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Medical Forum / General / Alternative / June 2008

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Strontium For Osteoporosis

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BoneLady - 23 Apr 2008 16:51 GMT
Are you interested in an alternative to prescription drugs for
osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
Actonel, or Boniva but without the dangerous side effects. For more
information about strontium for treating osteoporosis, please visit
Strontium For Bones at http://strontiumforbones.blogspot.com/.  My
blog offers visitors discussions, information, and links which will be
updated periodically.
trigonometry1972@gmail.com | - 23 Apr 2008 18:36 GMT
> On Apr 23, 8:51 am, BoneLady <srsuppor...@gmail.com> wrote:
> Are you interested in an alternative to prescription drugs for
[quoted text clipped - 4 lines]
> blog offers visitors discussions, information, and links which will be
> updated periodically

The blog took too long download when I wanted to comment for impatient
me.
The blog mentions also taking 1200 mg of calcium, 500 mg of Magnesium,
and a 1000 IU of D.

I'll suggest you use some other form than magnesium oxide as it
has quite poor absorbed out of the gut. Citrate or even sulfate
forms are better absorbed. Split the dose 3 or 4 ways to avoid
loose bowels.

Don't assume a 1000 IU of D is enough. If you are made of
money have your late winter serum value checked as the
is likely your yearly nadir value for 25 OH vitamin D.
Choose vitamin D3 especially if you are taking large
loading dose. The body doesn't hang on to the so-called
vitamin D2 (really analog to what is the real vitamin....Vitamin D3).
Consider taking a higher dose during the Fall and Winter months.
Also consider taking a large vitamin K2. And there are
various forms of K2 the two that are available here in the
States over the counter are vitamin K2 MK-4 and MK-7.
If you live in Canada, Health Canada wants you to hurry
up and break a bone and die as the forbid vitamin K supplements.
For no good reasons other than the exercise of power.
Vitamin K helps to prevent ectopic
calcifications. Which is a bugaboo of the anti-vitamin crowd
when it comes to vitamin D use. Interestingly
high PTH levels caused by low vitamin D levels are
a risk factor for ectopic calcium deposits in the soft tissues.
Think milligrams not micrograms on the topic of vitamin K
supplementation.
The Werewolf's Lair - 23 Apr 2008 22:24 GMT
Signature

"Those who cannot learn from history are doomed to repeat it". -- George
Santayana
<trigonometry1972@gmail.com> wrote in message
news:ee1bb584-3f71-4af9-85e1-99dcd0cb9df7@p25g2000hsf.googlegroups.com...

> Are you interested in an alternative to prescription drugs for
> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 3 lines]
> blog offers visitors discussions, information, and links which will be
> updated periodically

The blog took too long download when I wanted to comment for impatient
me.

You must be real impatient, as even with dial-up, this blog only takes a
minute to download so please come back and check it out and make your
comments.

The blog mentions also taking 1200 mg of calcium, 500 mg of Magnesium,
and a 1000 IU of D.

I'll suggest you use some other form than magnesium oxide as it
has quite poor absorbed out of the gut. Citrate or even sulfate
forms are better absorbed. Split the dose 3 or 4 ways to avoid
loose bowels.

Don't assume a 1000 IU of D is enough.

Clinical trials have shown that 1000 IU is a safe and effective amount for
Vitamin D. Taking too much D, as it is stored in the body, could result in
not only toxicity but loss of calicium from bone and calcium deposits in
arteries and organs.

If you are made of money have your late winter serum value checked as the
is likely your yearly nadir value for 25 OH vitamin D.
Choose vitamin D3 especially if you are taking large
loading dose. The body doesn't hang on to the so-called
vitamin D2 (really analog to what is the real vitamin....Vitamin D3).
Consider taking a higher dose during the Fall and Winter months.
Also consider taking a large vitamin K2. And there are
various forms of K2 the two that are available here in the
States over the counter are vitamin K2 MK-4 and MK-7.
If you live in Canada, Health Canada wants you to hurry
up and break a bone and die as the forbid vitamin K supplements.
For no good reasons other than the exercise of power.
Vitamin K helps to prevent ectopic
calcifications. Which is a bugaboo of the anti-vitamin crowd
when it comes to vitamin D use. Interestingly
high PTH levels caused by low vitamin D levels are
a risk factor for ectopic calcium deposits in the soft tissues.
Think milligrams not micrograms on the topic of vitamin K
supplementation.
Kevysmom - 23 Apr 2008 22:43 GMT
> "Those who cannot learn from history are doomed to repeat it". -- George
> Santayana

I hope not, I would hate another 4 more years of a republican
president.

On Apr 23, 5:24 pm, "The Werewolf's Lair" <werewolfk...@earthlink.net>
wrote:
> --
> "Those who cannot learn from history are doomed to repeat it". -- George
[quoted text clipped - 51 lines]
> Think milligrams not micrograms on the topic of vitamin K
> supplementation.
BoneLady - 24 Apr 2008 21:14 GMT
On Apr 23, 1:36 pm, "trigonometry1...@gmail.com |"
<trigonometry1...@gmail.com> wrote:
> > On Apr 23, 8:51 am, BoneLady <srsuppor...@gmail.com> wrote:
> > Are you interested in an alternative to prescription drugs for
[quoted text clipped - 7 lines]
> The blog took too long download when I wanted to comment for impatient
> me.

