Medical Forum / Diseases and Disorders / AIDS / April 2007
Denialism
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GMCarter - 10 Apr 2007 17:02 GMT In any form...same sh.t stinks whether it's Bush and climate changed caused by humans (and greedy low life bastards like Bush/Cheney) or an Ahmadinejad denying the Nazi holocaut against Jews, muslims, gays and lesbians, gypsies, etc. Or fools that want to believe HIV doesn't cause AIDS.
George M. Carter
http://www.truthout.org/docs_2006/041007P.shtml \There Is Climate Change Censorship - and it's the Deniers Who Dish it Out By George Monbiot The Guardian UK
Tuesday 10 April 2007
Global warming scientists are under intense pressure to water down findings, and are then accused of silencing their critics.
The drafting of reports by the world's pre-eminent group of climate scientists is an odd process. For months scientists contributing to the Intergovernmental Panel on Climate Change tussle over the evidence. Nothing gets published unless it achieves consensus. This means that the panel's reports are conservative - even timid. It also means that they are as trustworthy as a scientific document can be.
Then, when all is settled among the scientists, the politicians sweep in and seek to excise from the summaries anything that threatens their interests.
The scientists fight back, but they always have to make concessions. The report released on Friday, for example, was shorn of the warning that "North America is expected to experience locally severe economic damage, plus substantial ecosystem, social and cultural disruption from climate change related events".
This is the opposite of the story endlessly repeated in the rightwing press: that the IPCC, in collusion with governments, is conspiring to exaggerate the science. No one explains why governments should seek to amplify their own failures. In the wacky world of the climate conspiracists no explanations are required. The world's most conservative scientific body has somehow been transformed into a conspiracy of screaming demagogues.
This is just one aspect of a story that is endlessly told the wrong way round. In the Sunday Telegraph and the Daily Mail, in columns by Dominic Lawson, Tom Utley and Janet Daley, the allegation is repeated that climate scientists and environmentalists are trying to "shut down debate." Those who say that man-made global warming is not taking place, they claim, are being censored.
Something is missing from their accusations: a single valid example. The closest any of them have been able to get is two letters sent - by the Royal Society and by the US senators Jay Rockefeller and Olympia Snowe - to that delicate flower ExxonMobil, asking that it cease funding lobbyists who deliberately distort climate science. These correspondents had no power to enforce their wishes. They were merely urging Exxon to change its practices. If everyone who urges is a censor, then the comment pages of the newspapers must be closed in the name of free speech.
In a recent interview, Martin Durkin, who made Channel 4's film The Great Global Warming Swindle, claimed he was subject to "invisible censorship". He seems to have forgotten that he had 90 minutes of prime-time television to expound his theory that climate change is a green conspiracy. What did this censorship amount to? Complaints about one of his programmes had been upheld by the Independent Television Commission. It found that "the views of the four complainants, as made clear to the interviewer, had been distorted by selective editing" and that they had been "misled as to the content and purpose of the programmes when they agreed to take part". This, apparently, makes him a martyr.
If you want to know what real censorship looks like, let me show you what has been happening on the other side of the fence. Scientists whose research demonstrates that climate change is taking place have been repeatedly threatened and silenced and their findings edited or suppressed.
The Union of Concerned Scientists found that 58% of the 279 climate scientists working at federal agencies in the US who responded to its survey reported that they had experienced one of the following constraints: 1. Pressure to eliminate the words "climate change", "global warming", or other similar terms from their communications; 2. Editing of scientific reports by their superiors that "changed the meaning of scientific findings"; 3. Statements by officials at their agencies that misrepresented their findings; 4. The disappearance or unusual delay of websites, reports, or other science-based materials relating to climate; 5. New or unusual administrative requirements that impair climate-related work; 6. Situations in which scientists have actively objected to, resigned from, or removed themselves from a project because of pressure to change scientific findings. They reported 435 incidents of political interference over the past five years.
In 2003, the White House gutted the climate-change section of a report by the Environmental Protection Agency. It deleted references to studies showing that global warming is caused by manmade emissions. It added a reference to a study, partly funded by the American Petroleum Institute, that suggested that temperatures are not rising. Eventually the agency decided to drop the section altogether.
After Thomas Knutson at the National Oceanographic and Atmospheric Administration (NOAA) published a paper in 2004 linking rising emissions with more intense tropical cyclones, he was blocked by his superiors from speaking to the media. He agreed to one request to appear on MSNBC, but a public affairs officer at NOAA rang the station and said that Knutson was "too tired" to conduct the interview. The official explained to him that the "White House said no". All media inquiries were to be routed instead to a scientist who believed there was no connection between global warming and hurricanes.
Last year Nasa's top climate scientist, James Hansen, reported that his bosses were trying to censor his lectures, papers and web postings. He was told by Nasa's PR officials that there would be "dire consequences" if he continued to call for rapid reductions in greenhouse gases.
Last month, the Alaskan branch of the US fish and wildlife service told its scientists that anyone travelling to the Arctic must understand "the administration's position on climate change, polar bears, and sea ice and will not be speaking on or responding to these issues".
At hearings in the US Congress three weeks ago, Philip Cooney, a former White House aide who had previously worked at the American Petroleum Institute, admitted he had made hundreds of changes to government reports about climate change on behalf of the Bush administration. Though not a scientist, he had struck out evidence that glaciers were retreating and inserted phrases suggesting that there was serious scientific doubt about global warming.
The guardians of free speech in Britain aren't above attempting a little suppression, either. The Guardian and I have now received several letters from the climate sceptic Viscount Monckton threatening us with libel proceedings after I challenged his claims about climate science. On two of these occasions he has demanded that articles are removed from the internet. Monckton is the man who wrote to Senators Rockefeller and Snowe, claiming that their letter to ExxonMobil offends the corporation's "right of free speech".
After Martin Durkin's film was broadcast, one of the scientists it featured, Professor Carl Wunsch, complained that his views on climate change had been misrepresented. He says he has received a legal letter from Durkin's production company, Wag TV, threatening to sue him for defamation unless he agrees to make a public statement that he was neither misrepresented nor misled.
Would it be terribly impolite to suggest that when such people complain of censorship, a certain amount of projection is taking place?
--------
Monbiot.com
HIV Positive - 10 Apr 2007 17:55 GMT >http://www.truthout.org/docs_2006/041007P.shtml
> Global warming scientists are under intense pressure to water down >findings, and are then accused of silencing their critics. It doesn't really matter: Global Dimming is far more worrying. :)
 Signature URL: http://hiv.positive.googlepages.com/ Moible: +447939991519
rocketscience - 10 Apr 2007 22:18 GMT > In any form...same sh.t stinks whether it's Bush and climate changed > caused by humans (and greedy low life bastards like Bush/Cheney) or an [quoted text clipped - 152 lines] > > Monbiot.com http://www.hiv-aids-factorfraud.com/
http://aidsmyth.addr.com/enteraidsmyth.htm
We are a global-reach voluntary group. Our goal is ensuring the interests of AIDS-diagnosed people are no longer secondary to the interests of drug suppliers, service providers and the AIDS research industry.
Did You Know that many experts now contend AIDS is not a fatal, incurable condition caused by HIV?
We bring you the voices of alternative scientists and reforming campaigners worldwide. We are independent of vested pharmaceutical and medical interests -offering readers and forum members, global news and leading edge views on diagnosis and treatment.
Most of the information you receive is commercially driven and based on misleading assumptions or unfounded estimates and predictions. The symptoms associated with AIDS are treatable using non-toxic, immune enhancing therapies that have restored health and have enabled those truly at risk to remain well.
rocketscience
GMCarter - 11 Apr 2007 12:08 GMT snip
>We are a global-reach voluntary group. Our goal is ensuring the >interests of AIDS-diagnosed people are ...forced to die an early death believing a whole load of hogswallop.
JOHN - 10 Apr 2007 23:53 GMT > In any form...same sh.t stinks whether it's Bush and climate changed > caused by humans (and greedy low life bastards like Bush/Cheney) or an [quoted text clipped - 3 lines] > > George M. Carter Your whole life revolves around HIV and AIDS, both full of numerous lies
what does that say about you?
Watch The Secret and give us a break
GMCarter - 11 Apr 2007 12:10 GMT >> In any form...same sh.t stinks whether it's Bush and climate changed >> caused by humans (and greedy low life bastards like Bush/Cheney) or an [quoted text clipped - 7 lines] > >what does that say about you? It says I want my friends and loved ones to stay alive and well. That I'm tired of watching most of my friends die.
It says I've WATCHED many people survive and do well, some for decades. MOST of those wind up taking ARV....and most do fairly well although it can often be a struggle.
>Watch The Secret and give us a break Why? The Secret is like Denialism. A load of fantasy.
I am a little tired of seeing HIV+ people buy your brand of lies and wind up dying of AIDS.
George M. Carter
HIV Positive - 11 Apr 2007 14:00 GMT >>Your whole life revolves around HIV and AIDS, both full of numerous lies >> >>what does that say about you?
>It says I want my friends and loved ones to stay alive and well. That >I'm tired of watching most of my friends die. > >It says I've WATCHED many people survive and do well, some for >decades. MOST of those wind up taking ARV....and most do fairly well >although it can often be a struggle. So you're saying that most of your friends have been diagnosed HIV+, taken ARVs and then died. Do you not seeing a pattern here?
Perhaps you need to widen your circle of friends a bit.
>I am a little tired of seeing HIV+ people buy your brand of lies and >wind up dying of AIDS. Is there a large number of HIV+ people who don't believe HIV=AIDS=Death? I thought only a tiny number of us didn't follow that theory. Virtually the whole medical establishment seems to be geared to pushing that hypothesis. None of the doctors I've seen, or literature I've read at the clinic, suggest anything else.
