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Medical Forum / General / Alternative / February 2008Corn and Cancer
"IP6 has the potential for adenocarcinoma" Oncol Rep. 2008 Feb;19(2):563-6. Links Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. McFadden DW, Riggs DR, Jackson BJ, Cunningham C. Department of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, USA. david.mcfadden@vtmednet.org. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is found in food sources high in fiber content. IP6 has been reported to have significant inhibitory effects against a variety of primary tumors. We hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. Two Barrett's-associated adenocarcinoma cell lines, SEG-1 and BIC-1, were treated with IP6 at 0.5, 1.0 and 5.0 mM concentrations. Cell viability was measured by MTT assay. Apoptosis and necrosis were evaluated by the Annexin V FITC assay. Reductions (P<0.001) in cellular proliferation were observed in both cell lines. IP6 decreased late apoptosis and necrosis in BIC cells, whereas in SEG-1 cells, early apoptosis, late apoptosis and necrosis were all increased by IP6. IP6 decreases cellular growth by pro-apoptotic mechanisms. Our findings suggest that IP6 has the potential to become an effective adjunct for Barrett's adenocarcinoma. Further studies are needed to evaluate safety and clinical utility of this agent in patients with Barrett's adenocarcinoma. PMID: 18202808 [PubMed - in process] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "IP6 has the potential for adenocarcinoma" > [quoted text clipped - 34 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk This paper does not alter my opinion, but rather strengtens it. My opinion is that IP6 is a natural poison, and insecticide, produced by plants. Big Pharma is always looking for some poison to use as a medicine. By injecting certain poisons into the body, these poisons will be routed out of the body as rapidly as possible, and possibly shipped to tumors being used as toxic waste sites. I learned nothing new here Iron, sorry. DrCee On Jan 27, 3:03 pm, drcee...@insightbb.com wrote: This paper does not alter my opinion, but rather strengtens it. << No accounting for stupidity. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > > "IP6 has the potential for adenocarcinoma" > [quoted text clipped - 49 lines] > > - Show quoted text - > On Jan 27, 3:03 pm, drcee...@insightbb.com wrote: This paper does not > alter my opinion, but rather strengtens it. << [quoted text clipped - 9 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Talking about yourself nodoubt? > "IP6 has the potential for adenocarcinoma" > > Oncol Rep. 2008 Feb;19(2):563-6. Links > Corn-derived carbohydrate inositol hexaphosphate inhibits > Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. It should be noted that dried corn products are a major dietary source of aflatoxin, a powerful carcinogen. >> "IP6 has the potential for adenocarcinoma" >> [quoted text clipped - 5 lines] > a major dietary source of aflatoxin, a powerful > carcinogen. So the conclusion is that we should teach our undeveloped digestion system how to deal with carcinogens. For example turn carcinogens into new brain cell so with bigger brains we can understand better what is really going on. On Jan 27, 2:42 pm, "Tom" <mnop...@abcdefghijkl.com> wrote:So the conclusion is that we should teach our undeveloped digestion system how to deal with carcinogens. << If phytase .. is what you are looking for .. IE: "how to deal with carcinogens" .. in this SPECIFIC case we are speaking about .. **phytate** / "how to deal with carcinogens" ,, found in every plant food .. then the fact the microbe which produces this phytase is found in your snot .. means .. ? We are long past this "undeveloped digestion system " .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > >> "IP6 has the potential for adenocarcinoma" > [quoted text clipped - 11 lines] > For example turn carcinogens into new brain cell so with bigger brains we > can understand better what is really going on. On Feb 6, 5:21 am, ironjustice <teamtan...