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Medical Forum / General / Alternative / May 2008Management Of Chronic Fatigue
http://www.majidali.com/Hypothesis.htm Majid Ali, M.D. ABSTRACT: A hypothesis is proposed that chronic fatigue is a state of accelerated oxidative molecular injury. Evidence supporting the hypothesis includes the following: 1. Spontaneity of oxidation in nature is the basic cause of the aging process for organisms capable of aerobic respiration. Redox dysregulations represent the initial events that lead to clinical disease processes. 2. Incidence of chronic fatigue is increasing, as is the oxidant stress in the Earth's atmosphere. 3. Evidence for oxidative cell membrane injury in chronic fatigue is furnished by changes in intracellular and extracellular ions. 4. Immunologic abnormalities that occur in chronic fatigue are consistent with initial oxidative injury. 5. Commonality of association of antigens of HLA-DR3 region with chronic fatigue syndrome and with other immune disorders such as rheumatoid arthritis, pemphigus vulgaris, systemic lupus erythematosus, and IgA and gold nephropathies. 6. Direct morphologic evidence of increased oxidative stress on the cell membrane is shown by the fact that we have found membrane deformities in up to 80% of erythrocytes in blood from chronic fatigue syndrome patients. These deformities are quickly reversed by administering ascorbic acid intravenously. 7. Changes in electromyopotentials observed in chronic fatigue patients are consistent with intracellular ionic and membrane changes. 8. Clinical entities commonly associated with chronic fatigue are known to increase oxidative molecular stress. 9. Clinical evidence obtained with relief of fatigue and related muscle symptoms with the use of oral and intravenous antioxidant nutrient therapy. From a clinical standpoint, this model for the molecular basis of chronic fatigue is useful for making therapeutic decisions for successful management of chronic fatigue without drug regimens. --------------- "Restriction of iron may have positive effects on health in general and aging in particular" Galaris D, Mantzaris M, Amorgianiotis C Oxidative stress and aging: the potential role of iron. [Journal Article] Hormones (Athens) 2008 Apr-Jun; 7(2):114-22. According to the free radical theory of aging proposed by Denham Harman more than 50 years ago, oxidatively modified cellular components accumulate continuously in the cells during the organism's lifespan leading to progressive decline of cellular functions. Since then, it has been shown that proteins, lipids, nucleic acids and other cell components undergo reversible and/or irreversible oxidative modifications during aging. Moreover, oxidized cell components can undergo further oxidative modifications leading to formation of products that cell degradation systems are incapable of removing. Accumulation of such non-degradable aggregates further inhibits the functionality of degradation systems, thus aggravating the effects and leading to a vicious cycle. In this presentation, we propose that the availability of intracellular iron in its redox active form (labile iron) represents the main catalyst that mediates extensive oxidative modifications of cellular components and ultimately leads to their accumulation and consequent cellular dysfunction. It is tempting to speculate that regulated restriction of labile iron may have positive effects on health in general and aging in particular. Hormones (Athens, Greece) [Hormones (Athens)] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk 50mg/kg Vitamin C for Chronic Fatigue. See, I'm not even telling you about the Kreb Cycle, and its need for Vitamin C for energy production (it is after all called the citric acid cycle) Article at http://www.krysalis.net/chronicfatigue.htm proposes why MSM may be of value for some CF and FMS'ers, too. > 6. Direct morphologic evidence of increased oxidative stress on the > cell membrane is shown by the fact that we have found membrane > deformities in up to 80% of erythrocytes in blood from chronic fatigue > syndrome patients. > These deformities are quickly reversed by administering ascorbic acid > intravenously. 50mg/kg Vitamin C for Chronic Fatigue. << Of course .. michael .. tells a person with HIGH ..chances of BEING iron overloaded / aplastic anemia .. to .."take vitamin C".. "Vitamin C, like any drug, can have serious side effects. For vitamin C, these effects appear more frequently in people who have iron overload (e.g., hemochromatosis or multiple transfusions) or who use unneeded iron supplements." Greg Froehlich, MD White River Junction, VT ------------------ See, I'm not even telling you about the Kreb Cycle, << Seeing what you know nothing about Vitamin C .. I'm glad you didn't tell us what you .. think .. you know .. about the Krebs .. cycle. Heh ..heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk for energy production (it is after all called the citric acid cycle) > Article athttp://www.krysalis.net/chronicfatigue.htmproposes why MSM > may be of value for some CF and FMS'ers, too. [quoted