And in my experience once people have been diagnosed HIV+ they are very eager to follow the HIV=AIDS=Death drug path.
 Signature URL: http://hiv.positive.googlepages.com/ Moible: +447939991519
GMCarter - 11 Apr 2007 17:27 GMT >>>Your whole life revolves around HIV and AIDS, both full of numerous lies >>> [quoted text clipped - 9 lines] >So you're saying that most of your friends have been diagnosed HIV+, >taken ARVs and then died. Do you not seeing a pattern here? No, I am not saying that. Most of my friends died in the 80s before even AZT was available. A number of others died in the early 90s when combinations like AZT/3TC were having a minimal impact.
Yes, some of my friends have died since HAART has been available. But a number of my friends who were VERY close to death are still here. And they attribute that to starting ARV therapy. And many to also using interventions like a potent multi and other CAM therapies.
>Perhaps you need to widen your circle of friends a bit. Perhaps you shouldn't be quite such an a.shole!
>>I am a little tired of seeing HIV+ people buy your brand of lies and >>wind up dying of AIDS. > >Is there a large number of HIV+ people who don't believe >HIV=AIDS=Death? Is there a large number of people who believe the earth is flat?
There are a lot of people living with HIV who realize that we all die. This is just rhetorical blathering.
>I thought only a tiny number of us didn't follow that >theory. Virtually the whole medical establishment seems to be geared >to pushing that hypothesis. None of the doctors I've seen, or >literature I've read at the clinic, suggest anything else. You will most probably discover that HIV leading to less than 100 T cells leads to potentially fatal illness.
>And in my experience once people have been diagnosed HIV+ they are >very eager to follow the HIV=AIDS=Death drug path. What is your experience? And why should we believe you since you remain anonymous?
George M. Carter
HIV Positive - 11 Apr 2007 18:28 GMT >>>>Your whole life revolves around HIV and AIDS, both full of numerous lies >>>> >>>>what does that say about you?
>>>It says I want my friends and loved ones to stay alive and well. That >>>I'm tired of watching most of my friends die. >>> >>>It says I've WATCHED many people survive and do well, some for >>>decades. MOST of those wind up taking ARV....and most do fairly well >>>although it can often be a struggle.
>>So you're saying that most of your friends have been diagnosed HIV+, >>taken ARVs and then died. Do you not seeing a pattern here?
>No, I am not saying that. Most of my friends died in the 80s before >even AZT was available. A number of others died in the early 90s when [quoted text clipped - 4 lines] >And they attribute that to starting ARV therapy. And many to also >using interventions like a potent multi and other CAM therapies. Things are all getting a big vague now. "Some...many...most."
Do you seek out only friends who have been diagnosed HIV+?
>>Perhaps you need to widen your circle of friends a bit.
>Perhaps you shouldn't be quite such an a.shole! Oh come on. You do seem to surround yourself with one type of person.
>>>I am a little tired of seeing HIV+ people buy your brand of lies and >>>wind up dying of AIDS.
>>Is there a large number of HIV+ people who don't believe >>HIV=AIDS=Death?
>Is there a large number of people who believe the earth is flat? > >There are a lot of people living with HIV who realize that we all die. >This is just rhetorical blathering. I don't think that's got anything to do with HIV or AIDS.
You seem be getting upset that someone disagrees with your HIV=AIDS=Death theory. I was just suggesting that most people agree with you, so I can't really understand what you're getting all worked up about.
Not everyone who disagrees with you is a liar or telling lies. Be happy: you have a lot of rich and powerful organisations on your side. Your government believes you, drug companies believe you, doctors believe you. And your friends believe you.
>>I thought only a tiny number of us didn't follow that >>theory. Virtually the whole medical establishment seems to be geared >>to pushing that hypothesis. None of the doctors I've seen, or >>literature I've read at the clinic, suggest anything else.
>You will most probably discover that HIV leading to less than 100 T >cells leads to potentially fatal illness. You seem a bit obsessed with my mortality. I'm not surprised your friends are dropping like flies with you whispering "you're going to die" in their ears.
I am fine. I am healthy.
If you were in the UK I'd pop round for coffee just to prove it. I think you'd be surprised how well I'm doing. I would come to the US if it wasn't so far away and you didn't have that AIDS thing over there. We have different HIV and AIDS here in the UK. :)
>>And in my experience once people have been diagnosed HIV+ they are >>very eager to follow the HIV=AIDS=Death drug path.
>What is your experience? And why should we believe you since you >remain anonymous? I've never met anyone in real life who has even considered that the HIV=AIDS=Death theory might not be correct. Everyone I've met are quite happy to drug themselves up to the eyeballs without even questioning it.
People are free to contact me and get to know me better if they wish. I publish a valid email address and telephone number.
 Signature URL: http://hiv.positive.googlepages.com/ Moible: +447939991519
GMCarter - 11 Apr 2007 22:41 GMT snip
>Things are all getting a big vague now. "Some...many...most." I haven't kept count.
>Do you seek out only friends who have been diagnosed HIV+? When I make friends with people, their HIV status is irrelevant.
>>>Perhaps you need to widen your circle of friends a bit. > >>Perhaps you shouldn't be quite such an a.shole! > >Oh come on. You do seem to surround yourself with one type of person. No. That's just another one of your disingenuous and ignorant projections.
snip
>You seem be getting upset that someone disagrees with your >HIV=AIDS=Death theory. I was just suggesting that most people agree >with you, so I can't really understand what you're getting all worked >up about. Because your beliefs kill people. It is upsetting to me. Perhaps you like to be blase about it. It wouldn't be so bad if idiots like Thabo Mbeki didn't buy the bullshit too and kill a lot of his own people as a result.
>Not everyone who disagrees with you is a liar or telling lies. Be >happy: you have a lot of rich and powerful organisations on your side. That's another reason. This denialist bullshit deflects from addressign the GENUINE problems. Like price gouging by pharma. Like Bush's deceit, lies and murder.
snip
>>You will most probably discover that HIV leading to less than 100 T >>cells leads to potentially fatal illness. > >You seem a bit obsessed with my mortality. I'm not surprised your >friends are dropping like flies with you whispering "you're going to >die" in their ears. I don't whisper that in anyone's ear. Again--more despicable rhetoric that sounds like Karl Rove.
>I am fine. I am healthy. And my prediction is that unless you seek treatment (are you taking any at all?), you will probably be very sick if not dead within 1-2 years.
>If you were in the UK I'd pop round for coffee just to prove it. I >think you'd be surprised how well I'm doing. I would come to the US >if it wasn't so far away and you didn't have that AIDS thing over >there. We have different HIV and AIDS here in the UK. :) You know, others said the same thing til they got their first bout of PCP or cryptococcal meningitis.
George M. Carter
HIV Positive - 12 Apr 2007 00:51 GMT >>Do you seek out only friends who have been diagnosed HIV+?
>When I make friends with people, their HIV status is irrelevant. You seem to have a lot of friends who have been diagnosed HIV+. Perhaps there's something in the water.
>>Oh come on. You do seem to surround yourself with one type of person.
>No. That's just another one of your disingenuous and ignorant >projections. Well, you did say you were tired of watching most of your friends die. Perhaps subconsciously you seek to befriend people who are dying.
>>You seem be getting upset that someone disagrees with your >>HIV=AIDS=Death theory. I was just suggesting that most people agree >>with you, so I can't really understand what you're getting all worked >>up about.
>Because your beliefs kill people. It is upsetting to me. Perhaps you >like to be blase about it. It wouldn't be so bad if idiots like Thabo >Mbeki didn't buy the bullshit too and kill a lot of his own people as >a result. I feel upset when I read about Mothers who have been diagnosed HIV+ being forced to give their new born HIV- babies AZT.
>>Not everyone who disagrees with you is a liar or telling lies. Be >>happy: you have a lot of rich and powerful organisations on your side.
>That's another reason. This denialist bullshit deflects from >addressign the GENUINE problems. Like price gouging by pharma. Like >Bush's deceit, lies and murder. Millions of people being poisoned in the name of profit is a genuine problem.
>>You seem a bit obsessed with my mortality. I'm not surprised your >>friends are dropping like flies with you whispering "you're going to >>die" in their ears.
>I don't whisper that in anyone's ear. Again--more despicable rhetoric >that sounds like Karl Rove. You keep telling ME I'm going to die.
>>I am fine. I am healthy.
>And my prediction is that unless you seek treatment (are you taking >any at all?), you will probably be very sick if not dead within 1-2 >years. Ah, there you go with the death stuff again.
>>If you were in the UK I'd pop round for coffee just to prove it. I >>think you'd be surprised how well I'm doing. I would come to the US >>if it wasn't so far away and you didn't have that AIDS thing over >>there. We have different HIV and AIDS here in the UK. :)
>You know, others said the same thing til they got their first bout of >PCP or cryptococcal meningitis. You're full of kind thoughts.
 Signature URL: http://hiv.positive.googlepages.com/ Moible: +447939991519
GMCarter - 12 Apr 2007 01:35 GMT >>>Do you seek out only friends who have been diagnosed HIV+? > >>When I make friends with people, their HIV status is irrelevant. > >You seem to have a lot of friends who have been diagnosed HIV+. I'm gay. I live in NYC. I joined ACT UP in 1989. I did performance art in the 80s. I think that brings me into contact with a lot of at risk people.
>Perhaps there's something in the water. NYC water is some of the best in the US. Or there'd be closer to 7 million people living with AIDS here.
>>>Oh come on. You do seem to surround yourself with one type of person. > [quoted text clipped - 3 lines] >Well, you did say you were tired of watching most of your friends die. >Perhaps subconsciously you seek to befriend people who are dying. We are all dying. And nope, I'd rather be with friends in this life a bit longer.
