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NITRIC OXIDE AND LIPID PEROXIDATION STATUS IN DIABETES MELLITUS AND
HYPERTENSION
Khan, Mudassir Ahmad (2000) NITRIC OXIDE AND LIPID PEROXIDATION STATUS
IN DIABETES MELLITUS AND HYPERTENSION. PhD thesis, University of
Karachi, Karachi.

Abstract
A total of 246 patients were included in this study, suffering from
diabetes mellitus, or essential hypertension and those having
hypertension in addition to diabetes mel1itus. 100 healthy persons
were also included in the study, as control subjects.
The purpose of study was to assess the levels of serum nitric oxide
and lipid peroxidation, in these disease states and healthy controls.
And also to compare the serum levels of nitrite, nitrate,
malondialdehyde, and lipid hydroperoxides on the basis of gender in
control healthy subjects.
Further to evaluate the effect on the status of serum nitric oxide and
lipid peroxidation before and after supplementation of vitamin E in
volunteer healthy control subjects and hypertensive patients.
Serum triglycerides, total cholesterol, low-density lipoprotein
cholesterol, very-low-density lipoprotein cholesterol, malondialdehyde
and hydroperoxide levels were significantly increased in all the
groups of patients whereas high-density lipoprotein cholesterol was'
significantly decreased in contrast to control subjects.
A non-significant increase was observed in levels of nitric oxide
metabolites, i.e., nitrite and nitrate in diabetic patients as
compared to non-diabetic control subjects.
On the other hand diabetic patients with hypertension showed
significantly high levels of nitrite and nitrate as compared to
control subjects, however the levels of these parameters were not
significantly different in diabetics with and without hypertension.
Indices of lipid peroxidation i.e., malondialdehyde and hydroperoxides
were found elevated in non-insulin dependent diabetics on comparison
with insulin dependent diabetic patients and healthy subjects.
No significant difference was noticed in serum concentrations of
nitrite and nitrate, when insulin- or non-insulin dependent diabetic
patients were compared with control subjects, or when both these types
were compared with each other.
Also on the basis of gender insignificant difference in serum nitrite
and nitrate levels, between control male and female subjects, and a
significant increase in the level of lipid peroxidation indices was
observed in control healthy males as compared to control healthy
female subjects.
Supplementation of vitamin E 600 mg daily for a period of 8 weeks was
done in volunteer healthy controls and hypertensive patients.
Results revealed no significant difference in serum lipids,
lipoproteins and nitric oxide metabolites concentration, whereas a
significant reduction in indices of lipid peroxidation were absented,
before and at the end of supplementation period, in both volunteer
healthy controls and hypertensive patients.
It is thus concluded that diabetes mellitus and essential hypertension
are associated with greater than normal lipid peroxidation.
This increase in oxidative stress may to some extent, contribute to
endothelial dysfunction and reduced nitric oxide bioavailability in
both the disease states.
The effect of vitamin E supplementation in reduction of lipid
peroxidation in both control subjects and hypertensive patients may
provide as a useful measure in protecting against the deleterious
effects of free radicals in health and disease.

Item Type: Thesis (PhD)
Uncontrolled Keywords: nitric oxide, lipid peroxidation, diabetes
mellitus, hypertension, serum triglycerides, cholesterol,
malondialdehyde, hydroperoxide
Subjects: Biological & Medical Sciences (c) > Medical Sciences (c2)
ID Code: 1134
Deposited By: Mr. Muhammad Asif
Deposited On: 03 January 2007

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