text clipped - 7 lines] > > - Show quoted text - Yep, vitamin C helps with the absorption of iron. You look at the world and see every person that's sick as a likely candidate for a diagnosis of iron overload. So you see it as your mission to get everyone to avoid iron excess. Well, let's let all who have been the recipient of that message tell you how they've started giving blood, become a vegetarian, started chelation therapy, all that. Everybody that wants to express their appreciation to John for pointing out the way to wellness please respond to this invitation. Let him know how thankful you are that he has pointed all this out to you. Go ahead, tell him how you feel about his giving you his message. On May 18, 12:21 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > 50mg/kg Vitamin C for Chronic Fatigue. << > [quoted text clipped - 42 lines] > > > - Show quoted text - http://www.majidali.com/Hypothesis.htm Majid Ali, M.D. ABSTRACT: A hypothesis is proposed that chronic fatigue is a state of accelerated oxidative molecular injury. Evidence supporting the hypothesis includes the following: 1. Spontaneity of oxidation in nature is the basic cause of the aging process for organisms capable of aerobic respiration. Redox dysregulations represent the initial events that lead to clinical disease processes. 2. Incidence of chronic fatigue is increasing, as is the oxidant stress in the Earth's atmosphere. 3. Evidence for oxidative cell membrane injury in chronic fatigue is furnished by changes in intracellular and extracellular ions. 4. Immunologic abnormalities that occur in chronic fatigue are consistent with initial oxidative injury. 5. Commonality of association of antigens of HLA-DR3 region with chronic fatigue syndrome and with other immune disorders such as rheumatoid arthritis, pemphigus vulgaris, systemic lupus erythematosus, and IgA and gold nephropathies. 6. Direct morphologic evidence of increased oxidative stress on the cell membrane is shown by the fact that we have found membrane deformities in up to 80% of erythrocytes in blood from chronic fatigue syndrome patients. These deformities are quickly reversed by administering ascorbic acid intravenously. 7. Changes in electromyopotentials observed in chronic fatigue patients are consistent with intracellular ionic and membrane changes. 8. Clinical entities commonly associated with chronic fatigue are known to increase oxidative molecular stress. 9. Clinical evidence obtained with relief of fatigue and related muscle symptoms with the use of oral and intravenous antioxidant nutrient therapy. From a clinical standpoint, this model for the molecular basis of chronic fatigue is useful for making therapeutic decisions for successful management of chronic fatigue without drug regimens. --------------- "Restriction of iron may have positive effects on health in general and aging in particular" Galaris D, Mantzaris M, Amorgianiotis C Oxidative stress and aging: the potential role of iron. [Journal Article] Hormones (Athens) 2008 Apr-Jun; 7(2):114-22. According to the free radical theory of aging proposed by Denham Harman more than 50 years ago, oxidatively modified cellular components accumulate continuously in the cells during the organism's lifespan leading to progressive decline of cellular functions. Since then, it has been shown that proteins, lipids, nucleic acids and other cell components undergo reversible and/or irreversible oxidative modifications during aging. Moreover, oxidized cell components can undergo further oxidative modifications leading to formation of products that cell degradation systems are incapable of removing. Accumulation of such non-degradable aggregates further inhibits the functionality of degradation systems, thus aggravating the effects and leading to a vicious cycle. In this presentation, we propose that the availability of intracellular iron in its redox active form (labile iron) represents the main catalyst that mediates extensive oxidative modifications of cellular components and ultimately leads to their accumulation and consequent cellular dysfunction. It is tempting to speculate that regulated restriction of labile iron may have positive effects on health in general and aging in particular. Hormones (Athens, Greece) [Hormones (Athens)] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 Isn't this the same stuff posted at the beginning of the thread? Why, by golly, it sure is. And the note in item #6 how the erythrocyte deformities were quickly reversed with intravenous administration of Vitamin C. It's still there, telling how to deal with the oxidative stress postulated by the author you've noted. Just wanted to help you with your crusade. On May 18, 7:20 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > http://www.majidali.com/Hypothesis.htm > [quoted text clipped - 75 lines] > > Man Is A Herbivore!http://tinyurl.com/a3cc3 Isn't this the same stuff posted at the beginning of the thread? << You have a reason to BE .. on this thread .. do ya .. ? You tell people with aplastic anemia to take .. iron .. I place one of many studies which show this NOT to be a good thing in people with aplastic anemia / transfusions. Sooo .. your medical advice is wanting. Try not to give medical advice. You may go to jail or lose your posting privileges .. YOU .. medical advice.. ? Heh .. heh .. On May 18, 4:32 pm, Michael B <baugh...