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Medical Forum / General / Alternative / May 2006Fanconi anemia / ANOTHER .. prize ?
http://bentham.org/cmc/contabs/cmc12-23.htm#6 <<snip>> findings concerning the discovery of iron-stimulated free radical cascades in Fanconi anemia <<snip>> Superoxide and Nitric Oxide in Pathological Conditions Associated with Iron Overload. The Effects of Antioxidants and Chelators I.B. Afanas'ev Free radicals are a one of damaging factors in diseases associated with iron overload. This review considers two principal questions: the mechanisms of free radical-mediated damage in cells and tissue and findings concerning the discovery of iron-stimulated free radical cascades in thalassemia and Fanconi anemia. There are two major precursors of all reactive oxygen and nitrogen species formed in living organism - superoxide (O2.-) and nitric oxide (NO). However, it has been shown that in addition to well-known mechanisms of the formation of reactive hydroxyl radicals and peroxynitrite from superoxide and NO, there are signal pathways by which these "physiological" radicals directly induce apoptosis, proton leak in mitochondria and an increase in oxygen consumption leading to cell death. In present review the mechanisms of free radical damage are considered with the particular emphasis of iron-induced free radical formation in thalassemia and Fanconi anemia. Furthermore free radical reactions leading to lipid peroxidation, LDL oxidation, the stimulation of apoptosis and other damaging processes are discussed. An importance of the chelating and antioxidant treatments of thalassemic and Fanconi anemia patients is also considered within the context of free radical damage and its prevention. http://www.cyto.purdue.edu/hmarchiv/1996/1661.htm Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Similar language, no prize no cigar, "iron overload" says it all, don't book a trip to oslo just yet. As the language of the abstract directly implies, the overload, not presence of normal levels, is one among other paths to the disorders. All you have "discovered" is that researchers often have common thinking and often are reacting to the research of each other, you have made no contribution in the least. Crude amateur agenda driven unrelated irrelevant musings aren't prize worthy. http://bentham.org/cmc/contabs/cmc12-23.htm#6 <<snip>> particular emphasis of iron-induced free radical formation <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > http://bentham.org/cmc/contabs/cmc12-23.htm#6 > > <<snip>> > particular emphasis of iron-induced free radical formation > <<snip>> So that is the ONLY and SOLE cause of disease in Fanconi's anaemia ? Here is the core part, iron plays a role in some of the cascades, prooxidants are the cause of all types, read and weep: "it has been shown that in addition to well-known mechanisms of the formation of reactive hydroxyl radicals and peroxynitrite from superoxide and NO, there are signal pathways by which these "physiological" radicals directly induce apoptosis, proton leak in mitochondria and an increase in oxygen consumption leading to cell death. In present review the mechanisms of free radical damage are considered with the particular emphasis of iron-induced free radical formation in thalassemia and Fanconi anemia." http://bentham.org/cmc/contabs/cmc12-23.htm#6 <<snip>> particular emphasis of iron-induced free radical formation <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Narrow snipping doesn't the truth change nor crude amateur agenda driven thinking support, not close, no cigar, no prize period. his was said to be in cases of iron overload in some examples of the apperance of the disorder, silk purses of pig's ears aren't made, nuff said. http://bentham.org/cmc/contabs/cmc12-23.htm#6 <<snip>> particular emphasis of iron-induced free radical formation <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk No cigar, no prize, no trip to nordic regions; same old same old amateur agenda driven glock, now if we invent a glock prize, hmmm... >>glock<< Heh .. heh .. Soooooo .. seems you are TARGETING my .. specific .. posts .. With your .. drivel .. The article says .. they are placing SPECIAL emphasis on free radical .. IRON .. induced .. damage .. You seem to .. think .. this is .. unimportant .. ON / in these medical newsgroups .. Do .. ya .. ? Ya .. fkg .. pussy .. Heh .. heh .. http://bentham.org/cmc/contabs/cmc12-23.htm#6 <<snip>> particular emphasis of iron-induced free radical formation <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Not only did you cheery pick that article but you cherry picked a few words in such a way as to spin the meaning you wanted from it while ignoring the other language that defeats your agenda driven goal. This is one for the glock prize for the cherry picking division and for dishonest use of research results. Repeating the cherry pick words doesn't save them, it only highlights the lengths to which some will go no matter how dishonest, or is it only the normal product of the crude amateur watching the vision of glory going down the drain. >>it only highlights the lengths to which some will go no matter how dishonest,<< Doesn't it .. mr .. religion .. Heh .. heh .. Falsify any medical studies .. lately .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Go in peace my friend. Bty, am I the first to mention that you are your own worst enemy? My only reason for replying to your posts is to make sure no one thinks the iron causes all disease notion has any validity. I could probably not bother as your response to correction, flaws in logic, failure to understand what is posted, etc. tells the story more forcefully then the mere simple truth of my posts do. May God bless and protect you. |
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