Watching people die is extraordinarily painful. I imagine you have had friends and loved ones die as well.
>>>You seem be getting upset that someone disagrees with your >>>HIV=AIDS=Death theory. I was just suggesting that most people agree [quoted text clipped - 8 lines] >I feel upset when I read about Mothers who have been diagnosed HIV+ >being forced to give their new born HIV- babies AZT. I become more upset that so many mothers don't have access to clean water and food.
>>>Not everyone who disagrees with you is a liar or telling lies. Be >>>happy: you have a lot of rich and powerful organisations on your side. [quoted text clipped - 5 lines] >Millions of people being poisoned in the name of profit is a genuine >problem. Millions of people denied treatment because of profit is a genuine problem.
>>>You seem a bit obsessed with my mortality. I'm not surprised your >>>friends are dropping like flies with you whispering "you're going to [quoted text clipped - 4 lines] > >You keep telling ME I'm going to die. LOL...you are. So am I. Unfortunately,if you are really HIV+ with a low CD4 count, chances are you will die relatively soon.
I could die tonight but the chances are somewhat less.
>>>I am fine. I am healthy. > [quoted text clipped - 3 lines] > >Ah, there you go with the death stuff again. Yep.
>>>If you were in the UK I'd pop round for coffee just to prove it. I >>>think you'd be surprised how well I'm doing. I would come to the US [quoted text clipped - 5 lines] > >You're full of kind thoughts. Just a dose of reality--I hope you will wise up and avoid these outcomes.
Your choice.
George M. Carter
Death - 12 Apr 2007 04:47 GMT "GMCarter" <fiar@verizon.net> wrote in message
> I'm gay. I live in NYC. I joined ACT UP in 1989. I did performance art... for the pharma companies. you still dance to their tunes like a good puppet.
You forgot to tell him how act-up booted your a.s out because of your pharma ties.
GMCarter - 12 Apr 2007 11:30 GMT >"GMCarter" <fiar@verizon.net> wrote in message > >> I'm gay. I live in NYC. I joined ACT UP in 1989. I did performance art... > >for the pharma companies. you still dance to their tunes >like a good puppet. Quite to the contrary! LOL....your still dancing to your own vitus of hate....look what happened to Imus.
>You forgot to tell him how act-up booted your a.s out >because of your pharma ties. So now you just make up lies, eh? I am still a member of ACT UP.
I have no pharma ties.
You are an anonymous coward, stuck in his miserable life of hate.
Best of luck, dear.
George M. Carter
Death - 12 Apr 2007 16:55 GMT "GMCarter" <fiar@verizon.net> wrote in message
> So now you just make up lies, eh? I am still a member of ACT UP. Yes, the splintered branch that left act-up over pharma ties. Denialism, lol, a wanna-be master of half-truths.
monty1945@lycos.com - 12 Apr 2007 23:22 GMT "...average survival following starting "highly toxic" ART is now 35 years (as compared to survival of less than 2 years without ART)..."
Talk about "denialism" - this is a blatant denial of reality I've heard in a very long time. Where in the world is the evidence for this? And by the way, I'm willing to be "infected" (with "HIV" and nothing else) if you agree to my terms. Since I am to live less than 2 years, according to you, if I live at least 4 years, you pay me three times the suggested retail price of the "HIV" drugs for the rest of my life (I will never take any of these drugs, nor do I take antibiotics or any other "medicine" - haven't for several years now, aside from 3 or 4 aspirin). You get $50,000 if I live 4 years or less, AND you can use this as an example of what happens to poor, deluded "denialists."
I am waiting...
monty1945@lycos.com - 12 Apr 2007 23:35 GMT Just out of curiousity, have you taken a look at actual causes of death of those said to be "HIV infected?" Are you suggesting that all those destroyed livers were destroyed by "HIV?" If so, this is a new claim, and I'd like to see what evidence you are basing this claim upon. However, as an "HIV/AIDS" apologist, a coherent, scientifically- sound explanation is the last thing I would expect you to respond with.
DavidT - 16 Apr 2007 18:53 GMT On 12 Apr, 23:35, monty1...@lycos.com wrote:
> Just out of curiousity, have you taken a look at actual causes of > death of those said to be "HIV infected?" Are you suggesting that all > those destroyed livers were destroyed by "HIV?" If so, this is a new > claim, and I'd like to see what evidence you are basing this claim > upon. Evidence, coming up....... (not that the liver deaths are due to HIV exactly, but that they are due to hepatitis coinfection, primarily, and evidence that patients do not all die from liver failure anyway, which is a denialist myth)
Remember, liver related deaths have only risen as a PROPORTION of total AIDS deaths because treatment with HAART has dramatically cut AIDS mortality overall.
According to this study, only 14.5% of deaths are liver related (and you will find only 2.7% of liver deaths are directly attributable to HAART if you actually read the study, which I doubt you will bother to do as I doubt you wish your prejudices to be challenged)
Again, slower this time... two point seven percent of liver deaths. Thats 0.4% of the total deaths.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=16908797&query_hl=3&itool=pubmed_docsum
rocketscience - 17 Apr 2007 13:25 GMT > On 12 Apr, 23:35, monty1...@lycos.com wrote: > [quoted text clipped - 22 lines] > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&... You lie like a rug.
How long have you been a shill for the drug industry, peddling your death pills to the unsuspecting?
Entire web sites devoted to HAART liver toxicity with links to articles:
http://www.hivandhepatitis.com/hiv_and_aids/hepatotoxicity/hepatotoxicity.html
http://www.hcvadvocate.org/hcsp/articles/Haart_2006.html
http://jac.oxfordjournals.org/cgi/content/full/50/5/763
http://aras.ab.ca/haart-liver.html
rocketscience
GMCarter - 17 Apr 2007 13:32 GMT snip
>You lie like a rug. > >How long have you been a shill for the drug industry, peddling your >death pills to the unsuspecting? LOL...speak for yourself, Frodlet. YOU'RE the one working for PHARMA to play Rovie SwiftBoat slut!
Now go on--start vomiting the vitriol all over.
DavidT - 17 Apr 2007 14:35 GMT > > On 12 Apr, 23:35, monty1...@lycos.com wrote: > [quoted text clipped - 30 lines] > Entire web sites devoted to HAART liver toxicity with links to > articles: Did you even bother to read the article I cited?
Yes, there are web links to liver toxicity articles. Lets see what they say shall we.....?
> http://www.hivandhepatitis.com/hiv_and_aids/hepatotoxicity/hepatotoxi... This one I canot access, but from the title I would predict this implicates viral hepatitis coinfection as a major factor.
> http://www.hcvadvocate.org/hcsp/articles/Haart_2006.html This one states: "In patients with HIV, the term "hepatotoxicity" may be misleading because some of these elevated liver tests may not be directly caused by the medication in question. Instead, acute viral hepatitis, reactivation of chronic hepatitis B or C, and alcohol ingestion may all play a role in such events. Of note, patients often take alternative and complementary medicines in association with HAART and several of these have been associated with clear-cut drug induced liver disease.2 In addition, an elevation of transaminases is a sensitive signal for liver injury; however it may not be specific or even clinically relevant, as most instances of 'transaminitis' improve despite drug continuation.3 Most often (70-85%), these enzyme elevations are not accompanied by symptoms."
> http://jac.oxfordjournals.org/cgi/content/full/50/5/763 This article starts by saying: "The life expectancy of HIV-positive subjects has dramatically improved with the use of triple drug combinations." It then goes on to describe a single AIDS case. The patient developed PCP, and had markedly deranged liver function, This settled, then the patient was put on HAART of which efavirenz was a component. The patient's liver function deteriorated again, and she died. The authors conclude efavirenz was to blame.
They report this case precisely BECAUSE of its rarity value. According to your ilk, thousands of patients have this happen to them all the time - so why on earth do you think that a prestigious science journal would want to publish a single case report? The authors state there are no previously recorded cases of efavirenz- induced liver failure, that is why;- This case is the first. They also say: "severe hepatitis remains very uncommon in patients receiving any HAART regimen."
> http://aras.ab.ca/haart-liver.html I cannot access this publication either, but judging by your citation expertise so far, I suspect it will agree with me also.
In conclusion, not only have you failed to comprehend anything I have explained to you regarding the cause and frequency of liver toxicity in HIV patients, you have cited articles that actually support my claims. You however are probably too stupid to appreciate this fact, as I see you have a significant comprehension difficulty.
Death - 18 Apr 2007 17:01 GMT "DavidT" <david199@volcanomail.com> wrote in message
> > http://aras.ab.ca/haart-liver.html > I cannot access this publication either, but judging by your citation > expertise so far, I suspect it will agree with me also. Here ya go, in toto:
Alberta Reappraising AIDS Society
David Crowe, President Phone: +1-403-289-6609 Fax: +1-403-289-6658 Email: David.Crowe@aras.ab.ca
Katherine Newell, Treasurer Box 61037, Kensington Postal Outlet Calgary, Alberta T2N 4S6 Canada Office Phone: +1-403-220-0129 Email: aras@aras.ab.ca Web: www.aras.ab.ca Rethinkers Quotes AZT HAART HIV Tests Transmission Library
Liver Damage HAART therapy can cause serious or even fatal liver damage.
