Need B12 and Isoleucine, usually not iron.

I just know I get uncomfortable and constipated for a week after my iron
infusion.  It is far better than the tablets, but I feel I need a week off
from life just to rest and eat light.

Tony
<ironjustice@aol.com> wrote in message
news:1126975330.696226.111600@z14g2000cwz.googlegroups.com...
Oral ferrous fumarate or intravenous iron sucrose for patients with
inflammatory bowel disease.
Erichsen K, Ulvik RJ, Nysaeter G, Johansen J, Ostborg J, Berstad A,
Berge RK, Hausken T
Scand J Gastroenterol. 2005 Sep ; 40(9): 1058-65

Objective. Iron therapy may reinforce intestinal inflammation by
catalysing production of reactive oxygen species. The effects of oral
ferrous fumarate and intravenous iron sucrose on clinical disease
activity and plasma redox status were investigated in patients with
inflammatory bowel disease (IBD).Material and methods. Nineteen
patients with iron deficiency anaemia and Crohn's disease (11) or
ulcerative colitis (8) were included in a crossover study. The patients
were randomly assigned to start treatment with ferrous fumarate
(Neo-fer(R)) 120 mg orally once daily or iron sucrose (Venofer(R)) 200
mg intravenously 3 times during a period of 14 days. Clinical disease
activity assessment and blood and faecal analysis were performed on
days 1 and 15.Results. Following oral ferrous fumarate clinical disease
activity (p=0.037), general well-being score (i.e. patients felt worse)
(p=0.027) and abdominal pain score (p=0.027) increased, while no
changes were seen following iron sucrose treatment. C-reactive protein
(CRP) and faecal calprotectin were unchanged after both treatments. As
compared with iron sucrose, ferrous fumarate increased Crohn's disease
activity index (CDAI) scores of general well-being (p=0.049), whereas
alterations in clinical disease activity (p=0.14) and abdominal pain
score (p=0.20) did not differ. Ferrous fumarate did not significantly
alter plasma malondialdehyde (MDA) or plasma antioxidants. Iron sucrose
increased plasma MDA (p=0.004) and decreased plasma vitamin C (p=0.017)
and betacarotene (p=0.008).Conclusions. Oral ferrous fumarate, but not
intravenous iron sucrose, increased clinical disease activity in IBD
patients. Intravenous iron sucrose increased intravascular oxidative
stress.

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Tom

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