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Medical Forum / Diseases and Disorders / AIDS / April 2006

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HIV's 3D structure revealed

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DavidT - 24 Jan 2006 13:24 GMT
http://news.bbc.co.uk/1/hi/health/4642940.stm

Do "vesicles" look like this?
DavidT - 24 Jan 2006 13:37 GMT
"Cryo EM has allowed Prof Fuller's team to take a closer look at what
happens after HIV invades our cells at a resolution of about two
thousandths of a millionth of a metre, enough to show the shape of the
protein building blocks but not to see component atoms.

Using inactivated forms of HIV that keep the same shape but can be
handled safely, his team focused on the infectious stage of the
viruses' life cycle to help ensure they were the same size. While the
viruses were bathed in a thin layer of supercooled water, so they did
not dry out, they were gradually tilted in a series of steps and
separate images taken.

By using a computer to combine hundreds of separate images, each taken
at a different tilt, the team could examine the three- dimensional
structure of each virus in detail that is usually only obtainable with
X-rays. The result is a tomogram, rather than a two-dimensional image,
so they were able to examine the 3D anatomy of the virus or use a
computer to make a slice by slice image. "We now have determined
three-dimensional structures for around 70 HIV virus particles," said
Prof Fuller "The result, the first tomograms of authentic HIV, teaches
us how a variable structure assembles to produce an infectious agent."

http://www.telegraph.co.uk/connected/main.jhtml?xml=/connected/2006/01/10/ecrhiv
10.xml&sSheet=/connected/2006/01/10/ixconnrite.html

Chris Noble - 24 Jan 2006 23:09 GMT
> "Cryo EM has allowed Prof Fuller's team to take a closer look at what
> happens after HIV invades our cells at a resolution of about two
[quoted text clipped - 19 lines]
>
> http://www.telegraph.co.uk/connected/main.jhtml?xml=/connected/2006/01/10/ecrhiv
10.xml&sSheet=/connected/2006/01/10/ixconnrite.html

The abstract for the scientific article is available here:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=16407061&query_hl=2&itool=pubmed_docsum


It is worth reading. Here's a small quote:"Concentrated, high-titer
(w109 infectious units per ml) preparations of HIV-1 particles with
minimal contamination of cellular vesicles were obtained as described
previously (Welker et al., 2000). The quality of the preparation can be
judged from Figure 1A"

On the website they have included a cool animation in the supplementary
information where they rotate virus particles in 3D.

The same group has previously published this article which is
avalialble free.

http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=12660176
http://www.pubmedcentral.gov/picrender.fcgi?artid=152888&blobtype=pdf

It has very nice cEM pictures of HIV. Indeed, I have posted links to it
many, many, many times.

Chris Noble
Iconoclaster - 26 Jan 2006 01:42 GMT
From the article:

"Unlike most of its fellow viruses, infectious HIV varies wildly in size
over its life cycle, from just under 100 nanometres to 350 nm."

WoooHaaaaaaahahahahahahahahahaha!!

My dear gullible friends: "Unlike most"?  There is NO virus in existence
that varies in size by a factor 3.  Vesicles do.  Materials that have to
be transported out of a cell must do so by budding from the cell mambrane.
So they take some of the membrane lipids with them as a vesicle.  Of
course the size of this vesicle depends on what is being transported.  But
a virus capsid has a fixed size, so the envelope around it should also be
of one size only.
wilyretrovirus - 26 Jan 2006 13:18 GMT
From the article:

"Unlike most of its fellow viruses, infectious HIV varies wildly in size
over its life cycle, from just under 100 nanometres to 350 nm."

>WoooHaaaaaaahahahahahahahahahaha!!

>My dear gullible friends: "Unlike most"?  There >is NO virus in
existence
>that varies in size by a factor 3

If we're expected to believe all the other "Alice in Wonderland" claims
about "HIV", why shouldn't we believe this one as well?
Chris Noble - 26 Jan 2006 21:04 GMT
> From the article:
>
[quoted text clipped - 5 lines]
> My dear gullible friends: "Unlike most"?  There is NO virus in existence
> that varies in size by a factor 3.

