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Medical Forum / General / Alternative / January 2008

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The wake-you-up pill ...how a controversial thyroid supplement could help tiredness

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Ilena Rose - 11 Jan 2008 22:54 GMT
http://ilenarose.blogspot.com
Health Lover

http://www.dailymail.co.uk/pages/live/articles/health/healthmain.html?in_article
_id=506717&in_page_id=1774


The first sign of a problem was excessive tiredness.

"I started needing a short nap in the afternoon; but eventually I was
sleeping for four hours during the day," says project manager Ina
Whitlam.

"It wasn't refreshing sleep, it was horrible and restless. But I
couldn't function without it."

Her condition gradually worsened, so eventually she was having to
sleep most of the day.

The otherwise fit and healthy 63-year-old had to give up her job with
Age Concern, but even then she couldn't throw off the feelings of
chronic exhaustion.

"One day I tried to go to the shops but I couldn't manage more than a
few steps," she recalls. "I had to give up and go back inside. I sat
down and cried."

Ina was also suffering from chronic constipation, as well as very dry
skin and thinning hair.

Specialists were unable to help; her GP simply dismissed her problem
as chronic fatigue syndrome.

Then four years ago - six years after her symptoms started - she saw a
doctor who suggested the problem was her thyroid, the tiny gland just
below the Adam's apple.

Scroll down for more ...
tired woman

Controversial: Dr Skinner helped many patients but was charged with
reckless prescribing

He prescribed an artificial form of thyroid hormone, thyroxine. The
benefits were almost immediate, says Ina. "Within four days my brain
had begun to clear and I was able to start sorting out some papers,"
she says.

"Gradually, all my other symptoms cleared up. It was a complete
transformation. I now sleep fine and get up at 7.30am.

"At the moment, I'm renovating a property - even doing the plastering
myself. Without hormone treatment I'd be confined to bed."

A veritable "good news" health story? In fact, last November, the
doctor - Dr Gordon Skinner - appeared before the General Medical
Council charged with reckless prescribing and was in danger of being
struck off.

This is because he'd been prescribing thyroxine contrary to NHS
guidelines; these state that patients should be given hormone
treatment only if blood tests show their levels of thyrotropin (a
thyroid-stimulating hormone) are outside the "normal" range.

The problem is that Dr Skinner disagrees with the official definition
of what is "normal." He believes that many patients, whose blood tests
show up as in the normal range, in fact need thyroxine.

He also refuses to rely on a blood test alone, but looks instead at
other factors, including symptoms.

His approach is highly controversial and is rejected by mainstream
doctors in the UK. However, he points out that in America the official
guidelines have recently been revised - as a result patients who would
be classified as normal in the UK would be given treatment in America.

According to some estimates, as many as a million Britons suffer from
poor thyroid function. The thyroid's job is to produce a number of
hormones that keep the body's various functions working at the right
pace.

If it produces too much of its hormones, everything goes too fast -
you lose weight, can't sleep and your heart races; but if it makes too
little your systems slow down - you suffer fatigue, dry skin,
constipation and can have difficulty concentrating.

The causes can include an infection or the body's own immune system
attacking the gland.

Although the condition is more common in women, men can also be
affected. Ina initially suspected an underactive thyroid (also known
as hypothyroidism).

"But when the endocrinologist got my blood test results back he said
coldly: 'You can put that idea out of your head. Your levels are
normal.'"

After that she had a variety of tests - a colon examination, a 36-hour
test for sleeping problems, and an investigation for skin cancer
because her dry skin was cracking so badly. But all proved negative.

"In the end my GP told me I had chronic fatigue syndrome and said
exasperatedly: "What more do you expect me to do? You'll have to live
with it." Then he offered me antidepressants.

"I suffered four more years of misery. My brain felt as if it was
wrapped in fog, I could barely get out of bed. I couldn't work, so I
had no money and eventually ran up a £15,000 bill on my credit card.

"I had to sell my 18th-century country cottage to pay it off."

Then, in July 2003, she saw Dr Skinner. "He was the first person to
see my symptoms as a whole picture and he gave me tests for several of
the thyroid hormones. He said my body needed more thyroid hormone than
the official guidelines said and put me on a replacement, thyroxine."