@hotmail.com> wrote:So the conclusion is that we should teach our undeveloped digestion system how to deal with carcinogens. << Seems the phytase found IN the grain is an effective INDUCER of zinc and iron absorption .. **contrary** to the accepted theoretical .. paradoxical .. killer .. phytate. Hmm .. heard that somewhere .. before. I guess the body doesn't let itself starve of iron .. after .. all .. "Valuable source of iron and zinc" They say that because phytate is easily overcome .. if .. .need .. be. doi:10.1016/j.lwt.2007.04.001 Copyright (c) 2007 Swiss Society of Food Science and Technology Published by Elsevier Ltd. Effect of wheat pearling on flour phytase activity, phytic acid, iron, and zinc content Zhenghui Liua, , , Haiyan Wanga, Xiu-E Wanga, Hongyan Xua, Derong Gaob, Guoping Zhangc, Peidu Chena and Dajun Liua aCollege of Agronomy, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China bLixiahe Agricultural Research Institute, Jiangsu Academy of Agricultural Science, Yangzhou 225007, China cDepartment of Agronomy, Zhejiang University, Kaixuan Road 268, Hangzhou 310029, China Received 2 August 2006; revised 2 April 2007; accepted 3 April 2007. Available online 10 April 2007. Abstract This study examined the effect of wheat pearling on distribution of phytase, phytic acid, iron, and zinc in wheat fractions derived from pearling and roller milling. Grains of four wheat varieties were first pearled by a rice polisher at four levels, i.e. non-pearling (unpearled), 5% pearling (5% of the original sample weight was pearled), 10% pearling, and 15% pearling, to produce pearling fines (PF) and pearled grains. The unpearled and pearled grains were then milled through a Bühler MLU-202 laboratory mill, producing eight milling fractions. Results showed that pearling had a positive effect on flour yield, which may be attributed to the reduced yield of coarse bran and the improved yield of first and second reduction fractions. PF had high levels of all the four components, indicating that they could be a valuable source of iron and zinc. In addition, the differences between flours from the pearled and unpearled wheat were slight in terms of these four components. Keywords: Phytase; Phytic acid; Iron; Zinc; Pearling; Wheat Abbreviations: B1-B3, break fractions 1-3; CB; Coarse bran; FB, fine bran; PF, pearling fines; P0; P5; P10; and P15, treatment of non- pearling, 5% pearling, 10 % pearling, and 15% pearling; R1-R3, reduction fractions 1-3. Corresponding author. Tel/fax: +86 25 84396475. LWT - Food Science and Technology Volume 41, Issue 3, April 2008, Pages 521-527 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jan 27, 2:42 pm, "Tom" <mnop...@abcdefghijkl.com> wrote:So the > conclusion is that we should teach our undeveloped digestion system [quoted text clipped - 38 lines] > > - Show quoted text - A two-year study by the Johns Hopkins University School of Medicine found that by monitoring volunteers' stool samples for corn content by volume over a period of one year, researchers could predict by as much as 92-percent a patient's probability of contracting lower digestive tract cacinomas. > A two-year study by the Johns Hopkins University School of Medicine > found that by monitoring volunteers' stool samples for corn content by > volume over a period of one year, researchers could predict by as much > as 92-percent a patient's probability of contracting lower digestive > tract cacinomas. Positively or negatively correlated? By corn did they mean corn as in frozen corn or corn on the cob, or corn as in high fructose corn syrup and refined corn flour as in tacos and corn bread. Was there any other food that people who eat lots of corn (or little corn) also eat. Is corn the cause or the marker.? I seldom eat corn, but there are whole cultures who traditionally eat corn as a large part of their diets. Do these people have more lower digestive tract carcinomas? Dolores >> A two-year study by the Johns Hopkins University School of Medicine >> found that by monitoring volunteers' stool samples for corn content by [quoted text clipped - 9 lines] > are whole cultures who traditionally eat corn as a large part of their > diets. Do these people have more lower digestive tract carcinomas? Well, that's the end of that thread. Asking epidemiological questions is a sure-fire way to kill these "magic food" threads. We recently had one who told us that vitamin A would prevent/cure all respiratory ailments, and I asked whether the Inuit (with their near-toxic A diet) records with the IHS showed any respiratory ailments. Dead silence. Similarly with Scudamore's "cayenne cures heart disease." All you have to do is ask if New Mexico has lower heart disease rates than Colorado. Now you bring up the fact that most of Mexico and a good bit of the southern United States uses maize as its primary source of starch, and in the case of Mexico as its #1 staple. As noted, it's the end of the thread. | The most important exclamation in science isn't "Eureka!" | | The most important exclamation is "What the BLEEP?" | +---------- D. C. Sessions <dcs@lumbercartel.com> ----------+ On Jan 27, 3:20 pm, Mark Thorson <nos...