Medical Forum / General / Alternative / September 2005
Green tea 'cuts Alzheimer's risk'
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C.Health - 21 Sep 2005 17:04 GMT http://news.bbc.co.uk/1/hi/health/4261558.stm
Green tea 'cuts Alzheimer's risk' An ingredient of green tea may help to protect the brain against the ravages of Alzheimer's disease, research in the US suggests. University of South Florida scientists found the component prevented Alzheimer's-like damage in the brains of mice bred to develop symptoms.
The component - EGCG - is already strongly suspected of offering protection against certain cancers.
The study is published in the Journal of Neuroscience.
It provides evidence that EGCG decreases production of the beta-amyloid protein thought to play a key role in the development of Alzheimer's symptoms.
A new generation of dietary supplements containing pure EGCG may lead to the greatest benefit for treating Alzheimer's disease Dr Doug Shytle
It is this protein that forms the characteristic plaques found in the brain of Alzheimer's patients which are thought to lead to nerve damage and memory loss.
After treating Alzheimer's mice for several months with daily injections of pure EGCG, the researchers observed a dramatic decrease - as much as 54% - of brain-clogging Alzheimer's plaques.
Lead researcher Dr Jun Tan said: "The findings suggest that a concentrated component of green tea can decrease brain beta-amyloid plaque formation.
"If beta-amyloid pathology in this Alzheimer's mouse model is representative of Alzheimer's disease pathology in humans, EGCG dietary supplementation may be effective in preventing and treating the disease."
Green tea contains many antioxidants, including those known as flavonoids, that can protect against damage to the brain caused by charged particles called free radicals.
Jim Chinnis - 21 Sep 2005 17:33 GMT >Green tea 'cuts Alzheimer's risk' The title is misleading. Green tea was not tested. In fact, the paper states that other compounds in green tea might make the ECGC ineffective.
Journalism at its best yet again. -- Jim Chinnis Warrenton, Virginia, USA
Mark Probert - 21 Sep 2005 20:15 GMT >>Green tea 'cuts Alzheimer's risk' > > The title is misleading. Green tea was not tested. In fact, the paper states > that other compounds in green tea might make the ECGC ineffective. > > Journalism at its best yet again. And Altmedders rely on newspaper articles for medical advice.
Scary.
LadyLollipop - 22 Sep 2005 08:14 GMT >>>Green tea 'cuts Alzheimer's risk' >> [quoted text clipped - 7 lines] > > Scary. Then there are those who are just plain dishonest and pick out certain parts and try to discredit the entire article.
Then there is Mark Probert, who tells blatant lies.
http://news.bbc.co.uk/1/hi/health/4261558.stm
Green tea 'cuts Alzheimer's risk'
An ingredient of green tea may help to protect the brain against the ravages of Alzheimer's disease, research in the US suggests. University of South Florida scientists found the component prevented Alzheimer's-like damage in the brains of mice bred to develop symptoms.
The component - EGCG - is already strongly suspected of offering protection against certain cancers.
The study is published in the Journal of Neuroscience.
It provides evidence that EGCG decreases production of the beta-amyloid protein thought to play a key role in the development of Alzheimer's symptoms.
A new generation of dietary supplements containing pure EGCG may lead to the greatest benefit for treating Alzheimer's disease Dr Doug Shytle
It is this protein that forms the characteristic plaques found in the brain of Alzheimer's patients which are thought to lead to nerve damage and memory loss.
After treating Alzheimer's mice for several months with daily injections of pure EGCG, the researchers observed a dramatic decrease - as much as 54% - of brain-clogging Alzheimer's plaques.
Lead researcher Dr Jun Tan said: "The findings suggest that a concentrated component of green tea can decrease brain beta-amyloid plaque formation.
"If beta-amyloid pathology in this Alzheimer's mouse model is representative of Alzheimer's disease pathology in humans, EGCG dietary supplementation may be effective in preventing and treating the disease."
Green tea contains many antioxidants, including those known as flavonoids, that can protect against damage to the brain caused by charged particles called free radicals.
However, the Florida team showed that other flavonoids in green tea actually block EGCG's ability to prevent the harmful build up of beta-amyloid.
Thus drinking green tea alone would not likely have a beneficial effect.
Supplements
Dr Doug Shytle, who also worked on the study, said: "This finding suggests that green tea extract selectively concentrating EGCG would be needed to override the counteractive effect of other flavonoids found in green tea."
"A new generation of dietary supplements containing pure EGCG may lead to the greatest benefit for treating Alzheimer's disease."
Humans would need a daily dose of 1,500 to 1,600 mg of EGCG to approximate the level that had a positive impact on mice.
That dosage has already been studied in healthy human volunteers and was found to be safe and well tolerated.
