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Medical Forum / General / Alternative / May 2008

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Bone Marrow Treatments Restore Nerves

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ironjustice - 07 May 2008 15:42 GMT
Isn't this the same treatment being replaced by bloodletting in
Sickle , Thalassemia and Leukemia .. ?
-----------------------------------
Bone Marrow Treatments Restore Nerves
5/7/2008

BETHESDA, Maryland (Reuters) - An experiment that went wrong may
provide a new way to treat multiple sclerosis, a Canadian researcher
said on Tuesday. Patients who got bone marrow stem-cell transplants --
similar to those given to leukemia patients -- have enjoyed a
mysterious remission of their disease.

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ironjustice - 07 May 2008 17:02 GMT
On May 7, 7:42 am, ironjustice <teamtan...@hotmail.com> wrote:Isn't
this the same treatment being replaced by bloodletting in
Sickle , Thalassemia and Leukemia .. ? <<

Sure sounds like the same treatment being replaced by iron reduction?

"bone marrow stem-cell transplants"

"pluripotent stem cells in the bone marrow"

Is it coincidence aplasia is linked to erythrocytosis / increased red
blood cell production and so is MS .. IE: polycythemia / viscosity of
the blood ?

"Complete recovery after iron chelation in aplastic anemia"

They treated this kid for five years .. aggressively .. and when and
ONLY when the kid was failing DUE TO their interventions / iron
buildup .. did they finally cure the kid.

Removed the iron **totally**  ..
IE: targeted the iron .. and the kid was cured.
---------

Complete hematopoietic recovery after continuous iron chelation
therapy in a patient with severe aplastic anemia with secondary
hemochromatosis.
Park SJ, Han CW

J Korean Med Sci 2008 Apr; 23(2):320-3.

A 16-yr-old male patient with hemochromatosis due to multiple packed
red blood cell transfusions was referred to our emergency center for
the treatment of severe aplastic anemia and dyspnea. He was diagnosed
with aplastic anemia at 11-yr of age.
He had received continuous transfusions because an HLA-matched marrow
donor was unavailable.
Following a continuous, approximately 5-yr transfusion, he was noted
to develop hemochromatosis.
He had a dilated cardiomyopathy and required diuretics and digitalis,
multiple endocrine and liver dysfunction, generalized bleeding, and
skin pigmentation.
A total volume of red blood cell transfusion before deferoxamine
therapy was about 96,000 mL.
He received a regular iron chelation therapy (continuous intravenous
infusion of deferoxamine, 50 mg/kg/day for 5
days q 3-4 weeks) for approximately seven years after the onset of
multiple organ failures.
His cytopenia and organ dysfunctions began to
be gradually recovered since about 2002, following a 4-yr
deferoxamine treatment.
He showed completely normal ranges of peripheral blood cell
counts, heart size, and liver function two years ago.
He has not
received any transfusions for the last four years.
This finding suggests that a continuous deferoxamine infusion may
play
a role in the immune regulation in addition to iron chelation effect.
Journal of Korean medical science
[J Korean Med Sci]
---------------------------------------------------------------------------­­­­-----

http://en.wikipedia.org/wiki/Aplastic_anemia

Treating aplastic anemia involves suppression of the immune system,
an effect achieved by daily medicine intake, or, in more severe
cases,
a bone marrow transplant, a potential cure but a risky procedure.[1]
The transplanted bone marrow replaces the failing bone marrow cells
with new ones from a matching donor.
The pluripotent stem cells in the bone marrow reconstitute all three
blood cell lines, giving the patient a new immune system, red blood
cells, and platelets.
However, besides the risk of graft failure, there is also a risk that
the newly created white blood cells may attack the rest of the body
("graft-versus-host disease").

Medical therapy of aplastic anemia often includes a short course of
anti-thymocyte globulin (ATG) or anti-lymphocyte globulin (ALG) and
several months of treatment with cyclosporin to modulate the immune
system.
Mild chemotherapy with agents such as cyclophosphamide and
vincristine may also be effective.
Antibodies therapy, such as ATG, targets T-cells, which are believed
to attack the bone marrow.
Steroids are generally ineffective.

In the past, before the above treatments became available, patients
with low leukocyte counts were often confined to a sterile room or
bubble (to reduce risk of infections), as in the famed case of Ted
DeVita.[2]

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DEAD PEOPLE WALKING
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> Isn't this the same treatment being replaced by bloodletting in
> Sickle , Thalassemia and Leukemia .. ?
[quoted text clipped - 16 lines]
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
ironjustice - 07 May 2008 17:14 GMT
On May 7, 9:02 am, ironjustice <ironjust...@cashette.com> wrote:  Is
it coincidence aplasia is linked to erythrocytosis / increased red
blood cell production and so is MS .. IE: polycythemia / viscosity of
the blood ? <<

Acta Haematol. 1994;92(3):136-9.Links
Coincidence of severe aplastic anaemia with multiple sclerosis or
thyroid disorders. Report of 5 cases.
Hinterberger-Fischer M, Kier P, Forstinger I, Lechner K, Kornek G,
Breyer S, Ogris H, Pont J, Hinterberger W.
Division of Hematology and Blood Coagulation, University of Vienna,
Austria.