@sonic.net> wrote: It should be noted that dried corn products are a major dietary source of aflatoxin, a powerful carcinogen. << Soo .. you **agree** taking phytate OUT of corn would be a .. bad .. idea. Since phytate IS the substance IN corn which keeps the aflatoxin in check .. ? Evaluation of the effect of phytic (inositol phosphate) and linoleic acids on the biosynthesis of aflatoxin S. SHAHID-ALI1, D. L. PARK2, and H. Njapau2. (1) Food Science Department, Louisiana State University, 111-Food Science Bldg., Baton Rouge, LA 70803, (2) Center for Food Safety & Applied Nutrition, Food and Drug Administration (FDA), 200 C St. S.W., Washington D.C., DC 20204 Consumption of mycotoxins, especially aflatoxin B1 (AFB1), is associated with occurrence of liver cancer. Naturally aflatoxin contaminated corn extracts show a lower mutagenic potential than pure AFB1 in the Salmonella/ microsomal assay, presumably due to the presence of inositol phosphates (InsPs) and linoleic acid. The role of InsPs and linoleic acid on the overall risk posed by AFB1 occurrence is important since they comprise more than 1% of the dry weight of cereals, oilseeds and nuts. This study was conducted to evaluate the effect of the presence of InsP analogs and linoleic acid, on aflatoxin production by Aspergillus flavus in Czapek-Dox liquid medium, and on corn during storage. Czapek-Dox medium, containing different phytic acid concentrations was inoculated with a spore suspension of Aspergillus flavus and AFB1 production was monitored by TLC during 25-days incubation at 28°C, in the presence/absence of various ions. In the storage study, whole kernel and cracked corn was also inoculated in the presence of varying amounts of phytic and linoleic acids, in a controlled environment for 5-weeks. Aflatoxin biosynthesis was monitored every 4-days using HPLC. Inhibition of AFB1 biosynthesis in liquid medium was observed as the concentration of InsP increased. Complete inhibition of AFB1 production was recorded at InsP levels of 0.5 and 1 mg/100ml in the absence of Fe++ and Zn++ ions. In storage, aflatoxin levels were ~50% lower in samples separately treated with phytic and linoleic acids after 14-days. Aflatoxin production in InsP-treated samples was substantially lower than Linoleic acid-treated samples. No such reductions were recorded in samples treated with phytic-linoleic acids combination. Although individually phytic and linoleic acids lower aflatoxin production, their simultaneous presence negates this effect. These results do not, however, reduce the benefits arising from reported inhibition of aflatoxin mutagenicity/biosynthesis by the same compounds. Session 3, Toxicology & Safety Evaluation 8:30 AM - 12:00 PM, 2002-06-17 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >> "IP6 has the potential for adenocarcinoma" >> [quoted text clipped - 5 lines] > a major dietary source of aflatoxin, a powerful > carcinogen. I love to eat corn that I buy in frozen packages. Is this considered dried? Will it be a source of aflatoxin? Should I stop eating frozen corn? >>> "IP6 has the potential for adenocarcinoma" >>> [quoted text clipped - 9 lines] >Is this considered dried? Will it be a source of aflatoxin? >Should I stop eating frozen corn? Probably not. Aflatoxin is produced by a fungus that likes dried corn, and peanuts among others. (it is a more serious problem in peanuts than in corn). Corn which is fresh when eaten, or when processed (canned or frozen), will not have the fungus, or aflatoxin. > "Mark Thorson" <nospam@sonic.net> wrote in message > > [quoted text clipped - 5 lines] > Is this considered dried? Will it be a source of aflatoxin? > Should I stop eating frozen corn? No. The aflatoxins are produced by a mold that infects corn while it is being dried. Frozen corn is generally speaking not dried. > > "Mark Thorson" <nos...@sonic.net> wrote in message > [quoted text clipped - 9 lines] > infects corn while it is being dried. Frozen corn > is generally speaking not dried. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ While eating peanuts, I occasionally crunch a bitter one with a foul taste. I immediately roll the mashed peanut with my tongue and spit it out with saliva. Is this sufficient to cancel the aflatoxin danger ? David H aka Reader Rabbit ~~~~~~~~~~~~~~~~~~~~ > While eating peanuts, I occasionally crunch a bitter one > with a foul taste. I immediately roll the mashed peanut > with my tongue and spit it out with saliva. Is this sufficient > to cancel the aflatoxin danger ? I wouldn't eat peanuts, even if I knew they weren't moldy, unless I knew my Thomsen-Friedenreich antigen status. In this study, 10 out of 36 participants were found to be positive for the Thomsen-Friedenreich antigen, which causes the cells of their rectum to divide rapidly (possible risk factor for colorectal cancer) when they eat peanuts. The color pictures which accompanied this article were quite frightening. Haven't had a peanut since! Gastroenterology 1998 Jan;114(1):44-9 Peanut ingestion increases rectal proliferation in individuals with mucosal expression