Medical Forum / General / Alternative / June 2008
Strontium For Osteoporosis
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BoneLady - 23 Apr 2008 16:51 GMT Are you interested in an alternative to prescription drugs for osteoporosis? Strontium builds stronger bones than drugs like Fosamax, Actonel, or Boniva but without the dangerous side effects. For more information about strontium for treating osteoporosis, please visit Strontium For Bones at http://strontiumforbones.blogspot.com/. My blog offers visitors discussions, information, and links which will be updated periodically.
trigonometry1972@gmail.com | - 23 Apr 2008 18:36 GMT > On Apr 23, 8:51 am, BoneLady <srsuppor...@gmail.com> wrote: > Are you interested in an alternative to prescription drugs for [quoted text clipped - 4 lines] > blog offers visitors discussions, information, and links which will be > updated periodically The blog took too long download when I wanted to comment for impatient me. The blog mentions also taking 1200 mg of calcium, 500 mg of Magnesium, and a 1000 IU of D.
I'll suggest you use some other form than magnesium oxide as it has quite poor absorbed out of the gut. Citrate or even sulfate forms are better absorbed. Split the dose 3 or 4 ways to avoid loose bowels.
Don't assume a 1000 IU of D is enough. If you are made of money have your late winter serum value checked as the is likely your yearly nadir value for 25 OH vitamin D. Choose vitamin D3 especially if you are taking large loading dose. The body doesn't hang on to the so-called vitamin D2 (really analog to what is the real vitamin....Vitamin D3). Consider taking a higher dose during the Fall and Winter months. Also consider taking a large vitamin K2. And there are various forms of K2 the two that are available here in the States over the counter are vitamin K2 MK-4 and MK-7. If you live in Canada, Health Canada wants you to hurry up and break a bone and die as the forbid vitamin K supplements. For no good reasons other than the exercise of power. Vitamin K helps to prevent ectopic calcifications. Which is a bugaboo of the anti-vitamin crowd when it comes to vitamin D use. Interestingly high PTH levels caused by low vitamin D levels are a risk factor for ectopic calcium deposits in the soft tissues. Think milligrams not micrograms on the topic of vitamin K supplementation.
The Werewolf's Lair - 23 Apr 2008 22:24 GMT  Signature "Those who cannot learn from history are doomed to repeat it". -- George Santayana <trigonometry1972@gmail.com> wrote in message news:ee1bb584-3f71-4af9-85e1-99dcd0cb9df7@p25g2000hsf.googlegroups.com...
> Are you interested in an alternative to prescription drugs for > osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 3 lines] > blog offers visitors discussions, information, and links which will be > updated periodically The blog took too long download when I wanted to comment for impatient me.
You must be real impatient, as even with dial-up, this blog only takes a minute to download so please come back and check it out and make your comments.
The blog mentions also taking 1200 mg of calcium, 500 mg of Magnesium, and a 1000 IU of D.
I'll suggest you use some other form than magnesium oxide as it has quite poor absorbed out of the gut. Citrate or even sulfate forms are better absorbed. Split the dose 3 or 4 ways to avoid loose bowels.
Don't assume a 1000 IU of D is enough.
Clinical trials have shown that 1000 IU is a safe and effective amount for Vitamin D. Taking too much D, as it is stored in the body, could result in not only toxicity but loss of calicium from bone and calcium deposits in arteries and organs.
If you are made of money have your late winter serum value checked as the is likely your yearly nadir value for 25 OH vitamin D. Choose vitamin D3 especially if you are taking large loading dose. The body doesn't hang on to the so-called vitamin D2 (really analog to what is the real vitamin....Vitamin D3). Consider taking a higher dose during the Fall and Winter months. Also consider taking a large vitamin K2. And there are various forms of K2 the two that are available here in the States over the counter are vitamin K2 MK-4 and MK-7. If you live in Canada, Health Canada wants you to hurry up and break a bone and die as the forbid vitamin K supplements. For no good reasons other than the exercise of power. Vitamin K helps to prevent ectopic calcifications. Which is a bugaboo of the anti-vitamin crowd when it comes to vitamin D use. Interestingly high PTH levels caused by low vitamin D levels are a risk factor for ectopic calcium deposits in the soft tissues. Think milligrams not micrograms on the topic of vitamin K supplementation.
Kevysmom - 23 Apr 2008 22:43 GMT > "Those who cannot learn from history are doomed to repeat it". -- George > Santayana I hope not, I would hate another 4 more years of a republican president.
On Apr 23, 5:24 pm, "The Werewolf's Lair" <werewolfk...@earthlink.net> wrote:
> -- > "Those who cannot learn from history are doomed to repeat it". -- George [quoted text clipped - 51 lines] > Think milligrams not micrograms on the topic of vitamin K > supplementation. BoneLady - 24 Apr 2008 21:14 GMT On Apr 23, 1:36 pm, "trigonometry1...@gmail.com |" <trigonometry1...@gmail.com> wrote:
> > On Apr 23, 8:51 am, BoneLady <srsuppor...@gmail.com> wrote: > > Are you interested in an alternative to prescription drugs for [quoted text clipped - 7 lines] > The blog took too long download when I wanted to comment for impatient > me. Try being more patient. My blog has been tested on dial-up and only takes less than a minute to load on 50Kps service.
