Medical Forum / General / Alternative / May 2008
Bone Marrow Treatments Restore Nerves
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ironjustice - 07 May 2008 15:42 GMT Isn't this the same treatment being replaced by bloodletting in Sickle , Thalassemia and Leukemia .. ? ----------------------------------- Bone Marrow Treatments Restore Nerves 5/7/2008
BETHESDA, Maryland (Reuters) - An experiment that went wrong may provide a new way to treat multiple sclerosis, a Canadian researcher said on Tuesday. Patients who got bone marrow stem-cell transplants -- similar to those given to leukemia patients -- have enjoyed a mysterious remission of their disease.
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ironjustice - 07 May 2008 17:02 GMT On May 7, 7:42 am, ironjustice <teamtan...@hotmail.com> wrote:Isn't this the same treatment being replaced by bloodletting in Sickle , Thalassemia and Leukemia .. ? <<
Sure sounds like the same treatment being replaced by iron reduction?
"bone marrow stem-cell transplants"
"pluripotent stem cells in the bone marrow"
Is it coincidence aplasia is linked to erythrocytosis / increased red blood cell production and so is MS .. IE: polycythemia / viscosity of the blood ?
"Complete recovery after iron chelation in aplastic anemia"
They treated this kid for five years .. aggressively .. and when and ONLY when the kid was failing DUE TO their interventions / iron buildup .. did they finally cure the kid.
Removed the iron **totally** .. IE: targeted the iron .. and the kid was cured. ---------
Complete hematopoietic recovery after continuous iron chelation therapy in a patient with severe aplastic anemia with secondary hemochromatosis. Park SJ, Han CW
J Korean Med Sci 2008 Apr; 23(2):320-3.
A 16-yr-old male patient with hemochromatosis due to multiple packed red blood cell transfusions was referred to our emergency center for the treatment of severe aplastic anemia and dyspnea. He was diagnosed with aplastic anemia at 11-yr of age. He had received continuous transfusions because an HLA-matched marrow donor was unavailable. Following a continuous, approximately 5-yr transfusion, he was noted to develop hemochromatosis. He had a dilated cardiomyopathy and required diuretics and digitalis, multiple endocrine and liver dysfunction, generalized bleeding, and skin pigmentation. A total volume of red blood cell transfusion before deferoxamine therapy was about 96,000 mL. He received a regular iron chelation therapy (continuous intravenous infusion of deferoxamine, 50 mg/kg/day for 5 days q 3-4 weeks) for approximately seven years after the onset of multiple organ failures. His cytopenia and organ dysfunctions began to be gradually recovered since about 2002, following a 4-yr deferoxamine treatment. He showed completely normal ranges of peripheral blood cell counts, heart size, and liver function two years ago. He has not received any transfusions for the last four years. This finding suggests that a continuous deferoxamine infusion may play a role in the immune regulation in addition to iron chelation effect. Journal of Korean medical science [J Korean Med Sci] --------------------------------------------------------------------------------
http://en.wikipedia.org/wiki/Aplastic_anemia
Treating aplastic anemia involves suppression of the immune system, an effect achieved by daily medicine intake, or, in more severe cases, a bone marrow transplant, a potential cure but a risky procedure.[1] The transplanted bone marrow replaces the failing bone marrow cells with new ones from a matching donor. The pluripotent stem cells in the bone marrow reconstitute all three blood cell lines, giving the patient a new immune system, red blood cells, and platelets. However, besides the risk of graft failure, there is also a risk that the newly created white blood cells may attack the rest of the body ("graft-versus-host disease").
Medical therapy of aplastic anemia often includes a short course of anti-thymocyte globulin (ATG) or anti-lymphocyte globulin (ALG) and several months of treatment with cyclosporin to modulate the immune system. Mild chemotherapy with agents such as cyclophosphamide and vincristine may also be effective. Antibodies therapy, such as ATG, targets T-cells, which are believed to attack the bone marrow. Steroids are generally ineffective.
In the past, before the above treatments became available, patients with low leukocyte counts were often confined to a sterile room or bubble (to reduce risk of infections), as in the famed case of Ted DeVita.[2]
Who loves ya. Tom
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> Isn't this the same treatment being replaced by bloodletting in > Sickle , Thalassemia and Leukemia .. ? [quoted text clipped - 16 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk ironjustice - 07 May 2008 17:14 GMT On May 7, 9:02 am, ironjustice <ironjust...@cashette.com> wrote: Is it coincidence aplasia is linked to erythrocytosis / increased red blood cell production and so is MS .. IE: polycythemia / viscosity of the blood ? <<
Acta Haematol. 1994;92(3):136-9.Links Coincidence of severe aplastic anaemia with multiple sclerosis or thyroid disorders. Report of 5 cases. Hinterberger-Fischer M, Kier P, Forstinger I, Lechner K, Kornek G, Breyer S, Ogris H, Pont J, Hinterberger W. Division of Hematology and Blood Coagulation, University of Vienna, Austria.