The Florida team now plans to study whether multiple oral doses of EGCG can reduce memory loss in Alzheimer's mice as well as reducing plaque formation.
Harriet Millward, of the Alzheimer's Research Trust, told the BBC News website: "This is quite encouraging progress, building on previous evidence that antioxidants in green tea might be beneficial to Alzheimer's patients either as treatment or prevention."
However, Dr Millward said the role of beta-amyloid in the brain was not well understood, and reducing levels too far might cause damage.
It was also not clear whether the formation of plaques was a cause of Alzheimer's, or just an effect of it.
Mark Probert - 22 Sep 2005 21:09 GMT >>>>Green tea 'cuts Alzheimer's risk' >>> [quoted text clipped - 12 lines] > > Then there is Mark Probert, who tells blatant lies. I said that altmedders rely on newspaper articles and you post a newspaper article which has been discredited.
> http://news.bbc.co.uk/1/hi/health/4261558.stm > [quoted text clipped - 70 lines] > It was also not clear whether the formation of plaques was a cause of > Alzheimer's, or just an effect of it. LadyLollipop - 23 Sep 2005 04:34 GMT >>>>>Green tea 'cuts Alzheimer's risk' >>>> [quoted text clipped - 15 lines] > I said that altmedders rely on newspaper articles and you post a newspaper > article which has been discredited. It hasn't been discredited, and I didn't post it.
>> http://news.bbc.co.uk/1/hi/health/4261558.stm >> [quoted text clipped - 74 lines] >> It was also not clear whether the formation of plaques was a cause of >> Alzheimer's, or just an effect of it. cathyb - 23 Sep 2005 04:47 GMT > >>>>>Green tea 'cuts Alzheimer's risk' > >>>> [quoted text clipped - 17 lines] > > It hasn't been discredited, and I didn't post it. It discredited itself with its ridiculous headline, which was patently untrue.
And Lollipop did (pointlessly) repost it above.
Bless her little cotton socks; why did she bother denying it?
Cathy
> >> http://news.bbc.co.uk/1/hi/health/4261558.stm > >> [quoted text clipped - 74 lines] > >> It was also not clear whether the formation of plaques was a cause of > >> Alzheimer's, or just an effect of it. LadyLollipop - 23 Sep 2005 06:41 GMT <snip usual belittling>
>> >>>>>Green tea 'cuts Alzheimer's risk' >> >>>> [quoted text clipped - 19 lines] >> >> It hasn't been discredited, and I didn't post it.
>> >> http://news.bbc.co.uk/1/hi/health/4261558.stm >> >> [quoted text clipped - 88 lines] >> >> It was also not clear whether the formation of plaques was a cause of >> >> Alzheimer's, or just an effect of it. IanW - 22 Sep 2005 10:58 GMT > >Green tea 'cuts Alzheimer's risk' > [quoted text clipped - 3 lines] > > Journalism at its best yet again. I pointed it out to them and they've corrected it.
Ian
Jim Chinnis - 22 Sep 2005 18:25 GMT "IanW" <whoever@whereever.com> wrote in part:
>> >Green tea 'cuts Alzheimer's risk' >> [quoted text clipped - 7 lines] > >Ian Thanks! -- Jim Chinnis Warrenton, Virginia, USA
RArmant - 21 Sep 2005 22:55 GMT http://www.jneurosci.org/cgi/content/short/25/38/0-i Another Reason to Drink Green Tea?
Kavon Rezai-Zadeh, Doug Shytle, Nan Sun, Takashi Mori, Huayan Hou, Deborah Jeanniton, Jared Ehrhart, Kirk Townsend, Jin Zeng, David Morgan, John Hardy, Terrence Town, and Jun Tan
If only it were so easy; it tastes good and it's good for you. This week, Rezai-Zadeh et al. report that a component of green tea modulated amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease in vitro and in vivo. Epigallocatechin-3-gallate (EGCG), the main polyphenolic component of green tea, reduced {beta}-amyloid (A{beta}) production in neurons cultured from APP-overexpressing mice (Tg APPSW). Notably, EGCG was more effective than whole green tea extract. {beta}-secretase and {alpha}-secretase process APP by parallel amyloidogenic and nonamyloidogenic pathways, respectively. EGCG boosted activity of the latter pathway, indicated by increased {alpha}-C-terminal fragment and soluble APP-{alpha}. Tumor necrosis factor (TNF)-{alpha} converting enzyme (TACE), a candidate {alpha}-secretase, increased after EGCG treatment, and {alpha}-secretase activity was reduced by TNF-{alpha} protease inhibitor-1 (TAPI-1), a selective TACE inhibitor. Treatment of Tg APPSW mice at 12 months of age with EGCG (provided as intraperitoneal injections, not by teacup) also promoted {alpha}-secretase activity. After 2 months of treatment, A{beta}-containing plaques were significantly reduced.
