drdach wrote:
Use of HIV as Vehicle for Gene Therapy:
Bio-Technology companies are gearing up to make bug bucks by injecting
HIV into people. I am not making this up. Turns out that HIV is an
excellent vehicle for gene thereapy for diseases like cystic fibrosis,
muscular dystrophy, hemophilia, retinitis pigmentosa, and maybe even
Alzheimer's disease. Don't worry about getting AIDS, they say is
perfectly safe. (see below)
HIV is being developed as a delivery system to provide successful gene
therapy in many diseases such as metabolic diseases, cancer, viral
infection, cystic fibrosis, muscular dystrophy, hemophilia, retinitis
pigmentosa, and maybe even Alzheimer's disease
Adler, Gifford, and Sumner; Naldini et al.; Amado and Chen, 1999
http://biology.kenyon.edu/slonc/gene-web/Lentiviral/Lentivi2.html
The use of HIV retroviral vectors for delivery of genes has been well
established in the last few years. Their properties make them
attractive for use in gene therapy since the products are stably
expressed due to integration into the cell chromosome, and seem to be
non-immunogenic.
http://www.stanford.edu/group/nolan/retroviral_systems/helix.html
Human immunodeficiency virus (HIV) is a highly efficient vehicle for
gene therapy . However safety is of major concern. We use the
complexity of HIV to provide safety features.
A third-generation lentivirus vector with a conditional packaging
system.
Dull T, Cell Genesys, Foster City, J Virol. 1998 Nov;72(11):8463-71.
http://jvi.asm.org/cgi/content/full/72/11/8463?view=long&pmid=9765382
Retroviral vectors are attractive tools for human gene therapy.
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene
Delivery
Romain Zufferey, Thomas Dull, Journal of Virology, December 1998, p.
9873-9880, Vol. 72, No. 12
http://jvi.asm.org/cgi/content/full/72/12/9873?view=long&pmid=9811723
In our laboratory we routinely produce and apply vectors derived from
the human immunodeficiency virus type 1 (HIV-1).
Comparison of HIV lentiviral vector titration methods.
Martine Geraerts1 , Sofie Willems1 , Veerle Lab for Mol Virology and
Gene Therapy, Flanders, Belgium BMC Biotechnology 2006, 6:34
doi:10.1186/1472-6750-6-34
http://www.biomedcentral.com/1472-6750/6/34
regards from www.drdach.com
brainfart - 22 Oct 2006 15:28 GMT
jdach wrote...
> The use of HIV retroviral vectors for delivery of genes has been well
> established in the last few years. Their properties make them
[quoted text clipped - 7 lines]
> gene therapy . However safety is of major concern. We use the
> complexity of HIV to provide safety features.
This is terrifying and it should be outlawed immediately. I'm all for
biotechnology, but this involves inserting foreign genes into the
most horrible virus on earth, not only risking that the patient might
suffer disease from the modified virus, but also that the altered virus
might be contagious and contaminate the general population with the
engineered genes.
They show their arrogance by claiming they have built various safety
features into the retrovirus, when if science really understood the
virus that thoroughly it would have found a cure or at least a vaccine
already. There will be unintended consequences that we can't even
imagine; for example, a virus modified with a corrective gene for
muscular dystrophy might cause the retrovirus to sprout legs and be
able to walk across great distances to find new hosts, rather than
requiring physical contact with body fluids. At the very least, the
modifications might cause airborne transmission or increased virulence.
tariq.1.rahim@spamgourmet.com - 04 Nov 2006 02:06 GMT
> jdach wrote...
> > The use of HIV retroviral vectors for delivery of genes has been well
[quoted text clipped - 8 lines]
> > gene therapy . However safety is of major concern. We use the
> > complexity of HIV to provide safety features.
we need more postings to alt.fan.unabomber. much more.
this group is dying.
Death - 04 Nov 2006 17:16 GMT
<tariq.1.rahim@spamgourmet.com>
MSNBC.com
Nov 4, 2006
EL CERRITO, Calif. - A man was arrested on suspicion of carrying a concealed weapon after
police found him outdoors - naked - and he told them he had a tool in his rectum, authorities
said.
