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Medical Forum / General / Alternative / April 2007Ferritin as inflammatory marker DEBUNKED
Seems .. hyperferritinemia .. does NOT .. "evidence inflammation" .. <<snip>> effect of the inflammatory status factor on ferritin level was very weak. <<snip>> Clin Biochem. 2007 Mar;40(5-6):359-64. Epub 2007 Jan 5. Links Evaluation of a model of latent pathologic factors in relation to serum ferritin elevation.Yamanishi H, Kimura S, Hata N, Iyama S, Kanakura Y, Iwatani Y. Laboratory for Clinical Investigation, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka 565-0871, Japan. yamaha@hp-lab.med.osaka- u.ac.jp OBJECTIVES: Serum ferritin increases in various disorders and clinical conditions. However, causal associations between the serum ferritin level and clinical factors that influence serum ferritin level are not well characterized. We report a model that quantitatively analyzes the causal relations between the serum ferritin level and clinical factors. DESIGN AND METHODS: We analyzed the ferritin level and other laboratory data in the sera of 274 patients. Structural equation modeling was used to verify causal relations and the adequacy of latent factors. RESULTS: Three factors representing clinical status were identified: cell damage, hepatic function, and inflammation. Serum iron (SI) had the strongest effect on serum ferritin elevation. The effect of the cell damage factor on serum ferritin indicated cell destruction, and that of the hepatic function factor represented decreased serum ferritin clearance. The cell damage factor also indirectly increased the ferritin level via SI or the hepatic function factor. The total effect of the inflammatory status factor on ferritin level was very weak. CONCLUSIONS: These causal relations may explain the mechanism of serum ferritin level elevation in various clinical conditions. PMID: 17292875 [PubMed - in process] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Sure, we have been telling you this for years, all the dog and tail claims you want to make are not supported. It also illustrates how many times you shoot yourself in the foot because you don't understand what you read. Welcome to scientific reality. >Seems .. hyperferritinemia .. does NOT .. "evidence inflammation" .. > [quoted text clipped - 44 lines] >DEAD PEOPLE WALKING >http://tinyurl.com/zk9fk >>On Apr 14, 12:07 pm, keystone.mark.com wrote: Sure, we have been telling you this for years,<< Excuse .. me .. ? YOU have been telling .. me .. ? .. something .. ? Explain what .. YOU .. have been telling .. ME .. Seems EVERYTHING .. I .. have been telling .. YOU .. seems to be coming to fruition .. Explain this .. patting on your own back .. that YOU .. claim .. Explain .. your .. claim .. TO .. fame .. Do it .. succinctly .. so .. I .. understand .. Explain it as you would to a .. retarded .. person .. I'd hate to .. **miss** .. your .. 'contribution' .. TO .. medicine .. other than .. killing people with your .. STUPIDITY .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Sure, we have been telling you this for years,<< Excuse .. me .. ?" YOU have been telling .. me .. ? .. something .. ?" That the scores of posts mentioning some correleation of iron levels with some disorder does not say anything about cause,ie. the dog and tail stories with which you have amused us. Just to make sure I read the full article to confirm what the abstract seems to outline. They used examples in liver tissue. Iron can rise for various reasons so when seen in some liver disorders what does it suggest with regard to inflamation also often seen? Disorders of the liver cause cell damage which releases iron and lowers the clearance of iron, which happens most in the liver. Both factors contribute to higher iron levels, more release and less clearance. The inflammation is a weak causal factor for the increased iron levels,, instead better understood as above. Or as restated in the first of the discussion section: "Although the serum ferritin level is related to body iron content under normal circumstances, extreme serum ferritin elevation (hyperferritinemia) is a nonspecific indicator of disorder and is attributed to ferritin elevation factors that are unevenly distributed irrespective of disease. These factors include iron overload, tissue damage, and inflammation. We used exploratory factor analysis of various clinical parameters and reported that serum ferritin levels change in response to these pathologic factors [21]. However, causal relations between these factors were not determined. In the present study, we quantitatively determined causal relations between the serum ferritin increase and these pathologic factors." >>On Apr 14, 2:43 pm, keyst...