Atmaca M, Kuloglu M, Tezcan E, Ustundag B
Antioxidant enzyme and malondialdehyde levels in patients with social
phobia. [JOURNAL ARTICLE]
Psychiatry Res 2008 Mar 11.

A growing body of reports have indicated that free radicals are
involved in the etiopathogenesis of some neuropsychiatric disorders.
In the present study, we aimed to evaluate whether antioxidant enzymes
(superoxide dismutase; SOD, glutathione peroxidase; GSH-Px, and
catalase; CAT) activity levels and malondialdehyde (MDA), a product of
lipid peroxidation, were associated with social phobia (SP).
Eighteen patients diagnosed with SP and 18 healthy controls were
enrolled. A clinical evaluation and measurements of MDA, SOD, GSH-Px
and CAT were performed.
Additionally, all patients were assessed with the Liebowitz Social
Anxiety Scale (LSAC).
The mean MDA, SOD, GSH-Px and CAT levels in the patient group were
significantly higher than those in the control group.
There was a positive correlation between LSAC scores and MDA, SOD, GSH-
Px and LSAC levels, and between the duration of illness, and MDA, SOD
and CAT levels in the patient group.
In conclusion, our results suggest that there may be a relationship
between increased antioxidant enzyme levels and MDA, and SP.
Psychiatry research [Psychiatry Res]

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