Home | Contact Us | FAQ | Search & Site Map | Link to Us
Sign In | Join | Other 45 Sites in Network
Home
Discussion Groups
General
GeneralCardiologyVisionDentistryPharmacyLaboratoryNutritionAlternative
Diseases and Disorders
AIDSAlzheimer'sArthritisAsthmaCancerBreast CancerDiabetesEpilepsyGlaucomaHepatitisHerpesLupusProstate BPHProstate CancerProstatitisSinusitisTinnitus

Medical Forum / General / Alternative / April 2006

Tip: Looking for answers? Try searching our database.

Amalgam still best for children?

Thread view: 
Enable EMail Alerts  Start New Thread
Thread rating: 
Peter Moran - 29 Apr 2006 22:21 GMT
This is a large prospective and randomised controlled trial

JAMA. 2006 Apr 19;295(15):1835-6.

Neurobehavioral effects of dental amalgam in children: a randomized clinical
trial.

DeRouen TA, Martin MD, Leroux BG, Townes BD, Woods JS, Leitao J,
Castro-Caldas A, Luis H, Bernardo M, Rosenbaum G, Martins IP.

Department of Dental Public Health Sciences, School of Dentistry, University
of Washington, Seattle, WA 98195, USA. derouen@u.washington.edu

CONTEXT: Dental (silver) amalgam is a widely used restorative material
containing 50% elemental mercury that emits small amounts of mercury vapor.
No randomized clinical trials have determined whether there are significant
health risks associated with this low-level mercury exposure. OBJECTIVE: To
assess the safety of dental amalgam restorations in children. DESIGN: A
randomized clinical trial in which children requiring dental restorative
treatment were randomized to either amalgam for posterior restorations or
resin composite instead of amalgam. Enrollment commenced February 1997, with
annual follow-up for 7 years concluding in July 2005. SETTING AND
PARTICIPANTS: A total of 507 children in Lisbon, Portugal, aged 8 to 10
years with at least 1 carious lesion on a permanent tooth, no previous
exposure to amalgam, urinary mercury level <10 microg/L, blood lead level
<15 microg/dL, Comprehensive Test of Nonverbal Intelligence IQ > or =67, and
with no interfering health conditions. INTERVENTION: Routine,
standard-of-care dental treatment, with one group receiving amalgam
restorations for posterior lesions (n = 253) and the other group receiving
resin composite restorations instead of amalgam (n = 254). MAIN OUTCOME
MEASURES: Neurobehavioral assessments of memory, attention/concentration,
and motor/visuomotor domains, as well as nerve conduction velocities.
RESULTS: During the 7-year trial period, children had a mean of 18.7 tooth
surfaces (median, 16) restored in the amalgam group and 21.3 (median, 18)
restored in the composite group. Baseline mean creatinine-adjusted urinary
mercury levels were 1.8 microg/g in the amalgam group and 1.9 microg/g in
the composite group, but during follow-up were 1.0 to 1.5 microg/g higher in
the amalgam group than in the composite group (P<.001). There were no
statistically significant differences in measures of memory, attention,
visuomotor function, or nerve conduction velocities (average z scores were
very similar, near zero) for the amalgam and composite groups over all 7
years of follow-up, with no statistically significant differences observed
at any time point (P values from .29 to .91). Starting at 5 years after
initial treatment, the need for additional restorative treatment was
approximately 50% higher in the composite group. CONCLUSIONS: In this study,
children who received dental restorative treatment with amalgam did not, on
average, have statistically significant differences in neurobehavioral
assessments or in nerve conduction velocity when compared with children who
received resin composite materials without amalgam. These findings, combined
with the trend of higher treatment need later among those receiving
composite, suggest that amalgam should remain a viable dental restorative
option for children. TRIAL REGISTRATION: clinicaltrials.gov Identifier:
NCT00066118.

Peter Moran
Jan Drew - 29 Apr 2006 23:34 GMT
"Peter Moran"
> This is a large prospective and randomised controlled trial
>
[quoted text clipped - 8 lines]
> Department of Dental Public Health Sciences, School of Dentistry,
> University of Washington, Seattle, WA 98195, USA. derouen@u.washington.edu

Nuff said....