Five patients with severe aplastic anaemia (SAA) who, simultaneously
(n = 3) or consecutively (n = 2), presented with multiple sclerosis
(MS) (n = 2) or immune hyperthyroidism (IHT) (n = 2) or subacute
thyroiditis (n = 1) are described. Two female patients with MS
developed SAA after a small dose of azathioprine. Another patient
simultaneously presented with IHT and SAA. SAA and MS responded to
cyclosporine while IHT required 131I. Relapsing SAA in 1 patient with
MS was treated with antithymocyte globulin (ATG) which induced acute
exacerbation of MS. Despite the low total dose of ATG (31.5 mg/kg),
complete remission of SAA was obtained. Two other patients developed
thyroid disorders, 42 and 106 months after successful
immunosuppression with ATG/high-dose methylprednisolone. IHT and
subacute thyroiditis were successfully treated with 131I or
prednisolone, respectively, without recurrence of SAA in both cases.
These are the first documented cases of SAA evolving in the course of
MS while the coincidence with IHT was already described. Since
enhanced expression of interferon-gamma plays a crucial role in SAA as
well as in MS and in IHT, similar pathogenetic principles may apply
for these seemingly unrelated disorders.

PMID: 7871951 [PubMed - indexed for MEDLINE]

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Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
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DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> On May 7, 7:42 am, ironjustice <teamtan...@hotmail.com> wrote:Isn't
> this the same treatment being replaced by bloodletting in
[quoted text clipped - 119 lines]
>
> - Show quoted text -
ironjustice - 07 May 2008 17:56 GMT
On May 7, 9:14 am, ironjustice <ironjust...@cashette.com> wrote: the
same treatment being replaced ? <<

"Ataxia, lower extremity spasticity , chorea ,neurological
dysfunction, cognitive decline"

"Oral chelating agents have not been used in neurological diseases of
iron metabolism."

"Oral chelation improved many symptoms."

J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):467-70. Epub 2007 Oct
2. Links
Aceruloplasminaemia with progressive atrophy without brain iron
overload: treatment with oral chelation.
Skidmore FM, Drago V, Foster P, Schmalfuss IM, Heilman KM, Streiff
RR.
University of Florida School of Medicine, North Florida/South Georgia
VA Medical Center, McKnight Brain Institute at UF, 100 S. Newell
Drive, Room L3-100, PO Box 100236, Gainesville, FL 32610-0236, USA.
frank.skidm...@neurology.ufl.edu

BACKGROUND:
Hereditary aceruloplasminaemia is a disorder of iron metabolism that
is characterised by iron accumulation in the brain and other visceral
organs. In previously reported cases, individuals with the disorder
were noted to have evidence of iron accumulation in the brain. Oral
chelating agents have not been used in neurological diseases of iron
metabolism.
METHODS:
A 54-year-old woman who presented with ataxia, lower extremity
spasticity and chorea was evaluated for evidence of the source of
neurological dysfunction. RESULTS: Blood studies revealed no
detectable ceruloplasmin. Marked iron overload was defined by a liver
biopsy, which showed a variegated pattern consistent with a primary
cause of iron overload. Review of MRI scans showed progressive brain
atrophy without visible iron accumulation occurring over a 5-year
period. The history suggested that neurodegeneration was coincident
with aggressive oral iron replacement. Oral chelation improved many
symptoms.
CONCLUSIONS:
Our findings in this patient suggest that disorders of iron transport
such as aceruloplasminaemia can be a cause of neurological symptoms
such as chorea and cognitive decline, as well as progressive
neurodegeneration in the absence of visible iron on MRI scans. We
found that oral iron chelation was effective at improving symptoms.

PMID: 17911185

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> On May 7, 9:02 am, ironjustice <ironjust...@cashette.com> wrote:  Is
> it coincidence aplasia is linked to erythrocytosis / increased red
[quoted text clipped - 165 lines]
>
> - Show quoted text -
ironjustice - 07 May 2008 18:05 GMT
On May 7, 9:56 am, ironjustice <ironjust...@cashette.com> wrote:"Oral
chelation improved many symptoms." <<

Just wanted to point out that they think it was caused by giving the
chick .. iron.

"Coincident with aggressive oral iron replacement"

"Ataxia, lower extremity spasticity , chorea ,neurological
dysfunction, cognitive decline"

"Oral chelating agents have not been used in neurological diseases of
iron metabolism."

"Oral chelation improved many symptoms."

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> On May 7, 9:14 am, ironjustice <ironjust...@cashette.com> wrote: the
> same treatment being replaced ? <<
[quoted text clipped - 225 lines]
>
> - Show quoted text -
timmythesaint - 07 May 2008 19:02 GMT
wow, a whole conversation with yourself. Must be noisy in there!
ironjustice - 07 May 2008 19:25 GMT
wow, a whole conversation with yourself. Must be noisy in there! <<

Come'ere .. let me grease ya .. down there .. timmy boi ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
 
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