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Medical Forum / General / Alternative / December 2007Writing On The Wall
This study compared the insulin sensitivity index against frequent or infrequent blood donors. The blood donations were found to positively affect the vascular system. They concluded .. though .. since this help occured WITHOUT the reduction of a **preconceived** .. amount of significant .. iron .. therefore .. the ron factor could not be of any significance. But as shown in previous studies .. low .. low .. low .. low .. low iron .. leads to recovery .. NOT .. "moderate or high" .. IE: "40 % enhancement of insulin-mediated glucose disposal The finding is in agreement with results from animal studies where, no matter how induced, Fe depletion consistently enhanced glucose disposal." Soooo .. they are STILL using the high markers / iron levels no big thing as their .. **preconceived** .. marker and therefore the upcoming clinical trial .. Iron Depletion in Diabetes" .. is going to be done using these .. **preconceived** .. markers / HELD / stopped at a HIGH marker and the clinical trial is .. doomed .. for failure. Doomed. -------------------------------------------------------------------------------- Diabetes Care Publish Ahead of Print published online ahead of print July 13, 2007 DOI: 10.2337/dc07-0748 Original Research Insulin Sensitivity, Vascular Function, and Iron Stores in Voluntary Blood Donors Haoyi Zheng, MD, PhD1, Milan Patel, MD1, Ritchard Cable, MD2, Lawrence Young, MD1 and Stuart D. Katz, MD, MS1 1Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, and 2The American Red Cross Blood Services, Farmington CT and Dedham MA stuart.katz@yale.edu ABSTRACT Objective:Reduced iron stores after blood donation are associated with improved vascular function and decreased cardiovascular risk. We sought to determine whether iron-dependent changes in glucose metabolism may contribute to improved vascular function in blood donors. Research Design and Methods:We conducted a prospective cross-sectional study in 21 high-frequency blood donors (8 donations in last 2 years) and 21 low-frequency blood donors (1-2 donations in last 2 years) aged 50-75 years. Serum markers of iron stores, whole body insulin sensitivity index during oral glucose tolerance testing, and flow- mediated dilation in the brachial artery were determined in all subjects. Results:Serum ferritin was decreased (median values 23 vs. 36 ng/ml, p<0.05), and flow-mediated dilation in the brachial artery was increased (median values 5.9% vs. 5.3%, p<0.05) in high-frequency donors when compared with low-frequency donors, but whole body insulin sensitivity index (median values 4.8 vs. 4.7) and related measures of glucose tolerance did not differ between groups. Flow-mediated dilation significantly decreased at 1 hour after oral glucose loading in both groups, but the decrease in flow-mediated dilation at 1 hour did not differ between high-frequency and low-frequency donors. Conclusions:High-frequency blood donation reduced serum ferritin and increased flow-mediated dilation when compared with low-frequency donation, but did not improve insulin sensitivity nor protect the vascular endothelium from the adverse effects of acute hyperglycemia after oral glucose loading. These findings suggest that the mechanisms linking blood donation to improved vascular function are not likely related to changes in glucose metabolism. High-frequency blood donation was associated with reduced iron stores and improved vascular function when compared with low-frequency blood donors, but measures of insulin sensitivity did not differ between groups. These findings suggest that the mechanisms linking blood donation to improved vascular function are not related to changes in glucose metabolism. HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum DOC News Copyright © 2007 by the American Diabetes Association. -------------------------------------------------------------------------------- Br J Nutr 2001 Oct;86(4):515-9 Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Hua NW, Stoohs RA, Facchini FS Department of Medicine, Division of Nephrology, San Francisco General Hospital, San Francisco, CA, USA. [Medline record in process] The efficacy of insulin in stimulating whole-body glucose disposal (insulin sensitivity) was quantified using direct methodology in thirty lacto-ovo vegetarians and in thirty meat-eaters. All subjects were adult, lean (BMI <23 kg/m2), healthy and glucose tolerant. Lacto-ovo vegetarians were more insulin sensitive than meat- eaters, with a steady-state plasma glucose (mmol/l) of 4.1 (95 % CI 3.5, 5.0) v. 6.9 (95 % CI 5.2, 7.5; respectively. In addition, lacto-ovo vegetarians had lower body Fe stores, as indicated by a serum ferritin concentration (mg/l) of 35 (95 % CI 21, 49) compared with 72 (95 % CI 45, 100) for meat-eaters To test whether or not Fe status might modulate insulin sensitivity, body Fe was lowered by phlebotomy in six male meat-eaters to levels similar to that seen in vegetarians, with a resultant approximately 40 % enhancement of insulin-mediated glucose disposal Our results demonstrate that lacto-ovo vegetarians are more insulin sensitive and have lower Fe stores than meat-eaters. In addition, it seems that reduced insulin sensitivity in meat-eaters is amenable to improvement by reducing body Fe. The latter finding is in agreement with results from animal studies where, no matter how induced, Fe depletion consistently enhanced glucose disposal. PMID: 11591239, UI: 21475355 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Very good, this supports another study that showed that frequency of blood donation and thus iron levels had no effect on diabetes risk. "in high-frequency donors when compared with low-frequency donors, but whole body insulin sensitivity index (median values 4.8 vs. 4.7) and related measures of glucose tolerance did not differ between groups." On Dec 28, 7:00 pm, ferr...