> The blog mentions also taking 1200 mg of calcium, 500 mg of Magnesium, > and a 1000 IU of D. [quoted text clipped - 24 lines] > Think milligrams not micrograms on the topic of vitamin K > supplementation. Taka - 25 Apr 2008 02:16 GMT IMHO boron is better and safer than Strontium for bone and cartilage health - do a search on it and see. Many parts of the World's soil are depleted of boron. I haven't seen yet how it actually works on molecular level but it looks like it has something to do with the membranes and lipid metabolism.
Taka
Marshall Price - 03 May 2008 23:33 GMT > On Apr 23, 1:36 pm, "trigonometry1...@gmail.com |" > <trigonometry1...@gmail.com> wrote: [quoted text clipped - 11 lines] > Try being more patient. My blog has been tested on dial-up and only > takes less than a minute to load on 50Kps service. I found it surprising that strontium (atomic number 38, directly below calcium in the periodic table) not only encourages osteoblasts and discourages osteoclasts, but it also enters sufficiently into bone mineralization to "confuse" the radiologists so they have to distinguish between real bone "density" and the "density" caused by the greater radio-opacity of strontium compared to calcium.
It makes me wonder how important strontium is in human nutrition, how abundant it is, and whether it ought to be added to soils.
 Signature Marshall Price of Miami Known to Yahoo as d021317c
Ron Peterson - 23 Apr 2008 23:12 GMT > Are you interested in an alternative to prescription drugs for > osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 3 lines] > blog offers visitors discussions, information, and links which will be > updated periodically. I don't believe that strontium is considered a nutrient and that makes it difficult to recommend.
And since strontium is more dense to xrays, it can cause misleading BMD tests.
The tests have only been done with strontium renelate which makes it hard to conclude that strontium citrate would have the same action.
-- Ron
BoneLady - 24 Apr 2008 17:20 GMT > > Are you interested in an alternative to prescription drugs for > > osteoporosis? athttp://strontiumforbones.blogspot.com/. > [quoted text clipped - 9 lines] > -- > Multiple clinical trials conducted since the 1950s using strontium gluconate,carbonate,lactate and chloride have attested to the efficacy of supplemental strontium in building strong bones. The ranelate studies are more recent. It is the elemental strontium itself that does the bone building. Strontium citrate has the advantage of better gastric tolerance.See my blog for links to some of the clinical studies. The person reading your dexa scan should make adjustments to the reading if you have been taking strontium. See http://www.osteopenia3.com/Strontium-dexa-scan.html. BoneLady at http://strontiumforbones.blogspot.com/
Marshall Price - 03 May 2008 23:39 GMT >>> Are you interested in an alternative to prescription drugs for >>> osteoporosis? athttp://strontiumforbones.blogspot.com/. > [quoted text clipped - 10 lines] >> Multiple clinical trials conducted since the 1950s using strontium gluconate,carbonate,lactate and chloride have attested to the efficacy of supplemental strontium in building strong bones. The ranelate studies are more recent. It is the elemental strontium itself that does the bone building. Strontium citrate has the advantage of better gastric tolerance.See my blog for links to some of the clinical studies. The person reading your dexa scan should make adjustments to the reading if you have been taking strontium. See http://www.osteopenia3.com/Strontium-dexa-scan.html. > BoneLady at http://strontiumforbones.blogspot.com/ Say, BoneLady, if you could limit the length of your lines to 72 characters, it'd make life easier for some of us. I hate having to fetch my mouse out of storage! :-)
 Signature Marshall Price of Miami Known to Yahoo as d021317c
BoneLady - 24 Apr 2008 20:43 GMT > > Are you interested in an alternative to prescription drugs for > > osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 15 lines] > -- > Ron Strontium is considered to be an essential nutrient like calcium and is available in small amounts from food. It is believed that the strontium-calcium bone matrix is far stronger than calcium matrix alone.
Ron Peterson - 30 Apr 2008 22:44 GMT > > I don't believe that strontium is considered a nutrient and that makes > > it difficult to recommend.
> Strontium is considered to be an essential nutrient like calcium and > is available in small amounts from food. It is believed that the > strontium-calcium bone matrix is far stronger than calcium matrix > alone. Who considers strontium to be an essential nutrient?
Is there a study that indicates that strontium in the bone matrix is the cause of higher bone strength?
-- Ron
Bruce in Bangkok - 01 May 2008 01:26 GMT >> > I don't believe that strontium is considered a nutrient and that makes >> > it difficult to recommend. [quoted text clipped - 8 lines] >Is there a study that indicates that strontium in the bone matrix is >the cause of higher bone strength? The physician's information sheet packed with the Strontium Renelate I am taking includes some details of the studies made:
Two placebo controlled phase III studies: SOTI and TROPOS study. SOTI involved 1,649 postmenopausal women with established osteoporosis (low lumber BMD and prevalent vertebral fracture) and a mean age of 70 years....1,556 patients over 80 years at inclusion...reduced the relative risk of fracture by 41 % over 3 years in the SOTI study (table 1)...