Never say never.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=14963166&query_hl=2&itool=pubmed_docsum

http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=14963166
http://www.pubmedcentral.gov/picrender.fcgi?artid=369243&blobtype=pdf

"The virions showed the broad range of diameters typical of
retroviruses."

"cEM permits reliable measurement of virus diameter, avoiding the
problems associated with viral membrane collapse when using
conventional techniques (11, 17). The diameters of viruses were
measured to the outer edge of the lipid bilayer. The three preparations
exhibited mean particle diameters of 130 ± 18 nm (n = 150), 129 ± 18
nm (n = 150), and 141 ± 14 nm (n = 300), with virus diameter ranging
between 50 and 210 nm. The mean diameter is significantly smaller than
that observed after negative staining (180 nm) and similar to that
observed after freeze drying (125 nm) (11). Data from preparations 1
and 2 were combined (Fig. 3) and exhibit a size distribution of a
breadth similar to that of HIV-1 (2) (Fig. 3). The large range of
diameters observed is typical of retrovirus preparations (2, 9, 17). In
most retroviruses, the Gag protein shell assembles either at the plasma
membrane or on an internal membrane and the lipid bilayer plays a
significant role in the assembly process (1). Assembly of Gag protein
and nucleic acid in vitro in the absence of a lipid bilayer leads to
the production of particles that are more homogeneous in size (16, 18).
Betaretroviridae species, in contrast, assemble their Gag protein
shells in the cytoplasm. The dramatic range in diameters seen within
retrovirus preparations, therefore, does not result solely from the use
of the lipid bilayer as an assembly platform."

Once again Iconoclaster's "textbook science" comes straight out of the
wrong orifice.

Chris Noble
wilyretrovirus - 26 Jan 2006 21:39 GMT
Chris,

I'm curious to see what Iconoclaster has to say about this.

Until then, I don't think the size of a make-believe virus ends up being
terribly important.
Iconoclaster - 31 Jan 2006 01:59 GMT
Mr. Noble, I've heard from various sources you're a con artist, but now I'm
sure of it.

First you cite 3 references.  Two of the links don't work, and the
remaining one leads to a paper pointing out that continuous poisoning with
HAART drugs is much better than allowing interruptions.

Then you include some text, supposedly from these references, that deals
with particles that are uncritically assumed to be "HIV", and shows that
these "somethings" vary in size.
Well, my point was that no virus varies significantly in size.  This is
only claimed for that magical virus, "HIV", because otherwise they cannot
explain the phenomenon of a heterogeneous collection of vesicles with
varying payloads.
Chris Noble - 31 Jan 2006 21:03 GMT
> Mr. Noble, I've heard from various sources you're a con artist, but now I'm
> sure of it.
>
> First you cite 3 references.  Two of the links don't work, and the
> remaining one leads to a paper pointing out that continuous poisoning with
> HAART drugs is much better than allowing interruptions.

PEBCAK.
All links work perfectly well.

All three links point to one single article that deals with
Cryoelectron microscopy of mouse mammary tumor virus. J Virol. 2004
Mar;78(5):2606-8.

One was to the abstract on Pubmed  PMID: 14963166
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=14963166&query_hl=2&itool=pubmed_docsum


The other two were to the full article that is available free on
pubmedcentral.
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=14963166

None of them mention HAART.

> Then you include some text, supposedly from these references, that deals
> with particles that are uncritically assumed to be "HIV", and shows that
> these "somethings" vary in size.

The papers are about mouse mammary tumor virus! Did you read the
titles?

> Well, my point was that no virus varies significantly in size.  This is
> only claimed for that magical virus, "HIV", because otherwise they cannot
> explain the phenomenon of a heterogeneous collection of vesicles with
> varying payloads.

Your point was a load of bullshit.