@paris.com wrote: iron levels had no effect on diabetes risk. << How come I ain't surprised you wouldn't be able to understand the study .. ? OR .. my explanation .. ? Because you are stupid .. buddieeee .. That ain't a .. good .. thing. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "in high-frequency donors when compared with low-frequency donors, but > whole body insulin sensitivity index (median values 4.8 vs. 4.7) and > related measures of glucose tolerance did not differ between groups." > On Dec 28, 7:00 pm, ferr...@paris.com wrote: iron levels had no effect > on diabetes risk. << [quoted text clipped - 20 lines] > > whole body insulin sensitivity index (median values 4.8 vs. 4.7) and > > related measures of glucose tolerance did not differ between groups."\ Now now Tommy, we put up with you and only call you names now and then. So be nice to someone speaks to you. You need to learn to think in shades of grey and not in black or white terms. Sci.med.nutrition will give you iron. Sci.med will remove you foreskin. Misc.health.alternative will implant you with silicone breasts and feed you Noni juice. Sci.med.nursing will give you a high enema. Alt.support.diabetes will finish the matter by inserting all their used needles into your buttocks. Very good, this supports another study that showed that frequency of blood donation and thus iron levels had no effect on diabetes risk. "in high-frequency donors when compared with low-frequency donors, but whole body insulin sensitivity index (median values 4.8 vs. 4.7) and related measures of glucose tolerance did not differ between groups." Jesus ate a mediterranean diet. On Dec 29, 6:31 am, ferr...@paris.com wrote: and thus iron levels had no effect on diabetes risk << That IS what you .. took home .. from the study .. isn't it. How come I ain't surprised you wouldn't be able to understand the study .. ? OR .. my explanation .. ? Because you are stupid .. buddieeee .. That ain't a .. good .. thing. The "iron levels" were never checked .. so the "iron levels" didn't come into it .. did they .. You figure the "iron levels" .. mild versus moderate or high .. came into it .. ? Do ya .. ? You should be .. going .. to .. Yale .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Very good, this supports another study that showed that frequency of > blood donation and thus iron levels had no effect on diabetes risk. [quoted text clipped - 4 lines] > > Jesus ate a mediterranean diet. On Dec 30, 6:02 pm, ironjustice <teamtan...@hotmail.com> wrote: mild versus moderate or high iron levels were not checked..<< Blood donation .. **frequency** .. doesn't come into it. DIET .. induces .. iron reduction .. "Phlebotomy alone **does not completely remove** iron-induced oxidative stress and a low iron diet induces an additional effect in iron reduction therapy " Hepatogastroenterology. 2005 Mar-Apr;52(62):563-6.Links Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C. Kimura F, Hayashi H, Yano M, Yoshioka K, Matsumura T, Fukuda T, Shigeto N, Yamahara S, Koushi F, Mishima Y, Yoshino T, Tanimoto M, Kimura I. Department of Internal Medicine, Tamano-Municipal Hospital, Tamano City, Okayama, Japan. f-kimura@po1.oninet.ne.jp BACKGROUND/AIMS: Iron-induced oxidative stress plays an important role in the pathogenesis of chronic hepatitis C. Both phlebotomy for removing body iron stores and low iron diet for minimizing portal iron supply to the liver have been shown to improve serum transaminase levels in patients with the disease. However, the cooperative effects of phlebotomy and low iron diet have not yet been elucidated in detail. METHODOLOGY: A pilot study was undertaken to investigate whether a low iron diet could improve the efficacy of phlebotomy in iron reduction therapy. Of 21 patients diagnosed with chronic hepatitis C, 10 patients were treated with phlebotomy alone (group A) while 11 patients were treated with a low iron plus phlebotomy (group B). Phlebotomy was repeated biweekly until serum ferritin levels reached 10 ng/mL in both A and B groups. In addition, a low iron diet (iron intake of 8 mg/day or less) was recommended for group B, followed by estimation of iron intake from daily diet records. RESULTS: Serum alanine aminotransferase levels were significantly improved from 106+/-30 to 68+/-22 IU/L (p<0.005, paired t-test) in group A and from 100+/-33 to 46+/-10 IU/L (p<0.002, paired t-test) in group B. The enzyme levels after treatment were significantly higher in group A (p<0.02, non-paired t-test), which showed a higher upward distribution of the enzyme activity. The estimated dietary iron intake in group B was reduced from 17.6+/-6.1 to 8.2+/-3.7 mg/day. CONCLUSIONS: These findings suggest that phlebotomy alone does not completely remove iron-induced oxidative stress and a low iron diet induces an additional effect in iron reduction therapy for chronic hepatitis C. PMID: 15816478 [PubMed - indexed for MEDLINE] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Dec 29, 6:31 am, ferr...@paris.com wrote: and thus iron levels had > no effect on diabetes risk << [quoted text clipped - 39 lines] > > - Show quoted text - |
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