Bruce-in-Bangkok (correct Address is bpaige125atgmaildotcom)
Ron Peterson - 03 May 2008 23:36 GMT On Apr 30, 7:26 pm, Bruce in Bangkok <decypher_signat...@signature.line> wrote:
> On Wed, 30 Apr 2008 14:44:21 -0700 (PDT), Ron Peterson > [quoted text clipped - 22 lines] > relative risk of fracture by 41 % over 3 years in the SOTI study > (table 1)... Does the information sheet analyze why the drug reduces the relative risk of fracture? Is it due to the strontium in the bone matrix?
-- Ron
Marshall Price - 04 May 2008 00:06 GMT >>> Are you interested in an alternative to prescription drugs for >>> osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 19 lines] > strontium-calcium bone matrix is far stronger than calcium matrix > alone. "Essential" usually has a special meaning in nutrition. Calcium is a "major mineral," while strontium is rarely mentioned in nutrition textbooks, and is usually treated as a "trace element" or micronutrient.
You'll find some interesting information about it if you use Google to search for:
strontium -kscripts site:orthomolecular.org
Their emphasis is on schizophrenia, but their investigations into micronutrients are coming up with interesting findings.
(Incidentally, the worldwide contamination of soils with strontium-90 during the era of atom bomb testing suggests another reason for considering the addition strontium to soils.)
 Signature Marshall Price of Miami Known to Yahoo as d021317c
BoneLady - 24 Apr 2008 20:47 GMT > > Are you interested in an alternative to prescription drugs for > > osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 9 lines] > And since strontium is more dense to xrays, it can cause misleading > BMD tests. The correction factor for strontium has been published and there is a link for it on my blog at http://strontiumforbones.blogspot.com in my links section.
> The tests have only been done with strontium renelate which makes it > hard to conclude that strontium citrate would have the same action. Biochemically, since all forms of strontium must dissociate in the stomach and then be protein-bound in the intestines, it doesn't matter which form you take, although the citrate, like calcium citrate, is very absorbable and has few side effects. The ranelate is a patented form so that Servier could market their drug in Europe. There is no real advantage to taking the ranelate form.
> -- > Ron Bruce in Bangkok - 24 Apr 2008 02:34 GMT >Are you interested in an alternative to prescription drugs for >osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 3 lines] >blog offers visitors discussions, information, and links which will be >updated periodically. As I am presently taking strontium ranelate under a doctor's supervision I note a number of differences in what is stated on the Blog spot and what my doctor discussed with me.
Calcium - The blog specifically mentions taking 1200 MG of calcium daily. My doctor advises me that if serum calcium levels are in the high normal range then the body cannot process additional calcium.
Vitamin D3 - The blog specifically mentions taking D3 daily. My doctor advises that providing D3 is being normally manufactured by the body there is no requirement for additional supplements
Magnesium - The blog specifically mentions taking Magnesium daily. My doctor advises that is serum levels of magnesium are normal no additional magnesium is required.
Finally the blog spot loads erratically so I tried http://strontiumforbones.com/ which appears to be much the same information for strontium except that it appears to be an advertizement for the sale of strontium capsules by an organization named "Relentless Improvement", "Premium-Quality Nutriceuticals"
Bruce-in-Bangkok (correct email address for reply)
Larry - 24 Apr 2008 03:23 GMT >>Are you interested in an alternative to prescription drugs for >>osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 11 lines] > daily. My doctor advises me that if serum calcium levels are in the > high normal range then the body cannot process additional calcium. Exactly
> Vitamin D3 - The blog specifically mentions taking D3 daily. My doctor > advises that providing D3 is being normally manufactured by the body > there is no requirement for additional supplements Exactly
> Magnesium - The blog specifically mentions taking Magnesium daily. My > doctor advises that is serum levels of magnesium are normal no [quoted text clipped - 8 lines] > Bruce-in-Bangkok > (correct email address for reply) A good reason to take any supplement or alternative advice given here with a grain of salt, and a good reason to see a good endocrinologist if you have osteoporosis or osteopenia ... to get a complete workup and find out exactly what supplements you need to take so you take no more and no less than you need.
Larry
Bruce in Bangkok - 24 Apr 2008 13:33 GMT >>>Are you interested in an alternative to prescription drugs for >>>osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 38 lines] > >Larry Unfortunately, in a sense,I have been consulting the same doctor for nearly 20 years. Prior to my retirement the clinic was my company's medical advisor and they still treat several of the original management staff. When a problem develops my doctor is prepared to discuss all aspects of the treatment as well as any alternate treatments and to consult if she feels it advisable. I don't seem to have many of the patient/doctor problems that I read about in the group.