"From January 2003 to June 2006, eight consecutive HIV-infected patients (seven Caucasian and one African) were referred for cryptogenic [unknown cause] liver disease.During the same period, 178 HIV-infected patients were admitted to the same unit for the treatment or the evaluation of chronic liver disease and 97 underwent liver biopsy.With the exception of HIV infection and the associated liver disease, none of these patients had significant co-morbidity, especially considering cardiac or renal pathology. They did not take any other hepatotoxic medication apart from antiretroviral drugs.No patients had had opportunistic infection.A clear nodular architecture was seen in seven patients, whereas in the last one, NRH [nodular regenerative hyperplasia of the liver] was suspected on the presence of sinusoidal dilatation in a clinical context of portal hypertension.To date, all patients are alive, and three are waiting for liver transplantation." Mallet V et al. Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients. AIDS. 2007 Jan 11;21(2):187-92. "We here report a 52-year-old white male (Centers for Disease Control and Prevention stage C3) with a 20-year history of multidrug-resistant HIV. In February 2005 he was started on an antiretroviral regimen with TPV and RTV (500/200 mg twice daily), continuing the existing regimen of zidovudine/lamivudine (300/150 mg twice daily) and T-20 (90 mg twice daily), which was started 12 months before without hepatic disorders.Two weeks after the initiation of the TPV containing regimen, the patient developed elevated liver enzymes.HBV DNA viral load was low with 20 000 copies/ml, autoimmune markers for hepatitis and cirrhosis were negative, excessive alcohol consumption was denied. Percutaneous liver biopsy showed a mild, non-active hepatitis with moderate lymphocyte infiltration in the portal areas and no intrahepatic steatosis. Following the patient's wish to interrupt the T-20 [enfuvirtide, a fusion inhibitor] treatment because of severe local skin reactions, and under the assumption of a hepatotoxic effect of the antiretroviral regimen T-20 was discontinued for 6 weeks. Shortly after, liver function improved with a 50% decrease in LFT values. Due to a weight loss of 10 kg and an elevation of the viral load treatment with T-20 was recommenced and 2 weeks later after an increase of the G-GT TPV/RTV was discontinued. The liver function tests returned to normal within 4 weeks." Julg B, Bogner J, Goebel F. Severe hepatotoxicity associated with the combination of enfuvirtide and tipranavir/ritonavir: case report. AIDS. 2006 Jul 13;20(11):1563. "Aptivus [tipranavir] co-administered with 200 mg Ritonavir has been associated with reports of clinical hepatitis and hepatic decompensation including some fatalities" Aptivus (tipranavir) prescribing information. Boehringer Ingelheim. 2006 Jun 27. "Considering the 86 patients in the follow-up study, 17 were found to be HBV-DNA positive, 13 on admission and four in the subsequent observation.28 (32.5%) experienced a hepatic flare [at least a tripling of the liver enzyme serum alanine aminotrasferase between two consecutive measurements].Of the 13 patients who were HBV-DNA positive on admission, two did not receive HAART; one of these two experienced a hepatic flare after a 12-month observation. The other 11 patients were treated with HAART containing lamivudine and were HBV-DNA negative at the subsequent check points. Of these 11, four became HBV-DNA positive under lamivudine treatment and experienced a hepatic flare; two of these four also experienced a hepatic flare after the discontinuation of the drug. Another two of these 11 patients (Fig. 1f, g) became HBV-DNA positive and experienced a hepatic flare, respectively, 4 and 8 months after lamivudine was discontinued because of lack of efficacy of the HAART regimen. The remaining five patients of the 11 treated remained HBV-DNA negative under HAART containing lamivudine and did not experience a hepatic flare.[in summary] in approximately half of the lamivudine treated patients occult HBV replication became detectable again after 12-40 months of lamivudine treatment, always associated with a hepatic flare." Filippini P et al. Impact of occult hepatitis B virus infection in HIV patients naive for antiretroviral therapy. AIDS. 2006 Jun 12;20(9):1253-1260. "Patients with steatosis [fat deposits in the liver] grade 2/3 [severe] were more likely to be receiving antiretroviral therapy than were patients with grade 1 [mild] steatosis (84% versus 77%) and patients without steatosis (69%). NRTI-based [nucleoside reverse-transcriptase inhibitors such as AZT] treatment was more frequent among patients with steatosis grade 2/3 than among patients with grade 1 or grade 0 steatosis (82%, 75% and 68%, respectively).Lipodystrophy [fat redistribution, also associated with long-term antiretroviral drug use] was present in 15.7% overall, i.e., 21% in patients with grade 2/3 steatosis, 15% in patients with grade 1 steatosis, and 11% in patients with no steatosis." Bani-Sadr F et al. Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors. AIDS. 2006 Feb 28;20(4):525-531. "Hepatocellular carcinoma (HCC) is an increasing cause of mortality in HIV-seropositive individuals.All HIV-infected subjects with a diagnosis of HCC included in three cancer registry databases were enrolled in the study [using HCC cases from Brescia, North Italy in 1995-1998 as controls].41 HIV-infected subjects with HCC were identified.31 patients (77%) were on highly active antiretroviral therapy." Puoti M et al. Hepatocellular carcinoma in HIV-infected patients: epidemiological features, clinical presentation and outcome. AIDS. 2004 Nov 19;18(17):2285-2293. "We report the first observation of acute hepatic cytolysis associated with atazanavir [a new azapeptide protease inhibitor].transaminase activity gradually increased after the introduction of atazanavir, with a marked increase between weeks 8 and 30 (up to 10 times the normal value). At admission, physical examination showed afebrile subclinical jaundice. The abdominal examination was strictly normal (no hepatomegaly). No signs of chronic liver disease or liver failure were found. Laboratory tests revealed major cytolysis [breakdown of cells in the liver]" Eholié SP et al. Acute hepatic cytolysis in an HIV-infected patient taking atazanavir. AIDS. 2004 Jul 23;18(11):1610-11. "Abnormalities in hepatic function have become one of the most common complications occurring among human immunodeficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART), and liver disease has become an increasingly important cause of morbidity and mortality in HIV-infected patients. We present a case of a patient with HIV infection and hepatotoxicity that exemplifies the complications currently observed during the treatment of such patients.Although coinfection with HCV and HIV has become a common clinical problem, optimal treatment of such patients remains to be defined and must be individualized to maximize benefit and tolerance." Kottilil S, Polis MA, Kovacs JA. HIV Infection, hepatitis C infection, and HAART: hard clinical choices. JAMA. 2004 Jul 14;292(2):243-50. "The most common laboratory abnormalities [found with Kaletra, a combination of the protease inhibitors Lopinavir and Ritonavir] are increases in some tests of liver function." Kaletra (lopinavir/ritonavir). The Center for AIDS. 2004 Apr. "when mortality [in British hemophiliacs] from other [non-HIV] causes was examined separately, a substantial increase over time remained, with the value during 1991-1996 almost double that for 1985-1990 and no appreciable decline in 1997-1999. The increase was entirely caused by an increase in liver disease, which during 1997-1999 was the certified cause of death for over 25% of deaths in HIV-infected individuals.For deaths that were classified neither as HIV related nor from liver disease, mortality remained virtually constant during 1985-1999, albeit at a higher level than that of HIV-uninfected individuals. It seems likely that at least some of these deaths were attributable to HIV, although there was no indication that the individuals concerned had developed an AIDS-defining condition. HAART has been associated with several categories of major toxic effects, but there was no evidence of any deaths occurring as a result of HAART in this population. [but what other explanation is there?]" Darby SC et al. The impact of HIV on mortality rates in the complete UK haemophilia population. AIDS. 2004 Feb 20;18(3):525-33. "Women with CD4+ counts >250 cells/mm3, including pregnant women receiving chronic treatment for HIV infection, are at considerably higher risk (12 fold) of hepatotoxicity [liver damage]. Some of these events have been fatal.The greatest risk of severe and potentially fatal hepatic events (often associated with rash) occurs in the first 6 weeks of VIRAMUNE [nevirapine] treatment. However, the risk continues after this time and patients should be monitored closely for the first 18 weeks of treatment with VIRAMUNE.In some cases hepatic injury progresses despite discontinuation of treatment. [Boehringer Ingelheim is the manufacturer of Nevirapine]" Shepard KV. Re: Clarification of risk factors for severe, life-threatening and fatal hepatotoxicity with VIRAMUNE (nevirapine). Boehringer Ingelheim. 2004 Feb. "30 non-HIV-infected individuals developed hepatotoxicity [liver toxicity] after 8 to 35 days of single-agent nevirapine (8 people) or a nevirapine-containing PEP regimen (22). Findings included ECOG grade 3 [confined to bed at least half the day] or 4 [completely disabled] hepatotoxicity (n = 14), fevers (n = 11), skin rashes (n = 8), eosinophilia (n = 6), and fulminant hepatic necrosis requiring an orthotopic liver transplant (n = 1). Rates of severe hepatotoxicity (grade 3 or 4) in non-HIV-infected individuals ranged from 10% (4/41) to 62% (5/8). Liver biopsy material from 2 individuals was consistent with a hypersensitivity syndrome." Patel SM et al. Serious Adverse Cutaneous and Hepatic Toxicities Associated With Nevirapine Use by Non-HIV-Infected Individuals. J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):120-125. "In multivariate analysis [of 692 Thai HIV patients], predictors of severe hepatotoxicity [liver toxicity] were HBV [Hepatitis B virus] or HCV [Hepatitis C virus] coinfection, and NNRTI[Non-Nucleoside Reverse Transcriptase Inhibitor]-containing therapy. Incidence of severe hepatotoxicity was particularly high among patients receiving nevirapine and nevirapine/efavirenz" Law WP et al. Risk of severe hepatotoxicity associated with antiretroviral therapy in the HIV-NAT Cohort, Thailand, 1996-2001. AIDS. 2003 Oct 17;17(15):2191-9. "306 patients started a nevirapine-containing regimen, of whom 8 developed an acute hepatitis (2.6%) in a median of 24 days. Transaminases peaked at 28 days. Injury pattern was in general mixed-hepatocellular. Withdrawal of the antiretroviral agent led to rapid restoration of transaminase levels and resolution of clinical symptoms." De Maat MM et al. Case series of acute hepatitis in a non-selected group of HIV-infected patients on nevirapine-containing antiretroviral treatment. AIDS. 2003 Oct 