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Medical Forum / General / Alternative / March 2008Iron and Brain Damage
Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy. [JOURNAL ARTICLE] J Perinatol 2008 Mar 6. Shouman BO, Mesbah A, Aly H Background: Iron delocalization or misregulation of iron metabolism may play a critical role in the pathology of hypoxic ischemic encephalopathy (HIE). Objective: To study iron metabolism and lipid peroxidation in newborn infants and to correlate non-protein-bound iron (NPBI) concentration with the severity of the post-asphyxial injury and subsequent short-term outcomes. Study Design: Concentrations of NPBI and malondialdehyde (MDA) in the serum and in the cerebrospinal fluid (CSF) were measured in eight healthy newborn infants and nine newborn infants suffering from moderately severe HIE. Short-term outcomes (death, survival with or without neurological abnormality) were noted at hospital discharge.Result:Serum and CSF concentrations of both NPBI and MDA were significantly increased in HIE infants when compared to controls. Serum iron was significantly increased and total iron binding capacity was significantly decreased in HIE infants compared to controls. Out of the nine HIE infants, four infants died and two infants survived with abnormal neurological findings at hospital discharge. These six infants with clinical sequels had significantly increased concentrations of NPBI in the serum and in the CSF; and increased concentrations of MDA in the CSF when compared to the other three who survived without short-term abnormalities. Conclusion: We conclude that hypoxia ischemia alters iron metabolism and lipid peroxidation in newborn infants; and that NPBI and MDA in the CSF are increased in infants with HIE. This study supports a role for iron in oxidative injury to the central nervous system after hypoxic ischemic insults. Journal of Perinatology advance online publication, 6 March 2008; doi:10.1038/jp.2008.22. Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Are we supposed to be hungry for iron or not? To iron, or not to iron: that is the question: > Iron metabolism and lipid peroxidation products in infants with > hypoxic ischemic encephalopathy. [JOURNAL ARTICLE] [quoted text clipped - 48 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Mar 28, 9:47 am, J666 <jeaa...@gmail.com> wrote: To iron, or not to iron: that is the question<< Actually no question was asked .. "increased non-protein-bound iron" Sounds like iron supplementation is required .. here .. Is that what you are saying .. ? Studies show targeting oxidation with iron chelators / binders .. IE: flavonoids and / or deferoxamine can relieve encephalopathy in animal models. The use of iron targeting drugs are being touted for the treatment of other neurodegenerative diseases such as ALS , MS , Alzheimer's and Parkinson's. Soooo .. the **evidence** as opposed to .. **question** .. is .. "iron may be involved in brain damage" .. Now if you want to destroy flavonoids in your food what you do is you have a high iron meal and the iron destroys your flavonoids. Now if flavonoids are what you have discerned is what is used to TREAT neurodegeneration then your **question** would be answered with .. no iron .. because iron destroys flavonoids but if you have NOT **understood** flavonoids 'may' be required .. then .. the answer .. you have to figure out yourself. No .. convincing will make you believe otherwise .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Are we supposed to be hungry for iron or not? > [quoted text clipped - 54 lines] > > - Show quoted text - |
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