Bruce-in-Bangkok (correct email address for reply)
trigonometry1972@gmail.com | - 24 Apr 2008 05:15 GMT > On Wed, 23 Apr 2008 08:51:51 -0700 (PDT), BoneLady > [quoted text clipped - 18 lines] > advises that providing D3 is being normally manufactured by the body > there is no requirement for additional supplements You have a far better chance of getting enough sun in your part of the world than in say Canada or the northern trier states of the lower 48 states of USA. Still the only way to be absolutely sure is to test, of course, you may judge that not to be cost effective.
> Magnesium - The blog specifically mentions taking Magnesium daily. My > doctor advises that is serum levels of magnesium are normal no > additional magnesium is required. I'd be less sure of this than your doctor is.
> Finally the blog spot loads erratically so I triedhttp://strontiumforbones.com/which appears to be much the same > information for strontium except that it appears to be an > advertizement for the sale of strontium capsules by an organization > named "Relentless Improvement", "Premium-Quality Nutriceuticals" And yes it was spam, I think it got it start spamming for customers on the Usenet, if that is who was posting it.
Still the grey market strontium citrate supplements are likely helpful, if strontium ranelate prescription form are helpful. The prescription form has company to press for it use. But that proves nothing other than the company knows how to sneer and fight legal and political battles. choose
> Bruce-in-Bangkok > (correct email address for reply) Larry is right on the need for a good workup of the endocrine system. Unfortunately, most endos aren't that good if replacing the needed hormones i.e. testosterone, LH by way of the analog HCG and will instead just use a bisphosphonate or the rPTH.
Pramesh Rutaji - 24 Apr 2008 05:22 GMT >> Are you interested in an alternative to prescription drugs for >> osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 11 lines] > daily. My doctor advises me that if serum calcium levels are in the > high normal range then the body cannot process additional calcium. Most Americans get plenty of calcium. The USA consumption of calcium is higher than most other places in the world and we have more osteoporosis than most of the world. While calcium is very important, it is less likely that one is deficient.
As to blood work, when I take a LOT of calcium citrate, my blood work shows no change. Perhaps I'm excreeting it somehow the excess is being placed in bone.
> Vitamin D3 - The blog specifically mentions taking D3 daily. My doctor > advises that providing D3 is being normally manufactured by the body > there is no requirement for additional supplements If you lived in the tropics and didn't were hardly any cloths most of the time, this would be true. In the USA, the majority of Americans are vitamin D deficient, even people living in Miami with an outdoor lifestyle. In the USA, cancer rates increase and one moves north. This is true of cardiovascular disease and many others. Vitamin D supplementation is almost necessary for everyone in the USA. The only way to know your vitamin D status is to get some blood work done. I take 7000 IU per day and my blood results are mid normal, 62 in a lab reference range of 32-100.
> Magnesium - The blog specifically mentions taking Magnesium daily. My > doctor advises that is serum levels of magnesium are normal no > additional magnesium is required. The majority of Americans are magnesium deficient. Your mileage may vary. Blood levels are not accurate for this - cellular levels are more important.
Vitamin K I believe is critical in for good bone formation as well. If you are low on K, calcium builds up in other parts of the body.
 Signature Pramesh Rutaji
p297tongue6221@newsguy.com - remove tongue to reply
BoneLady - 24 Apr 2008 17:33 GMT > On Wed, 23 Apr 2008 08:51:51 -0700 (PDT), BoneLady > [quoted text clipped - 29 lines] > > Bruce-in-Bangkok I have absolutely nothing to do with http://strontiumforbones.com/,nor was I even aware of its existence. BoneLady at http://strontiumforbones.blogspot.com/.
BoneLady - 24 Apr 2008 20:48 GMT > On Wed, 23 Apr 2008 08:51:51 -0700 (PDT), BoneLady > [quoted text clipped - 30 lines] > Bruce-in-Bangkok > (correct email address for reply) My blog at http://strontiumforbones.blogspot.com is non-commercial and is NOT associated with the commercial site, www.strontiumforbones.com. My blog carries no ads and is strictly for info and the promotion of non-prescription strontium.
Marshall Price - 04 May 2008 00:43 GMT >> Are you interested in an alternative to prescription drugs for >> osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 28 lines] > Bruce-in-Bangkok > (correct email address for reply) I'm surprised your doctor is relying on serum levels for assessing calcium and magnesium status. That's no good. Besides, his lab may be using inexpensive equipment that doesn't give an accurate assessment of ionic calcium; it's tricky. See the Merck Manual article about hypercalcemia, the main cause of which is "excessive bone resorption with respect to new bone formation and release of Ca into the ECF" (extracellular fluid). -- /Merck Manual,/ 16th ed, p. 1009
And as for telling you that vitamin D is "normally manufactured by the body," that's pretty good evidence he hasn't been keeping up with the science. Only if your skin is oily and you get plenty of sunlight on it (not a good idea, IMHO) are you likely to get enough vitamin D that way. Otherwise, a lack of vitamin D may cause serum levels of calcium (and magnesium?) to be high, because the calcium is remaining in your blood and not getting into your cells.