of peanut lectin receptor. Ryder SD, Jacyna MR, Levi AJ, Rizzi PM, Rhodes JM. Department of Gastroenterology, Northwick Park Hospital, Middlesex, England. BACKGROUND & AIMS: The Thomsen-Friedenreich blood group antigen (galactose beta 1,3-N-acetyl galactosamine alpha-) acts as an oncofetal antigen in the colonic epithelium, with low expression in normal adult epithelia but increasing to fetal levels of expression in hyperplasia or malignancy. Peanut lectin is one of the commonest dietary lectins that binds this antigen. The aim of this study was to determine whether peanut ingestion can alter rectal epithelial proliferation. METHODS: Thirty-six patients with normal colonic mucosa consumed 100 g of peanuts each day for 5 days. Rectal mitotic index was measured before and after ingestion, and changes in proliferation were correlated with immunohistochemical detection of lectin receptor expression by colonocytes and fecal lectin activity as measured by hemagglutination assay. RESULTS: Peanut ingestion caused a 41% increase in rectal mucosal proliferation in individuals with macroscopically normal mucosa who express TF antigen in their rectal mucosae (10 of 36 patients studied). The proliferative response correlated with fecal hemagglutinating activity, and peanut lectin could be shown immunohistochemically within the rectal mucosa. CONCLUSIONS: The common expression of galactose beta 1,3-N-acetyl galactosamine alpha- by hyperplastic and neoplastic epithelia may therefore be functionally important because it allows interaction with mitogenic dietary lectins. This could be an important mechanism for the association between diet and colorectal cancer. > > While eating peanuts, I occasionally crunch a bitter one > > with a foul taste. I immediately roll the mashed peanut [quoted text clipped - 54 lines] > This could be an important mechanism for the > association between diet and colorectalcancer. Very interesting study. There are perhaps many other mitogenic dietary lectins in different plant foods (beans, grains, nuts) which may stimulate neoplasia in susceptible people. The gluten/celiac disease may be another major example. That's why the meat + high fat and low carb diets work. It's difficult to do genetic tests but could the "common" food intolerance tests measuring just IgG antibodies help in this respect? Or is the sensitivity related to the blood types like Adamo says? Taka One has to be sure the corn they are eating is not GMO. If it is, then you can get sick very fast. Cows are fed GMO corn, and if you do a bit of research, you will find that you should never give cattle corn. Ever. www.winr.us/twistedpickle >> "IP6 has the potential for adenocarcinoma" >> [quoted text clipped - 5 lines] > a major dietary source of aflatoxin, a powerful > carcinogen. > One has to be sure the corn they are eating is not GMO. > If it is, then you can get sick very fast. And that's because of what? GMO organisms have the same genetic heritage as the plants from which they are made. How could it make anybody sick? How could adding good genes (such as the genes for making beta-carotene) make a food bad? http://en.wikipedia.org/wiki/Golden_rice That could save the eyesight of people in many underdeveloped countries, who would otherwise go blind from vitamin A deficiency. Why are you against that? > That could save the eyesight of people in > many underdeveloped countries, who would > otherwise go blind from vitamin A deficiency. > > Why are you against that? In the land of the blind, the one-eyed man is king. | The most important exclamation in science isn't "Eureka!" | | The most important exclamation is "What the BLEEP?" | +---------- D. C. Sessions <dcs@lumbercartel.com> ----------+ > One has to be sure the corn they are eating is not GMO. If it is, then you > can get sick very fast. > Cows are fed GMO corn, and if you do a bit of research, you will find that > you should never give cattle corn. Ever. Unfortunately, there really isn't any non-GM corn outside of seed banks -- and the stuff you grow from them isn't terribly appetizing. | The most important exclamation in science isn't "Eureka!" | | The most important exclamation is "What the BLEEP?" | +---------- D. C. Sessions <dcs@lumbercartel.com> ----------+ >One has to be sure the corn they are eating is not GMO. If it is, then you >can get sick very fast. Why? >Cows are fed GMO corn, and if you do a bit of research, you will find that >you should never give cattle corn. Ever. Why not?  SignaturePeter Bowditch aa #2243 The Millenium Project http://www.ratbags.com/rsoles Australian Council Against Health Fraud http://www.acahf.org.au Australian Skeptics http://www.skeptics.com.au To email me use my first name only at ratbags.com |
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