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Medical Forum / General / Alternative / March 2007Iron Levels Predict Diabetes
Diabetologia. 2007 Mar 2; [Epub ahead of print]Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC- Norfolk prospective study.Forouhi NG, Harding AH, Allison M, Sandhu MS, Welch A, Luben R, Bingham S, Khaw KT, Wareham NJ. MRC Epidemiology Unit, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge, CB1 9NL, UK, nita.foro...@mrc-epid.cam.ac.uk. AIMS/HYPOTHESIS: The aim of this study was to examine the association between baseline body iron stores and new-onset diabetes. SUBJECTS AND METHODS: We studied the association between baseline serum ferritin concentration and type 2 diabetes in 360 clinically incident diabetes cases and 758 controls nested within the EPIC (European Prospective Investigation of Cancer)-Norfolk Cohort Study. Serum ferritin levels were categorised into five groups: sex-specific quartiles of the normal range of ferritin and a group with clinically raised ferritin below levels indicative of haemochromatosis. RESULTS: Baseline serum ferritin was higher among cases than control participants (geometric mean: men 96.6 vs 67.8 ng/ml, respectively, p < 0.001; women 45.9 vs 34.8 ng/ml, respectively, p = 0.005). In analyses adjusted for known risk factors (age, BMI, sex, family history, physical activity, smoking habit) and dietary factors measured by 7-day food diary, the risk of diabetes was markedly elevated in participants with clinically raised ferritin compared with the lowest quartile (odds ratio [OR] 7.4, 95% CI 3.5-15.4). Further adjustment for potential confounding by inflammation (C-reactive protein, IL-6 and fibrinogen) had no material impact on the observed association, while adjustment for hepatic enzymes (alanine aminotransferase and gamma glutamyl transferase) and adiponectin attenuated the magnitude of association, but it remained statistically significant (OR 3.2 [1.3-7.6]). CONCLUSIONS/ INTERPRETATION: Serum ferritin is an important and independent predictor of the development of diabetes. This finding may have important implications for understanding the aetiology of diabetes. PMID: 17333112 [PubMed - as supplied by publisher] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk http://www.medicinenet.com/script/main/art.asp?articlekey=62280 Low Iron Could Help Spur Baldness WEDNESDAY, May 31 (HealthDay News) -- Could iron deficiency be key to baldness? The answer is yes, according to researchers at the Cleveland Clinic, who reviewed scientific literature on the connection published over the past 40 years. "If doctors can understand fully the relationship between iron deficiency and hair loss, then they can help people regrow hair more effectively," study leader Dr. Wilma Bergfeld, head of clinical research in the department of dermatology, said in a prepared statement. "We believe that iron deficiency may be related to many forms of hair loss and that people may need higher levels of iron stores than previously thought to regrow hair." The review of data suggests that iron deficiency may be linked to several of the most common kinds of hair loss. However, there is not enough evidence to suggest universal screening for iron deficiency in hair-loss patients and further research is required, the researchers said. The findings appear in the May issue of the Journal of the American Academy of Dermatology. Iron deficiency is the world's most common nutritional deficiency. It can be caused by inadequate dietary intake of iron, excessive menstrual bleeding, and other forms of blood loss. Treatment includes adequate dietary intake of iron and, when appropriate, iron supplements. Doctors at the Cleveland Clinic routinely screen for iron deficiency in patients with hair loss. If iron deficiency is detected and treated in the early stages, patients may be able to grow hair more effectively, the researchers said. -- Robert Preidt SOURCE: Cleveland Clinic, news release, May 15, 2006 On Mar 5, 9:45 am, "redbea...@bigmailbox.net" <l...@inorbit.com> wrote: > http://www.medicinenet.com/script/main/art.asp?articlekey=62280 > [quoted text clipped - 37 lines] > > SOURCE: Cleveland Clinic, news release, May 15, 2006 When was the last time you seen an .. iron deficient .. man .. ? They don't exist .. Baldness does .. at a very high rate .. very high rate .. Men are NEVER iron deficient .. sooo .. the numbers don't add .. up .. And again the Framington study confirmed high rate of iron excess as opposed to ANY iron deficiency at .. all .. Last year, Richard Wood, a Tufts University nutrition expert, and his colleagues analyzed blood iron levels in more than 1,000 men and women, ages 67 to 96, in the landmark, long-term Framingham Heart Study. While 2.7% had abnormally low levels of iron, more than four times that many -- 12.9% -- had too much of the mineral, according to the research, published in the American Journal of Clinical Nutrition. http://www.findarticles.com/p/articles/mi_qn4196/is_20021007/ai_n10838995 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > When was the last time you seen an .. iron deficient .. man .. ? > > They don't exist .. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1471-0528.1964.tb04380.x TREATMENT OF 300 CASES OF IRON DEFICIENCY OF PREGNANCY BY TOTAL DOSE INFUSION OF IRON-DEXTRAN COMPLEX http://www.bmj.com/cgi/content/full/314/7075/206 Lesson of the week: prevalence of concomitant disease in patients with iron deficiency anaemia http://www.springerlink.com/content/t0m6108882744p53/ Porphyrin synthesis and metabolism in iron deficiency anaemia. I. In-vivo-studies http://www.jstage.jst.go.jp/article/nmc/46/12/46_589/_article Cerebral Venous Sinus Thrombosis Associated With Iron Deficiency -Two Case Reports- Found these in two minutes. I'm sure there's a few more out there. Even the article you posted says "Iron deficiency is a significant problem for many people" >>Found these in two minutes. I'm sure there's a few more out there. Even the article you posted says "Iron deficiency is a significant problem for many people" When was the last time you seen an .. iron deficient .. man .. ? They don't exist .. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1471-0528.1964.tb0... TREATMENT OF 300 CASES OF IRON DEFICIENCY OF PREGNANCY BY TOTAL DOSE INFUSION OF IRON-DEXTRAN COMPLEX << Pregnant .. men .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>Found these in two minutes. I'm sure there's a few more out there. Even >>>the [quoted text clipped - 11 lines] > > Pregnant .. men .. ? And the other examples? >>On Mar 6, 12:40 am, "Manky Badger" And the other examples<< I believe you have .. already .. HAVE had this explained to you .. Hasn't .. it .. ? You've already been shown the studies .. Yet .. you AGAIN .. ask the same .. question .. Why IS .. that .. ? You didn't like the first .. explanation .. ? You don't .. BELIEVE .. the first explanation .. ? You figure I am going to CHANGE .. the explanation .. ? They've been killing the womens' children in the womb by giving them this iron .. attempting to achieve a "nice high hemoglobin" .. sooo .. UNTIL you show the OUTCOME .. of those studies .. IE: birth outcome .. then your 'questioning' of ME .. is either .. one driven by your .. BEING .. a jrkff / dldo / fkdinthheadscrwbll / medical professional .. OR .. one driven by an **inability to understand** and / or **remember** .. stuff .. Sooo .. either way .. just stay off my threads .. You are too stupid .. or a fkdinthheadscrwbll .. Healthy Pregnant Women's Iron Intake Advice Too High Main Category: Pregnancy News Article Date: 01 Jun 2006 - 2:00am (PDT) A new study conducted by researchers at Children's Hospital Oakland Research Institute (CHORI), in close collaboration with scientists at the National Institute of Perinatology in Mexico, is the first to show that the current iron supplement recommendation for pregnant women who are not anemic is too high and could lead to birth complications for infants such as premature birth and low birth weight. This new research conflicts with recommendations from the World Health Organization (WHO) and the Centers for Disease Control (CDC). It is hoped that the results of this study will lead to new recommendations from both organizations. The study, featured in the May issue of Archives of Medical Research, suggests that pregnant women who are not anemic should take iron supplements weekly rather than daily. Women who are anemic have low levels of healthy red blood cells and need higher doses of iron supplementation. The study shows that pregnant women who are not anemic and follow the recommended daily dosage can suffer from iron overload and are more likely to experience birth complications. Iron deficiency is common among women of childbearing age. Consequently, doctors have ordered daily supplements of 60 to 120 mg of iron to prevent or correct anemia and iron deficiency during pregnancy. "What happens is that excess iron in pregnancy can drive the hemoglobin levels above desirable levels, so that by the end of the second trimester of pregnancy, 27 percent of the non-anemic women in our study had hemoglobin levels that were undesirably high," said Fernando Viteri, MD, Scientist at Children's Hospital Oakland Research Institute (CHORI). "In these women, the risk of delivering premature babies or newborns with low birth weight quadrupled." In contrast, only 7 percent of the women on weekly supplements developed high hemoglobin levels. The reason for the weekly dose - and in far smaller amounts - is biological and corresponds with the turnover of the