 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / Alternative / March 2008Interleukin-6 In Moderately to Severely Disabled Women
Carbonyls can be caused by too much iron in the body. Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community. [Journal Article] J Gerontol A Biol Sci Med Sci 2008 Feb; 63(2):179-83. Dayhoff-Brannigan M, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD Background. Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6. Methods. Serum protein carbonyls and IL-6 were measured in 739 women, age >/=65 years, in the Women's Health and Aging Study I. Results. Geometric mean of protein carbonyls was 0.082 nmol/mg. After adjusting for age and smoking status, log(e) serum protein carbonyls were associated with log(e) IL-6 (beta = 0.143, standard error [SE] = 0.048, p =.003) in linear regression analyses and with elevated IL-6 (>/=2.5 pg/mL) (odds ratio = 1.38, 95% confidence interval, 1.02-1.86, p =.037) in logistic regression analyses. Conclusion. Oxidative damage to proteins is independently associated with serum IL-6 among older women living in the community. Increased oxidative stress may be a factor involved in the pathogenesis of the proinflammatory state that occurs in older adults. -------------------------------------------------------------------------------- More from this journal The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Mar 4, 8:45 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:Carbonyls can be caused by too much iron in the body. << "A therapeutic vitamin cocktail" "Suggesting that pyridoxal or pyridoxal phosphate were antioxidants and/or Fe/Cu chelators" Those phosphate groups .. again .. Would that be my .. free bisphosphonate .. ? http://tinyurl.com/37w2xb Research Article Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents Rhea Mehta, Nandita Shangari, Peter J. O'Brien * Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada. Fax: +1-416-978-8511 email: Peter J. O'Brien (peter.obrien@utoronto.ca) *Correspondence to Peter J. O'Brien, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada. Fax: +1-416-978-8511 Funded by: National Cancer Institute of Canada; Grant Number: 015066 Natural Sciences and Engineering Research Council of Canada; Grant Number: 3783-03 Keywords Advanced glycation end products * Advanced lipid end products * Cytotoxicity * Lipid peroxidation * Reactive oxygen species Abstract Carbonyls generated by autoxidation of carbohydrates or lipid peroxidation have been implicated in advanced glycation end product (AGE) formation in tissues adversely affected by diabetes complications. Tissue AGE and associated pathology have been decreased by vitamin B1/ B6 in trials involving diabetic animal models. To understand the molecular cytoprotective mechanisms involved, the effects of B1/B6 vitamers against cytotoxicity induced by AGE/advanced lipid end product (ALE) carbonyl precursors (glyoxal/acrolein) have been compared to cytotoxicity induced by oxidative stress (hydroperoxide) or mitochondrial toxins (cyanide/copper). Thiamin was found to be best at preventing cell death induced by carbonyl stress and mitochondrial toxins but not oxidative stress cell death suggesting that thiamin pyrophosphate restored pyruvate and - ketoglutarate dehydrogenases inhibited by mitochondrial toxicity. However, B6 vitamers were most effective at preventing oxidative stress or lipid peroxidation cytotoxicity suggesting that pyridoxal or pyridoxal phosphate were antioxidants and/or Fe/Cu chelators. A therapeutic vitamin cocktail could provide maximal prevention against carbonyl stress toxicity associated with diabetic complications. -------------------------------------------------------------------------------- Received: 3 October 2006; Revised: 3 May 2007 Digital Object Identifier (DOI) 10.1002/mnfr.200600190 About DOI Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Carbonyls can be caused by too much iron in the body. > [quoted text clipped - 35 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Mar 4, 9:34 am, ironjustice <teamtan...@hotmail.com> wrote:Thiamin was found to be best at preventing cell death << http://www.nutristrategy.com/nutrition/thiamin.htm Thiamin sources: * Thiamin is found in whole grains, soybeans, peas, liver, kidney, lean cuts of pork, legumes, seeds, and nuts. Would that be my .. free bisphosphonate .. ? Whole grains .. ? http://tinyurl.com/37w2xb Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Mar 4, 8:45 am, "ironjust...@aol.com" <ironjust...@aol.com> > wrote:Carbonyls can be caused by too much iron in the body. << [quoted text clipped - 108 lines] > > - Show quoted text - |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.