Ina Whitlam was just one of many hundreds of patients who sent
testimonies to the General Medical Council investigation in Dr
Skinner's support.

A dozen more patients appeared before the panel itself and told
similar stories. Among them was Della Rhodes, a business woman and the
head of a large company.

She described how, despite always playing sport, she'd suddenly put on
30lb, and had begun to feel extremely tired, while finding it
increasingly hard to make vital decisions at work.

Her doctor had told her to join Weight Watchers and a gym. "Dr Skinner
was the first person to really listen to me," she said. "Within two
weeks of starting thyroxine my symptoms began to clear up."

Paul Shopland gave a harrowing account of how his son Chris, diagnosed
at the age of nine with chronic fatigue syndrome, lost ten years of
his life.

"Some of the time he couldn't leave his bed," said Paul. "Chris was
effectively confined to home. He couldn't go to school so his
education came to a stop and he was virtually friendless."

During that time the only treatment he was offered was "pacing" -
gradually increasing the amount of activity he did.

Last year, however, after seeing Dr Skinner and being prescribed
thyroxine, he went rock climbing in the Cheddar Gorge; a year after
starting hormone therapy his symptoms had gone.

It seemed a bizarre situation: a doctor who was in danger of having
his career ruined because he had helped hundreds of patients who,
until they found him, feared there was no help for their condition.

And yet, according to Professor Tony Weetman, president of the British
Thyroid Association and one of the expert witnesses testifying against
Dr Skinner, what most of these patients were really suffering from was
"somatoform disorder," meaning that their symptoms were largely
psychological. They just thought they were ill; the thyroxine acted as
a kind of placebo.

Furthermore, the evidence shows that treating patients whose tests are
normal makes no difference, says Dr Colin Dayan, a consultant senior
lecturer in endocrinology at the University of Bristol.

"And we are worried that giving them thyroid replacement therapy when
they don't need it could put them at risk of stroke, heart problems
and osteoporosis later on."

Professor Weetman agrees it can be dangerous to treat those in the
normal range: "Many people in their 50s and 60s may experience fatigue
and weight gain, so the blood test has been invaluable in diagnosing
those who have thyroid problems and those who haven't," he says.

"Doctors who collude with these patients and treat them for an illness
they don't have could overlook a genuine and more serious diagnosis
such as cancer or liver disease."

But this assumes that everybody reacts in the same way to their
thyroid levels; Dr Skinner and his patients believe they don't.

What's more, the "healthy" levels for other body chemicals such as
cholesterol have been changed recently.

In fact, whether you are found to be inside or outside the normal
range can depend on where the test is being done.

One of the patients who testified for Dr Skinner had been declared in
Germany to have an underactive thyroid but was "healthy" in the UK.

The difference between the test levels in the UK and America is even
more striking.

The test for low thyroid measures levels of thyroid stimulating
hormone. In the UK "normal" levels are defined as between 0.5 and 5.
In America the range is 0.3 to 3, which means more Americans are
diagnosed as hypothyroid.

The situation has been made even more confusing by the result of Dr
Skinner's hearing. Even though he was found guilty of "reckless
prescribing" and "impaired ability to practice" the General Medical
Council has decided that he should be allowed to continue treating
patients in the way he has been.

The main limitation that has been put on him is that he can take on
new patients only if they have been referred by a GP. His clinical
procedures also have to be checked by the Council every six months for
the next three years.

A major factor in this decision was undoubtedly the emotional
testimonials of his grateful patients.

In her summing up, the chairlady of the panel hearing the case said:
"It is clear that you are a caring and compassionate doctor whose
overwhelming concern is the care and well-being of your patients, many
of whom have pleaded that you should be allowed to continue to
practice."

Since the hearing, new research has suggested that patients with
levels of 1.4 to 4.99 (officially "normal" in the UK) were at a
greater risk of developing thyroid cancer.

Giving a thyroid supplement reduces these levels - but this won't be
happening under current UK guidelines.

Dr Dayan says the key is more research. "I wouldn't treat outside the
normal levels myself. But provided patients are made fully aware of
the risks, and if blood tests were taken and they were monitored
properly, I think there may be a case for it."