Now the TRUTH.

NOT from *Organized medicine..OR Dentistry*

http://www.patsullivan.com/blog/files/Boyd_Haley_Response_NIDCR_JAMA_...

http://www.patsullivan.com/blog/2006/04/mercury_amalgam.html

Preliminary Comments on   â?oNeurobehavioral Effects of Dental Amalgam in
Childrenâ?,   T. A. De Rouen, et al,   JAMA, April 19, 2006

In justifying the study design the authorâ?Ts state on page 1 that â?othere
is little or no evidence concerning health effects of low level mercury
exposure from amalgam, especially in childrenâ?.   In fact, there are over
3,000 peer-reviewed studies in the medical literature(3) that were submitted
by parties in the FDA amalgam docket to the FDA (4), that document the
mechanisms by which mercury(from amalgam) commonly causes over 30 chronic
health conditions.  And there are hundreds are peer-reviewed studies and
clinical studies that document that many thousands of patients with  these
conditions have improved after amalgam replacement(2). While it is clear
that hundreds of thousands (or millions) of children have had their health
adversely affected by mercury, since there are multiple exposure mechanisms
its not clear the extent to which dental amalgam is responsible(7).

But the main problem with the study design appears to be the choice of what
conditions were tested for and the kinds of tests that were used.   In
describing why the chosen conditions were tested for and in what manner, the
authors stated on page 2 of the study that the target organs for elemental
mercury exposure from amalgam were identified to be the renal system and
neurological functions(memory, attention/concentration, and
motor/visuomotor).  Actually, while there is documentation in the medical
literature of many other types of health effects, there is little evidence
in the literature on common renal effects.(1,2,3). And there are other types
of health effects that have been well documented in the literature to be
more commonly caused by mercury than attention or memory(though these also
have been documented to be commonly caused by mercury exposure).

The following analysis shows that the basic assumptions that the authors say
they based their study design on were not valid, and the study does not
demonstrate what it has been suggested to demonstrate.  In fact, due to the
poor study design the study is not very useful.  It had been documented by
millions of medical lab tests that those with amalgam fillings commonly have
mercury exposures between 5 and 10 times that of the average person with no
amalgams (5), and that mercury accumulates in the brain and major organs in
direct proportion to the number of amalgam surfaces.  It has likewise been
documented in the medical literature by thousands of studies that mercury
and other toxic metals exposures are synergistic and cumulative, and
commonly cause chronic autoimmune, neurological, hormonal, and reproductive
problems later in life(3), depending on individual susceptibility(6).
Thus it was clear that the study design exposing children to a known highly
neurotoxic and immunotoxic substance that commonly causes adverse effects
was highly unethical.  And also, the effects that might happen in the early
years of exposure has little relevance to whether amalgam is safe as a
filling material.  The study was not designed to determine anything about
the long term health or safety effects on this population of children.  Or
even on the most common types of conditions known to be commonly caused by
dental amalgam or the types of cardiovascular effects found in a similar
test of children from the Faeroe Islands.

Questionnaire results of 1569 patients (1) regarding health problems that
have been documented to be commonly caused by mercury toxicity found the
following distribution:

Condition                    % with Condition          %  improved after
Amalgam Replacement

Fatigue/lack of energy (12)    51%
86%
Headaches/migraines (8)      37%                                         87%
Allergy/skin conditions (10)  34%                                        84%
Vision Problems                    29%
63%
Cardiovascular problems(9)   27%                                        70%
(tachycardia/irregular heartbeat/
 high blood pressure/chest pain)
Depression/anxiety    (11)    27%                                        90%
Dizzyness(could be cardio)   22%                                        88%
Oral conditions         (13)     20%
85%
ADD/lack of concentration    17%                                        80%
Memory Loss            (8)       17%
73%
MS/Parkinsonâ?Ts/tremor  (10) 15%                                        78%

Similar patterns and recovery results after amalgam filling replacement have
also been documented in a larger group of over 60,000 patients(2).
Thousands of peer-reviewed studies documenting the mechanism by which
mercury commonly causes these conditions are in the literature(3).   It is
seen that there are 8 major types of health conditions known to be caused by
mercury that are more commonly seen in the population than the  types of
conditions that these studies chose to attempt to test for.

