RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes

Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links

Common presence of non-transferrin-bound iron among patients with type
2 diabetes.

Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RC.

Department of Preventive Medicine, School of Medicine, Kyungpook
University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
lee_dh@knu.ac.kr.

OBJECTIVE: Recently, we reported increased cardiovascular disease
mortality among supplemental vitamin C users with type 2 diabetes in a
prospective cohort study. Because vitamin C may cause oxidative stress
in the presence of redox active iron, we hypothesized that
non-transferrin-bound iron (NTBI), a form of iron susceptible to redox
activity, may be present in patients with type 2 diabetes. RESEARCH
DESIGN AND METHODS: We measured serum NTBI levels using
high-performance liquid chromatography in 48 patients with known
diabetes (at least 5 years duration since diagnosis), 49 patients with
newly diagnosed diabetes, and 47 healthy control subjects (frequency
matched on age and sex). RESULTS: NTBI was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes.
Mean NTBI values varied significantly between the three groups, with
the highest values being observed in patients with known diabetes and
the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29 vs.
0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
saturation were very similar among the three groups, yet NTBI was
strongly associated with serum total iron (r = 0.74, P < 0.01) and
percent transferrin saturation (r = 0.70, P < 0.01) among the patients
with known diabetes. CONCLUSIONS: Consistent with our hypothesis, these
data demonstrate the common existence of NTBI in type 2 diabetic
patients with a strong gradient with severity. Prospective cohort
studies are required to clarify the clinical relevance of increased
NTBI levels.

PMID: 16644642 [PubMed - in process]

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