Try being more patient. My blog has been tested on dial-up and only
takes less than a minute to load on 50Kps service.

> The blog mentions also taking 1200 mg of calcium, 500 mg of Magnesium,
> and a 1000 IU of D.
[quoted text clipped - 24 lines]
> Think milligrams not micrograms on the topic of vitamin K
> supplementation.
Taka - 25 Apr 2008 02:16 GMT
IMHO boron is better and safer than Strontium for bone and cartilage
health - do a search on it and see.  Many parts of the World's soil
are depleted of boron.  I haven't seen yet how it actually works on
molecular level but it looks like it has something to do with the
membranes and lipid metabolism.

Taka
Marshall Price - 03 May 2008 23:33 GMT
> On Apr 23, 1:36 pm, "trigonometry1...@gmail.com |"
> <trigonometry1...@gmail.com> wrote:
[quoted text clipped - 11 lines]
> Try being more patient. My blog has been tested on dial-up and only
> takes less than a minute to load on 50Kps service.

  I found it surprising that strontium (atomic number 38, directly
below calcium in the periodic table) not only encourages osteoblasts and
discourages osteoclasts, but it also enters sufficiently into bone
mineralization to "confuse" the radiologists so they have to distinguish
between real bone "density" and the "density" caused by the greater
radio-opacity of strontium compared to calcium.

  It makes me wonder how important strontium is in human nutrition, how
abundant it is, and whether it ought to be added to soils.

Signature

Marshall Price of Miami
Known to Yahoo as d021317c

Ron Peterson - 23 Apr 2008 23:12 GMT
> Are you interested in an alternative to prescription drugs for
> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 3 lines]
> blog offers visitors discussions, information, and links which will be
> updated periodically.

I don't believe that strontium is considered a nutrient and that makes
it difficult to recommend.

And since strontium is more dense to xrays, it can cause misleading
BMD tests.

The tests have only been done with strontium renelate which makes it
hard to conclude that strontium citrate would have the same action.

--
   Ron
BoneLady - 24 Apr 2008 17:20 GMT
> > Are you interested in an alternative to prescription drugs for
> > osteoporosis? athttp://strontiumforbones.blogspot.com/. >
[quoted text clipped - 9 lines]
> --
>      Multiple clinical trials conducted since the 1950s using strontium gluconate,carbonate,lactate and chloride have attested to the efficacy of supplemental strontium in building strong bones. The ranelate studies are more recent. It is the elemental strontium itself that does the bone building. Strontium citrate has the advantage of better gastric tolerance.See my blog for links to some of the clinical studies. The person reading your dexa scan should make adjustments to the reading if you have been taking strontium. See http://www.osteopenia3.com/Strontium-dexa-scan.html.
BoneLady at http://strontiumforbones.blogspot.com/
Marshall Price - 03 May 2008 23:39 GMT
>>> Are you interested in an alternative to prescription drugs for
>>> osteoporosis? athttp://strontiumforbones.blogspot.com/. >
[quoted text clipped - 10 lines]
>>      Multiple clinical trials conducted since the 1950s using strontium gluconate,carbonate,lactate and chloride have attested to the efficacy of supplemental strontium in building strong bones. The ranelate studies are more recent. It is the elemental strontium itself that does the bone building. Strontium citrate has the advantage of better gastric tolerance.See my blog for links to some of the clinical studies. The person reading your dexa scan should make adjustments to the reading if you have been taking strontium. See http://www.osteopenia3.com/Strontium-dexa-scan.html.
> BoneLady at http://strontiumforbones.blogspot.com/

  Say, BoneLady, if you could limit the length of your lines to 72
characters, it'd make life easier for some of us.  I hate having to
fetch my mouse out of storage!  :-)

Signature

Marshall Price of Miami
Known to Yahoo as d021317c

BoneLady - 24 Apr 2008 20:43 GMT
> > Are you interested in an alternative to prescription drugs for
> > osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 15 lines]
> --
>     Ron

Strontium is considered to be an essential nutrient like calcium and
is available in small amounts from food. It is believed that the
strontium-calcium bone matrix is far stronger than calcium matrix
alone.
Ron Peterson - 30 Apr 2008 22:44 GMT
> > I don't believe that strontium is considered a nutrient and that makes
> > it difficult to recommend.

> Strontium is considered to be an essential nutrient like calcium and
> is available in small amounts from food. It is believed that the
> strontium-calcium bone matrix is far stronger than calcium matrix
> alone.

Who considers strontium to be an essential nutrient?

Is there a study that indicates that strontium in the bone matrix is
the cause of higher bone strength?

--
  Ron
Bruce in Bangkok - 01 May 2008 01:26 GMT
>> > I don't believe that strontium is considered a nutrient and that makes
>> > it difficult to recommend.
[quoted text clipped - 8 lines]
>Is there a study that indicates that strontium in the bone matrix is
>the cause of higher bone strength?

The physician's information sheet packed with the Strontium Renelate I
am taking includes some details of the studies made:

Two placebo controlled phase III studies: SOTI and TROPOS study. SOTI
involved 1,649 postmenopausal women with established osteoporosis (low
lumber BMD and prevalent vertebral fracture) and a mean age of 70
years....1,556 patients over 80 years at inclusion...reduced the
relative risk of fracture by 41 % over 3 years in the SOTI study
(table 1)...