MMTV varies significantly in size. Look at the results.
Or will you simply deny the reality?

Try lying more convincingly next time.

Chris Noble
Iconoclaster - 01 Feb 2006 02:38 GMT
>"All links work perfectly well."

They do now.  But just go back to your post of Jan.26, and click on the
links.  Two of them don't work, and the third is irrelevant.

But let's stick with the links you give in your latest post of Jan. 31st.
They do work.
This paper, being from the same comic duo Briggs - Fuller, also mentions
the variability in size of MMTV.  Small wonder:  They're the same guys of
the  "HIV in 3D" paper.  And yes, also in this paper they mention HIV as a
comparison.  Never before did I see such a line of reasoning toward a
preconceptual result.  The comparison of the size distributions of HIV and
MMTV in fig. 3 should make anybody suspicious of this work.  Comparison
with a virus that has never been obtained in pure form?  Hm, peculiar...
It is not so surpring that the size of a lipid envelope varies with the
payload.  If 2 cores of whatever must be accomodated, a bigger vesicle is
required.
A virus capsid is produced by self-assembly, according to strict geometric
principles.  Usually around a nucleic acid structure.  But that's not
absolutely necessary, as some virus preparations show empty protein
capsids.  So building up the core around the RNA (as the authors suggest)
is not required.
What the virus core drags along from  the host cell when it buds from the
mebrane may indeed be variable.
As the authors also had "HIV" on culture, they may have handled their MMTV
culture in the same sloppy way that is customary in "HIV science.
No, this paper does not look convincing to me.  And I doubt it will
convince other colleagues.
Chris Noble - 01 Feb 2006 04:39 GMT
> >"All links work perfectly well."
>
[quoted text clipped - 24 lines]
> No, this paper does not look convincing to me.  And I doubt it will
> convince other colleagues.

Do you have any comments that directly address aspects of the paper.

Your entire argument boils down to "it can't be HIV becasue HIV doesn't
exist". Preconceptual thinking.

Here is another study on MuLV again showing considerable variation in
size.

http://www.pubmedcentral.gov/picrender.fcgi?artid=22596&blobtype=pdf

So lets recapitulate  the evidence so far:

Iconoclaster:  Well, my point was that no virus varies significantly in
size.

Me: Here are three papers showing that virions of Rous sarcoma virus,
mouse mammary tumor virus and murine leukemia virus all vary
significantly in size.

Iconoclaster:  Well, my point was that no virus varies significantly in
size.

Simply saying "because I said so" doesn't go far in science. Do you
have any papers to support your claim?

Chris Noble
DavidT - 01 Feb 2006 13:19 GMT
>Simply saying "because I said so" doesn't
>go far in science. Do you have any
>papers to support your claim?

I wouldn't hold your breath Chris...
Iconoclaster - 08 Feb 2006 00:46 GMT
>"I wouldn't hold your breath Chris..."

Wrong again.
Gary Stein - 06 Feb 2006 21:22 GMT
Chris;

Claster is such a fool it is probably the length of your links that is
causing his problems with links not working. I recommend that you include a
link created by the TinyURL.com website as well as the full link in your
posts then Claster will have no excuse when it comes to links not working.

Just go to http://tinyurl.com/ and it will explain to you how to use the
service. I find the most reliable method is to have the special TinyURL Link
in the toolbar of my browser. Once this is on your toolbar, you'll be able
to make a TinyURL at the click of a button. By clicking on the toolbar
button, a TinyURL will be created for the page you are currently at. You can
then simply copy it and post it into any document, email, or Usenet message.

Gary Stein

>> >"All links work perfectly well."
>>
[quoted text clipped - 55 lines]
>
> Chris Noble
Iconoclaster - 08 Feb 2006 00:44 GMT
>"Simply saying "because I said so" doesn't go far in science. Do you have
any papers to support your claim?"

