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Medical Forum / General / Alternative / September 2005Iron chelation / African sleeping sickness
Biokemistri Nigerian Society for Experimental Biology ISSN: 0795-8080 Vol. 16, No. 2, 2004, pp. 56-63 Bioline Code: bk04020 Biokemistri, Vol. 16, No. 2, 2004, pp. 56-63 Iron chelation excludes protein synthesis inhibition in the tetracycline management of African trypanosomosis Justine T. EKANEM, Titilayo O. JOHNSON, Iyabo S. ADENIRAN and Valeelat OKEOLA Abstract Ribonucleotide reductase, an iron requiring enzyme necessary in the production of deoxyribonucleotides required for replication in cell division and proliferation is induced during the S phase of the cell cycle. We have compared the trypanocidal properties of four antibiotics that show bactericidal activities by destabilizing ribosome-mRNA complex to inhibit protein synthesis. Tetracycline and oxytetracycline that have iron chelating properties extended the lifespan of trypanosome infected rats from 6 and 5 days of control to 15 and 12 days respectively while chloramphenicol and streptomycin that have no iron chelating properties could not extend the lifespan of infected rats. We confirm our earlier report that iron chelation plays a prominent role in the tetracycline management of African trypanosomosis. Keywords Tetracycline, iron chelation, T. brucei, growth inhibition © Copyright 2004 - Nigerian Society for Experimental Biology Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "Ribonucleotide reductase, an iron requiring enzyme necessary in the production of deoxyribonucleotides required for replication in cell division and proliferation is induced during the S phase of the cell cycle. " In other words, iron must be present for normal cell life and duplication, without it we would soon die. Thank you for this. So .. you WOULD iron supplement these .. poor .. 'anemic' .. malnourished people .. with .. iron .. Eh .. Heh .. heh ... We confirm our earlier report that iron chelation plays a prominent role in the tetracycline management of African trypanosomosis. << Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "So .. you WOULD iron supplement these .. poor .. 'anemic' .. malnourished people .. with .. iron .." Nope, malnutrition is not the cause of the disorder. I know what is but don't want to spoil your fun on the search enjines trying to find it also. The part of the abstract said iron is needed for normal cell growth, nothing to do with the above and in direct contridiction to the round peg/square hole reasoning you employ in posting these often contridicting hole in foot creating abstracts. . >>contridicting << I thought I'd let it pass the first time you spelled it wrong .. But .. ContrAdicting .. There .. you learned something to.. day .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "I thought I'd let it pass the first time you spelled it wrong .." But the important question is did you clean up after yourself after passing it? Or are you contridicting yourself again? |
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