17;17(15):2209-14. "In 655 individuals receiving HIV postexposure prophylaxis (PEP), drug-induced aminotransferase alterations were frequent and severe in the nevirapine-including regimen, rare and mild-to-moderate in other combinations, and always reversible. Grade 3-4 incidence in protease inhibitor or nevirapine PEP was 0.5 and 25.0 per 100 person-months, respectively. Apart from nevirapine, continuing PEP appears to be safe [but without long-term follow-up this claim is a bit shaky] even in the case of aminotransferase alterations. The usefulness of routine monitoring of liver function during PEP could be re-considered." Puro V et al. Drug-induced aminotransferase alterations during antiretroviral HIV pos-exposure prophylaxis. AIDS. 2003 Sep 5;17(13):1988-90. "Nucleoside reverse transcriptase inhibitors (NRTIs) induce mitochondrial toxic effects resulting in multiple organ disorders. Liver involvement has been associated mainly with severe lactic acidosis and massive steatosis [fatty degeneration].13 patients with HIV infection treated with NRTI-based regimens had low-grade abnormal liver test results associated with digestive and nonspecific general symptoms. Histologic examination of liver samples showed diffuse steatosis in only 6 cases and mild steatosis in the remaining cases.In all cases, ultrastructural study disclosed mitochondrial abnormalities. Our work demonstrates that NRTI-induced toxic effects in the liver may occur as indolent [without symptoms] nonspecific disease [but probably not forever, as the side effects worsen]" Van Huyen JP et al. Toxic effects of nucleoside reverse transcriptase inhibitors on the liver. Value of electron microscopy analysis for the diagnosis of mitochondrial cytopathy. Am J Clin Pathol. 2003 Apr;119(4):546-55. "755 HIV-seropositive patients consecutively prescribed new [i.e. changed, not necessarily the first] ART [anti-retroviral therapy] were selected.26 cases of SH [severe hepatotoxicity] were observed with an incidence of 4.2% person-years. Liver failure (LF) was rarely seen (1.1 per 100 person-years).Death occurred during follow-up in 7 of 26 (27%) patients, all of whom showed LF and baseline CD4 count less than 200 cells/mm. Relapse of SH was observed after ART was recommenced in 7 of 17 (41%) patients. [Note that Severe Hepatotoxicity was also somewhat associated with IV drug abuse and alcohol abuse, which may have been contributing factors]" Puoti M et al. Severe hepatotoxicity during combination antiretroviral treatment: incidence, liver histology, and outcome. J Acquir Immune Defic Syndr. 2003 Mar 1;32(3):259-67. "the liver-related mortality rate was.twice as high after 1996, when highly active antiretroviral therapy (HAART) was introduced." Thio CL et al. HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). Lancet. 2002 Dec 14;360:1921-6. "In this investigation, 492 patients.prescribed antiretroviral drugs between April 1989 and September 2000 were included.The median duration of follow-up of the cohort was 1,392 days. HCV [Hepatitis C] infection was present in 323 (68%). Mortality attributable to AIDS decreased from 4.5 to 1.8 per 100 persons per year. Mortality due to liver failure increased from 0.3 to 0.5 per 100 persons per year. The survival of patients with and without HCV infection was similar. Although liver failure is an increasing cause of death among HIV-infected patients receiving HAART, HCV infection has still no impact on the survival of HIV-infected patients." Macias J et al. Mortality due to Liver Failure and Impact on Survival of Hepatitis Virus Infections in HIV-Infected Patients Receiving Potent Antiretroviral Therapy. Eur J Clin Microbiol Infect Dis. 2002 Nov;21(11):775-81. "Liver fat content was significantly higher in the HAART+LD+ group than the HIV-.group [obviously not taking HAART].The severity of the insulin resistance syndrome in patients with HAART-associated lipodystrophy [abnormal fat distribution] is related to the extent of fat accumulation in the liver" Sutinen J et al. Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS. 2002 Nov 8;16(16):2183-93. "We describe a patient in whom disseminated intravascular coagulation (DIC) developed within 6 days after starting abacavir for the treatment of HIV infection [resulting in kidney failure and liver abnormalities]" Dargere S et al. Disseminated intravascular coagulation as a manifestation of abacavir hypersensitivity reaction. AIDS. 2002 Aug 16;16(12):1696-967. "Whether by HAART, viral hepatitis, or alcohol, transaminitis (elevated ALT and AST [liver enzyme levels]) is common among those with HIV infection... In unadjusted analyses, CD4 [immune cell counts], VL [viral load], and AST were significant predictors of survival in both cohorts (p<0.001). ALT was significant only in CHORUS [one cohort].Transaminitis is a major determinant of survival and should be carefully considered in all phases of HIV therapy [note that the cumulative length of treatment with antiretroviral drugs, which are known to be toxic to the liver, was not considered]" Justice AC et al. HIV survival: liver function tests independently predict survival. XIV International AIDS Conference. 2002 Jul;MoOrB1058. "The occurrence of a severe elevation of [the liver enzymes] transaminases was associated with poorer survival, although HCV [Hepatitis C Virus] was not. If liver toxicity may be treatment induced, plasma drug concentrations could guide dosage adjustments ofantiretroviral treatments currently prescribed to optimize their use." Rancinan C et al. Is hepatitis C virus co-infection associated with survival in HIV-infected patients treated by combination antiretroviral therapy?. AIDS. 2002 Jul 5;16(10):1357-62. "Of the 560 patients, 44 (7.9%) developed grade 4 LEEs [Liver Enzyme Elevation].9 cases were excluded from the analysis [due to other explanations for their liver problems] leaving 35 cases.6 (17.1%) of 35 patients were symptomatic. The most frequently occurring symptoms were jaundice, dark urine, clay-colored stools, malaise, nausea, vomiting, and right upper quadrant discomfort.the risk factors significantly associated with grade 4 LEE.were higher baseline ALT levels, chronic HBV [Hepatitis B] infection [which could be a surrogate for the user of additional drugs] , chronic HCV [Hepatitis C] infection [also possibly a surrogate for the use of other drugs], the use of first-line potent antiretroviral combination regimens in patients without prior NRTI [Nucleoside Reverse Transcriptase Inhibitor] treatment, recent start of nevirapine or ritonavir, and female sex. Furthermore, among patients chronically coinfected with HBV, discontinuing the use of 3TC was associated with the development of grade 4 LEE.[but] 5 (14%) had recently discontinued the use of 3TC while a chronic HBV infection was present [which could indicate that 3TC caused the liver problems, but that 3TC was stopped before the LEE worsened to grade 4]" Ferdinand WNM et al. Incidence of and Risk Factors for Severe Hepatotoxicity Associated with Antiretroviral Combination Therapy. J Infect Dis. 2002 Jun 14;186:23-31. "Current highly active antiretroviral therapy (HAART) is based on combination regimens with substances from three different classes: nucleoside reverse transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI).HAART-associated toxicity has evolved as the main reason to discontinue or modify antiretroviral therapy. Hepatotoxicity [liver damage] appears to be of particular importance in this context as it can occur with any antiretroviral regimen currently in use. Most remarkably, longitudinal surveys have not only reported an increased incidence of hepatic injury in HAART-treated patients but also identified life-threatening hepatotoxic events and end-stage liver disease in patients on antiretroviral treatment. Since rational alternatives to HAART [i.e. not taking HAART is not rational] are currently not available to control HIV infection, understanding the pathophysiology as well as a profound knowledge of how to prevent and to treat HAART-related liver damage will be a continuous challenge [and source of income] for the present and future generations of hepatologists." Spengler U et al. Antiretroviral drug toxicity -- a challenge for the hepatologist?. J Hepatol. 2002 Feb;36(2):283-94. "In a case-control study, 70 patients taking nevirapine (200 mg twice a day) triple combinations were chosen and classified into two groups, one including subjects who developed any grade of hepatotoxicity [liver disease], and a control group including subjects without transaminase elevations. The use of nucleoside analogs was comparable in both groups...The peak in transaminase levels [surrogate marker for liver toxicity] among the 33 subjects of the first group occurred at a median time of 6.1 months after beginning nevirapine-based therapy...our preliminary findings support the theory that nevirapine-associated liver toxicity occurring after several months on therapy is not part of a systemic hypersensitivity reaction, and seems to be correlated with higher plasma drug concentrations involving a dose-dependent mechanism" Gonzalez de Requena D et al. Liver toxicity caused by nevirapine. AIDS. 2002 Jan 25;16(2):290-1. "A number of patients experienced grade 3-4 laboratory abnormalities in liver function tests, cholesterol, and triglycerides while receiving this drug combination" Mangum EM, Graham KK. Lopinavir-Ritonavir: a new protease inhibitor. Pharmacotherapy. 2001 Nov;21(11):1352-63. "In conclusion, we believe that our patient developed liver failure and portal hypertension in the absence of cirrhosis because of long-term nucleoside-analogue therapy without development of symptomatic lactic acidaemia. Gliclazide and metformin are not related to hepatocellular damage; however, tuberculostatic drugs used might have accelerated this process. This case suggests that even mild hyperlactaemia, which occurs in 15-35% of nucleoside-analogue-treated patients, can be associated with progressive liver damage" Kronenberg A et al. Liver failure after long-term nucleoside analogue therapy. Lancet. 2001 Sep 1;358(9283):759-60. "We describe four instances of reversible hepatocellular [liver] damage associated with the use of nevirapine in patients with HIV infection...Evidence of malaise, skin rash, and icteric hepatitis [jaundice] with pruritis [skin rash] occurred 4-6 weeks after the beginning of nevirapine therapy...In all cases, liver test results declined to normal or near normal levels, and pruritus disappeared 4-6 weeks after discontinuation of the medication. No patient was rechallenged with the drug." Bonacini et al. Jaundice and hepatocellular damage associated with Nevirapine therapy. Am J Gastroenterol. 2001;96(5):1571-4. "The cases of 2 patients with nevirapine-associated hepatotoxicity [liver damage].are reported here. Both patients' conditions improved following withdrawal of nevirapine..Until a better understanding of the clinical spectrum and pathophysiology of nevirapine-associated hepatotoxicity is realized, treatment will remain largely empiric [translation: we are not too sure what we are doing, but we never like to take a drug away from a patient]" Bundow D et al. Optimal Treatment of Nevirapine-Associated Hepatotoxicity Remains Uncertain. The AIDS Reader. 