Researchers identify cancer preventive properties in common vitamin
supplement
Early laboratory research has shown that resveratrol, a common dietary
supplement, suppresses the abnormal cell formation that leads to most
types of breast cancer, suggesting a potential role for the agent in
breast cancer prevention. Resveratrol is a natural substance found in
red wine and red grapes. It is sold in extract form as a dietary
supplement at most major drug stores.

"Resveratrol has the ability to prevent the first step that occurs
when estrogen starts the process that leads to cancer by blocking the
formation of the estrogen DNA adducts. We believe that this could stop
the whole progression that leads to breast cancer down the road," said
Eleanor G. Rogan, Ph.D., a professor in the Eppley Institute for
Research in Cancer and Allied Diseases at the University of Nebraska
Medical Center.

Rogan was the lead author of the report that was published in the July
2008 issue of Cancer Prevention Research, a journal of the American
Association for Cancer Research.

For the current study, Rogan and colleagues measured the effect of
resveratrol on cellular functions known to contribute to breast
cancer.

The formation of breast cancer is a multi-step process which differs
depending on type of disease, a patient's genetic makeup and other
factors. However, scientists know that many breast cancers are fueled
by increased estrogen, which collects and reacts with DNA molecules to
form adducts. Rogan and colleagues found that resveratrol was able to
suppress the formation of these DNA adducts.
"This is dramatic because it was able to be done with fairly low
concentrations of resveratrol to stop the formation of these DNA
adducts in the cells we studied," said Rogan. Although researchers
experimented with up to 100 µmol/L of resveratrol, the suppression of
DNA adducts was seen with 10 µmol/L. A glass of red wine contains
between 9 and 28 µmol/L of resveratrol.

The researchers also found that resveratrol suppressed the expression
of CYP1B1 and the formation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin,
two known risk factors for breast cancer.

Rogan said resveratrol works by inducing an enzyme called quinone
reductase, which reduces the estrogen metabolite back to inactive
form. By making estrogen inactive, resveratrol decreases the
associated risk.

The current study was conducted in laboratory cultures, and will need
to be confirmed in larger human trials, Rogan said.

Source: American Association for Cancer Research

--------------------

Researchers Show Resveratrol
Works In The Brain By Metal Chelating Effects

Researchers now convincingly show that, via its iron-chelating
effects, resveratrol is able to cross barriers that protect the brain
from entry of toxins (blood/brain barrier) and reduce oxidation
(spoilage) of fats and increase the activity of protective
antioxidant
enzymes in the brain of healthy rodents.
The research has application for age-related brain disorders such as
Alzheimer's and Parkinson's disease.

Resveratrol decreased malondialdehyde (an end product of oxidation of
fats) in brain tissues by -300%.
Doses ranging (in human equivalents) from 87.5 to 875 milligrams were
effective in this regard.
Higher doses were not more effective.

Resveratrol also significantly increased the activity of antioxidant
enzymes superoxide dismutase, catalase and peroxidase by 160%, 270%
and 210% (see above chart).
The forms of most of these protective enzymes were iron-controlling
proteins, confirming that resveratrol's primary action is via its
ability to control metallic metals.
Loose (free) iron causes tissue damage in all forms of age-related
brain disease.
While a relatively high dose of resveratrol was shown to be
most effective (875 milligrams human equivalent dose), this was only a
7-day study.
It is expected that a life-long accumulation of iron in brain tissues
will require a high loading dose and a lower maintenance dose.
The current fad of ultra-high dose resveratrol supplementation
may be beneficial initially, but lead to anemias over longer term
use.
-Resveratrol News April 2007

http://www.resveratrolnews.com/page77.htm

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