@mark.com wrote: The inflammation is a weak causal factor for the increased iron levels<< > Excuse .. me .. ?" > YOU have been telling .. me .. ? .. something .. ?" [quoted text clipped - 27 lines] > quantitatively determined causal relations between the serum ferritin > increase and these pathologic factors." ???? You didn't actually.. claim .. your .. prize .. there .. buddieeeee .. Why .. is .. that .. ? You cannot .. explain .. TO .. a .. retarded person .. ? I .. guess .. so .. "The inflammation is a weak causal factor for the increased iron levels" You .. reiterated .. the FACT .. inflammation is CAUSED .. by .. the increased .. FERRITIN / iron .. NOT .. the other way around .. You are .. claiming .. you .. said this .. ? Claim .. it .. Go .. ahead .. claim it .. Tell all the kids you have been DISREGARDING .. with your .. hyperferritinemia .. knowledge .. that you just .. didn't .. care .. TO .. **treat** .. but are VERY .. **happy** .. to .. hurt .. with the iron supplementation / infusions / injections and suppositories .. you .. wonderful .. medical .. professional .. Claim .. it .. Heh .. heh .. Now .. fk .. off .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "You .. reiterated .. the FACT .. inflammation is CAUSED .. by .. the increased .. FERRITIN / iron .. NOT .. the other way around .." No, iron levels were caused by cell damage releasing iron stored in the cell. Added to this was a lowered iron clerance level because of the cell damage in the liver which normally clears the iron. Thus increased iron levels were these two factors in sum. The inflammation was not the cause of the increased levels. The cell damage as source of iron increases has been brought to your attention before, now your own abstract confirms it. Just to say there is a correlation with iron level and some disorder says nothing about what causes what, the dog and tail story. Bty, this is a keeper which can be brought to your attention as each new post is made with a mere correlation stated to deflate any casual claim you might make. >>On Apr 14, 4:20 pm, keyst...@mark.com wrote: Bty, this is a keeper which can be brought to your attention as each new post is made with a mere correlation stated to deflate any casual claim you might make.<< Soooo .. I guess .. your prize .. you were unable to .. claim .. after all. Yep it's a .. keeper .. "Inflammation does NOT .. cause .. hyperferritinemia .." .. JUST .. like **I / me / myself** .. have been saying .. But NOW .. you say .. YOU said it .. ? Now .. repeat after .. me .. YOU .. say .. out .. loud .. "I .. have ALWAYS .. known inflammation does NOT .. cause .. hyperferritinemia.. and have tried to explain .. in vain .. NOT to give iron to these kids" .. Just cut and snip the above phrase and place it into the next post .. Just so .. we .. together are in agreement WHAT .. you .. claim. You claim you 'know' about iron and have ALWAYS .. known .. "inflammation does NOT cause hyperferritinemia" .. Just repeat .. it .. Repeat that .. it ain't .. hard .. You seem to be able to prattle on like some nppyhdedhoonspeed .. BUT .. you cannot seem to .. admit to the .. above .. Admit it .. like you were told .. Just say it out loud so you can .. hang .. yourself .. "I knew the kids had iron on board but still injected them with iron because .. I was told to .. " .. Just .. admit your stupidity .. It seems you and your ilk have a problem with .. admission .. you seem to like to kill people but NOT .. admit .. it .. was done because of .. **stupidity**. How come .. ? Would it mean you are .. collectively .. a bunch of .. pussies .. ? Must .. be .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>On Apr 14, 4:20 pm, keyst...@mark.com wrote: > You seem to be able to prattle on like some nppyhdedhoonspeed .. nppyhdedhoonspeed ? Sorry - don't get this one? ""Inflammation does NOT .. cause .. hyperferritinemia .." .." Nor is high levels of iron the cause of the disorders with which it can be associated, the damage of cells in a disorder releases iron and the liver's ability to clear the increased levels is decreased. Taken together these two factors are the cause of higher iron levels associated with some disorders, the dog and tail thing you know. Because of the cell damage, higher inflimation goes with higher iron levels but is not the cause of it, the dog and tail story you know. The abstract is a keeper for the reasons mentioned before. >>On Apr 14, 4:20 pm, keyst...@mark.com wrote: Bty, this is a keeper which can be brought to your attention as each new post is made with a mere correlation stated to deflate any casual claim you might make.