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Medical Forum / General / Alternative / June 2008Age Related Illness Accumulation
Looks like these protein carbonyls seem to follow the progression of .. age related iron accumulation. Does iron cause protein carbonyls? By .. george .. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63:179-183 (2008) (c) 2008 The Gerontological Society of America Oxidative Protein Damage Is Associated With Elevated Serum Interleukin-6 Levels Among Older Moderately to Severely Disabled Women Living in the Community Margaret Dayhoff-Brannigan, Luigi Ferrucci, Kai Sun, Linda P. Fried, Jeremy Walston, Ravi Varadhan, Jack M. Guralnik and Richard D. Semba 1 Johns Hopkins Medical Institutions, Baltimore, Maryland. 2 Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland. 3 Epidemiology, Demography, and Biometry Branch, National Institute on Aging, Bethesda, Maryland. Address correspondence to Richard Semba, MD, 550 N. Broadway, Suite 700, Baltimore, MD 21205. E-mail: rdsemba@jhmi.edu Background. Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6. Methods. Serum protein carbonyls and IL-6 were measured in 739 women, age 65 years, in the Women's Health and Aging Study I. Results. Geometric mean of protein carbonyls was 0.082 nmol/mg. After adjusting for age and smoking status, loge serum protein carbonyls were associated with loge IL-6 (β = 0.143, standard error [SE] = 0.048, p =.003) in linear regression analyses and with elevated IL-6 (2.5 pg/mL) (odds ratio = 1.38, 95% confidence interval, 1.02-1.86, p =.037) in logistic regression analyses. Conclusion. Oxidative damage to proteins is independently associated with serum IL-6 among older women living in the community. Increased oxidative stress may be a factor involved in the pathogenesis of the proinflammatory state that occurs in older adults. Key Words: Inflammation * Interleukin-6 * Oxidative stress * Protein carbonyls ------------------------- Protein carbonyl formation on mucosal proteins in vitro and in dextran sulfate-induced colitis - footprints of peroxynitrite in vivo Authors: Blackburn A.C.; Doe W.F.; Buffinton G.D.1 Source: Free Radical Biology and Medicine, Volume 27, Number 3, August 1999 , pp. 262-270(9) Keywords: Inflammatory bowel disease; Protein carbonyls; Western blotting; Dextran sulfate; Inflammation; Hypochlorous acid; Iron; Free radical Language: English Document Type: Research article DOI: 10.1016/S0891-5849(99)00065-9 Affiliations: 1: *Division of Molecular Medicine, John Curtin School of Medical Research Australian National University, Canberra, Australia Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Jun 3, 12:22 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:Protein carbonyl << Oxidative protein damage is associated with poor grip strength among older women living in the community Caitlin Howard1, Luigi Ferrucci2, Kai Sun1, Linda P. Fried1, Jeremy Walston1, Ravi Varadhan1, Jack M. Guralnik3, and Richard D. Semba1 1Johns Hopkins Medical Institutions Baltimore, Maryland 2Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 3Epidemiology, Demography and Biometry Branch, National Institute on Aging, Bethesda, Maryland Running Head: Oxidative protein damage and grip strength Correspondence to: Caitlin Howard, 550 N. Broadway, Suite 700, Baltimore, MD 21205. Tel. (410) 955-3571, Fax (410) 955-1322, email: chowar17@jhmi.edu Page 1 of 19 Articles in PresS. J Appl Physiol (March 22, 2007). doi: 10.1152/japplphysiol.00133.2007 Copyright © 2007 by the American Physiological Society. 2 Abstract Grip strength, an indicator of muscle strength, has been shown to be a predictor of poor outcomes among older adults. Protein carbonylation, an indicator of oxidative damage toproteins, leads to cellular dysfunction and a decline in tissue function. Oxidative stress has beenimplicated in the pathogenesis of sarcopenia. The objective was to determine whether serumprotein carbonyl concentrations are associated with grip strength in older women living in thecommunity. A cross- sectional study was conducted in 672 women, aged 65 and older, from the Women’s Health and Aging Study (WHAS) I, the one-third most disabled women residing in thecommunity in Baltimore, Maryland. Protein carbonyl and grip strength was measured in eachpatient. In a multivariate analysis adjusting for age, race, body mass index, and Mini-MentalStatus Examination score, protein carbonyls (nmol/mg) were associated with grip strength (beta = -6.77, P < 0.01). The statistical association was unchanged after adjusting for hypertension,congestive heart failure, and depression. Ordered logistic regression models adjusted for theabove factors showed that protein carbonyls are associated with increased odds of being in thelower quartiles of grip strength (Odds Ratio 8.74, 95% Confidence Interval 1.06 – 71.89, P =0.043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults. Keywords: aging, sarcopenia, interleukin-6, oxidative stress, protein carbonyls Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Looks like these protein carbonyls seem to follow the progression > of .. age related iron accumulation. [quoted text clipped - 74 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk |
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