"Chlorogenic acids and the flavonols"

Isolation and Structure Elucidation of Antioxidant Polyphenols from
Quince (Cydonia vulgaris) Peels. [JOURNAL ARTICLE]
J Agric Food Chem 2008 Mar 19.
Fiorentino A, D'Abrosca B, Pacifico S, Mastellone C, Piscopo V, Caputo
R, Monaco P

Thirteen new compounds, as well as 16 already known, have been
isolated from organic extracts of peels of Cydonia vulgaris, a fruit
of a shrub belonging to the same tribe as the apple. All of the
structures were elucidated by EI- or ESI-MS and (1)H and (13)C NMR
after purification of individual compounds by HPLC.
Thirteen fatty acid esters of cinnamyl alcohols, three fatty acid
esters of hydroxybenzoic acid, three fatty acid esters of
hydroxybenzaldehyde, three glucosides of aromatic acids, four
chlorogenic acids, two flavonols, and a benzylamine have been
identified.
The fatty acid moieties have been identified by GC-MS analysis of the
methanolysis products. All of the compounds were tested for their
radical scavenging and antioxidant activities by measuring their
capacity to scavenge the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical
and anion superoxide radical and to induce the reduction of Mo(VI) to
Mo(V).
The chlorogenic acids and the flavonols exhibited more antioxidant and
radical scavenger capacity than the positive standards alpha-
tocopherol and ascorbic acid.
The results of the tests were analyzed by cluster analysis that
grouped all of the compounds on the basis of the substituents on the
aromatic ring.
Journal of agricultural and food chemistry [J Agric Food Chem]
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<<snip>>
Iron chelation by chlorogenic acid as a natural antioxidant
<<snip>>

http://tinyurl.com/5unq2

Blood. 2004 Oct 15;104(8):2514-22. Epub 2004 Jun 29. Related Articles,
Links

Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38
mitogen-activated protein kinase-dependent apoptosis in chronic
myelogenous
leukemic cells.

Bandyopadhyay G, Biswas T, Roy KC, Mandal S, Mandal C, Pal BC,
Bhattacharya S,
Rakshit S, Bhattacharya DK, Chaudhuri U, Konar A, Bandyopadhyay S.

Division of Immunology, Indian Institute of Chemical Biology, 4, Raja
S. C.
Mullick Rd, Kolkata-, India.

We report that chlorogenic acid (Chl) induces apoptosis of several
Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and
primary
cells from CML patients in vitro and destroys Bcr-Abl-positive K562
cells in
vivo. In contrast, this compound has no effect on the growth and
viability of
Bcr-Abl-negative lymphocytic and myeloid cell lines and primary CML
cells.
Sodium chlorogenate (NaChl) exhibits 2-fold higher efficiency in
killing K562
cells compared with Chl. NaChl also induces growth inhibition of
squamous cell
carcinoma (HSC-2) and salivary gland tumor cells (HSG), although at 50-
fold
higher concentration. NaChl inhibits autophosphorylation of p210(Bcr-
Abl)
fusion protein rapidly. We demonstrate that p38 phosphorylation is
increased in
Bcr-Abl-positive cells after treatment with NaChl and closely
paralleled the
inhibition of Bcr-Abl phosphorylation. NaChl did not increase
phosphorylation
of p38 in Bcr-Abl-negative cells including HSC-2 and HSG that are
responsive to
this compound, indicating that p38 activation by NaChl is dependent on
Bcr-Abl
kinase inhibition. Inhibition of p38 activity by SB203580
significantly reduced
NaChl-induced apoptosis of K562 cells, whereas activation of p38 by
anisomycin
augmented the apoptosis. These findings indicate that inhibition of
Bcr-Abl
kinase leading to activation of p38 mitogen-activated protein (MAP)
kinase may
play an important role in the anti-CML activity of Chl.

PMID: 15226183 [PubMed - in process]

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