<< Soooo .. I guess .. your prize .. you were unable to .. claim .. after all. Yep it's a .. keeper .. "Inflammation does NOT .. cause .. hyperferritinemia .." .. JUST .. like **I / me / myself** .. have been saying .. But NOW .. you say .. YOU said it .. ? Now .. repeat after .. me .. YOU .. say .. out .. loud .. "I .. have ALWAYS .. known inflammation does NOT .. cause .. hyperferritinemia.. and have tried to explain .. in vain .. NOT to give iron to these kids" .. Just cut and snip the above phrase and place it into the next post .. Just so .. we .. together are in agreement WHAT .. you .. claim. You claim you 'know' about iron and have ALWAYS .. known .. "inflammation does NOT cause hyperferritinemia" .. Just repeat .. it .. Repeat that .. it ain't .. hard .. You seem to be able to prattle on like some nppyhdedhoonspeed .. BUT .. you cannot seem to .. admit to the .. above .. Admit it .. like you were told .. Just say it out loud so you can .. hang .. yourself .. "I knew the kids had iron on board but still injected them with iron because .. I was told to .. " .. Just .. admit your stupidity .. It seems you and your ilk have a problem with .. admission .. you seem to like to kill people but NOT .. admit .. it .. was done because of .. **stupidity**. How come .. ? Would it mean you are .. collectively .. a bunch of .. pussies .. ? Must .. be .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>On Apr 14, 4:20 pm, keyst...@mark.com wrote: No, iron levels were caused by cell damage releasing iron stored in the cell. Added to this was a lowered iron clerance level because of the cell damage in the liver which normally clears the iron. Thus increased iron levels were these two factors in sum. The inflammation was not the cause of the increased levels. The cell damage as source of iron increases has been brought to your attention before, now your own abstract confirms it. Just to say there is a correlation with iron level and some disorder says nothing about what causes what, the dog and tail story.<< The .. HEMOLYSIS .. of the RED BLOOD CELLS .. causes **hyper**- ferritinemia .. as evidenced below .. the ferritin is CREATED .. when .. the iron and heme are present .. **TOGETHER** .. and 'coincidentally' .. red blood cells are made UP .. of .. ? .. heme and iron .. Hemolysis .. hemo-lysis / destroyed red blood cell yields / creates heme and iron which then creates **ferritin** TO .. ? .. **store** .. ? .. store .. ? .. iron .. ? That .. is .. 'what' .. ferritin .. DOES .. Didn't you know .. that .. ? Did you think hyperferritinemia / it .. was caused by .. ? .. hmmm .... inflammation .. ? I .. think .. you .. do .. So .. the hyperferritinemia found in .. people .. is the result of increased iron either through ingestion OF iron .. or .. hemolysis of red blood cells. Heme controls antioxidants and iron in ferritin October 11, 2005 - Discovery could improve or create treatments for several chronic illnesses Oakland, CA- A new study conducted by scientists at Children's Hospital Oakland Research Institute could help researchers develop new treatments for a variety of health conditions that are all related to abnormal iron metabolism. More than one million Americans have abnormal iron levels in their bodies. For example, iron excess can lead to a long list of health problems including diabetes, heart failure, liver cancer, arthritis and severe fatigue. Ferritin is a protein that stores or releases iron in the body as it is needed. Until now, scientists were convinced that the only way to develop new therapies for treating iron overload was to focus on iron metabolism. But a new study published in the October 10th issue of the Proceedings of the National Academy of Sciences is the first to demonstrate that the ferritin gene can be controlled by heme, and other common antioxidant regulators. Heme is the molecule that activates many protective genes and is also the part of the blood that uses iron to carry oxygen from our lungs to the rest of the body. Previously, scientists only focused on genes that were regulated by iron for iron related diseases. Now it is clear that heme might be a "master switch" for iron genes, and antioxidant genes, which are the genes that protect and repair damage caused by oxygen radicals. If that mechanism is found, heme could help scientists unravel the cause and cures of several chronic illnesses. "This new information will dramatically change the way researchers think about solving certain health problems involving iron or inflammation," said Elizabeth Theil, Ph.D., Senior Scientist at Children's Hospital Oakland Research Institute and co-author of the study. "For the first time we