Prostaglandins Leukot Essent Fatty Acids. 2005 Aug 2; [Epub ahead of
print] Related Articles, Links

Increased excretion of a lipid peroxidation biomarker in autism.

Ming X, Stein TP, Brimacombe M, Johnson WG, Lambert GH, Wagner GC.

Department of Neurosciences, UMDNJ-New Jersey Medical School, 90 Bergen
Street, Suite 8100, Newark, NJ 07103, USA; Department of Pediatrics,
Robert Wood Johnson Medical School, Center for Childhood
Neurotoxicology and Exposure Assessment, New Brunswick, NJ, USA.

It is thought that autism could result from an interaction between
genetic and environmental factors with oxidative stress as a potential
mechanism linking the two. One genetic factor may be altered
oxidative-reductive capacity. This study tested the hypothesis that
children with autism have increased oxidative stress. We evaluated
children with autism for the presence of two oxidative stress
biomarkers. Urinary excretion of 8-hydroxy-2-deoxyguanosine (8-OHdG)
and 8-isoprostane-F2alpha (8-iso-PGF2alpha) were determined in 33
children with autism and 29 healthy controls. 8-iso-PGF2alpha levels
were significantly higher in children with autism. The isoprostane
levels in autistic subjects were variable with a bimodal distribution.
The majority of autistic subjects showed a moderate increase in
isoprostane levels while a smaller group of autistic children showed
dramatic increases in their isoprostane levels. There was a trend of an
increase in 8-OHdG levels in children with autism but it did not reach
statistical significance. There was no significant correlation between
the levels of the biomarkers and vitamin intake, dietary supplements,
medicine, medical disorders, or history of regression. These results
suggest that the lipid peroxidation biomarker is increased in this
cohort of autistic children, especially in the subgroup of autistic
children.

PMID: 16081262 [PubMed - as supplied by publisher]

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Med Hypotheses. 2003 Aug;61(2):220-2. Related Articles, Links

Excess dietary iron is the root cause for increase in childhood autism
and allergies.

Padhye U.

2990 River Meadows, Canton, Michigan 48188, USA.

Autism is a profoundly and poorly understood developmental disorder
that impairs a person's social and communication abilities. I propose a
hypothesis that the excessive dietary iron consumed by today's infants
is the root cause of increased cases of Autism, allergies and other
childhood diseases. Iron is a powerful immune system modulator. Excess
iron causes hyperactive immune system. This hyperactive immune system
attacks undigested food peptides. The chemicals released during these
intense allergic reactions can damage surrounding tissue.
Neurodegeneration is caused by combination of, oxidative stress induced
by free iron radicals and intense immune reactions. Iron chelators have
shown beneficial results in Autism and allergies.

Publication Types:
Review
Review, Tutorial

PMID: 12888307 [PubMed - indexed for MEDLINE]

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