Sure.  But they're older, and not on the web.  Here's a classic:

D.L.D. Caspar & A. Klug (Sir Aaron to you): Physical principles in the
construction of regular viruses,  Cold Spring Harbor Symp. Quant. Biol.
27, 1 (1962)

And:
A. Klug, W. Longley, R. Leberman: Arrangement of protein subunits and the
distribution of nucleic acid in Turnip Yellow Mosaic Virus. I. X-ray
diffraction studies,  J. Mol. Biol. 15, 315 (1966)

J.T. Finch & A. Klug: Arrangement of protein subunits and the distribution
of nucleic acid in Turnip Yellow Mosaic Virus,  J. Mol. Biol. 15, 344
(1966)
Chris Noble - 08 Feb 2006 01:08 GMT
> >"Simply saying "because I said so" doesn't go far in science. Do you have
> any papers to support your claim?"
[quoted text clipped - 13 lines]
> of nucleic acid in Turnip Yellow Mosaic Virus,  J. Mol. Biol. 15, 344
> (1966)

You appear to have some major problems with logic.

You made the statement that no viruses vary significantly in size.

Giving examples such as TYMV that do have regular sizes does not prove
your statement.

On the other hand when I give you several examples of viruses that do
show significant size variations it directly falsifies your claim.

To use an analogy again. You say all swans are white and produce 3
photographs of white swans. I produce 3 photographs of black swans. Is
the statement "all swans are white" true or false.

It is a demonstrable fact that not all viruses are as regular as TYMV.

Can you get in contact with Sir Aaron Klug and ask him to confirm your
claim that no virus varies significantly in size?

You may want to ask why he has his name on HIV research.
http://tinyurl.com/e262f

Chris Noble
Iconoclaster - 08 Feb 2006 23:52 GMT
>"On the other hand when I give you several examples of viruses that do
show significant size variations it directly falsifies your claim."

You did no such thing.  Three of those papers were crap.  Only the
excellent 1976 paper came up with size distributions for 3 known
retroviruses.  But these distributions were by no means as broad as the
factor 3 present-day virus-hacks want to sell us.
Those measurements and purifications were a tour de force, by the way.  
It's amazing they got distributions that were relatively sharp.

O have an idea:  Why don't you try these same methods they used 30 years
ago on HIV?  I could use a good laugh.

>"Can you get in contact with Sir Aaron Klug and ask him to confirm your
claim that no virus varies significantly in size?"

I probably could, but haven't seen him for years.

>"You may want to ask why he has his name on HIV research."

Cigarette money, I guess.  He's the 7th author, out of 8.  All this
genetics sh.t is definitely not his bag.  Maybe he drove the getaway car.
Chris Noble - 09 Feb 2006 00:29 GMT
> >"On the other hand when I give you several examples of viruses that do
> show significant size variations it directly falsifies your claim."
>
> You did no such thing.  Three of those papers were crap.

Crap? Because you say so? Isn't it a bit obvious that you reject any
papers that contradict your beliefs. This is the thing about Denialism.
You keep following the same trajectory you are locked into you end up
denying all aspects of science.

> Only the
> excellent 1976 paper came up with size distributions for 3 known
[quoted text clipped - 10 lines]
>
> I probably could, but haven't seen him for years.

Well go on. Just do it.

While you are at it contact the University of Leiden and see if you can
arrange to do experiments on HIV there.

> >"You may want to ask why he has his name on HIV research."
>
> Cigarette money, I guess.  He's the 7th author, out of 8.  All this
> genetics sh.t is definitely not his bag.  Maybe he drove the getaway car.

Why did he sign the Durban Declaration?

Is this genetics sh.t your bag? You keep on trying to convince someone,
perhaps yourself, that RNA viruses don't generally mutate.

Chris Noble
Iconoclaster - 09 Feb 2006 03:06 GMT
>"You keep following the same trajectory you are locked into you end up
denying all aspects of science."

Well, excuse me!  I didn't recognize it as science when I looked at it.

>"Why did he sign the Durban Declaration?"

I don't know.  But he's older than I am, so...