2001;11(11):577-80 www.medscape.com/SCP/TAR/2001/v11.n11/a1111.03.bund/a1111.03.bund-01.html. "A comprehensive retrospective review of more than 10,000 adult AIDS patients participating in 21 different AIDS Clinical Trials Group (ACTG) studies [confirms]... that antiretroviral therapy is associated with a high rate of severe hepatotoxicity [liver damage], regardless of drug class or combination. Dr. Chung of Massachusetts General Hospital in Boston presented the findings to the Digestive Disease Week annual meeting...The researchers evaluated data for AIDS patients, enrolled in ACTG studies between 1991 and 2000. The subjects were taking a variety of drug combinations including one or more nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs)...Overall, 10% of patients developed grade 3 and 4 hepatotoxicity and 23% of them had to discontinue therapy permanently. According to the data, 2.5% of all deaths in the study period were liver related. NNRTI[non-nucleoside reverse-transcriptase inhibitors]-containing regimens, especially those including nevirapine and efavirenz, were particularly hard on the liver, with high rates of discontinuation." High Rate of Severe Liver Toxicity Associated With Antiretroviral Therapy. Reuters Health. 2001 May 23. "Acute hepatitis with lactic acidosis is a life-threatening but [sometimes] reversible toxic effect on mitochondria of HIV-1 nucleoside-analogue treatment [later this letter notes that 80% of patients with lactate greater than 10 mmol/L die]. We report fatal portal hypertension, liver failure, and persistent mitochondrial dysfunction in a man aged 65 years with HIV-1 infection who had recovered from nucleoside-analogue-induced acute hepatitis and lactic acidaemia more than 18 months previously. We believe that symptom-free patients who receive nucleoside-analogue therapy should have hepatic [liver] function constantly monitored, especially those with past or present lactic acidaemia." Carr A et al. Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia. Lancet. 2001 May 5;357:1412. "The antiretroviral drugs used to fight HIV, particularly the protease inhibitors, place a great strain on the liver, the organ whose function it is to metabolize them...When Brian Klein of San Francisco found out that he was HIV-positive in 1996, he immediately started on a three-drug regimen that included a protease inhibitor. "Within two weeks I got extremely sick," he recalled. "I became jaundiced. I lost 15 pounds. They did some tests, and, lo and behold, I had hepatitis C [or liver damage from the protease inhibitors generated auto-antibodies misidentified as from Hepatitis C]. They pulled me off the medications because this was all new at the time and they didn't know what to do." Tuller D. Hepatitis C poses new threat to many with AIDS. NY Times. 2001 May 1. "In 1998-1999, 11 (50%) of 22 deaths were due to end-stage liver disease, compared with 3 (11.5%) of 26 in 1991 and 5 (13.9%) of 36 in 1996 (P = .003). In 1998-1999, 55% of patients had nondetectable plasma HIV RNA levels and/or CD4 cell counts of >200 cells/mm3 within the year before death. Most of the patients that were tested had detectable antibodies to hepatitis C virus (75% of patients who died in 1991, 57.7% who died in 1996, and 93.8% who died in 1998-1999; P = NS). In 1998-1999, 7 patients (31.8%) discontinued antiretroviral therapy because of hepatotoxicity, compared with 0 in 1991 and 2 (5.6%) in 1996. End-stage liver disease is now the leading cause of death in our hospitalized HIV-seropositive population." McGovern B et al. Increasing Mortality Due to End-Stage Liver Disease in Patients with Human Immunodeficiency Virus Infection. Clin Infect Dis. 2001 Feb 1;32(3):492-497 http://www.journals.uchicago.edu/CID/journal/issues/v32n3/000297/brief/000297.ab stract.html. "We retrospectively examined the causes of death of HIV-seropositive patients at our institution in 1991, 1996, and 1998-1999. In 1998-1999, 11 (50%) of 22 deaths were due to end-stage liver disease, compared with 3 (11.5%) of 26 in 1991 and 5 (13.9%) of 36 in 1996.In 1998-1999, 7 patients (31.8%) discontinued antiretroviral therapy because of hepatotoxicity, compared with 0 in 1991 and 2 (5.6%) in 1996. End-stage liver disease is now the leading cause of death in our hospitalized HIV-seropositive population." Bica I et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis. 2001 Feb 1;32(3):492-7. "In a cohort of 1,047 human immunodeficiency virus type 1-infected patients started on protease inhibitors (PIs), the incidence of severe hepatic [liver] cytolysis (alanine aminotransferase concentration five times or more above the upper limit of the normal level>=5N) was 5% patient-years after a mean follow-up of 5 months...At the onset of severe cytolysis, 2 patients were receiving Saquinavir (SQV), 5...Ritonavir (RTV), 7...Indinavir (IDV), 5...Nelfinavir (NFV), 1...SQV and RTV, 1...IDV and NFV, and 1...RTV and NFV" Savès M et al. Hepatitis B or Hepatitis C Virus Infection Is a Risk Factor for Severe Hepatic Cytolysis after Initiation of a Protease Inhibitor-Containing Antiretroviral Regimen in Human Immunodeficiency Virus-Infected Patients. Antimicrob Agents Chemother. 2000 Dec;44(12):3451-5 http://aac.asm.org/cgi/content/abstract/44/12/3451. "treatment with certain PIs [Protease Inhibitors] is associated with fat redistribution, hyperlipidemia (high fat levels in the blood), or both...we examined the effects of PIs on lipid synthesis in cultured hepatocytes [liver cells] and AKR/J mice. The results showed that NFV [nelfinavir] and RTV [ritonavir] increased serum TG [triglyceride] levels in mice...ABT-378, NFV, RTV, and SQV [saquinavir], but not APV [amprenavir] or IDV [indinavir], increased TG synthesis and RTV increased CH [cholesterol] synthesis in HepG2 [liver] cells...select PIs affect multiple, distinct metabolic pathways, perhaps accounting for the different side effects observed for each PI" Lenhard JM et al. HIV protease inhibitors stimulate hepatic triglyceride synthesis. Arterioscler Thromb Vasc Biol. 2000 Dec;20:2625-9. "While the risk of transmission of HIV via a needlestick is approximately 0.3%, the risk of serious adverse effects of these preventive strategies remains undefined. We report a case of a health care worker who experienced serious morbidity from PEP [post-exposure prophylaxis]...A 43-year-old female, African American phlebotomist sustained a needlestick injury after drawing blood from an HIV- and hepatitis C virus (HCV) infected patient. She received PEP with zidovudine, lamivudine, and nevirapine. Triple therapy including nevirapine was selected based on the source patient's advanced disease, antiretroviral treatment history, and severity of the exposure...The patient required an orthotopic liver transplant 35 days following initiation of PEP. Pathology of the native liver showed confluent hepatic necrosis...We think that this patient had a severe hypersensitivity reaction to nevirapine that resulted in hepatic failure...This case raises the question of whether the safety profile of nevirapine warrants its use as a prophylactic medication in health care workers who are exposed to HIV when the risk of transmission is low." Sha BE, Proia LA, Kessler HA. Adverse Effects Associated With Use of Nevirapine in HIV Postexposure Prophylaxis for 2 Health Care Workers [second case]. JAMA. 2000 Dec 6;284(21):2723. "The existing sections [of the product label for Nevirapine/Viramune] have been updated to provide additional warning information about the risk of severe, life-threatening and in some cases, fatal hepatotoxicity [liver damage] that have been reported in patients treated with Viramune. Although clinical presentation varied among patients, frequently occurring features included non-specific prodromal [early] signs and symptoms of fatigue, malaise, anorexia and nausea, with or without abnormal serum transaminase levels. In these reports, symptoms progressed to jaundice, hepatomegaly [enlarged liver], elevation of transaminase levels and hepatic [liver] failure over several days." Haehl M. Severe, life-threatening and fatal cases of hepatotoxicity with VIRAMUNE. Boehringer Ingelheim Roxane Laboratories. 2000 Nov. "Severe hepatotoxicity was observed in 31 (10.4%) of 298 patients...Risk of severe hepatoxicity was 5-fold higher for patients taking [the protease inhibitor] ritonavir, which accounted for half of all cases...Likewise, more than half of cases of severe hyperbilirubinemia [excess of bilirubin] were associated with indinavir use" Sulkowski MS et al. Hepatotoxicity associated with antiretroviral therapy in adults infected with Human Immunodeficiency Virus and the role of Hepatitis C or B virus infection. JAMA. 2000 Jan 5;283(1):74-80. "Liver disease has become the leading cause of death among HIV patients at a Massachusetts hospital, a report issued on Friday...[by] Dr. Barbara McGovern, a professor at Tufts University School of Medicine and a member of staff at Lemuel Shattuck Hospital in Jamaica Plains, Mass. The findings were reported on Friday at the annual meeting of the Infectious Diseases Society of America in Philadelphia. McGovern said HIV patients who take a powerful combination of AIDS drugs called highly active antiretroviral therapy (HAART) were at particular risk because of the drug's potential toxicity to the liver. One-third of HIV patients with underlying liver disease at Lemuel Shattuck have had to stop taking HAART." Liver disease raises questions for AIDS patients. Reuters. 1999 Nov 19. "hepatotoxicity is frequently seen in patients under HAART, and can force the withdrawal of antiviral treatment in a significant proportion of patients, occasionally resulting in fatal outcome." Rodriguez-Rosado R et al. Hepatotoxicity after introduction of highly active antiretroviral therapy. AIDS. 1998 Jul 9;12(10):1256. "We analysed the first 187 patients who began highly active antiretroviral therapy (HAART) in a reference centre for HIV/AIDS located in Madrid. Examination of liver function was made at baseline and after 1 month of starting treatment.A significant increase in transaminases (more than twofold) was recognized in 26 (13.9%) patients, whereas bilirubin increases above 2.5 g/l were seen in seven (3.7%) individuals. Eleven (5.9%) subjects needed to stop the medication because of either hepatic cytolysis [liver cell death] (nine patients), or hyperbilirubinaemia (one patient), or both (one patient). Four (2.1%) individuals developed clinical hepatic decompensation, and one of them died. This patient was receiving stavudine, lamivudine plus indinavir, and he had been diagnosed with multiple chronic hepatitis (hepatitis B, C and D), although this was his first episode of clinical liver failure.In conclusion, hepatotoxicity is frequently seen in patients under HAART, and can force the withdrawal of antiviral treatment in a significant proportion of patients, occasionally resulting in fatal outcome." Rodriguez-Rosado R et al. Hepatotoxicity after introduction of highly active antiretroviral therapy. AIDS. 1998 Jul 9;12(10):1256. Leave your feedback. We like to hear from you!