Bruce-in-Bangkok
(correct Address is bpaige125atgmaildotcom)
Ron Peterson - 03 May 2008 23:36 GMT
On Apr 30, 7:26 pm, Bruce in Bangkok
<decypher_signat...@signature.line> wrote:
> On Wed, 30 Apr 2008 14:44:21 -0700 (PDT), Ron Peterson
>
[quoted text clipped - 22 lines]
> relative risk of fracture by 41 % over 3 years in the SOTI study
> (table 1)...

Does the information sheet analyze why the drug reduces the relative
risk of fracture? Is it due to the strontium in the bone matrix?

--
  Ron
Marshall Price - 04 May 2008 00:06 GMT
>>> Are you interested in an alternative to prescription drugs for
>>> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 19 lines]
> strontium-calcium bone matrix is far stronger than calcium matrix
> alone.

  "Essential" usually has a special meaning in nutrition.  Calcium is a
"major mineral," while strontium is rarely mentioned in nutrition
textbooks, and is usually treated as a "trace element" or micronutrient.

  You'll find some interesting information about it if you use Google
to search for:

  strontium -kscripts site:orthomolecular.org

  Their emphasis is on schizophrenia, but their investigations into
micronutrients are coming up with interesting findings.

  (Incidentally, the worldwide contamination of soils with strontium-90
during the era of atom bomb testing suggests another reason for
considering the addition strontium to soils.)

Signature

Marshall Price of Miami
Known to Yahoo as d021317c

BoneLady - 24 Apr 2008 20:47 GMT
> > Are you interested in an alternative to prescription drugs for
> > osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 9 lines]
> And since strontium is more dense to xrays, it can cause misleading
> BMD tests.

The correction factor for strontium has been published and there is a
link for it on my blog at http://strontiumforbones.blogspot.com in my
links section.

> The tests have only been done with strontium renelate which makes it
> hard to conclude that strontium citrate would have the same action.

Biochemically, since all forms of strontium must dissociate in the
stomach and then be protein-bound in the intestines, it doesn't matter
which form you take, although the citrate, like calcium citrate, is
very absorbable and has few side effects. The ranelate is a patented
form so that Servier could market their drug in Europe. There is no
real advantage to taking the ranelate form.

> --
>     Ron
Bruce in Bangkok - 24 Apr 2008 02:34 GMT
>Are you interested in an alternative to prescription drugs for
>osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 3 lines]
>blog offers visitors discussions, information, and links which will be
>updated periodically.

As I am presently taking strontium ranelate under a doctor's
supervision I note a number of differences in what is stated on the
Blog spot and what my doctor discussed with me.

Calcium - The blog specifically mentions taking 1200 MG of calcium
daily. My doctor advises me that if serum calcium levels are in the
high normal range then the body cannot process additional calcium.

Vitamin D3 - The blog specifically mentions taking D3 daily. My doctor
advises that providing D3 is being normally manufactured by the body
there is no requirement for additional supplements

Magnesium - The blog specifically mentions taking Magnesium daily. My
doctor advises that is serum levels of magnesium are normal no
additional magnesium is required.

Finally the blog spot loads erratically so I tried
http://strontiumforbones.com/ which appears to be much the same
information for strontium except that it appears to be an
advertizement for the sale of strontium capsules by an organization
named "Relentless Improvement", "Premium-Quality Nutriceuticals"

Bruce-in-Bangkok
(correct email address for reply)
Larry - 24 Apr 2008 03:23 GMT
>>Are you interested in an alternative to prescription drugs for
>>osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 11 lines]
> daily. My doctor advises me that if serum calcium levels are in the
> high normal range then the body cannot process additional calcium.
Exactly

> Vitamin D3 - The blog specifically mentions taking D3 daily. My doctor
> advises that providing D3 is being normally manufactured by the body
> there is no requirement for additional supplements
Exactly

> Magnesium - The blog specifically mentions taking Magnesium daily. My
> doctor advises that is serum levels of magnesium are normal no
[quoted text clipped - 8 lines]
> Bruce-in-Bangkok
> (correct email address for reply)

A good reason to take any supplement or alternative advice given here
with a grain of salt, and a good reason to see a good endocrinologist if
you have osteoporosis or osteopenia ... to get a complete workup and
find out exactly what supplements you need to take so you take no more
and no less than you need.

Larry
Bruce in Bangkok - 24 Apr 2008 13:33 GMT
>>>Are you interested in an alternative to prescription drugs for
>>>osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 38 lines]
>
>Larry

Unfortunately, in a sense,I have been consulting the same doctor for
nearly 20 years. Prior to my retirement the clinic was my company's
medical advisor and they still treat several of the original
management staff. When a problem develops my doctor is prepared to
discuss all aspects of the treatment as well as any alternate
treatments and to consult if she feels it advisable. I don't seem to
have many of the patient/doctor problems that I read about in the
group.

Bruce-in-Bangkok
(correct email address for reply)
trigonometry1972@gmail.com | - 24 Apr 2008 05:15 GMT
> On Wed, 23 Apr 2008 08:51:51 -0700 (PDT), BoneLady
>
[quoted text clipped - 18 lines]
> advises that providing D3 is being normally manufactured by the body
> there is no requirement for additional supplements

You have a far better chance of getting enough sun in your
part of the world than in say Canada or the northern trier
states of the lower 48 states of USA.
Still the only way to be absolutely sure
is to test, of course, you may judge that not to be
cost effective.