RArmant - 21 Sep 2005 23:18 GMT > A new generation of dietary supplements containing pure EGCG may lead to >the greatest benefit for treating Alzheimer's disease >Dr Doug Shytle http://www.teavigo.com/
RArmant - 21 Sep 2005 23:59 GMT >> A new generation of dietary supplements containing pure EGCG may lead to >>the greatest benefit for treating Alzheimer's disease >>Dr Doug Shytle > >http://www.teavigo.com/ http://store.yahoo.com/iherb/teavigo.html
Jim Chinnis - 22 Sep 2005 00:27 GMT RArmant <rarmant@sbcglobal.net> wrote in part:
>>> A new generation of dietary supplements containing pure EGCG may lead to >>>the greatest benefit for treating Alzheimer's disease [quoted text clipped - 3 lines] > >http://store.yahoo.com/iherb/teavigo.html Only $5 per day.. -- Jim Chinnis Warrenton, Virginia, USA jchinnis@alum.mit.edu
LadyLollipop - 22 Sep 2005 08:18 GMT <snip lies + harassment> .
> RArmant <rarmant@sbcglobal.net> wrote in part: > [quoted text clipped - 6 lines] >> >>http://store.yahoo.com/iherb/teavigo.html Jim Chinnis - 22 Sep 2005 18:28 GMT "LadyLollipop" <LadyLollipop@insightbb.com> wrote in part:
><snip lies + harassment> >. [quoted text clipped - 8 lines] >>> >>>http://store.yahoo.com/iherb/teavigo.html What is the cost of 1600 mg of EGCG? I came up with about $5 US on the site mentioned. The dose given mice is equivalent to about 1600 mg per day for a human.
What is it that you disagree with? Or don't you know? -- Jim Chinnis Warrenton, Virginia, USA
LadyLollipop - 22 Sep 2005 18:37 GMT > "LadyLollipop" <LadyLollipop@insightbb.com> wrote in part: > [quoted text clipped - 20 lines] > -- > Jim Chinnis Warrenton, Virginia, USA People are not mice.
Mark Probert - 22 Sep 2005 21:09 GMT >>"LadyLollipop" <LadyLollipop@insightbb.com> wrote in part: >> [quoted text clipped - 23 lines] > > People are not mice. You are.
LadyLollipop - 23 Sep 2005 04:36 GMT Childish and a waste of bandwidth
>>>"LadyLollipop" <LadyLollipop@insightbb.com> wrote in part: >>> [quoted text clipped - 26 lines] > > You are. Rich - 23 Sep 2005 07:54 GMT > Childish and a waste of bandwidth So now you are a defender of the bandwidth? Perhaps we can discuss it in a long thread wherein you can post your usual ten to thirty Kbytes of links and plagiarized material. LOL!
 Signature
--Rich
Recommended websites:
http://www.ratbags.com/rsoles http://www.acahf.org.au http://www.quackwatch.org/ http://www.skeptic.com/ http://www.csicop.org/
Mark Probert - 23 Sep 2005 14:33 GMT > Childish and a waste of bandwidth So why did you post?
RArmant - 22 Sep 2005 20:44 GMT >"LadyLollipop" <LadyLollipop@insightbb.com> wrote in part: > [quoted text clipped - 14 lines] >mentioned. The dose given mice is equivalent to about 1600 mg per day for a >human. 135mg_egcg/cap x 60caps = 8.1g_egcg/bottle 8.1g/$18 = 450mg per dollar (1600mg/day)/(450mg/$) = $3.56 per day
If you buy 4 bottles at a time: 64/(18 x 4) x $3.56 = $3.16 per day
In the near future there might be less costly sources for egcg -- if it doesn't get Rx'ed.
Don't forget these mice were bred to simulate Alzheimer's. A little egcg on a regular basis might decrease the risk of Alzheimer's for humans.
DHA appears to arrest the progression of Alzheimer's in mice at about 1.5g per 1000 Calories. Maybe DHA and egcg taken together would be even more effective against Alzheimer's.
Jim Chinnis - 22 Sep 2005 21:47 GMT RArmant <rarmant@sbcglobal.net> wrote in part:
>>"LadyLollipop" <LadyLollipop@insightbb.com> wrote in part: >> [quoted text clipped - 32 lines] >1.5g per 1000 Calories. Maybe DHA and egcg taken together would be >even more effective against Alzheimer's. It's possible. There is also evidence for curcumin. -- Jim Chinnis Warrenton, Virginia, USA
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