intestinal lining, which renews itself every five to six days. The fresh cells are programmed to absorb iron according to the person's iron reserves and needs. The cells absorb more if reserves are depleted and less if they are adequate. Dr. Viteri's research concludes that iron supplementation is still beneficial, but must be regulated based on whether a woman is anemic. About Children's Hospital & Research Center Oakland Children's Hospital & Research Center Oakland is a designated Level I pediatric trauma center and the largest pediatric critical care facility in the region. The hospital has 181 licensed beds and 166 hospital-based physicians in 31 specialties, more than two thousand five hundred employees, and an operating budget of $287 million. The hospital's research institute has an annual budget of $41 million with more than 300 basic and clinic investigators. Children's Hospital Oakland Research Institute (CHORI) has made significant progress in areas including pediatric obesity, cancers, sickle cell disease, AIDS/HIV, hemophilia and cystic fibrosis. Diana Yee d...@mail.cho.org Children's Hospital & Research Center at Oakland http://www.childrenshospitaloakland.org ------------------------------------------------------------------------------------------------------- Association between higher cumulative doses of recombinant erythropoietin and risk for retinopathy of prematurity. Brown MS, Barón AE, France EK, Hamman RF J AAPOS. 2006 Apr ; 10(2): 143-9 BACKGROUND: Retinopathy of prematurity is a complication of premature birth that varies in its severity. The incidence and severity of retinopathy of prematurity at our perinatal center in a regional referral hospital changed substantially during 1995 to 1998 and presented us with an opportunity to examine whether there was a protective effect on risk of retinopathy associated with exposure to recombinant erythropoietin. METHODS: We undertook a retrospective cohort study. From January 1995 through December 1998, charts of infants weighing<1500 g, who were 30 weeks' gestation or less, and who were admitted and survived to the first eye examination at 6 weeks were reviewed. Primary and secondary risk factors were recorded from the first 6 weeks of life. Of the eligible infants, 327 of 390 (84%) had complete records and retinal examinations. The probability for progression of retinopathy was estimated by logistic regression multivariate analysis using the continuation-ratio model. RESULTS: The overall incidence of retinopathy of prematurity was 36%. Recombinant erythropoietin exposure, as total 6-week dose, was independently associated with an increased risk for progression of retinopathy, OR=1.27 per 500 units/kg (95%CI=1.04, 1.55, P=0.02). Postnatal day of recombinant erythropoietin initiation also was associated with retinopathy risk but did not reach conventional statistical significance, OR=1.07 (CI=1.00, 1.14, P=0.07). CONCLUSIONS: These findings identify an association between cumulative recombinant erythropoietin exposure, used to reduce blood transfusions in premature infants, and an increased risk for retinopathy of prematurity. The nonhematopoietic properties of erythropoietin may account for the above findings, however further evaluation with confirmation is required. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>On Mar 6, 12:40 am, "Manky Badger" And the other examples<< They've been killing the womens' children in the womb by giving them this iron .. attempting to achieve a "nice high hemoglobin" .. sooo .. UNTIL you show the OUTCOME .. of those studies .. IE: birth outcome .. then your 'questioning' of ME .. is either .. one driven by your .. BEING .. a jrkff / dldo / fkdinthheadscrwbll / medical professional .. OR .. one driven by an **inability to understand** and / or **remember** .. stuff .. ___________________________________________ Don't you think that *if* there is anything in this anti-iron theory of yours you would get far more credibility if you were to attempt to discuss the matter rationally rather than posting an article which actually goes against the conclusion you assign to it. And then resorting to purile insults when evidence fails you? "fkdinthheadscrwbll" is a new one, I quite like being a "fkdinthheadscrwbll", especially one who sees no reason to change my views on iron therapies. > <ironjust...