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Medical Forum / General / Alternative / July 2008Retinitis Pigmentosa and Oxidative Stress
Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA Free Radic Biol Med 2008 Jun 28. Retinitis pigmentosa (RP) is a group of diseases in which many different mutations cause rod photoreceptor cells to die and then gradually cone photoreceptors die due to progressive oxidative damage. In this study, we have shown that peroxynitrite-induced nitrosative damage also occurs. In the rd1 mouse model of RP, there was increased staining for S- nitrosocysteine and nitrotyrosine protein adducts that are generated by peroxynitrite. Peroxynitrite is generated from nitric oxide (NO) and superoxide radicals. After degeneration of rods, injection of hydroethidine resulted in strong fluorescence in the retina of rd1 mice, indicating high levels of superoxide radicals, and this was reduced, as was nitrotyrosine staining, by apocynin, suggesting that overaction of NADP(H) oxidase is at least partially responsible. Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS) inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine staining and significantly increased cone survival, indicating that NO- derived peroxynitrite contributes to cone cell death. Treatment with 7-nitroindazole, a relatively specific inhibitor of neuronal NOS, also significantly reduced cone cell death, but aminoguanidine, a relatively specific inhibitor of inducible NOS, did not. These data suggest that NO generated by neuronal NOS exacerbates oxidative damage to cones in RP and that combined therapy to reduce NO and oxidative stress should be considered. Free radical biology & medicine [Free Radic Biol Med] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Another purely genetic disorder. If you have the genes for it you will get it. If you have the gene for blue eyes you will have them. Jesus ate a mediterranean diet. "Therapy to reduce oxidative stress should be considered." ----- Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA Free Radic Biol Med 2008 Jun 28. Retinitis pigmentosa (RP) is a group of diseases in which many different mutations cause rod photoreceptor cells to die and then gradually cone photoreceptors die due to progressive oxidative damage. In this study, we have shown that peroxynitrite-induced nitrosative damage also occurs. In the rd1 mouse model of RP, there was increased staining for S- nitrosocysteine and nitrotyrosine protein adducts that are generated by peroxynitrite. Peroxynitrite is generated from nitric oxide (NO) and superoxide radicals. After degeneration of rods, injection of hydroethidine resulted in strong fluorescence in the retina of rd1 mice, indicating high levels of superoxide radicals, and this was reduced, as was nitrotyrosine staining, by apocynin, suggesting that overaction of NADP(H) oxidase is at least partially responsible. Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS) inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine staining and significantly increased cone survival, indicating that NO- derived peroxynitrite contributes to cone cell death. Treatment with 7-nitroindazole, a relatively specific inhibitor of neuronal NOS, also significantly reduced cone cell death, but aminoguanidine, a relatively specific inhibitor of inducible NOS, did not. These data suggest that NO generated by neuronal NOS exacerbates oxidative damage to cones in RP and that combined therapy to reduce NO and oxidative stress should be considered. Free radical biology & medicine [Free Radic Biol Med] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk ""Therapy to reduce oxidative stress should be considered."" What therapy for blue eyes? This disorder is entirely a genetic one . It is not caused by what one eats or does not eat. It is a "X" related genetic disorder. Jesus ate a mediterranean diet. "Therapy to reduce oxidative stress should be considered." ----- Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA Free Radic Biol Med 2008 Jun 28. Retinitis pigmentosa (RP) is a group of diseases in which many different mutations cause rod photoreceptor cells to die and then gradually cone photoreceptors die due to progressive oxidative damage. In this study, we have shown that peroxynitrite-induced nitrosative damage also occurs. In the rd1 mouse model of RP, there was increased staining for S- nitrosocysteine and nitrotyrosine protein adducts that are generated by peroxynitrite. Peroxynitrite is generated from nitric oxide (NO) and superoxide radicals. After degeneration of rods, injection of hydroethidine resulted in strong fluorescence in the retina of rd1 mice, indicating high levels of superoxide radicals, and this was reduced, as was nitrotyrosine staining, by apocynin, suggesting that overaction of NADP(H) oxidase is at least partially responsible. Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS) inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine staining and significantly increased cone survival, indicating that NO- derived peroxynitrite contributes to cone cell death. Treatment with 7-nitroindazole, a relatively specific inhibitor of neuronal NOS, also significantly reduced cone cell death, but aminoguanidine, a relatively specific inhibitor of inducible NOS, did not. These data suggest that NO generated by neuronal NOS exacerbates oxidative damage to cones in RP and that combined therapy to reduce NO and oxidative stress should be considered. Free radical biology & medicine [Free Radic Biol Med] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk ""Therapy to reduce oxidative stress should be considered."" What therapy for blue eyes? This disorder is entirely a genetic one . It is not caused by what one eats or does not eat. It is a "X" related genetic disorder. Jesus ate a mediterranean diet. "Therapy to reduce oxidative stress should be considered." ----- Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA Free Radic Biol Med 2008 Jun 28. Retinitis pigmentosa (RP) is a group of diseases in which many different mutations cause rod photoreceptor cells to die and then gradually cone photoreceptors die due to progressive oxidative damage. In this study, we have shown that peroxynitrite-induced nitrosative damage also occurs. In the rd1 mouse model of RP, there was increased staining for S- nitrosocysteine and nitrotyrosine protein adducts that are generated by peroxynitrite. Peroxynitrite is generated from nitric oxide (NO) and superoxide radicals. After degeneration of rods, injection of hydroethidine resulted in strong fluorescence in the retina of rd1 mice, indicating high levels of superoxide radicals, and this was reduced, as was nitrotyrosine staining, by apocynin, suggesting that overaction of NADP(H) oxidase is at least partially responsible. Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS) inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine staining and significantly increased cone survival, indicating that NO- derived peroxynitrite contributes to cone cell death. Treatment with 7-nitroindazole, a relatively specific inhibitor of neuronal NOS, also significantly reduced cone cell death, but aminoguanidine, a relatively specific inhibitor of inducible NOS, did not. These data suggest that NO generated by neuronal NOS exacerbates oxidative damage to cones in RP and that combined therapy to reduce NO and oxidative stress should be considered. Free radical biology & medicine [Free Radic Biol Med] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk ""Therapy to reduce oxidative stress should be considered."" What therapy for blue eyes? This disorder is entirely a genetic one . It is not caused by what one eats or does not eat. It is a "X" related genetic disorder. Jesus ate a mediterranean diet. / On Jul 25, 6:31 am, ferr...@ironcity.com wrote: What therapy for blue eyes? << Why don't you step up .. Step .. up .. Heh .. heh .. Fk off .. you pathetic little loser .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Regarding RP: What exactly do you have to lose from the truth? ""Therapy to reduce oxidative stress should be considered."" What therapy for blue eyes? This disorder is entirely a genetic one . It is not caused by what one eats or does not eat. It is a "X" related genetic disorder. Jesus ate a mediterranean diet. On Jul 25, 7:14 am, ferr...@ironcity.com wrote:What exactly do you have to lose from the truth? << Yeah ..buddy .. what DO you have to lose .. ? ""Therapy to reduce oxidative stress should be considered." It .. obviously .. says .. ""Therapy to reduce oxidative stress should be considered." You seem to be having a hard time **understanding** that .. How come .. ? Stupidity .. ? What .. Explain it .. Explain how you think these researchers didn't find .. and report .. to those that are interested .. that .. ""Therapy to reduce oxidative stress should be considered." Your .. "blue eyes" is your .. "jeez I don't understand how that could be" .. is that right .. ? Are you asking ME .. a question .. ? What question are you asking .. ? I can't seem to understand what you are asking .. You should be more .. succinct .. If you are looking for their email addresses you may find them if you look very hard .. Otherwise .. buddy .. personally .. ? .. I don't really give a fk HOW they discovered the NEED for antioxidants .. You understand .. ? I ain't .. interested .. in HOW or why they discovered the NEED for antioxidant .. therapy. YOU got a .. problem WITH .. me .. not giving a fk .. ? Do ya .. ? Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Regarding RP: > [quoted text clipped - 8 lines] > > Jesus ate a mediterranean diet. Are we seeing first hand the results of "rust" in the brain or the cognitive problems of low iron? Regarding RP: What exactly do you have to lose from the truth? ""Therapy to reduce oxidative stress should be considered."" What therapy for blue eyes? This disorder is entirely a genetic one . It is not caused by what one eats or does not eat. It is a "X" related genetic disorder. Jesus ate a mediterranean diet. On Jul 25, 2:19 pm, ferr...@ironcity.com wrote: Are we seeing first hand the results of "rust" in the brain or the cognitive problems of low iron? << You got something to say you little .. pussy .. ? Do ya .. ? How come you can't just step up .. eh .. How come .. Have you ever wondered that .. ? Heh .. heh .. You little pussy .. Retinitis and cognitive problems .. ? No mention of that .. Eye is pretty close to the brain .. so yes .. it could be the rust .. or oxidative stress as the more learned of us .. speak. Is it oxidative stress you are thinking about .. ? Let's see with your retention skills .. ? It is probably cognition you are talking about .. No .. the article didn't say there was cognition problems it said it .. what .. ? Antioxidant therapy for people who are .. blind .. Isn't that .. right .. mr .. medical .. guy .. You guys really make me want to .. go to the ICU .. Heh .. heh .. I wonder if that is why you guys get acosted sooo .. much .. you write articles about it .. eh .. ya little limpwristed .. pussy . . Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Regarding RP: > [quoted text clipped - 8 lines] > > Jesus ate a mediterranean diet. " Are we seeing first hand the results of "rust" in the brain or the cognitive problems of low iron? Does low iron cause irritation and confused thinking? Jesus ate a mediterranean diet. "Therapy to reduce oxidative stress should be considered." ----- Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA Free Radic Biol Med 2008 Jun 28. Retinitis pigmentosa (RP) is a group of diseases in which many different mutations cause rod photoreceptor cells to die and then gradually cone photoreceptors die due to progressive oxidative damage. In this study, we have shown that peroxynitrite-induced nitrosative damage also occurs. In the rd1 mouse model of RP, there was increased staining for S- nitrosocysteine and nitrotyrosine protein adducts that are generated by peroxynitrite. Peroxynitrite is generated from nitric oxide (NO) and superoxide radicals. After degeneration of rods, injection of hydroethidine resulted in strong fluorescence in the retina of rd1 mice, indicating high levels of superoxide radicals, and this was reduced, as was nitrotyrosine staining, by apocynin, suggesting that overaction of NADP(H) oxidase is at least partially responsible. Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS) inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine staining and significantly increased cone survival, indicating that NO- derived peroxynitrite contributes to cone cell death. Treatment with 7-nitroindazole, a relatively specific inhibitor of neuronal NOS, also significantly reduced cone cell death, but aminoguanidine, a relatively specific inhibitor of inducible NOS, did not. These data suggest that NO generated by neuronal NOS exacerbates oxidative damage to cones in RP and that combined therapy to reduce NO and oxidative stress should be considered. Free radical biology & medicine [Free Radic Biol Med] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk ""Therapy to reduce oxidative stress should be considered."" What therapy for blue eyes? This disorder is entirely a genetic one . It is not caused by what one eats or does not eat. It is a "X" related genetic disorder. Jesus ate a mediterranean diet. |
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