understand that ferritin is one of the protective genes the body uses to protect us from the damage caused by oxygen radicals. " To find out what controlled ferritin genes; scientists studied cultures of liver cells. They found that iron, by itself, was a weak signal by linking different pieces of ferritin DNA to a "reporter" gene and measuring the amount of reporter protein when cells were fed extra iron, heme, or sulforphane. Iron had practically no effect, but with heme or sulforphane much "reporter" was produced. Scientists discovered that ferritin is a gene with two kinds of genetic controllers: DNA plus mRNA. Iron regulates the mRNA. When the two regulators were combined in the experiment, heme made the cells produce huge amounts of reporter protein-three times more than either one alone. Both DNA and mRNA carry genetic information. DNA is the blueprint, protected in the nucleus, and mRNA is the working copies used to manage day-to-day information and cell work. "Our research shows that ferritin mRNA is sensitive to iron, ferritin DNA is sensitive to antioxidants like sulforphane and heme coordinates both DNA and mRNA," said Korry Hintze, a postdoctoral fellow at Children's Hospital Oakland Research Institute and co-author of the study. "Now we know that ferritin is central to both iron and oxygen metabolism." Children's Hospital & Research Center at Oakland Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk The cell damage as source of iron increases has been brought to your attention before, now your own abstract confirms it. Just to say there is a correlation with iron level and some disorder says nothing about what causes what, the dog and tail story.<< "The .. HEMOLYSIS .. of the RED BLOOD CELLS .. causes **hyper**- ferritinemia .. as evidenced below .. the ferritin is CREATED .. when .. the iron and heme are present .. **TOGETHER** .. and 'coincidentally' .. red blood cells are made UP .. of .. ? .. heme and iron .." In the abstract you provided and other instances brought to your attention the source of the iron was that released from damaged cells. >>On Apr 17, 7:37 am, keyst...@mark.com wrote: In the abstract you provided and other instances brought to your attention the source of the iron was that released from damaged cells.<< Well as far as I've been able to .. see .. about this .. thread .. **thread** .. IS .. you've .. attempted .. to .. divert from the FACT .. "inflammation does not cause hyperferritinemia .. " .. Now .. what do we have .. ? We have .. people / patients .. who have been .. **misdiagnosed** .. killed and maimed by the medical profession .. BY **stupidity** and/ or ignorance. And the .. response OF .. 'one of the medical profession' .. ? .. you .. "The iron comes from a damaged cell .. " .. ???? You didn't even KNOW the iron was there .. and killed women , men and children. And based upon your .. reaction .. TO .. this discovery .. are going to CONTINUE .. to kill men , women and children .. And .. just in case you ARE as stupid as you act .. a .. destroyed cell .. IS .. a red blood cell .. a r-e-d b-l-o-o-d .. **cell** .. Now .. maybe you should go tell your buddies not to hurt any more .. kids .. before somebody takes .. umbridge .. and gives you .. precisely what you .. so .. RICHLY .. deserve .. Try not to let them take almost a .. year .. before SOMEBODY .. like the FDA .. has to tell them their .. job .. or like a .. clown .. on .. the .. internet .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Ok I've been reading this board for exactly two days, and I see what you're on about now. I saw your "Jesuswasavegetarian" stuff, a little of it. "This message speaks to vegetarianism and bloodletting/iron deprivation to treat ALL disease." Bloodletting? Vegetarianism to treat ALL disease? Maybe this is not the right forum for you- perhaps there is a forum out there that also believes in your fringe theories. Why don't you go talk to them? Why try to aggressively evangalize everyone else? You only annoy people! And Jesus most certainly was NOT a vegetarian. I can give plenty of scriptures to prove that mankind was given meat for food by GOD, that the priests were given meat for their food (and Jesus was our High Priest), that God declared all meat to be clean- without regard to OT laws of Kosher. But, I'm not going to bother- for I can tell right away what the reaction would be. Babble on all you like, but know that you are only annoying people, and making yourself look like a freak and a fool. >>On Apr 18, 8:24 am, Caya <Caya...@gmail.com> wrote:<< Caya .. nice name for a .. dog .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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