>"Is this genetics sh.t your bag? You keep on trying to convince someone,
perhaps yourself, that RNA viruses don't generally mutate."

Will you stop saying that?  You always take it out of context anyway.  And
yes, I have a hangup with geneticists.  Too much hot air.
Chris Noble - 09 Feb 2006 04:01 GMT
> >"You keep following the same trajectory you are locked into you end up
> denying all aspects of science."
[quoted text clipped - 10 lines]
> Will you stop saying that?  You always take it out of context anyway.  And
> yes, I have a hangup with geneticists.  Too much hot air.

I'll keep on quoting you as long as I like.

The sentences that follow that one do nothing to make the statement any
truer. You claim there is no evidence for Viruses mutating in vivo. I
simply point to the high evolution rate in wild circulating viruses
such as influenza virus and poliovirus that demonstrate that these
viruses have high mutation rates.

My experinece is that people have hangups with things they don't
understand. You have very little understanding of genetics. Not only
that you are too lazy to bother learning so you choose to call it hot
air.

Chris Noble
Iconoclaster - 11 Feb 2006 00:24 GMT
>"I'll keep on quoting you as long as I like."

Hey, now that I'm thinking about it, that's great!  That's how one becomes
a prophet - being quoted often.

>"You claim there is no evidence for Viruses mutating in vivo. I simply
point to the high evolution rate in wild circulating viruses
such as influenza virus and poliovirus that demonstrate that these viruses
have high mutation rates."

I can go along with that to some extent in the case of influenza virus.
These viruses have the possibility of reassortment and recombination.  So
we may see a different strain (or strains) every flu season.  But in the
case of polio, with its puny genome, it may not be just hot air, but out
and out swindle.  Please don't forget that the polio vaccines have been
controversial since the fifties, and are mistrusted by many.  And again,
it's big money and big egos that are causing the suspicion.

>"You have very little understanding of genetics."

I'm always first in line when there is something new to learn.  But I
understand something about genetics that few others understand:  They are
overplaying their hand.  And about poker, I do know.
Brian Mailman - 11 Feb 2006 03:35 GMT
>>"I'll keep on quoting you as long as I like."
>
> Hey, now that I'm thinking about it, that's great!  That's how one becomes
> a prophet - being quoted often.

Helter skelter!
Chris Noble - 11 Feb 2006 05:18 GMT
> >"I'll keep on quoting you as long as I like."
>
> Hey, now that I'm thinking about it, that's great!  That's how one becomes
> a prophet - being quoted often.

Dan Quayle was quoted often.

> >"You claim there is no evidence for Viruses mutating in vivo. I simply
> point to the high evolution rate in wild circulating viruses
[quoted text clipped - 4 lines]
> These viruses have the possibility of reassortment and recombination.  So
> we may see a different strain (or strains) every flu season.

The new strain that is seen every year is different because of genetic
drift (ie point mutations) not genetic shift. The genetic drift is up
to 1% in the hemagglutin and neuraminidase genes. The circulating
strains (in humans) of influenza A have been H3N2 and H1N1. The
Spansish/1918 flu is not believed to have arisen through recombination
but through the mutation of a non-human virus to one that is capable of
virulently infecting humans.

> But in the
> case of polio, with its puny genome, it may not be just hot air, but out
> and out swindle.  Please don't forget that the polio vaccines have been
> controversial since the fifties, and are mistrusted by many.  And again,
> it's big money and big egos that are causing the suspicion.

Sure Olen Kew is just in it for the money. Sabin and Salk were just
greedy. The only honest person is Iconoclutter who contributed  ...
what? to the world.

> >"You have very little understanding of genetics."
>
> I'm always first in line when there is something new to learn.  But I
> understand something about genetics that few others understand:  They are
> overplaying their hand.  And about poker, I do know.

You have just demonstrated that you have very little understanding of
the role of genetic drift and genetic shift in the epidemiology of
influenza.