 Signature Marshall Price of Miami Known to Yahoo as d021317c
Bruce in Bangkok - 04 May 2008 10:36 GMT >>> Are you interested in an alternative to prescription drugs for >>> osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 44 lines] >calcium (and magnesium?) to be high, because the calcium is remaining in >your blood and not getting into your cells. Not to argue with you but in much of S.E. Asia vitamin D is pretty much disregarded by physicians as it is extremely rare for low levels to be found. Some time ago I attempted to have my Vit D levels tested and found that no lab in Bangkok performed the tests as, pointed out to me by a doctor, "because of the amount of sunlight the average Thai is exposed to no one had insufficient vitamin D".
I might point out that labs in Thailand appear to offer a pretty comprehensive breadth of tests I suspect that the inability to obtain the test for Vitamin D lies with the lack of requests for it rather then any "backwardness" in the management of the lab.
Bruce-in-Bangkok (correct Address is bpaige125atgmaildotcom)
trigonometry1972@gmail.com | - 05 May 2008 22:17 GMT On May 4, 2:36 am, Bruce in Bangkok <decypher_signat...@signature.line> wrote:
> On Sat, 03 May 2008 19:43:03 -0400, Marshall Price > [quoted text clipped - 63 lines] > Bruce-in-Bangkok > (correct Address is bpaige125atgmaildotcom) The very fact you are banging away on a keyboard suggests you are or have been at risk for not getting enough vitamin D. I've seen research showing this is even true in some of the southern cities nearer the subtropics. So unless one is out in the noon day sun planting rice, I suggest one is at some risk.
The body will maintain calcium serum levels in someone lacking enough vitamin D and or dietary calcium by raising the parathyroid hormone and raiding the bone for mineral.
Physicians are often behind the times plus sometimes the "received" disease etiology is often somewhat incomplete or inaccurate.
Bruce in Bangkok - 06 May 2008 03:24 GMT On Mon, 5 May 2008 14:17:11 -0700 (PDT), "trigonometry1972@gmail.com
|" <trigonometry1972@gmail.com> wrote:
>On May 4, 2:36 am, Bruce in Bangkok ><decypher_signat...@signature.line> wrote: [quoted text clipped - 81 lines] >"received" disease etiology is often somewhat incomplete >or inaccurate. Good God Man! The fact that I'm sitting here typing on my computer is evidence that I don't get enough sunlight? And I live on a sailboat in Southern Thailand and I'm a nice toasty brown color from the sun? In fact I now need to apply sun block to both ears because of sun damage to my skin. How many hours a day do you believe it requires, in a tropical area where temperatures are in the 100's during the middle of the day, to generate sufficient Vit D?
Certainly the body can steal calcium from the bones. As I'm sure that you know the bone calcium process is a continuous calcium in/calcium out process.
I suppose I am at fault as I should have added the words "in my case" to my comments about my calcium, etc. Mia Culpa.
Bruce-in-Bangkok (correct Address is bpaige125atgmaildotcom)
trigonometry1972@gmail.com | - 06 May 2008 07:45 GMT On May 5, 7:24 pm, Bruce in Bangkok <decypher_signat...@signature.line> wrote:
> On Mon, 5 May 2008 14:17:11 -0700 (PDT), "trigonometry1...@gmail.com > [quoted text clipped - 102 lines] > Bruce-in-Bangkok > (correct Address is bpaige125atgmaildotcom) Well now the rest of us have reason to believe you are replete in vitamin D. Unless you have some odd genetic problem having to do with it. I am guilty as well, my "assuming" is just a technique for getting people to elaborate a bit more.
Whole range of things can result in the weakening of bone. Anyway Sr ranelate looks like a reasonable treatment. I certainly try to add a vitamin K2 supplement to the mix. There are other issues such as excess PTH levels due some glandular tumor, effects of some meds such as the PPI meds or prednisone, the lack of testosterone which results in too little of estradiol in the bones. Some people have poor absorption of nutrients due celiac disease or some other like disease process.
Live well, be happy and skip a stone for the rest of us....Trig
Turin - 24 Apr 2008 03:26 GMT > Are you interested in an alternative to prescription drugs for > osteoporosis? Strontium builds stronger bones than drugs like Fosamax, [quoted text clipped - 3 lines] > blog offers visitors discussions, information, and links which will be > updated periodically. But, Does it build REALLY strong bones? A guy I know - Ken Pangborn - needs SOMETHING ...f.cking fast. At over 500 lbs., his skeleton is warping like a room full of peeling wallpaper.
In fact, I'm not certain that a treatment based on Strontium would be adequate for his particular need ...something more like adamantium might be more in order, here.
We should, perhaps, not rule out any of the radioactive elements, either. If Dude gets any fatter, then there's a danger that a black hole is soon to form at the same coordinates where his french fry filled stomach hangs over his belt. A lot of Floridians are scared of either that happening, or their state falling flat into the ocean, before California goes.
....In which case, maybe we should let the bastard's bone break down. It's a lose-lose if you ask most people...
