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Medical Forum / General / Alternative / April 2007Nasunin Chelates Iron
Noda Y, Kaneyuki T, Igarashi K, Mori A, Packer L Antioxidant activity of nasunin, an anthocyanin in eggplant. [Journal Article] Res Commun Mol Pathol Pharmacol 1998 Nov; 102(2) :175-87. Delphinidine-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin was isolated as purple colored crystals from eggplant peels, Solanum melongena L. 'Chouja'. Using an electron spin resonance spectrometer and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), spin trapping, hydroxyl (.OH) or superoxide anion radicals (02*-) generated by the Fenton reaction or the hypoxanthine-xanthine oxidase system were measured as DMPO-OH or DMPO-OOH spin adducts. L-Ascorbic acid 2- [3,4-dihydro-2,5,7,8-tetra-methyl-2-(4,8,12-trimethyltridecyl)-2 H-1- benzopyran-6yl-hydrogen phosphate] potassium salt (EPC-K1) and bovine erythrocyte superoxide dismutase (SOD) were used as standards for .OH and O2*-, respectively. Nasunin directly scavenged O2*- with a potency of 143+/-8 SOD-equivalent units/mg), and inhibited formation of DMPO- OH (0.65+/-0.07 EPC-K1 micromol/mg). A spectrophotometric study showed that nasunin formed an iron complex with a molar ratio of nasunin : Fe3+ of 2 : 1. Therefore, hydroxyl radical scavenging by nasunin is not due to direct radical scavenging but inhibition of .OH generation by chelating iron. Nasunin (1 microM) significantly protected against lipid peroxidation of brain homogenates (p<0.001) as measured by malonaldehyde and 4-hydroxyalkenals. These findings demonstrate that nasunin is a potent O2*- scavenger and iron chelator which can protect against lipid peroxidation. ---------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk I wonder if there are any of those .. purple .. crystals in this .. purple .. stuff .. ? Remember .. 'anemia' .. is relative to .. **intelligence** .. OF .. medical professionals. Such as anemic women don't have diabetic dead babies. http://www.sciencedaily.com/releases/2002/12/021213062321.htm "Too Much Grape Juice Could Cause Iron Deficiency The same antioxidant compounds in dark grape juice that are noted for their health benefits in fighting heart disease may have a downside, according to new research in the Journal of Agricultural and Food Chemistry. In cell studies, scientists with the U.S. Department of Agriculture and Cornell University found that polyphenols in purple (also called red) grape juice can inhibit the uptake of iron, which could increase the risk of iron-deficiency anemia." -------------------------------------------------------------------------- http://abcnews.go.com/Health/story?id=2959851&page=1 Grape and Berry Juices: Elixers for Long Life? Grape Juice-Industry-Funded Study Finds They May Help Prevent Alzheimer's, Heart Disease By AMMU KANNAMPILLY Mar. 17, 2007 Americans drink half the world's orange juice -- 21 quarts per person each year. Most of them do so because of reasons connected to taste and to the perceived health benefits of a glass of O.J. every day. But that may change soon. According to a new study by scientists at the University of Glasgow in Scotland, purple grape juice is now your best bet for preventing heart disease, Alzheimer's disease and a host of other chronic ailments. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "ironjust...@aol.com" <ironjust...@aol.com> wrote: > Remember .. 'anemia' .. is relative to .. **intelligence** .. OF .. > medical professionals. So that's why you're so stupid; too much bloodletting has made you anemic. And dumb as a box of rocks. > Such as anemic women don't have diabetic dead babies. This may qualify as the most moronic thing you have ever written. Sylvia >Delphinidine-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an >anthocyanin was isolated as purple colored crystals from eggplant >peels, Solanum melongena L. 'Chouja'. Using an electron spin resonance Peckerhead! Joan; > On 30 Apr 2007 06:55:18 -0700, "ironjust...@aol.com" > [quoted text clipped - 4 lines] > > Peckerhead! LOL! I'm gonna steal this epithet for Tommy! Sylvia (still giggling!) |
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