> Magnesium - The blog specifically mentions taking Magnesium daily. My
> doctor advises that is serum levels of magnesium are normal no
> additional magnesium is required.

I'd be less sure of this than your doctor is.

> Finally the blog spot loads erratically so I triedhttp://strontiumforbones.com/which appears to be much the same
> information for strontium except that it appears to be an
> advertizement for the sale of strontium capsules by an organization
> named "Relentless Improvement", "Premium-Quality Nutriceuticals"

And yes it was spam, I think it got it start spamming for
customers on the Usenet, if that is who was posting it.

Still the grey market strontium citrate supplements are likely
helpful, if strontium ranelate prescription form are helpful.
The prescription form has company to press for
it use. But that proves nothing other than the
company knows how to sneer and fight legal
and political battles.
choose

> Bruce-in-Bangkok
> (correct email address for reply)

Larry is right on the need for a good workup of
the endocrine system. Unfortunately, most
endos aren't that good if replacing the needed
hormones i.e. testosterone, LH by way of the analog
HCG and will instead just use a bisphosphonate
or the rPTH.
Pramesh Rutaji - 24 Apr 2008 05:22 GMT
>> Are you interested in an alternative to prescription drugs for
>> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 11 lines]
> daily. My doctor advises me that if serum calcium levels are in the
> high normal range then the body cannot process additional calcium.

Most Americans get plenty of calcium.  The USA consumption of calcium is
higher than most other places in the world and we have more osteoporosis
than most of the world.  While calcium is very important, it is less
likely that one is deficient.

As to blood work, when I take a LOT of calcium citrate, my blood work
shows no change.  Perhaps I'm excreeting it somehow the excess is being
placed in bone.

> Vitamin D3 - The blog specifically mentions taking D3 daily. My doctor
> advises that providing D3 is being normally manufactured by the body
> there is no requirement for additional supplements

If you lived in the tropics and didn't were hardly any cloths most of
the time, this would be true.  In the USA, the majority of Americans are
vitamin D deficient, even people living in Miami with an outdoor
lifestyle.  In the USA, cancer rates increase and one moves north.  This
is true of cardiovascular disease and many others.  Vitamin D
supplementation is almost necessary for everyone in the USA.  The only
way to know your vitamin D status is to get some blood work done.  I
take 7000 IU per day and my blood results are mid normal, 62 in a lab
reference range of 32-100.

> Magnesium - The blog specifically mentions taking Magnesium daily. My
> doctor advises that is serum levels of magnesium are normal no
> additional magnesium is required.

The majority of Americans are magnesium deficient.  Your mileage may
vary.  Blood levels are not accurate for this - cellular levels are more
important.

Vitamin K I believe is critical in for good bone formation as well.  If
you are low on K, calcium builds up in other parts of the body.

Signature

Pramesh Rutaji

p297tongue6221@newsguy.com - remove tongue to reply

BoneLady - 24 Apr 2008 17:33 GMT
> On Wed, 23 Apr 2008 08:51:51 -0700 (PDT), BoneLady
>
[quoted text clipped - 29 lines]
>
> Bruce-in-Bangkok
I have absolutely nothing to do with http://strontiumforbones.com/,nor
was I even aware of its existence. BoneLady at
http://strontiumforbones.blogspot.com/.
BoneLady - 24 Apr 2008 20:48 GMT
> On Wed, 23 Apr 2008 08:51:51 -0700 (PDT), BoneLady
>
[quoted text clipped - 30 lines]
> Bruce-in-Bangkok
> (correct email address for reply)

My blog at http://strontiumforbones.blogspot.com is non-commercial and
is NOT associated with the commercial site, www.strontiumforbones.com.
My blog carries no ads and is strictly for info and the promotion of
non-prescription strontium.
Marshall Price - 04 May 2008 00:43 GMT
>> Are you interested in an alternative to prescription drugs for
>> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 28 lines]
> Bruce-in-Bangkok
> (correct email address for reply)

  I'm surprised your doctor is relying on serum levels for assessing
calcium and magnesium status.  That's no good.  Besides, his lab may be
using inexpensive equipment that doesn't give an accurate assessment of
ionic calcium; it's tricky.  See the Merck Manual article about
hypercalcemia, the main cause of which is "excessive bone resorption
with respect to new bone formation and release of Ca into the ECF"
(extracellular fluid). -- /Merck Manual,/ 16th ed, p. 1009

  And as for telling you that vitamin D is "normally manufactured by
the body," that's pretty good evidence he hasn't been keeping up with
the science.  Only if your skin is oily and you get plenty of sunlight
on it (not a good idea, IMHO) are you likely to get enough vitamin D
that way.  Otherwise, a lack of vitamin D may cause serum levels of
calcium (and magnesium?) to be high, because the calcium is remaining in
your blood and not getting into your cells.

Signature

Marshall Price of Miami
Known to Yahoo as d021317c

Bruce in Bangkok - 04 May 2008 10:36 GMT
>>> Are you interested in an alternative to prescription drugs for
>>> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 44 lines]
>calcium (and magnesium?) to be high, because the calcium is remaining in
>your blood and not getting into your cells.

Not to argue with you but in much of S.E. Asia vitamin D is pretty
much disregarded by physicians as it is extremely rare for low levels
to be found. Some time ago I attempted to have my Vit D levels tested
and found that no lab in Bangkok performed the tests as, pointed out
to me by a doctor, "because of the amount of sunlight the average Thai
is exposed to no one had insufficient vitamin D".