And in all of those types of conditions, peer-reviewed studies and clinical
studies have found that the majority of those who had amalgam fillings
replaced properly had health improvement after replacement.    There are few
studies documenting significant renal effects from dental amalgam exposure,
so itâ?Ts not clear why the authors chose to test for renal effects.  There
is some question as to what the study being reviewed actually measured
regarding neurological effects, since other studies have documented that
mercury from amalgam and other toxic metals commonly cause ADD/attention
deficit(7), as well as memory problems(perhaps more later in life)(8) and
that the majority with such conditions usually improve after amalgam
replacement.
   It should also be noted that since the effects of toxic exposures are
known to be synergistic and cumulative, the results of a study in one
country or population do not necessarily apply to another country or
population- that has significantly different patterns of toxic exposures,
such as the extremely high mercury thimerosal exposures to children in the
U.S. in the 1990s which are documented to have significantly impacted that
population(7).

(1)  Patterns of chronic conditions in 1569 patients and percent recovery
after amalgam filling replacement,
http://www.home.earthlink.net/~berniew1/hgrecovp.html
(2) Results of amalgam filling replacement in over 60,000 patients monitored
by peer-reviewed or clinical studies,
http://www.home.earthlink.net/~berniew1/hgremove.html
(3) Mechanisms by which mercury(from dental amalgam) commonly causes over 30
chronic health conditions (over 4,000 peer-reviewed & Govâ?Tt studies
cited),
http://www.home.earthlink.net/~berniew1/indexa.html
(4) Listing and abstracts and compilation of medical studies submitted to
the FDA dental amalgam safety docket,
http://www.flcv.com/fdatally.html
http://www.flcv.com/fdarev.html
http://www.flcv.com/fdarevl.html
(5) Dental amalgam is the largest source of both inorganic and methyl
mercury in most people with dental amalgams,
http://www.home.earthlink.net/~berniew1/damspr1.html
(6) http://www.home.earthlink.net/~berniew1/suscept.html
(7) http://www.flcv.com/tmlbn.html
    http://www.flcv.com/kidshg.html
    http://www.flcv.com/autismc.html
(8) Mechanisms by which mercury is documented to cause neurological
conditions, B Windham(Ed) â?"over 150 cites,
http://www.home.earthlink.net/~berniew1/neurohg.html
(9) Mechanisms by which mercury is documented to cause cardiovascular
conditions, -  over 150 cites,
http://www.home.earthlink.net/~berniew1/cardio.html
(10) Mechanisms by which mercury is documented to cause
autoimmune/immune conditions, over 150 cites,
http://www.home.earthlink.net/~berniew1/ms.html
http://www.home.earthlink.net/~berniew1/immunere.html
(11) Mechanisms by which mercury is documented to cause depression/mood
disorders, over 100 cites,
http://www.home.earthlink.net/~berniew1/depress.html
(12) Mechanisms by which mercury is documented to cause
fatigue/CFS/FMS, over 150 cites,
http://www.home.earthlink.net/~berniew1/cfsfm.html

(13) Mechanisms by which mercury is documented to cause oral conditions,
over 100 cites,
http://www.home.earthlink.net/~berniew1/periodon.html

B. Windham,  Research Director and President,   DAMS, Intl.
Barnesdale - 30 Apr 2006 16:36 GMT
Stuart Hyderman wonderful chiropractor
> This is a large prospective and randomised controlled trial
>
[quoted text clipped - 51 lines]
>
> Peter Moran
 
Sign In
Join
My Latest Posts
My Monitored Threads
My Blog
My Photo Gallery
My Profile
My Homepage

Start New Thread
Enable EMail Alerts
Rate this Thread



©2008 Advenet LLC   Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.