The man was lying on a tree stump, masturbating beside a nature path, near a Bay Area Rapid
Transit station Thursday, police said.
John Sheehan, 33, of Pittsburg, was initially arrested on suspicion of indecent exposure. But
when asked whether he was carrying anything police should know about, Sheehan mentioned the
tool, said El Cerrito Detective Cpl. Don Horgan.
"You can't get much more concealed than that," Horgan said.
Officers drew their weapons and firefighters were called to the scene. Sheehan removed a 6-inch
metal awl wrapped in black electrical tape without incident.
Sheehan, who was paroled from state prison last week, was then booked into jail on suspicion of
parole violations, indecent exposure and one felony count of possessing a concealed weapon.
"When you're talking about an awl or an ice pick and you're dealing with somebody who's fresh
out of prison, it's a weapon. That's a stabbing instrument," Horgan said.
It was not immediately clear what Sheehan was on parole for. A person answering the phone at
the jail Friday night did not know whether Sheehan had a lawyer.
© 2006 The Associated Press.
Chris Noble - 23 Oct 2006 02:22 GMT
> drdach wrote:
>
[quoted text clipped - 51 lines]
>
> regards from www.drdach.com
Don't worry there is no evidence that HIV exists
http://www.theperthgroup.com/SCIPAPERS/MHMONT.pdf
Chris Noble
Death - 24 Oct 2006 16:10 GMT
"jdach" <drdach@drdach.com> wrote in message
> Bio-Technology companies are gearing up to make bug bucks by injecting
> HIV into people. ...
Aids experts demand sacking of S Africa's health minister
JOHANNESBURG - More than 80 international scientists, including a Nobel laureate, have appealed
to South Africa's president to fire his controversial health minister for what they say are
"pseudo-scientific" policies on Aids.
Calls for the dismissal of Health Minister Manto Tshabalala-Msimang for promoting alternative
treatments have grown since last month's global Aids conference in Toronto.
Experts have criticised President Thabo Mbeki's government for underplaying anti-retroviral
(ARV) drugs and promoting home-grown Aids treatments such as garlic, beetroot and lemon at the
conference.
"To have as health minister a person who now has no international respect is an embarrassment
to the South African government," said the letter, dated September 4.
"We therefore call ... for an end to the disastrous, pseudo-scientific policies that have
characterised the South African government's response to HIV/Aids."
South Africa is the centre of Africa's Aids pandemic with some 5.4 million HIV/Aids cases.
A government Aids plan launched in 2003 promised to treat 380,000 people by now, but it has
only achieved half of the target, said the letter, which appeared on an Aids activists' website
www.aidstruth.org/letter-to-mbeki.php
"Many people are therefore dying unnecessarily," it said.
Among the letter's 82 signatories are David Baltimore, who won the Nobel Prize in medicine in
1975, and Robert Gallo, who co-discovered that the HIV virus was the cause of Aids.
Mbeki's spokesman confirmed the scientists' letter had been received by the president's office,
but said Mbeki may not have read it since he has been busy this week with the visit of Russian
President Vladimir Putin.
The government says it has one of the biggest ARV drug treatment programmes in the world but
also insists nutrition and traditional medicine must be an integral part of the plan to treat
HIV/Aids.
But the scientists said they were worried about unproven remedies for Aids being marketed in
South Africa, some which have the implicit or explicit support of the health minister.
"We condemn all those who profit from this type of quackery, at the expense of the sick and
dying," the letter said.
A new study last month said South Africa faced close to 9 million new HIV cases by 2025 if the
crisis was not contained.
Zachie Achmat of the Treatment Action Campaign, which launched protests against the health
minister last month, welcomed the letter.
"This gives our president the opportunity to unite the whole country (on the Aids crisis) and
deal with the biggest obstacle to that unity, which is the health minister," he said.
- REUTERS