I might point out that labs in Thailand appear to offer a pretty
comprehensive breadth of tests I suspect that the inability to obtain
the test for Vitamin D lies with the lack of requests for it rather
then any "backwardness" in the management of the lab.

Bruce-in-Bangkok
(correct Address is bpaige125atgmaildotcom)
trigonometry1972@gmail.com | - 05 May 2008 22:17 GMT
On May 4, 2:36 am, Bruce in Bangkok
<decypher_signat...@signature.line> wrote:
> On Sat, 03 May 2008 19:43:03 -0400, Marshall Price
>
[quoted text clipped - 63 lines]
> Bruce-in-Bangkok
> (correct Address is bpaige125atgmaildotcom)

The very fact you are banging away on a keyboard suggests
you are or have been at risk for not getting enough vitamin D.
I've seen research showing this is even true in some of the southern
cities
nearer the subtropics.
So unless one is out in the noon day sun planting rice, I suggest
one is at some risk.

The body will maintain calcium serum levels in someone lacking
enough vitamin D and or dietary calcium by raising the parathyroid
hormone and raiding the bone for mineral.

Physicians are often behind the times plus sometimes the
"received" disease etiology is often somewhat  incomplete
or inaccurate.
Bruce in Bangkok - 06 May 2008 03:24 GMT
On Mon, 5 May 2008 14:17:11 -0700 (PDT), "trigonometry1972@gmail.com
|" <trigonometry1972@gmail.com> wrote:

>On May 4, 2:36 am, Bruce in Bangkok
><decypher_signat...@signature.line> wrote:
[quoted text clipped - 81 lines]
>"received" disease etiology is often somewhat  incomplete
>or inaccurate.

Good God Man! The fact that I'm sitting here typing on my computer is
evidence that I don't get enough sunlight? And I live on a sailboat in
Southern Thailand and I'm a nice toasty brown color from the sun? In
fact I now need to apply sun block to both ears because of sun damage
to my skin. How many hours a day do you believe it requires, in a
tropical area where temperatures are in the 100's during the middle of
the day, to generate sufficient Vit D?

Certainly the body can steal calcium from the bones. As I'm sure that
you know the bone calcium process is a continuous calcium in/calcium
out process.

I suppose I am at fault as I should have added the words "in my case"
to my comments about my calcium, etc. Mia Culpa.

Bruce-in-Bangkok
(correct Address is bpaige125atgmaildotcom)
trigonometry1972@gmail.com | - 06 May 2008 07:45 GMT
On May 5, 7:24 pm, Bruce in Bangkok
<decypher_signat...@signature.line> wrote:
> On Mon, 5 May 2008 14:17:11 -0700 (PDT), "trigonometry1...@gmail.com
>
[quoted text clipped - 102 lines]
> Bruce-in-Bangkok
> (correct Address is bpaige125atgmaildotcom)

Well now the rest of us have reason to believe you are
replete in vitamin D. Unless you have some odd
genetic problem having to do with it. I am guilty as well,
my "assuming" is just a technique for getting people
to elaborate a bit more.

Whole range of things can result in the weakening
of bone. Anyway Sr ranelate looks like a reasonable
treatment. I certainly try to add a vitamin K2 supplement
to the mix. There are other issues such as excess
PTH levels due some glandular tumor, effects of
some meds such as the PPI meds or prednisone,
the lack of testosterone which results in too little
of estradiol in the bones. Some people have
poor absorption of nutrients due celiac disease or
some other like disease process.

Live well, be happy and skip a stone for the
rest of us....Trig
Turin - 24 Apr 2008 03:26 GMT
> Are you interested in an alternative to prescription drugs for
> osteoporosis? Strontium builds stronger bones than drugs like Fosamax,
[quoted text clipped - 3 lines]
> blog offers visitors discussions, information, and links which will be
> updated periodically.

But, Does it build REALLY strong bones?  A guy I know - Ken Pangborn -
needs SOMETHING ...f.cking fast.  At over 500 lbs., his skeleton is
warping like a room full of peeling wallpaper.

In fact, I'm not certain that a treatment based on Strontium would be
adequate for his particular need ...something more like adamantium
might be more in order, here.

We should, perhaps, not rule out any of the radioactive elements,
either.  If Dude gets any fatter, then there's a danger that a black
hole is soon to form at the same coordinates where his french fry
filled stomach hangs over his belt.  A lot of Floridians are scared of
either that happening, or their state falling flat into the ocean,
before California goes.

....In which case, maybe we should let the bastard's bone break down.
It's a lose-lose if you ask most people...

- - -

The face of an angel.
The charm of the devil.

....and, the power of a god:

Turin

I have such sites to show you...
------------------------

http://www.myspace.com/turin_turambar
http://groups.google.com/group/Men_First/
http://turinturambar.fortunecity.com/blog/

------------------------

"He who changeth, altereth, misconstrueth, argueth with, deleteth, or
maketh a lie about these words or causeth them to not be known shall
burn in hell forever and ever...."

-----
trigonometry1972@gmail.com | - 01 May 2008 08:18 GMT
Strontium ranelate reduces the risk of vertebral fractures
in patients with osteopenia.
Seeman E, Devogelaer JP, Lorenc R, Spector T,
Brixen K, Balogh A, Stucki G, Reginster JY.

