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Human Papillomavirus (HPV) DNA   March 7, 2007
http://www.fda.gov/OHRMS/DOCKETS/DOCKETS/07p0210/07p-0210-ccp0001-01-vol1.pdf

Since the 1990's, medical
science has confirmed that most of the HPV infections, even caused by
the so-called "high-risk"
HPVs, are self-limiting. Only persistent infection caused and
maintained by certain genotypes of
HPV, often with low intracellular viral load, is truly of "high risk"
to the host in causing
precancerous lesions of the cervix .

3) Most women who become infected with HPV are able to eradicate the
virus and suffer no
apparent long-term consequences to their health . But a few women
develop a persistent infection
that can eventually lead to pre-cancerous changes in the cervix [1]

"Most women who become infected with HPV are able to eradicate the
virus and suffer no
apparent long-term consequences to their health . But a few women
develop a persistent infection
that can eventually lead to pre-cancerous changes in the cervix ."
". . .most infections are short-lived and not associated with cervical
cancer."

4) Most infections are short-lived and not associated with cervical
cancer [1] .

5) Persistent HPV infection, not the HPV virus itself, is the pivotal
promoter in causing cervical
precancerous lesions and cancer [8-11] . Most of HPV infections, even
caused by "high-risk"
genotypes, are transient with normal Pap cytology in sexually active
young women [4-7] . In 93%
of initially infected women, the same viral type is not detected upon
re-examination four
menstrual cycles later [20] . The median duration of positivity
detectable by PCR for a specific
HPV type in these young women is 168 days [21] .

8) Injection of HPV vaccines into women who have concurrent
vaccine-relevant HPV type
infections evidenced by sero-positive and PCR-positive tests may
increase the risk, by about
44.6%, of developing high-grade precancerous lesions in the cervix
[14] .