© Copyright March 20, 2007 10:05:28 AM: Alberta Reappraising AIDS Society
DavidT - 19 Apr 2007 10:33 GMT > "DavidT" <david...@volcanomail.com> wrote in message > [quoted text clipped - 5 lines] > > Alberta Reappraising AIDS Society This is a dissident web site, so as expected, they try and misrepresent the truth. There ARE cases of hepatotoxicity from HAART - I do not dispute this. But by their lopsided reporting of the issue they are trying to create the impression that AIDS patients are all dropping like flies because of liver failure from HAART.
The truth is somewhat different, as can be shown by this one quote in the ARAS site (which they forgot to edit out, presumably):
"Mortality attributable to AIDS decreased from 4.5 to 1.8 per 100 persons per year. Mortality due to liver failure increased from 0.3 to 0.5 per 100 persons per year."
This was in the MACS cohort.
All the data show exactly what I am saying - AIDS mortality has declined dramatically with introduction of HAART, while liver toxicity has risen only fractionally. The liver deaths are usually the result of coinfections of Hep C causing liver failure (because HIV patients are now living for decades, rather than years) and have little to do with drug toxicity.
Death - 19 Apr 2007 16:37 GMT "DavidT" <david199@volcanomail.com> wrote in message
> ... > All the data show exactly what I am saying - AIDS mortality has [quoted text clipped - 3 lines] > are now living for decades, rather than years) and have little to do > with drug toxicity. Once again you go from HIV to AIDS and back again as if they were one-in-the-same. You use HIV patients to demonstrate that AIDS patients are living longer.
Here is a list you may want to read over:
Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)
acetaminophen salicylates (doses over 2 grams daily)
Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)
acebutolol indomethacin phenylbutazone allopurinol isoniazid phenytoin atenolol ketoconazole piroxicam carbamazepine- labetalol probenecid cimetidine maprotiline pyrazinamide dantrolene metoprolol quinidine diclofenac mianserin- quinine diltiazem naproxen ranitidine enflurane para-aminosalicylic acid sulfonamides ethambutol penicillins sulindac- ethionamide phenelzine tricyclic antidepressants halothane phenindione valproic acid ibuprofen phenobarbital verapamil
Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER
adrenocortical steroids phenothiazines sulfonamides antithyroid drugs phenytoin- tetracyclines isoniazid salicylates valproic acid methotrexate
Drugs that may cause CHOLESTATIC JAUNDICE
actinomycin D chlorpropamide erythromycin amoxicillin/clavulanate cloxacillin flecainide azathioprine cyclophosphamide flurazepam captopril cyclosporine flutamide- carbamazepine danazol glyburide carbimazole diazepam gold cephalosporins disopyramide griseofulvin chlordiazepoxide enalapril- enalapril haloperidol ketoconazole norethandrolone sulfonamides mercaptopurine oral contraceptives tamoxifen methyltestosterone oxacillin thiabendazole- nifedipine penicillamine tolbutamide nitrofurantoin phenothiazines tricyclic antidepressants nonsteroidal phenytoin troleandomycin anti-inflammatory drugs propoxyphene verapamil
Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)
allopurinol gold phenytoin aspirin hydralazine procainamide carbamazepine isoniazid quinidine chlorpromazine- isoniazid quinidine chlorpromazine nitrofurantoin sulfonamides diltiazem penicillin tolbutamide disopyramide phenylbutazone
Drugs that may cause CHRONIC LIVER DISEASE
Drugs that may cause active chronic hepatitis
acetaminophen (chronic use, large doses) dantrolene methyldopa isoniazid nitrofurantoin
Drugs that may cause liver cirrhosis or fibrosis (scarring)
methotrexate terbinafine HCI (Lamisil, Sporanox) nicotinic acid
Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis)
chlorpromazine/valproic acid (combination)
imipramine thiabendazole phenothiazines tolbutamide chlorpropamide/erythro-mycin (combination) phenytoin
Drugs that may cause LIVER TUMORS (benign and malignant)
anabolic steroids oral contraceptives thorotrast danazol testosterone
Drugs that may cause DAMAGE TO LIVER BLOOD VESSELS
adriamycin dacarbazine thioquanine anabolic steroids mercaptopurine vincristine azathioprine methotrexate vitamin A (excessive doses) carmustine mitomycin cyclophosphamide/cyclo-sporine (combination) oral contraceptives
Death - 18 Apr 2007 16:56 GMT "DavidT" <david199@volcanomail.com> wrote in message
> Evidence, coming up....... Kewl
(not that the liver deaths are due to HIV
> exactly, but that they are due to hepatitis coinfection, ... lol, as I thought. Hiv plus co-infection is AIDS and not to be confused with medicine induced liver deaths.
GMCarter - 13 Apr 2007 11:21 GMT >"...average survival following starting "highly toxic" ART is now 35 >years [quoted text clipped - 3 lines] >heard in a very long time. Where in the world is the evidence for >this? Check out PubMed. Or do a google search. There's ample evidence. Which you will simply ignore because it doesn't fit your preconceived notions...which are pretty wacky in general.
Best of luck, dear!
GMCarter - 13 Apr 2007 11:20 GMT >"GMCarter" <fiar@verizon.net> wrote in message >> >> So now you just make up lies, eh? I am still a member of ACT UP. > >Yes, the splintered branch that left act-up over pharma ties. >Denialism, lol, a wanna-be master of half-truths. OK--so an anonymous guy just makes stuff up and expects folks will believe him! Another student of the failed Karl Rove School of Swift Boat Smearing lies! LOL....
Evidence for any of this nonsense? The only "splinter" group of ACT UP happened in SF when denialists took over. Now they've all died because they bought your lies.
George M. Carter
Death - 18 Apr 2007 17:10 GMT "GMCarter" <fiar@verizon.net> wrote in message
> OK--so an anonymous guy just makes stuff up and expects folks will > believe him! Another student of the failed Karl Rove School of Swift [quoted text clipped - 3 lines] > happened in SF when denialists took over. Now they've all died because > they bought your lies. No, they died because of perverted faggot sex.
So, you do admit to a "splinter" group? I'm not quite the liar you wish your-self to believe. You strengthen my statement of one group going pharma even after you deny it, lol, see above.
That is mighty faggot of ya Carter.
GMCarter - 19 Apr 2007 11:44 GMT snip
>No, they died because of perverted faggot sex. Nope--they died from HIV infection that led to AIDS.
You're lying yet again--but that's no surprise!
Just stay away from Virginia Tech. They don't need any more of your kind there.
Death - 19 Apr 2007 16:48 GMT "GMCarter" <fiar@verizon.net> wrote in message
> " Death" <Death@yourdoor.net> > > > snip > >No, they died because of perverted faggot sex. > > Nope--they died from HIV infection that led to AIDS. Yep, a direct result of personal behavior, perverted faggot sex.
> You're lying yet again--but that's no surprise! If that helps you sleep nights, kewl. Absent the perverted faggot sex, they would not have gotten HIV infection that led to AIDS.
You continue to cry about drugs, but that comes long after the behavior that led to AIDS, that being: sticking your dick in a sh.t-hole or having a dick stuck in yours.
GMCarter - 20 Apr 2007 11:45 GMT >"GMCarter" <fiar@verizon.net> wrote in message > [quoted text clipped - 6 lines] >> >Yep, a direct result of personal behavior, perverted faggot sex. Huh...you want to talk about the horrors of lifestyle choices? Of course, a hideous nasty piece of sh.t like you never has sex, so perhaps it's moot.
But look at the vile hetero lifestyle! They lie to each other, cheat on each other, beat, maim and murder each other. They have children they hate, harm, beat, abandon and kill! They f.ck each other in the a.s. They eat each other's genitals. They sh.t and urinate on each other. They do drugs, they drink and smoke and inject things, drop pills by prescription in the tons--heteros are so vile and disgusting.
One can only hope they'll see the light, turn queer and stop burdening the planet with so many unwanted and unsupportable children!
Undoubtedly, irony is lost on you.
