The patients with PSC (or other sclerotic biliary disorders) scar
their biliary tree, this results in a permanent loss of function with
limited ability for regeneration. Once the serum bilirubin starts to
rise, a seemingly irreversible, medically untreatable disorder is
present and liver transplantation is the only viable, long-term
alternative. Different options of treatment modalities have been
discussed on:
http://www.surgerysearch.blogspot.com/

Dr. Jitendra Agrawal, Kanpur, India.