was recovery of glutathione depletion and inhibition of the activities of antioxidant enzymes. Similarly, in animals given the higher dose of garlic oil (100 mg/kg body weight) the enhanced blood urea nitrogen and serum creatinine levels, which are indicative of renal injury, showed a reduction of about 30% and 40%, respectively, in comparison with the group treated with Fe-NTA alone. Pretreatment with garlic oil also ameliorated the Fe-NTA-mediated induction of ODC activity and enhancement of [3H]thymidine incorporation into DNA in a dose-dependent manner. Our data suggest that garlic oil is a potent chemopreventive agent and may suppress Fe-NTA-induced nephrotoxicity. PMID: 9674956, UI: 98337713 -------------------------- http://www.clinicaltrials.gov/show/NCT00230087 Iron Depletion Therapy for Type 2 DM and NAFLD This study is currently recruiting patients. Verified by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) March 2006 --------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "Diabetes incidence is increasing worldwide, and there is a continuing > need to develop effective treatments"Diabetes incidence is increasing [quoted text clipped - 77 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > Injection-free treatment for diabetes patients? > > 19 November 2008 > > A compound found in garlic is the basis of a potential orally- > available drug candidate for types 1 and 2 diabetes. What!, NOT another drug displaced by another friggin herbal supplement!!! Shhhh! I just heard shots in the drug company's CEO office. 3 CHEERS!!!!. Anyone want to join me? >> Injection-free treatment for diabetes patients? >> [quoted text clipped - 8 lines] > Shhhh! I just heard shots in the drug company's > CEO office. Read for content: "potential orally-available drug candidate" If the substance in question is effective at doses that would require lethal quantities of garlic per day, then people won't be getting it from food, they'll be getting extracts from (with for it) ... a drug company. | The brighter the stupid burns, the more | | chance that someone will see the light. | +- D. C. Sessions <dcs@lumbercartel.com> -+ |
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