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Medical Forum / General / Alternative / May 2008Pathogens Require Iron
Crusade for iron: iron uptake in unicellular eukaryotes and its significance for virulence. Sutak R, Lesuisse E, Tachezy J, Richardson DR Trends Microbiol 2008 May 7. The effective acquisition of iron is a pre-requisite for survival of all organisms, especially parasites that have a high iron requirement. In mammals, iron homeostasis is meticulously regulated; extracellular free iron is essentially unavailable and host iron availability has a crucial role in the host-pathogen relationship. Therefore, pathogens use specialized and effective mechanisms to acquire iron. In this review, we summarize the iron-uptake systems in eukaryotic unicellular organisms with particular focus on the pathogenic species: Candida albicans, Tritrichomonas foetus, Trypanosoma brucei and Leishmania spp. We describe the diversity of their iron-uptake mechanisms and highlight the importance of the process for virulence. Trends in microbiology [Trends Microbiol] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Crusade for iron: iron uptake in unicellular eukaryotes and its > significance for virulence. [quoted text clipped - 5 lines] > all organisms, especially parasites that have a high iron requirement. > In mammals, iron homeostasis is meticulously regulated OK, Tom. Straight question. No rants, no dots. The article says "In mammals, iron homeostasis is meticulously regulated". in countless posts you've said that it isn't. Would you like to revise your views on iron absorbtion and excretion in view of this article? You''ve forgotten your word .. You didn't write it down .. http://search.msn.com/results.aspx?q=braindeadferrous&FORM=MSNH Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > > Crusade for iron: iron uptake in unicellular eukaryotes and its > > significance for virulence. [quoted text clipped - 11 lines] > in countless posts you've said that it isn't. Would you like to revise your > views on iron absorbtion and excretion in view of this article? Perhaps you woud like to considerwhat you just posted: "The effective acquisition of iron is a pre-requisite for survival of all organisms" > Perhaps you woud like to considerwhat you just posted: > > "The effective acquisition of iron is a pre-requisite for survival of > all organisms" I bet you he wouldn't ! Perhaps you woud like to consider what you just posted: "The effective acquisition of iron is a pre-requisite for survival of all organisms" << I think you believe you've pointed something ..out ..? Is that what you are getting .. at .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On May 12, 1:59 pm, Mike Collins <qmi...@gmail.com> wrote: Perhaps you woud like to consider what you just posted: "The effective acquisition of iron is a pre-requisite for survival of all organisms" << I think you believe you've pointed something ..out ..? Is this the relevant part to your pointing out the fact iron is required by all organisms? THAT is why the body produces iron binding substances to remove the iron away from the pathogen disallowing the pathogen from getting its' food / iron. Iron is required by all / everything .. it is the very basis of life .. WHEN .. **regulated** / kept in check / no random rusting. That is why they kill people with Aids when they give them iron .. it feeds the pathogen. Ochoa TJ, Cleary TG Effect of lactoferrin on enteric pathogens. [JOURNAL ARTICLE] Biochimie 2008 Apr 18. Much has been learned in recent years about the mechanisms by which breastfeeding improves child health and survival. However, there has been little progress in using these insights to improve pediatric care. Factors that are important for protecting the breast fed infant might be expected to decrease the adverse effects of weaning on diarrhea, growth, and development. Lactoferrin, an iron-binding protein with multiple physiological functions (anti-microbial, anti- inflammatory, and immunomodulatory), is one of the most important proteins present in mammalian milk. Protection against gastroenteritis is the most likely biologically relevant activity of lactoferrin. Multiple in vitro and animal studies have shown a protective effect of lactoferrin on infections with enteric microorganisms, including rotavirus, Giardia, Shigella, Salmonella and the diarrheagenic Escherichia coli. Lactoferrin has two major effects on enteric pathogens: it inhibits growth and it impairs function of surface expressed virulence factors thereby decreasing their ability to adhere or to invade mammalian cells. Thus, lactoferrin may protect infants from gastrointestinal infection by preventing the attachment by enteropathogens in the gut. Recently several clinical trials in children have started to address this issue. Whether lactoferrin can prevent a significant portion of diarrheal disease remains to be determined. -------------------------------------------------------------------------------- Biochimie [Biochimie] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Is that what you are getting .. at .. ? > [quoted text clipped - 6 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk |
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