I say you are overplaying your hand. You take a smattering of knowledge
here and there from 40 years ago and then try to pretend you are an
expert.

You repeatedly say things that are demonstrably wrong. You repeatedly
reveal your ignorance.

Chris Noble
wilyretrovirus - 11 Feb 2006 18:05 GMT
"You repeatedly say things that are demonstrably wrong. You repeatedly
reveal your ignorance."

If Iconoclaster is so demonstrably wrong and repeatedly reveals his
ignorance, why the hell are you spending so much time on him?

If what you say is true, then you shouldn't be wasting so much time and
energy on Iconoclaster.  

The fact that there are reams of posts from you, attempting to refute
every little minute point or detail he brings up speaks volumes.
Gary Stein - 11 Feb 2006 19:38 GMT
> "You repeatedly say things that are demonstrably wrong. You repeatedly
> reveal your ignorance."
[quoted text clipped - 7 lines]
> The fact that there are reams of posts from you, attempting to refute
> every little minute point or detail he brings up speaks volumes.

You meant to say, "The fact that there are reams of posts from you, that
refute
every little minute point or detail he  (claster) brings up speaks volumes."
Yes it does speak volumes about clasters inability to absorb any new data
that has been developed since his days in graduate school. Sadly his mind
seems to have shut down at that point and since then been totally unable to
broaden it's knowledge base.

Gary Stein
Iconoclaster - 12 Feb 2006 02:57 GMT
>"Yes it does speak volumes about clasters inability to absorb any new data
that has been developed since his days in graduate school. Sadly his mind
seems to have shut down at that point and since then been totally unable
to broaden it's knowledge base."

Oh come now, Mr. Stein!  You put 29 papers on my plate once, and I did
absorb them.  Had to spit them out again, sorry to say, because there were
lots of things wrong with them.
But it's not really necessary to read up on most of this stuff.  You guys
make it soooo easy for us.  Who needs graduate school?  9-year old Susie
can kick your butts.
Chris Noble - 17 Feb 2006 21:55 GMT
> "You repeatedly say things that are demonstrably wrong. You repeatedly
> reveal your ignorance."
>
> If Iconoclaster is so demonstrably wrong and repeatedly reveals his
> ignorance, why the hell are you spending so much time on him?

That is a very good question. Indeed most people that are far more
intelligent than me do ignore people like him. I should learn something
too.

> If what you say is true, then you shouldn't be wasting so much time and
> energy on Iconoclaster.

Thank you for the advice. I will take you up on it.

> The fact that there are reams of posts from you, attempting to refute
> every little minute point or detail he brings up speaks volumes.

Have you read "Intelligent Design" websites. You will also find
comments there saying that Darwinists spend so much time attempting to
discredit ID they must be afraid. This proves that the holes in
"Darwinism" are now getting so big that the whole theory is about to
collapse. Hell, you don't even have to be an expert in biology to see
all the flaws in the theory.

Iconoclaster asserts that HIV does not exist without providing any
justifiable reasons for this belief. When he does provide reasons such
as "viruses don't generally mutate" he is invariably wrong. You may
call this a minute point but it is not. RNA viruses lack a proof
reading mechanism to correct the errors inherent in all polymerase
enzymes. Sometimes the wrong base is added. All RNA viruses have high
mutation rates. I have provided numerous examples of  viruses such as
influenza and polio that have comparable mutation rates to HIV.

Iconoclaster simply repeates his initial claim and provides no evidence
to support his case. At this stage there will be know people with
scientific training in a biological field that take him seriously. You
can choose to beleive him or not.

Chris Noble
wilyretrovirus - 17 Feb 2006 23:22 GMT
"Have you read "Intelligent Design" websites. You will also find comments
there saying that Darwinists spend so much time attempting to
discredit ID they must be afraid. This proves that the holes in
"Darwinism" are now getting so big that the whole theory is about to
collapse. Hell, you don't even have to be an expert in biology to see all
the flaws in the theory."