Austin Health, University of
Melbourne, Australia. egos@unimelb.edu.au

Many fractures occur in women with moderate fracture
risk caused by osteopenia. Strontium ranelate was
studied in 1431 postmenopausal women with osteopenia.
Vertebral fracture risk reduction of 41-59% was
shown depending on the site and fracture status at
baseline. This is the first report of antivertebral
fracture efficacy in women with vertebral osteopenia.

INTRODUCTION:
Women with osteoporosis are at high risk
for fracture. However, more than one half of all
fractures in the community originate from the larger
population at more moderate risk of fracture caused by
osteopenia. Despite this, evidence for antifracture
efficacy in these persons is limited. The aim of this
study was to determine whether strontium ranelate,
a new drug that reduces fracture risk in women with o
steoporosis, is also effective in women with osteopenia.

MATERIALS AND METHODS:
Data from the Spinal Osteoporosis Therapeutic Intervention
study (SOTI; n = 1649) and the TReatment Of Peripheral
OSteoporosis (TROPOS; n = 5091) were pooled to evaluate
the antivertebral fracture efficacy of strontium ranelate
in women with lumbar spine (LS) osteopenia with any BMD
value at the femoral neck (FN; N = 1166) and in 265
women with osteopenia at both sites (intention-to-treat analysis).
The women were randomized to strontium ranelate 2 g/d orally
or placebo for 3 yr.

RESULTS:
No group differences were present
in baseline characteristics that may influence fracture
outcome independent of therapy. In women with LS osteopenia,
treatment reduced the risk of vertebral fracture by 41%
(RR = 0.59; 95% CI, 0.43-0.82), by
59% (RR = 0.41; 95% CI, 0.17-0.99) in the 447 patients
with no prevalent fractures, and
by 38% (RR = 0.62; 95% CI, 0.44-0.88) in the 719 patients
with prevalent fractures. In women with osteopenia at
both sites, treatment reduced the risk of fracture
by 52% (RR = 0.48; 95% CI, 0.24-0.96).

CONCLUSIONS:
Strontium ranelate safely reduces the risk of vertebral
fractures in women with osteopenia with or without a prevalent
fracture.

PMID: 17997711
trigonometry1972@gmail.com | - 01 May 2008 08:18 GMT
Strontium ranelate reduces the risk of vertebral fractures
in patients with osteopenia.
Seeman E, Devogelaer JP, Lorenc R, Spector T,
Brixen K, Balogh A, Stucki G, Reginster JY.

Austin Health, University of
Melbourne, Australia. egos@unimelb.edu.au

Many fractures occur in women with moderate fracture
risk caused by osteopenia. Strontium ranelate was
studied in 1431 postmenopausal women with osteopenia.
Vertebral fracture risk reduction of 41-59% was
shown depending on the site and fracture status at
baseline. This is the first report of antivertebral
fracture efficacy in women with vertebral osteopenia.

INTRODUCTION:
Women with osteoporosis are at high risk
for fracture. However, more than one half of all
fractures in the community originate from the larger
population at more moderate risk of fracture caused by
osteopenia. Despite this, evidence for antifracture
efficacy in these persons is limited. The aim of this
study was to determine whether strontium ranelate,
a new drug that reduces fracture risk in women with o
steoporosis, is also effective in women with osteopenia.

MATERIALS AND METHODS:
Data from the Spinal Osteoporosis Therapeutic Intervention
study (SOTI; n = 1649) and the TReatment Of Peripheral
OSteoporosis (TROPOS; n = 5091) were pooled to evaluate
the antivertebral fracture efficacy of strontium ranelate
in women with lumbar spine (LS) osteopenia with any BMD
value at the femoral neck (FN; N = 1166) and in 265
women with osteopenia at both sites (intention-to-treat analysis).
The women were randomized to strontium ranelate 2 g/d orally
or placebo for 3 yr.

RESULTS:
No group differences were present
in baseline characteristics that may influence fracture
outcome independent of therapy. In women with LS osteopenia,
treatment reduced the risk of vertebral fracture by 41%
(RR = 0.59; 95% CI, 0.43-0.82), by
59% (RR = 0.41; 95% CI, 0.17-0.99) in the 447 patients
with no prevalent fractures, and
by 38% (RR = 0.62; 95% CI, 0.44-0.88) in the 719 patients
with prevalent fractures. In women with osteopenia at
both sites, treatment reduced the risk of fracture
by 52% (RR = 0.48; 95% CI, 0.24-0.96).

CONCLUSIONS:
Strontium ranelate safely reduces the risk of vertebral
fractures in women with osteopenia with or without a prevalent
fracture.

PMID: 17997711
BoneLady - 06 Jun 2008 17:18 GMT
On May 1, 3:18 am, "trigonometry1...@gmail.com |"
<trigonometry1...@gmail.com> wrote:
> Strontium ranelate reduces the risk of vertebral fractures
> in patients with osteopenia.
[quoted text clipped - 52 lines]
>
> PMID: 17997711

Thank you for the informative article on strontium ranelate, a
prescription drug not available in the U.S.A. Strontium citrate is
available without a prescription. Since it is the strontium that is
incorporated into the bone matrix, any easily assimilable strontium
salt should work just as well in preventing bone fractures.Please
visit my non-commercial blog on strontium for osteoporosis and
osteopenia at http://strontiumforbones.blogspot.com/

BoneLady
DrollTroll - 08 Jun 2008 17:57 GMT
On May 1, 3:18 am, "trigonometry1...@gmail.com |"
<trigonometry1...@gmail.com> wrote:
> Strontium ranelate reduces the risk of vertebral fractures
> in patients with osteopenia.
[quoted text clipped - 53 lines]
>
> PMID: 17997711

Thank you for the informative article on strontium ranelate, a
prescription drug not available in the U.S.A. Strontium citrate is
available without a prescription. Since it is the strontium that is
incorporated into the bone matrix, any easily assimilable strontium
salt should work just as well in preventing bone fractures.Please
visit my non-commercial blog on strontium for osteoporosis and
osteopenia at http://strontiumforbones.blogspot.com/

BoneLady
===============================

Non-commercial, eh??