- - -
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....and, the power of a god:
Turin
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trigonometry1972@gmail.com | - 01 May 2008 08:18 GMT Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. Seeman E, Devogelaer JP, Lorenc R, Spector T, Brixen K, Balogh A, Stucki G, Reginster JY.
Austin Health, University of Melbourne, Australia. egos@unimelb.edu.au
Many fractures occur in women with moderate fracture risk caused by osteopenia. Strontium ranelate was studied in 1431 postmenopausal women with osteopenia. Vertebral fracture risk reduction of 41-59% was shown depending on the site and fracture status at baseline. This is the first report of antivertebral fracture efficacy in women with vertebral osteopenia.
INTRODUCTION: Women with osteoporosis are at high risk for fracture. However, more than one half of all fractures in the community originate from the larger population at more moderate risk of fracture caused by osteopenia. Despite this, evidence for antifracture efficacy in these persons is limited. The aim of this study was to determine whether strontium ranelate, a new drug that reduces fracture risk in women with o steoporosis, is also effective in women with osteopenia.
MATERIALS AND METHODS: Data from the Spinal Osteoporosis Therapeutic Intervention study (SOTI; n = 1649) and the TReatment Of Peripheral OSteoporosis (TROPOS; n = 5091) were pooled to evaluate the antivertebral fracture efficacy of strontium ranelate in women with lumbar spine (LS) osteopenia with any BMD value at the femoral neck (FN; N = 1166) and in 265 women with osteopenia at both sites (intention-to-treat analysis). The women were randomized to strontium ranelate 2 g/d orally or placebo for 3 yr.
RESULTS: No group differences were present in baseline characteristics that may influence fracture outcome independent of therapy. In women with LS osteopenia, treatment reduced the risk of vertebral fracture by 41% (RR = 0.59; 95% CI, 0.43-0.82), by 59% (RR = 0.41; 95% CI, 0.17-0.99) in the 447 patients with no prevalent fractures, and by 38% (RR = 0.62; 95% CI, 0.44-0.88) in the 719 patients with prevalent fractures. In women with osteopenia at both sites, treatment reduced the risk of fracture by 52% (RR = 0.48; 95% CI, 0.24-0.96).
CONCLUSIONS: Strontium ranelate safely reduces the risk of vertebral fractures in women with osteopenia with or without a prevalent fracture.
PMID: 17997711
trigonometry1972@gmail.com | - 01 May 2008 08:18 GMT Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. Seeman E, Devogelaer JP, Lorenc R, Spector T, Brixen K, Balogh A, Stucki G, Reginster JY.
Austin Health, University of Melbourne, Australia. egos@unimelb.edu.au
Many fractures occur in women with moderate fracture risk caused by osteopenia. Strontium ranelate was studied in 1431 postmenopausal women with osteopenia. Vertebral fracture risk reduction of 41-59% was shown depending on the site and fracture status at baseline. This is the first report of antivertebral fracture efficacy in women with vertebral osteopenia.
INTRODUCTION: Women with osteoporosis are at high risk for fracture. However, more than one half of all fractures in the community originate from the larger population at more moderate risk of fracture caused by osteopenia. Despite this, evidence for antifracture efficacy in these persons is limited. The aim of this study was to determine whether strontium ranelate, a new drug that reduces fracture risk in women with o steoporosis, is also effective in women with osteopenia.
MATERIALS AND METHODS: Data from the Spinal Osteoporosis Therapeutic Intervention study (SOTI; n = 1649) and the TReatment Of Peripheral OSteoporosis (TROPOS; n = 5091) were pooled to evaluate the antivertebral fracture efficacy of strontium ranelate in women with lumbar spine (LS) osteopenia with any BMD value at the femoral neck (FN; N = 1166) and in 265 women with osteopenia at both sites (intention-to-treat analysis). The women were randomized to strontium ranelate 2 g/d orally or placebo for 3 yr.
RESULTS: No group differences were present in baseline characteristics that may influence fracture outcome independent of therapy. In women with LS osteopenia, treatment reduced the risk of vertebral fracture by 41% (RR = 0.59; 95% CI, 0.43-0.82), by 59% (RR = 0.41; 95% CI, 0.17-0.99) in the 447 patients with no prevalent fractures, and by 38% (RR = 0.62; 95% CI, 0.44-0.88) in the 719 patients with prevalent fractures. In women with osteopenia at both sites, treatment reduced the risk of fracture by 52% (RR = 0.48; 95% CI, 0.24-0.96).
CONCLUSIONS: Strontium ranelate safely reduces the risk of vertebral fractures in women with osteopenia with or without a prevalent fracture.