Chris, I've never looked at any "Intelligent Design" websites.  I couldn't
care less if there's some sort of debate going on between Darwinists and
the Intelligent Design folks.  I doubt that you're afraid of Iconoclaster,
but you've really spent a good deal of time and energy debating/discussing
with him.  There must be a reason or two for that.

"Iconoclaster asserts that HIV does not exist without providing any
justifiable reasons for this belief. When he does provide reasons such
as "viruses don't generally mutate" he is invariably wrong. You may call
this a minute point but it is not. RNA viruses lack a proof
reading mechanism to correct the errors inherent in all polymerase
enzymes. Sometimes the wrong base is added. All RNA viruses have high
mutation rates. I have provided numerous examples of  viruses such as
influenza and polio that have comparable mutation rates to HIV."

"Iconoclaster simply repeates his initial claim and provides no evidence
to support his case. At this stage there will be know people with
scientific training in a biological field that take him seriously. You can
choose to beleive him or not."

You two can debate the point about mutation all you like.  Whether you or
Iconoclaster "wins", I doubt that I'll suddenly become convinced that HIV
causes AIDS.
Death - 18 Feb 2006 00:22 GMT
"wilyretrovirus" <purfling@nospam.yahoo.com> wrote in message

> You two can debate the point about mutation all you like.  Whether you or
> Iconoclaster "wins", I doubt that I'll suddenly become convinced that HIV
> causes AIDS.

There is one vote for the ham sandwich.
Chris Noble - 18 Feb 2006 01:15 GMT
> "Have you read "Intelligent Design" websites. You will also find comments
> there saying that Darwinists spend so much time attempting to
[quoted text clipped - 6 lines]
> care less if there's some sort of debate going on between Darwinists and
> the Intelligent Design folks.

The point that I am making is that people that see "Intelligent Design"
as a political/religous movement that has a number of negative
consequences are faced with a serious dilemma. Do you ignore them? In
that case IDers claim that "Darwinists" are afraid of a debate because
they know that evolution is full of holes. Do you spend time dealing
with the specific claims made by IDers. In that case IDers claim that
this proves that "Darwinists" are afraid and that evolution is full of
holes. The analogy with HIV "dissidents" is obvious. The reason I use
analogies often is that they enable people to see the issue in
perspective.

> I doubt that you're afraid of Iconoclaster,
> but you've really spent a good deal of time and energy debating/discussing
> with him.  There must be a reason or two for that.

There are several reasons. Firstly I think it is good to respond to
specific claims by people like Iconocluster. That being said people
like Iconocluster rarely make any specific claims. My hope is that
there are people out there who may be skeptical of "HIV science" who
read what I post and then think that maybe they should also be
skeptical of what the "HIV dissidents" say. Iconocluster is
demonstrably wrong in many of his arguments for the non-existence of
HIV. I don't expect you to take my word that there is overwhelming
evidence for the existence of HIV but I also would like to think that
you also apply the same skepticism to people like Iconocluster.

I respect the decisions that people diagnosed with HIV infection make
about their own health even if I do not think they are bcked by the
available evidence. There are long term non-progressors. All ARVs have
differing degrees of side-effects that can be extremely serious. None
of them can clear all HIV from the body. Everybody has to make their
own decision. That decision can and should change when someone's health
changes. I hope that everyone keeps an open mind.

What does annoy me is when people like Iconocluster who has not been
diagnosed with HIV infection starts telling people to ignore their
doctors and not to take ARV. I have absolutely no respect for people
like that.

> "Iconoclaster asserts that HIV does not exist without providing any
> justifiable reasons for this belief. When he does provide reasons such
[quoted text clipped - 13 lines]
> Iconoclaster "wins", I doubt that I'll suddenly become convinced that HIV
> causes AIDS.

Thanks for being honest. There is probably little I could say to
convince you. The scientific arguments are technical.

