Coenzyme Q10 is an energy coenzyme that plays an essential role in
mitochondrial electron transport and is fundamental for energy
production in our cells. Coenzyme Q10 is also an antioxidant. Its
ability to quench free radicals helps maintain the structural
integrity and stability of cell membranes (including intracellular
membranes). It further serves to reduce oxidation of low-density
lipoprotein (LDL) cholesterol. Evidence suggests that the most
important antioxidant activity of Coenzyme Q10 involves regeneration
of Vitamin E. CoQ10 is also called ubiquinone, a name that signifies
its ubiquitous (widespread) distribution in the human body. Highest
levels of Coenzyme Q10 are found in the heart, liver, kidney and
pancreas.

CoQ10 supplementation has been shown to have therapeutic benefits for
several diseases. Among the best-documented effects involve cases of
heart failure, ischemic heart disease, certain muscular dystrophies,
hypertension, and periodontal disease.

CoQ10 is synthesized in all cells of the body, especially in liver
cells. It is also absorbed from the foods we eat. Major sources of
dietary CoQ10 include meats, fish, and vegetable oils particularly
soybean, sesame, and rapeseed oils. Vegetables are generally low in
CoQ10 with the exception of spinach and broccoli. As aging occurs, the
body's ability to synthesize CoQ10 diminishes significantly.
Deficiencies may also result from reduced assimilation from dietary
sources. Coenzyme Q10 supplements are generally considered safe and
are best absorbed by the body when taken with foods. The usual
maintenance dose is 10-30 mg per day, although higher doses are used
therapeutically to treat heart and blood vessel disease.

References:

Kagan VE, Nohl H, Quinn PJ. Coenzyme Q: Its role in scavenging and
generation of radicals in membranes. In Cadenas E and Packer L,
editors. Handbook of Antioxidants. New York:Marcel Dekker Inc 1996; p
174-80.

Burke BE, Neuenschwander R, Olson RD Randomized, double-blind, placebo-
controlled trial of coenzyme Q10 in isolated systolic hypertension.
South Med J 2001 Nov;94(11):1112-7.

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