PMID: 17997711
BoneLady - 06 Jun 2008 17:18 GMT On May 1, 3:18 am, "trigonometry1...@gmail.com |" <trigonometry1...@gmail.com> wrote:
> Strontium ranelate reduces the risk of vertebral fractures > in patients with osteopenia. [quoted text clipped - 52 lines] > > PMID: 17997711 Thank you for the informative article on strontium ranelate, a prescription drug not available in the U.S.A. Strontium citrate is available without a prescription. Since it is the strontium that is incorporated into the bone matrix, any easily assimilable strontium salt should work just as well in preventing bone fractures.Please visit my non-commercial blog on strontium for osteoporosis and osteopenia at http://strontiumforbones.blogspot.com/
BoneLady
DrollTroll - 08 Jun 2008 17:57 GMT On May 1, 3:18 am, "trigonometry1...@gmail.com |" <trigonometry1...@gmail.com> wrote:
> Strontium ranelate reduces the risk of vertebral fractures > in patients with osteopenia. [quoted text clipped - 53 lines] > > PMID: 17997711 Thank you for the informative article on strontium ranelate, a prescription drug not available in the U.S.A. Strontium citrate is available without a prescription. Since it is the strontium that is incorporated into the bone matrix, any easily assimilable strontium salt should work just as well in preventing bone fractures.Please visit my non-commercial blog on strontium for osteoporosis and osteopenia at http://strontiumforbones.blogspot.com/
BoneLady ===============================
Non-commercial, eh??
Yet you fail, afaict, to mention *any other* non-strontium modality--pretty narrow focus for an old lady w/ osteo. lol.
Well, at least your citrate, discounted, seems reasonable in price, but the mere--and likely artificial--inhibition of bone resorption is likely not the be-all and end-all, either, as normal resorption/deposition is an equilibrium process. Osteo indicates something else is amiss in the process--see below.
The resorption of bone is likely the shedding of skin, digestive mucosal cells, etc. Ie, resorption/deposition keeps bone "fresh"--as long as the deposition part occurs!
You omit exercise, calcium, magnesium, vit D, and a host of other trace minerals associated w/ bone, boron being just one.
And strategies for the above, such as divided doses for all nutrients, ESP calcium, which is 1. not easily absorbed to begin with, and 2. whose absorption can quite decrease with age.
For someone with osteo, I would recommend something on the order of 200-250 mg four to six times a day.
High amounts of phosphoric acid, as in Coke, supposedly wreak havoc with bone density, and greatly increase Ca requirements.
Studies have also shown that there is no greater nutritional bull than "calcium absorbability" schemes. Turns out that the plain, cheap Calcium carbonate is absorbed as well or better than chelates, and all the other crap. This is because most calcium compounds are cleaved right in the stomach, so it ultimately it is only ionic calcium reaching the gut, no matter how it is compounded. Overly-complexing calcium, such as in strong chelates and carboxylic acids (a common food moeity), actually hinders absorption.
Exercise should probably not be percussive, such as in running, but not this namby-pamby useless stuff either. As much weight, range of motion, both in extension and compression, as the old body will safely allow. Uphill walking, weights, hanging, calisthenics, **isometrics**, and perhaps an experimental brief jog or two, as tolerated, on very soft surfaces--sand, dirt, etc, in good sneakers. Perhaps as a precursor to attempts at jogging would be mild "bouncing" to very slight jumping, as in jumping rope. This is actually fairly low impact, if the knees are kept bent, and low impact if the feet don't leave the floor. Burns calories, too.
Isometrics are a powerful method, intrinsically employed by yoga, QiChong, and less so in the more interesting Tai Chi. Simply standing on one leg, with eyes closed if possible, for 15+ seconds, is surprisingly difficult, even for me --a Dr. Roizen recommendation as a test of aging, but a great exercise in its own right, both neural and muscular. Many people will have to steady themselves with a chair or wall, but the goal is to do it freestanding.
Mild dips of the knee (very shallow one-legged kneebends) will substantially load the leg, hips. The deep one-legged kneebends is a very advanced technique among martial artists. Shallow or deep, this is a super-exercise for *anyone*.
There are a number of isometric websites, and numerous techniques. Gadgets are unnecessary, and in fact, the two best isometric aids are a broomstick and a rope. Limb against limb are super as well.
Older people, unsteady or insecure, should certainly guard against falls, have padding/cushions/matts around, and something or someone to hold on to. 4" foam is great (upholstery shops). Older people can start by simply shifting the weight from one foot to another, before outright raising one leg. Walking in place, lifting each knee as high as is safely tolerable, is not a bad start either.
Roizen talked about the importance of learning how to fall in older people. 4" foam is good for this also, and the mere act of rolling onto one's back and then climbing back up into a standing position multiple times is no trivial thing, even for un-old people. 10 reps of that will leave anyone starting to breathe heavy.
 Signature DT
trigonometry1972@gmail.com | - 01 May 2008 08:18 GMT Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. Seeman E, Devogelaer JP, Lorenc R, Spector T, Brixen K, Balogh A, Stucki G, Reginster JY.
Austin Health, University of Melbourne, Australia. egos@unimelb.edu.au
Many fractures occur in women with moderate fracture risk caused by osteopenia. Strontium ranelate was studied in 1431 postmenopausal women with osteopenia. Vertebral fracture risk reduction of 41-59% was shown depending on the site and fracture status at baseline. This is the first report of antivertebral fracture efficacy in women with vertebral osteopenia.