George M. Carter
Death - 20 Apr 2007 16:46 GMT "GMCarter" <fiar@verizon.net> wrote in message
> Huh...you want to talk about the horrors of lifestyle choices? Of > course, a hideous nasty piece of sh.t like you never has sex, so > perhaps it's moot. lol, poor bitter Killer Karter. Yes, lets talk about the horrors of lifestyle choices.
> But look at the vile hetero lifestyle! They lie to each other, cheat > on each other, beat, maim and murder each other. They have children > they hate, harm, beat, abandon and kill! They f.ck each other in the > a.s. They eat each other's genitals. They sh.t and urinate on each > other. They do drugs, they drink and smoke and inject things, drop > pills by prescription in the tons--heteros are so vile and disgusting. yep, that is faggots to a tee.
> One can only hope they'll see the light, turn queer and stop burdening > the planet with so many unwanted and unsupportable children! Indeed, abort all faggots and aids will die out in one generation.
> Undoubtedly, irony is lost on you. Not at all. I hope you can say the same.
HIV Positive - 12 Apr 2007 15:01 GMT >I'm gay. I live in NYC. I joined ACT UP in 1989. I did performance art >in the 80s. I think that brings me into contact with a lot of at risk >people. Well, I think that just goes to prove my point about you befriending people who are dying. Or, in this case, those you think are dying.
People involved with ACT UP probably all follow the HIV=AIDS=Death idea. Once people have been conditioned to believe they are infected with a deadly virus and will die, it's hardly surprising the prognosis comes true.
 Signature URL: http://hiv.positive.googlepages.com/ Moible: +447939991519
DavidT - 12 Apr 2007 10:09 GMT You clearly haven't been paying attention for the last decade or so. What makes you think all doctors subscribe to the HIV=AIDS=Death concept? This is something the denialists have been saying, but please show us some evidence that it is the prevailing dogma as you say it is. Links to orthodox medical sites would do. I won't hold my breath
FYI, not everyone with HIV may necessarily go on to develop AIDS, for a variety of reasons. And not everyone with AIDS may die from it - average survival following starting "highly toxic" ART is now 35 years (as compared to survival of less than 2 years without ART).
rocketscience - 12 Apr 2007 14:38 GMT > You clearly haven't been paying attention for the last decade or so. > What makes you think all doctors subscribe to the HIV=AIDS=Death [quoted text clipped - 8 lines] > average survival following starting "highly toxic" ART is now 35 years > (as compared to survival of less than 2 years without ART). Yes that is correct, not only people are living 35 year with HIV.
They are doing it on NO DRUGS.
The HIV drugs are poisons and cause a list of adverse side effects leading to liver failure.
HIV drugs are a form of iatrogenic genocide. The HIV drugs (intentionally or not) such as AZT
eliminated a segment of the population considered as "undesirebale", namely IV drug addicts, minority groups and
homosexuals like your partner, Carter.
see this video:
http://www.hiv-aids-factorfraud.com/
http://aidsmyth.addr.com/enteraidsmyth.htm
We are a global-reach voluntary group. Our goal is ensuring the interests of AIDS-diagnosed people are no longer secondary to the interests of drug suppliers, service providers and the AIDS research industry.
Did You Know that many experts now contend AIDS is not a fatal, incurable condition caused by HIV?
We bring you the voices of alternative scientists and reforming campaigners worldwide. We are independent of vested pharmaceutical and medical interests -offering readers and forum members, global news and leading edge views on diagnosis and treatment.
Most of the information you receive is commercially driven and based on misleading assumptions or unfounded estimates and predictions. The symptoms associated with AIDS are treatable using non-toxic, immune enhancing therapies that have restored health and have enabled those truly at risk to remain well.
rocketscience
RJ - 13 Apr 2007 16:00 GMT > http://aidsmyth.addr.com/enteraidsmyth.htm > [quoted text clipped - 19 lines] > > rocketscience I notice you have a link there for Continuum. Continuum is no longer published because Huw Christie and Jody Wells died of AIDS. Why weren't their symptoms treatable? Why did they not remain well? Any ideas?
DavidT - 13 Apr 2007 18:25 GMT > I notice you have a link there for Continuum. Continuum is no longer > published because Huw Christie and Jody Wells died of AIDS. Why > weren't their symptoms treatable? Why did they not remain well? Any > ideas? They never took toxic antiretrovirals either, did they? And here was me thinking that NOT taking drugs if you were HIV positive was a sure fire way of living forever. ;)
rocketscience - 14 Apr 2007 09:23 GMT > >http://aidsmyth.addr.com/enteraidsmyth.htm > [quoted text clipped - 26 lines] > > - Show quoted text - Why did you kill Arthur Ashe and 250,000 countless others with AZT?
Anti-HIV drugs are highly toxic poisons which esentially eliminate the IV drug addicts, homosexuals and the minority groups from society.
Anti-HIV drugs = iatrogenic genocide.
rocketscience
GMCarter - 14 Apr 2007 10:58 GMT snip
>Why did you kill Arthur Ashe and 250,000 countless others with AZT? AZT monotherapy sucked and some of us knew it at the time.
AIDS killed Arthur Ashe and countless others. Most people die from AIDS without ever seeing ARV.
Why do you persist in lying?
RJ - 15 Apr 2007 01:10 GMT On Apr 14, 4:23 am, "rocketscience" <rocketscience13...@gmail.com> wrote:
> > >http://aidsmyth.addr.com/enteraidsmyth.htm > [quoted text clipped - 35 lines] > > rocketscience Standard tactic - can't answer the question so throw out one of your own. If HIV drugs really do what you're saying, why do so few people die or experience toxicity during long term follow up in trials? Why did people in the SMART study that interrupted therapy do worse than those that continued (all of the >5,000 people in that study had been on ARVs for an average of six years prior to even joining the trial - what was that about toxic poison?).
Where did you get that 250,000 figure by the way? Have you seen the IMS data for the number of AZT scrips that were filled in the time period you're referring to? Hint: it is not compatible with the number you picked up from some denialist website.
rocketscience - 15 Apr 2007 18:01 GMT > On Apr 14, 4:23 am, "rocketscience" <rocketscience13...@gmail.com> > wrote: [quoted text clipped - 53 lines] > > - Show quoted text - How long have you been working for the drug industry?
DavidT - 16 Apr 2007 09:25 GMT On 15 Apr, 18:01, "rocketscience" <rocketscience13...@gmail.com> wrote:
> > On Apr 14, 4:23 am, "rocketscience" <rocketscience13...@gmail.com> > > wrote: [quoted text clipped - 57 lines] > > - Show quoted text - LOL- I quote RJ again - "Standard tactic - can't answer the question so throw out one of your own."
GMCarter - 16 Apr 2007 11:32 GMT snip
>> How long have you been working for the drug industry?- Hide quoted text - >> >> - Show quoted text - > >LOL- I quote RJ again - "Standard tactic - can't answer the question >so throw out one of your own." And an ad hominem one at that. Typoical Frodlet/Rove activity.
On the other hand, I cannot recommend strongly enough that people read "The Truth About the Drug Companies" by Marcia Angell, MD. Excellent book. Refutes lies such as that it costs $800 million to bring a drug to market.
Thanks for the research on CD4 count variability, David. That was interesting.
George M. Carter
Death - 18 Apr 2007 17:30 GMT "GMCarter" <fiar@verizon.net> wrote in message
> On the other hand, I cannot recommend strongly enough that people read > "The Truth About the Drug Companies" by Marcia Angell, MD. Excellent > book. Refutes lies such as that it costs $800 million to bring a drug > to market. That you would want drugs placed on the market quick-time is not in question.
The epidemic of AZT and other anti-HIV/AIDS medications
4.1. DNA terminators licensed as a cure. In 1987 the American and European illicit drug epidemic had been joined by a new epidemic of toxic legal drugs, the DNA chain-terminators, such as AZT, that are prescribed to hundreds of thousands of HIV-positives together with a litany of other orthodox and unorthodox anti-HIV/AIDS drugs (see 4.2. and Table 7). In America AZT was licensed in record time as an antiviral drug in 1987 by the Food and Drug Administration (FDA) based on studies conducted by its sister institutions from the Department of HHS, the National Cancer Institute 147 and the NIAID 148 together with the drug's manufacturer Burroughs Wellcome.
The fast approval of AZT" despite its inherent toxicity" was a major coup of AIDS researchers 149. By going public more aggressively than any other scientists before, American AIDS researchers from the NIAID, NCI and CDC had mobilized patients, homosexual AIDS risk groups and journalists to demand protection from the predicted AIDS explosion at any cost. As a result of this pressure the FDA and AIDS researchers fast-tracked first the approval of AZT and then that of ever-more untested anti-HIV/AIDS drugs 150. Surprisingly, all of these drugs were eagerly welcomed by the medical and public press and above all by unsuspecting AIDS patients. The politics behind the approval of AZT first by the FDA and the American medical orthodoxy, and then by the rest of the world has been described in two recent books, Good intentions 151 and Inventing the AIDS Virus 11.
AZT and other DNA chain-terminators are now used both as AIDS prophylaxis and therapy in the hope that they will terminate HIV DNA synthesis without terminating cell DNA synthesis 152. However, there are several problems with this optimistic plan:
1) The licensing study conducted in 1986 by the National Cancer Institute (NCI) and Burroughs Wellcome had erroneously underestimated the toxicity of AZT for human cells a 1000-fold 147! Although at least 7 independent studies have since pointed out this 1000-fold error 153-159, the recommended prescription dose has only been reduced 3-fold, from 1.5 g of AZT per day in 1987 to 0.5 g now 160, 161.
2) The initial success of the American clinical licensing study conducted by the NIAID and Burroughs Wellcome, that claimed a 19-fold reduced AIDS-mortality 148, could not be reproduced by numerous independent studies from other countries, including the UK 162, France 163, The Netherlands 164, Australia 165, and also not by an independent American study that was not suppo
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