Yet you fail, afaict, to mention *any other* non-strontium modality--pretty
narrow focus for an old lady w/ osteo.  lol.

Well, at least your citrate, discounted, seems reasonable in price, but the
mere--and likely artificial--inhibition of bone resorption is likely not the
be-all and end-all, either, as normal resorption/deposition is an
equilibrium process.
Osteo indicates something else is amiss in the process--see below.

The resorption of bone is likely the shedding of skin, digestive mucosal
cells, etc.  Ie, resorption/deposition keeps bone "fresh"--as long as the
deposition part occurs!

You omit exercise, calcium, magnesium, vit D, and a host of other trace
minerals associated w/ bone, boron being just one.

And strategies for the above, such as divided doses for all nutrients, ESP
calcium, which is 1. not easily absorbed to begin with, and 2. whose
absorption can quite decrease with age.

For someone with osteo, I would recommend something on the order of 200-250
mg  four to six times a day.

High amounts of phosphoric acid, as in Coke, supposedly wreak havoc with
bone density, and greatly increase Ca requirements.

Studies have also shown that there is no greater nutritional bull than
"calcium absorbability" schemes.
Turns out that the plain, cheap Calcium carbonate is absorbed as well or
better than chelates, and all the other crap.
This is because most calcium compounds are cleaved right in the stomach, so
it ultimately it is only ionic calcium reaching the gut, no matter how it is
compounded.
Overly-complexing calcium, such as in strong chelates and carboxylic acids
(a common food moeity), actually hinders absorption.

Exercise should probably not be percussive, such as in running, but not this
namby-pamby useless stuff either.
As much weight, range of motion, both in extension and compression, as the
old body will safely allow.
Uphill walking, weights, hanging, calisthenics, **isometrics**, and perhaps
an experimental brief jog or two, as tolerated, on very soft surfaces--sand,
dirt, etc, in good sneakers.
Perhaps as a precursor to attempts at jogging would be mild "bouncing" to
very slight jumping, as in jumping rope.  This is actually fairly low
impact, if the knees are kept bent, and low impact if the feet don't leave
the floor.  Burns calories, too.

Isometrics are a powerful method, intrinsically employed by yoga, QiChong,
and less so in the more interesting Tai Chi.
Simply standing on one leg, with eyes closed if possible, for 15+ seconds,
is surprisingly difficult, even for me --a Dr. Roizen recommendation as a
test of aging, but a great exercise in its own right, both neural and
muscular.
Many people will have to steady themselves with a chair or wall, but the
goal is to do it freestanding.

Mild dips of the knee (very shallow one-legged kneebends) will substantially
load the leg, hips.  The deep one-legged kneebends is a very advanced
technique among martial artists.
Shallow or deep, this is a super-exercise for *anyone*.

There are a number of isometric websites, and numerous techniques.
Gadgets are unnecessary, and in fact, the two best isometric aids are a
broomstick and a rope.  Limb against limb are super as well.

Older people, unsteady or insecure, should certainly guard against falls,
have padding/cushions/matts around, and something or someone to hold on to.
4" foam is great (upholstery shops).  Older people can start by simply
shifting the weight from one foot to another, before outright raising one
leg.
Walking in place, lifting each knee as high as is safely tolerable, is not a
bad start either.

Roizen talked about the importance of learning how to fall in older people.
4" foam is good for this also, and the mere act of rolling onto one's back
and then climbing back up into a standing position multiple times is no
trivial thing, even for un-old people.  10 reps of that will leave anyone
starting to breathe heavy.

Signature

DT

trigonometry1972@gmail.com | - 01 May 2008 08:18 GMT
Strontium ranelate reduces the risk of vertebral fractures
in patients with osteopenia.
Seeman E, Devogelaer JP, Lorenc R, Spector T,
Brixen K, Balogh A, Stucki G, Reginster JY.

Austin Health, University of
Melbourne, Australia. egos@unimelb.edu.au

Many fractures occur in women with moderate fracture
risk caused by osteopenia. Strontium ranelate was
studied in 1431 postmenopausal women with osteopenia.
Vertebral fracture risk reduction of 41-59% was
shown depending on the site and fracture status at
baseline. This is the first report of antivertebral
fracture efficacy in women with vertebral osteopenia.

INTRODUCTION:
Women with osteoporosis are at high risk
for fracture. However, more than one half of all
fractures in the community originate from the larger
population at more moderate risk of fracture caused by
osteopenia. Despite this, evidence for antifracture
efficacy in these persons is limited. The aim of this
study was to determine whether strontium ranelate,
a new drug that reduces fracture risk in women with o
steoporosis, is also effective in women with osteopenia.