Five patients with severe aplastic anaemia (SAA) who, simultaneously (n = 3) or consecutively (n = 2), presented with multiple sclerosis (MS) (n = 2) or immune hyperthyroidism (IHT) (n = 2) or subacute thyroiditis (n = 1) are described. Two female patients with MS developed SAA after a small dose of azathioprine. Another patient simultaneously presented with IHT and SAA. SAA and MS responded to cyclosporine while IHT required 131I. Relapsing SAA in 1 patient with MS was treated with antithymocyte globulin (ATG) which induced acute exacerbation of MS. Despite the low total dose of ATG (31.5 mg/kg), complete remission of SAA was obtained. Two other patients developed thyroid disorders, 42 and 106 months after successful immunosuppression with ATG/high-dose methylprednisolone. IHT and subacute thyroiditis were successfully treated with 131I or prednisolone, respectively, without recurrence of SAA in both cases. These are the first documented cases of SAA evolving in the course of MS while the coincidence with IHT was already described. Since enhanced expression of interferon-gamma plays a crucial role in SAA as well as in MS and in IHT, similar pathogenetic principles may apply for these seemingly unrelated disorders.
PMID: 7871951 [PubMed - indexed for MEDLINE]
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
> On May 7, 7:42 am, ironjustice <teamtan...@hotmail.com> wrote:Isn't > this the same treatment being replaced by bloodletting in [quoted text clipped - 119 lines] > > - Show quoted text - ironjustice - 07 May 2008 17:56 GMT On May 7, 9:14 am, ironjustice <ironjust...@cashette.com> wrote: the same treatment being replaced ? <<
"Ataxia, lower extremity spasticity , chorea ,neurological dysfunction, cognitive decline"
"Oral chelating agents have not been used in neurological diseases of iron metabolism."
"Oral chelation improved many symptoms."
J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):467-70. Epub 2007 Oct 2. Links Aceruloplasminaemia with progressive atrophy without brain iron overload: treatment with oral chelation. Skidmore FM, Drago V, Foster P, Schmalfuss IM, Heilman KM, Streiff RR. University of Florida School of Medicine, North Florida/South Georgia VA Medical Center, McKnight Brain Institute at UF, 100 S. Newell Drive, Room L3-100, PO Box 100236, Gainesville, FL 32610-0236, USA. frank.skidm...@neurology.ufl.edu
BACKGROUND: Hereditary aceruloplasminaemia is a disorder of iron metabolism that is characterised by iron accumulation in the brain and other visceral organs. In previously reported cases, individuals with the disorder were noted to have evidence of iron accumulation in the brain. Oral chelating agents have not been used in neurological diseases of iron metabolism. METHODS: A 54-year-old woman who presented with ataxia, lower extremity spasticity and chorea was evaluated for evidence of the source of neurological dysfunction. RESULTS: Blood studies revealed no detectable ceruloplasmin. Marked iron overload was defined by a liver biopsy, which showed a variegated pattern consistent with a primary cause of iron overload. Review of MRI scans showed progressive brain atrophy without visible iron accumulation occurring over a 5-year period. The history suggested that neurodegeneration was coincident with aggressive oral iron replacement. Oral chelation improved many symptoms. CONCLUSIONS: Our findings in this patient suggest that disorders of iron transport such as aceruloplasminaemia can be a cause of neurological symptoms such as chorea and cognitive decline, as well as progressive neurodegeneration in the absence of visible iron on MRI scans. We found that oral iron chelation was effective at improving symptoms.
PMID: 17911185
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
> On May 7, 9:02 am, ironjustice <ironjust...@cashette.com> wrote: Is > it coincidence aplasia is linked to erythrocytosis / increased red [quoted text clipped - 165 lines] > > - Show quoted text - ironjustice - 07 May 2008 18:05 GMT On May 7, 9:56 am, ironjustice <ironjust...@cashette.com> wrote:"Oral chelation improved many symptoms." <<
Just wanted to point out that they think it was caused by giving the chick .. iron.
"Coincident with aggressive oral iron replacement"
"Ataxia, lower extremity spasticity , chorea ,neurological dysfunction, cognitive decline"
"Oral chelating agents have not been used in neurological diseases of iron metabolism."
"Oral chelation improved many symptoms."
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
> On May 7, 9:14 am, ironjustice <ironjust...@cashette.com> wrote: the > same treatment being replaced ? << [quoted text clipped - 225 lines] > > - Show quoted text - timmythesaint - 07 May 2008 19:02 GMT wow, a whole conversation with yourself. Must be noisy in there!
ironjustice - 07 May 2008 19:25 GMT wow, a whole conversation with yourself. Must be noisy in there! <<
Come'ere .. let me grease ya .. down there .. timmy boi ..
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
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