Anxiety and cognitive effects of quercetin liposomes in rats.
Nanomedicine 2008 Jan 29.
Priprem A, Watanatorn J, Sutthiparinyanont S, Phachonpai W,
Muchimapura S

Quercetin, an effective flavonol used as an antioxidant, was
investigated for its anxiolytic and cognitive activities in male
Wistar rats. Oral quercetin (300 mg/kg body weight/day) was compared
with oral and intranasal quercetin liposomes (20 mug/day). Quercetin
liposomes, in a mixture of egg phosphatidylcholine, cholesterol, and
quercetin (2:1:1) and dispersed in 50% polyethylene glycol in water,
were approximately 200 nm in mean particle diameter and negative
surface charge with a range of encapsulation efficiency of 60% to 80%.
Anxiolytic and cognitive-enhancing effects of quercetin, conventional
and liposomal, were subjected to elevated plus maze and Morris water
maze tests, respectively. Both conventional and quercetin liposomes
showed anxiolytic and cognitive-enhancing effects. A lower dose and a
faster rate were observed with intranasal quercetin liposomes when
compared with oral quercetin, conventional and liposomal. The
intranasal quercetin liposomes are effective in the delivery of
quercetin to the central nervous system.
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Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine]

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