@aol.com> wrote in message > [quoted text clipped - 20 lines] > "fkdinthheadscrwbll", especially one who sees no reason to change my views > on iron therapies. is it my iron levels being too high that causes me to act like a fkdinthheadscrwbll? or am i just a jrkff? >>especially one who sees no reason to change my views on iron therapies<< Actually .. you see the thread .. ? It is a simple .. thread .. medical study .. CONFIRMING what was said over a year and a half ago .. by ME .. http://tinyurl.com/3asena The iron levels predicted the diabetes .. Simple .. really .. And you were ON this thread FOR a .. reason .. ? To say something about the iron deficiency IN these diabetics / people with diabetes .. ? What iron deficiency .. ? There was iron **excess** .. in these people who develope diabetes .. You disagree there is NOT ..? Pretty much goes with the free floating iron they found in all diabetics .. Eh .. That would be .. an .. association .. But you can't seem to put two and two together .. ? Now why is that .. ? The clinical trial recruiting for iron reduction for diabetes seems to have garnered enough attention to .. what .. ? fund a study of reduction of iron in diabetes .. ? The study seems to confirm somewhat the COMPETENCY of these researchers .. You disagree .. ? That's because you are .. stupid .. Isn't it .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>especially one who sees no reason to change my views > on iron therapies<< [quoted text clipped - 7 lines] > > The iron levels predicted the diabetes .. Diabetes.... in a thread entitled "Low Iron Could Help Spur Baldness" - you're losing it, Tom > http://www.medicinenet.com/script/main/art.asp?articlekey=62280 > [quoted text clipped - 37 lines] > > SOURCE: Cleveland Clinic, news release, May 15, 2006 The history of the word manure is so educationally and intellectually stimulating, that I thought I should pass it on to the fine members of this outstanding community who are truly appreciative of the finer things in life. Manure...The True Story In the 16th and 17th centuries, everything had to be transported by ship and it was also before commercial fertilizer's invention, so large shipments of manure were common, at that time it was called a load of Berrier, by the sailors. It was shipped dry, because in dry form it weighed a lot less than when wet, but once water (at sea) hit it, it not only became heavier, but the process of fermentation began again, of which a by product is methane gas. As the stuff was stored below decks in bundles you can see what could (and did) happen. Methane began to build up below decks and the first time someone came below at night with a lantern, BOOOOM! Several ships were destroyed in this manner before it was determined just what was happening After that, the bundles of manure were always stamped with the term "Ship High In Transit" on them, which meant for the sailors to stow it high enough off the lower decks so that any water that came into the hold would not touch this volatile cargo and start the production of methane. Thus evolved the term "S.H.I.T. " , (Ship High In Transport) which has come down through the centuries and is in use to this very day. You probably did not know the true history of this word. Neither did I. I had always thought it was a golf term! >The history of the word manure is so educationally and intellectually >stimulating, that I thought I should pass it on to the fine members of this >outstanding community who are truly appreciative of the finer things in >life. > > Manure...The True Story Lest anyone be misled, it isn't a true story. -- David Wright :: alphabeta at prodigy.net These are my opinions only, but they're almost always correct. "HPV shots don't cause promiscuity. Tequila shots do." -- Bill Maher >>The history of the word manure is so educationally and intellectually >>stimulating, that I thought I should pass it on to the fine members of [quoted text clipped - 5 lines] > > Lest anyone be misled, it isn't a true story. But yet you support the spammer? LOL< @ Ahole > -- David Wright :: alphabeta at prodigy.net > These are my opinions only, but they're almost always correct. > "HPV shots don't cause promiscuity. Tequila shots do." -- Bill Maher >> But yet you support the spammer? LOL< @ Ahole<< You disagree with the result of the study ..? You are saying the iron levels did NOT .. predict the diabetes .. ? That means you are .. stupid .. You don't know what spam is .. you can't understand a medical study .. ???? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>> But yet you support the spammer? LOL< @ Ahole<< > [quoted text clipped - 5 lines] > > You don't know what spam is .. you can't understand a medical study .. He's laughing at you, Tommy. >>>The history of the word manure is so educationally and intellectually >>>stimulating, that I thought I should pass it on to the fine members of [quoted text clipped - 7 lines] > >But yet you support the spammer? No. I also don't support nitwits like you who post 6000-line articles. -- David Wright :: alphabeta at prodigy.net These are my opinions only, but they're almost always correct. "HPV shots don't cause promiscuity. Tequila shots do." -- Bill Maher |
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