Thyroid Patient Advocacy-UK; www.tpa-uk.org.uk; British Thyroid
Foundation; www.btf-thyroid.org; Thyroid UK www.thyroiduk.org
The One True Zhen Jue - 11 Jan 2008 23:35 GMT
> http://ilenarose.blogspot.com
> Health Lover
[quoted text clipped - 38 lines]
> had begun to clear and I was able to start sorting out some papers,"
> she says.

What does the use of a pharmaceutical, thyroxine, have to do with
alternative health?  Sure, its a nice example of using a mainstream
medicine for an off-label purpose, but it is off-topic in MHA.

Do make a note of it.
trigonometry1972@gmail.com - 12 Jan 2008 02:48 GMT
On Jan 11, 3:35 pm, The One True Zhen Jue <Andrew_King...@yahoo.com>
wrote:

> >http://ilenarose.blogspot.com
> > Health Lover
[quoted text clipped - 44 lines]
>
> Do make a note of it.

You are clueless  "One False Zhen Goy"

This is indeed alternative medicine, good alternative medicine not
homeopathy or some other "New Age" alternative health.
Until the morons in standard medicine realize the
so-called nomal ranges include levels of hormone that
are suboptimal such treatment is indeed alternative health/medicine.
The One True Zhen Jue - 12 Jan 2008 05:33 GMT
On Jan 11, 9:48 pm, trigonometry1...@gmail.com wrote:
> On Jan 11, 3:35 pm, The One True Zhen Jue <Andrew_King...@yahoo.com>
> wrote:
[quoted text clipped - 49 lines]
>
> You are clueless  "One False Zhen Goy"

By your logic, the use of Ritalin to treat chronic fatigue would be
alternative medicine.  It is not.
By that same logic, the use of botox to treat wrinkles could also be
construed as alternative medicine.

> This is indeed alternative medicine, good alternative medicine not
> homeopathy or some other "New Age" alternative health.

Well, at least we agree that homeopathy & "New Age" stuff is crap.
Nice!

> Until the morons in standard medicine realize the
> so-called nomal ranges include levels of hormone that
> are suboptimal such treatment is indeed alternative health/medicine.

Uh, by what logic do you reach that conclusion?  You seem to be
begging the question and shooting the moon.
Add that to your twisted interpretation of my nym and you're epitome
of screwing the pooch.
Stop that!

- Hide quoted text -

> - Show quoted text -
trigonometry1972@gmail.com - 12 Jan 2008 22:31 GMT
On Jan 11, 9:33 pm, The One True Zhen Jue <Andrew_King...@yahoo.com>
wrote:
> On Jan 11, 9:48 pm, trigonometry1...@gmail.com wrote:
>
[quoted text clipped - 56 lines]
> By that same logic, the use of botox to treat wrinkles could also be
> construed as alternative medicine.

If the use of Ritalin is frowned on or if alternatively minded
Doc are using it, I'd called alternative medicine.

Botox isn't alt medicine as it isn't frowned on. It
is just a quick fix and a money maker.

> > This is indeed alternative medicine, good alternative medicine not
> > homeopathy or some other "New Age" alternative health.
>
> Well, at least we agree that homeopathy & "New Age" stuff is crap.
> Nice!

Yes, we do agree on list of things.

> > Until the morons in standard medicine realize the
> > so-called nomal ranges include levels of hormone that
> > are suboptimal such treatment is indeed alternative health/medicine.
>
> Uh, by what logic do you reach that conclusion?  You seem to be
> begging the question and shooting the moon.

I was referring to number of things especially along the lines
of androgen/testosterone replacement therapy and the issues
of when to treat. I could provide whole list of resarch papers
published on the topic. And then we could compare
how far the standard treatment programs fall from
the research and "best practices."
And one can lurk in the respective
Yahoo and Usenet groups and see what the patients
consider to be good treatment and what they
think about their endos or other treating physicians.
It would even be useful to compare the woeful
poor treatment provided by the British NHS and
the "best practices" here in the States or even
to those in the Great Land down under.

I wasn't shooting the moon but I was using
a shotgun only loaded with rock salt.

> Add that to your twisted interpretation of my nym and you're epitome
> of screwing the pooch.

I try.

> Stop that!

For now and maybe for weeks to come.

<snip>
 
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