INTRODUCTION: Women with osteoporosis are at high risk for fracture. However, more than one half of all fractures in the community originate from the larger population at more moderate risk of fracture caused by osteopenia. Despite this, evidence for antifracture efficacy in these persons is limited. The aim of this study was to determine whether strontium ranelate, a new drug that reduces fracture risk in women with o steoporosis, is also effective in women with osteopenia.
MATERIALS AND METHODS: Data from the Spinal Osteoporosis Therapeutic Intervention study (SOTI; n = 1649) and the TReatment Of Peripheral OSteoporosis (TROPOS; n = 5091) were pooled to evaluate the antivertebral fracture efficacy of strontium ranelate in women with lumbar spine (LS) osteopenia with any BMD value at the femoral neck (FN; N = 1166) and in 265 women with osteopenia at both sites (intention-to-treat analysis). The women were randomized to strontium ranelate 2 g/d orally or placebo for 3 yr.
RESULTS: No group differences were present in baseline characteristics that may influence fracture outcome independent of therapy. In women with LS osteopenia, treatment reduced the risk of vertebral fracture by 41% (RR = 0.59; 95% CI, 0.43-0.82), by 59% (RR = 0.41; 95% CI, 0.17-0.99) in the 447 patients with no prevalent fractures, and by 38% (RR = 0.62; 95% CI, 0.44-0.88) in the 719 patients with prevalent fractures. In women with osteopenia at both sites, treatment reduced the risk of fracture by 52% (RR = 0.48; 95% CI, 0.24-0.96).
CONCLUSIONS: Strontium ranelate safely reduces the risk of vertebral fractures in women with osteopenia with or without a prevalent fracture.
PMID: 17997711
trigonometry1972@gmail.com | - 01 May 2008 18:47 GMT Sorry about the multiple postings, Google was behaving oddly last night and it didn't seem to be accepting my postings.
More on the topic.
1: Aust Fam Physician. 2007 Aug;36(8):631-2.
Strontium ranelate--does it affect the management of postmenopausal osteoporosis?
Winzenberg T, Powell S, Jones G.
Menzies Research Institute, University of Tasmania. tania.winzenberg@utas.edu.au
This series of articles facilitated by the Cochrane Musculoskeletal Group (CMSG) aims to place the findings of recent Cochrane musculoskeletal reviews in a context immediately relevant to general practitioners. This article considers whether the availability of strontium ranelate affects the management of postmenopausal osteoporosis.
PMID: 17676187 [PubMed - indexed for MEDLINE]
Full article is available by way of a PUBMED link to site with no charge for the article. ===================================
1: J Bone Miner Res. 2005 Sep;20(9):1569-78. Epub 2005 Apr 27.
Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone.
Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ.
Laboratoire d'Histodynamique Osseuse, Faculté de Médecine R. Laennec, Université C. Bernard-Lyon 1, Lyon, France.
In monkeys, long-term strontium ranelate administration results in a dose-dependent bone strontium uptake (mainly into newly formed bone) that preserves the degree of mineralization of bone and the bone mineral at the crystal level, showing its safety at bone mineral level.
INTRODUCTION: Strontium ranelate simultaneously increases bone formation and decreases bone resorption, leading to prevention of bone loss and increase in bone mass and bone strength in normal and ovariectomized rats. This study investigated the interactions of stable strontium (Sr) with bone mineral in monkeys after long-term strontium ranelate treatment and after a period of treatment withdrawal.
MATERIALS AND METHODS: Iliac bone was obtained from untreated monkeys, monkeys at the end of a 52-week strontium ranelate administration (200, 500, 1250 mg/kg/day orally), and in parallel groups 10 weeks after the end of strontium ranelate administration (same three doses; n = 3-7). Sr uptake and distribution in bone mineral were quantified by X-ray microanalysis, changes at the crystal level by X-ray diffraction, and the degree of mineralization of bone (DMB) by quantitative microradiography.
RESULTS: After strontium ranelate administration, dose-dependent Sr uptake occurred into cortical and cancellous bone, with higher content (1.6 times) in new than in old bone. This Sr uptake decreased (50%) 10 weeks after treatment withdrawal; the decrease occurred almost exclusively in new bone. At the end of strontium ranelate treatment and after its withdrawal, a preservation of crystal characteristics was observed, suggesting that Sr was only faintly linked to crystals by ionic substitution and of DMB.
CONCLUSIONS: These results show the absence of a deleterious effect of long-term strontium ranelate treatment on bone mineralization, confirming the histomorphometric observations made in postmenopausal osteoporotic women treated with strontium ranelate.
PMID: 16059629 [PubMed - indexed for MEDLINE]
Related Links
The mineralization of bone tissue: a forgotten dimension in osteoporosis research. [Osteoporos Int. 2003] PMID:12730799
Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. [J Bone Miner Res. 1996] PMID:8864905
Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. [J Bone Miner Res. 2004] PMID: 15537445
Strontium ranelate in osteoporosis. [Curr Pharm Des. 2002] PMID: 12171530
Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). [Bone. 2001] PMID: 11502480 =====================
Final note: Other salts other than ranelate of strontium worked in rodents.
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