MATERIALS AND METHODS:
Data from the Spinal Osteoporosis Therapeutic Intervention
study (SOTI; n = 1649) and the TReatment Of Peripheral
OSteoporosis (TROPOS; n = 5091) were pooled to evaluate
the antivertebral fracture efficacy of strontium ranelate
in women with lumbar spine (LS) osteopenia with any BMD
value at the femoral neck (FN; N = 1166) and in 265
women with osteopenia at both sites (intention-to-treat analysis).
The women were randomized to strontium ranelate 2 g/d orally
or placebo for 3 yr.

RESULTS:
No group differences were present
in baseline characteristics that may influence fracture
outcome independent of therapy. In women with LS osteopenia,
treatment reduced the risk of vertebral fracture by 41%
(RR = 0.59; 95% CI, 0.43-0.82), by
59% (RR = 0.41; 95% CI, 0.17-0.99) in the 447 patients
with no prevalent fractures, and
by 38% (RR = 0.62; 95% CI, 0.44-0.88) in the 719 patients
with prevalent fractures. In women with osteopenia at
both sites, treatment reduced the risk of fracture
by 52% (RR = 0.48; 95% CI, 0.24-0.96).

CONCLUSIONS:
Strontium ranelate safely reduces the risk of vertebral
fractures in women with osteopenia with or without a prevalent
fracture.

PMID: 17997711
trigonometry1972@gmail.com | - 01 May 2008 18:47 GMT
Sorry about the multiple postings, Google was behaving oddly last
night and it didn't seem to be accepting my postings.

More on the topic.

1: Aust Fam Physician. 2007 Aug;36(8):631-2.

Strontium ranelate--does it affect the management of postmenopausal
osteoporosis?

Winzenberg T, Powell S, Jones G.

Menzies Research Institute, University of Tasmania.
tania.winzenberg@utas.edu.au

This series of articles facilitated by the Cochrane
Musculoskeletal Group (CMSG) aims to place the findings
of recent Cochrane musculoskeletal reviews in a
context immediately relevant to general practitioners.
This article considers whether the availability of
strontium ranelate affects the management of
postmenopausal osteoporosis.

PMID: 17676187 [PubMed - indexed for MEDLINE]

Full article is available by way of a PUBMED link to site with no
charge for the article.
===================================

1: J Bone Miner Res. 2005 Sep;20(9):1569-78.
Epub 2005 Apr 27.

Long-term strontium ranelate administration in
monkeys preserves characteristics of bone mineral
crystals and degree of mineralization of bone.

Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ.

Laboratoire d'Histodynamique Osseuse,
Faculté de Médecine R. Laennec, Université
C. Bernard-Lyon 1, Lyon, France.

In monkeys, long-term strontium ranelate administration
results in a dose-dependent bone strontium uptake
(mainly into newly formed bone) that
preserves the degree of mineralization of bone
and the bone mineral at the crystal level,
showing its safety at bone mineral level.

INTRODUCTION:
Strontium ranelate simultaneously increases bone formation
and decreases bone resorption, leading to prevention of
bone loss and increase in bone mass and bone strength in
normal and ovariectomized rats. This study investigated
the interactions of stable strontium (Sr) with bone
mineral in monkeys after long-term strontium
ranelate treatment and after a period of treatment withdrawal.

MATERIALS AND METHODS:
Iliac bone was obtained from untreated monkeys, monkeys at
the end of a 52-week strontium ranelate administration
(200, 500, 1250 mg/kg/day orally), and in parallel
groups 10 weeks after the end of strontium ranelate
administration (same three doses; n = 3-7).
Sr uptake and distribution in bone mineral were
quantified by X-ray microanalysis, changes at the
crystal level by X-ray diffraction, and the degree of
mineralization of bone (DMB) by quantitative
microradiography.

RESULTS:
After strontium ranelate administration, dose-dependent
Sr uptake occurred into cortical and cancellous bone,
with higher content (1.6 times) in new than in old bone.
This Sr uptake decreased (50%) 10 weeks after treatment
withdrawal; the decrease occurred almost exclusively in new
bone. At the end of strontium ranelate treatment and after
its withdrawal, a preservation of crystal characteristics
was observed, suggesting that Sr was only
faintly linked to crystals by ionic substitution and of DMB.

CONCLUSIONS:
These results show the absence of a deleterious
effect of long-term strontium ranelate
treatment on bone mineralization, confirming
the histomorphometric observations made in postmenopausal
osteoporotic women treated with strontium ranelate.

PMID: 16059629 [PubMed - indexed for MEDLINE]

Related Links

   The mineralization of bone tissue: a forgotten dimension in
osteoporosis
research. [Osteoporos Int. 2003] PMID:12730799

   Strontium distribution and interactions with bone mineral in
monkey iliac bone
after strontium salt (S 12911) administration. [J Bone Miner Res.
1996]
PMID:8864905

   Strontium ranelate improves bone resistance by increasing bone
mass and improving
architecture in intact female rats. [J Bone Miner Res. 2004] PMID:
15537445

   Strontium ranelate in osteoporosis. [Curr Pharm Des. 2002] PMID:
12171530

   Strontium ranelate inhibits bone resorption while maintaining bone
formation in
alveolar bone in monkeys (Macaca fascicularis). [Bone. 2001] PMID:
11502480
=====================

Final note:
Other salts other than ranelate of strontium worked in rodents.
 
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