@bellsouth.net> wrote: Why, by golly, it sure is. And the note in item #6 how the erythrocyte deformities were quickly reversed with intravenous administration of Vitamin C. It's still there, telling how to deal with the oxidative stress postulated by the author you've noted. Just wanted to help you with your crusade. << Help .. ? Who you trying to fool .. ? Postulated means .. guessing .. he wasn't guess .. he say they were "quickly reversed". You consider that to BE .. postulation .. do ya .. ? Who cares whether he cures them with vitamin C or not. The postulation IS .. oxidative stress leading to chronic fatigue. You gonna inject some vitamin C are ya .. ? How you going to manage to DO .. that .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On May 18, 7:20 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > [quoted text clipped - 79 lines] > > - Show quoted text - Oh, John, I just SO ENJOY working with you. Gives me that warm fuzzy feeling. Know what I mean? Naah, I don't tell the ones with aplastic anemia to take iron, I remind them that YOUR cited commentary told about reversal of erythrocyte damage from the oxidative stress with use of intravenous Vitamin C. You DO read these things before you post them, don't you? I'd hate to think a Health Research Analyst such as yourself would just post something without noting such an obvious suggestion towards dealing with the damage of oxidative stress. Of course, it isn't like it's a new revelation, Vitamin C is used to reduce radiation injury, too. But, hey, now that I'm your partner on this, what do you mean by "> Who cares whether he cures them with vitamin C or not. > The postulation IS .. oxidative stress leading to chronic fatigue." You're the one telling people how to manage Chronic Fatigue. And you have done it by reminding them that IV Vitamin C corrected the tissue deformities. GOOD FOR YOU!!. Isn't he great? He gave a better alternative than becoming a grass-eater. Take the vitamin C to reduce the effect of oxidative stress. John, what a stroke of genius on your part. Or was it just a stroke? On May 18, 7:51 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > Isn't this the same stuff posted at the beginning of the thread? << > [quoted text clipped - 127 lines] > > > - Show quoted text - On May 18, 5:22 pm, Michael B <baugh...@bellsouth.net> wrote:Take the vitamin C to reduce the effect of oxidative stress.<< "Vitamin C, like any drug, can have serious side effects. For vitamin C, these effects appear more frequently in people who have iron overload (e.g., hemochromatosis or multiple transfusions) or who use unneeded iron supplements." Greg Froehlich, MD White River Junction, VT ------------------------------- Go ahead .. Tell everyone to take vitamin C .. Make sure you tell them to tell the pharmacist they are diabetic .. that way the fits won't cause any kind of a 'stir' at the checkoutcounter .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Oh, John, I just SO ENJOY working with you. Gives me that warm > fuzzy feeling. Know what I mean? [quoted text clipped - 160 lines] > > - Show quoted text - Diabetics are a specific population that may not benefit from vitamin C dose rates of over 250mg/day. And if the pharmacist is doing the job in an appropriate fashion, the administration will likely be suggested at divided doses of 50mg each. Sure glad you still love me, John. But certainly not in a Biblical way. On May 18, 8:51 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > Go ahead .. > [quoted text clipped - 6 lines] > Who loves ya. > Tom If vitamin C was a "drug" the FDA would regulate it! I'm off to have an orange now LOL CB On May 18, 5:22 pm, Michael B <baugh...@bellsouth.net> wrote:Take the vitamin C to reduce the effect of oxidative stress.<< "Vitamin C, like any drug, can have serious side effects. For vitamin C, these effects appear more frequently in people who have iron overload (e.g., hemochromatosis or multiple transfusions) or who use unneeded iron supplements." Greg Froehlich, MD White River Junction, VT ------------------------------- Go ahead .. Tell everyone to take vitamin C .. Make sure you tell them to tell the pharmacist they are diabetic .. that way the fits won't cause any kind of a 'stir' at the checkoutcounter .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Oh, John, I just SO ENJOY working with you. Gives me that warm > fuzzy feeling. Know what I mean? [quoted text clipped - 166 lines] > > - Show quoted text - > See, I'm not even telling you about the Kreb Cycle, and its need for > Vitamin C for energy production (it is after all called the citric > acid cycle) Wow! Ascorbic acid in energy metabolism? What'll they think of next?  SignatureMarshall Price of Miami Known to Yahoo as d021317c |
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