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Synergic interaction between ascorbic acid and antibiotics against
Pseudomonas aeruginosa

Luciana CursinoI, II; Edmar Chartone-SouzaI; Andréa Maria Amaral
NascimentoI, *

IDepartamento de Biologia Geral; Universidade Federal de Minas Gerais;
Avenida Antônio Carlos, 6627; 31270-901; Belo Horizonte - MG - Brazil
IIDepartamento de Genética ESALQ/USP; Av. Pádua Dias, 11; 1340-097;
Piracicaba - SP - Brazil

ABSTRACT

Studies were carried out on in vitro combination of ascorbic acid (AA)
with six antibiotics against 12 multi-resistant Pseudomonas aeruginosa
isolates. Synergic activity was detected with AA chloramphenicol,
kanamycin, streptomycin and tetracycline. Indifference was observed to
any antibiotics and antagonism only for chloramphenicol. Results
indicated that multiresistant P. aeruginosa was affected by combination
of AA and antibiotics. Future research on ascorbic acid-antimicrobial
interactions may find new methods to control strains of multiresistant
P. aeruginosa.

Key words: Ascorbic acid, antibiotic, synergy, Pseudomonas aeruginosa

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-891320050003000
07&lng=en&nrm=iso&tlng=en