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Medical Forum / General / Alternative / September 2005Cause of renal dysfunction is iron overload
Urine biochemical markers of early renal dysfunction are associated with iron overload in beta-thalassaemia. Koliakos G, Papachristou F, Koussi A, Perifanis V, Tsatra I, Souliou E, Athanasiou M Clin Lab Haematol. 2003 Apr ; 25(2): 105-9 Renal dysfunction in thalassemia patients can be attributed to chronic anemia, and iron overload as well as to desferioxamine (DFO) toxicity. We analyzed the urine of 91 well-maintained homozygous beta-thalassemia patients, with no evidence of renal disease, for early evidence of kidney dysfunction by means of electrophoresis and quantitative biochemical tests. Measurement of liver magnetic resonance imaging (MRI) T2 values and serum ferritin concentration was used to estimate iron overload. In 55 of the 91 patients, urine analysis indicated signs of tubular dysfunction. The urine concentration of albumin and beta 2-microglobulin, as well as the activity of N-acetyl-beta-D-glucosaminidase (NAG), correlated positively with serum ferritin concentration and liver iron deposition, as detected by MRI T2 values. This suggested that the cause of renal dysfunction in homozygous beta-thalassemia is iron overload. On the other hand, the same urine markers did not correlate with age, indicating that chronic anemia or desferrioxamine (DFO) treatment are not related to renal dysfunction in thalassemia. Abstract · PubMed · FullText · SFX · GS · Order · Clip · Citation · BibTeX · Related · TouchGraph · References · Tag tags: annotation: Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking There is a minimal, optimal, max level of any nutritional substance, iron included. What good does it do to post these abstracts for a genetic condition where a very small fraction of 1 percent of the population is involved and who are in far excess of the max amount of iron that normal people encounter? What good does it do to post these abstracts for a genetic condition << Thalassemia is the equivalent of a .. 'mouse model of iron overload' .. except in .. humans .. You somehow think .. manipulating the genes in a mouse TO .. produce .. a mouse model of iron overload .. is somehow DIFFERENT from reaching out the door so to speak .. and GRABBING .. a .. HUMAN model of iron overload .. who is ALREADY .. genetically predisposed .. They are NOT .. different .. and a kidney failing due to iron overload .. is a .. kidney .. failing .. due .. to .. iron .. overload . Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "Thalassemia" is the name in rodents for a genetic disorder in humans, please do tell what it is so your confusion on this point will not linger. It affects a very very very small number of people which led to my original question. How does posting this give us any insight into iron in normal amounts found in people not having the genetic disorder and in absolutely no risk of renal failure? > What good does it do to post these abstracts for a genetic > condition > << > > Thalassemia is the equivalent of a .. 'mouse model of iron overload' .. > except in .. humans .. It's accepted that there is a connection between thalassaemia & the hereditary haemochromatosis, and it's no secret that the thalassaemia majors do get iron overloads from transfusions. But to say that " Thalassemia is the equivalent of a .. 'mouse model of iron overload' .. except in .. humans .." ... what is THAT supposed to mean ? > You somehow think .. manipulating the genes in a mouse TO .. produce .. > a mouse model of iron overload .. is somehow DIFFERENT from reaching [quoted text clipped - 3 lines] > They are NOT .. different .. and a kidney failing due to iron overload > .. is a .. kidney .. failing .. due .. to .. iron .. overload . But what is the cause of the iron overload in this specific case ? > Who loves ya. > Tom [quoted text clipped - 7 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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