I do understand how your personal experience has determined your
opinions. I also respect your opinions although I think they are not
supported by the overall evidence. I hope you also respect the opinions
of people who have had different experiences to you. Some people who
post to this newsgroup have been critically ill before they started
taking ARVs. Since taking ARVs for many years they have been well.

I hope that the people you know who are HIV+ continue to keep their
health. If they have been HIV+ for 20+ years and still have high CD4+
counts then it would seem certain that they are indeed long-term
non-progressors. I hope that if they do begin to progress to AIDS that
they keep an open mind about treatment. They may still decide not to
take ARVs and I would personally understand that decision.

Chris Noble
Iconoclaster - 19 Feb 2006 01:37 GMT
>"My hope is that there are people out there who may be skeptical of "HIV
science" who read what I post and then think that maybe they should also
be
skeptical of what the "HIV dissidents" say."

Just when I thought we would never agree on anything, you came through.
Getting people to think for themselves is also my goal.  I'm not looking
for my own flock of disciples. I'm in complete agreement with your
statement.

>"What does annoy me is when people like Iconocluster who has not been
diagnosed with HIV infection starts telling people to ignore their
doctors and not to take ARV."

I'll discourage anybody who is about to commit suicide from actually doing
it.  But the final decision is not mine.  But why should all the
information be one-sided?  Somebody who is fearing for his or her life
should have *all* the available information, not just the orthodox line.
You say something like "well, the ARV's have some nasty side-effects, but
they postpone the moment when you die of AIDS"  (I hope I represented your
view correctly).  I, on the other hand, say: "Those nasty effects of the
ARV's are not side effects, but the main effects.  And dying from ARV's is
more terrifying than dying from any of the AIDS diseases.  Get treated for
what ailment you *really* have.  Forget about AIDS."
Now if everybody would frame those words and hang them over his bed...
GMCarter - 19 Feb 2006 12:33 GMT
>I'll discourage anybody who is about to commit suicide from actually doing
>it.  But the final decision is not mine.  

To the contrary--you will try to discourage people from using
medications that will save their lives. And they wind up dead, like
David Pasquarelli, if they buy your sibilant lies and your abject
ignorance
Iconoclaster - 22 Feb 2006 23:03 GMT
>"And they wind up dead, like David Pasquarelli, if they buy your sibilant
lies and your abject
ignorance"

We've been through this before.  Pasquarelli didn't die until het had
decided to take the toxic drugs after all.
Brian Mailman - 23 Feb 2006 00:02 GMT
>>"And they wind up dead, like David Pasquarelli, if they buy your sibilant
> lies and your abject
> ignorance"
>
> We've been through this before.  Pasquarelli didn't die until het had
> decided to take the toxic drugs after all.

That guy that was killed by lightning a few weeks ago didn't get hit
until he went out to play golf.  Therefore, playing golf means you'll
get hit by lightning.

B/
Chris Noble - 23 Feb 2006 00:48 GMT
> >"And they wind up dead, like David Pasquarelli, if they buy your sibilant
> lies and your abject
> ignorance"
>
> We've been through this before.  Pasquarelli didn't die until het had
> decided to take the toxic drugs after all.

Sure, the PCP, anemia, thrush, meningitis, mycobacterium and CMV that
occured before he started taking ARVs had absolutely nothing whatsoever
to do with his death. He could have just popped an aspirin and been
better the next day.

Chris Noble
Iconoclaster - 23 Feb 2006 01:38 GMT
>"Sure, the PCP, anemia, thrush, meningitis, mycobacterium and CMV that
occured before he started taking ARVs had absolutely nothing whatsoever
to do with his death. He could have just popped an aspirin and been better
the next day."

Well now, that's not exactly what I claimed.  I never knew the man, but I
assume that he was in bad health already.  And then, at the last moment,
the ARV's pushed him over the edge.  He should have taken an aspirin
instead.  Not that I think that would have done him any good, but it still
would have been better than toxic ARV's.
Chris Noble - 23 Feb 2006 04:03 GMT
> >"Sure, the PCP, anemia, thrush, meningitis, mycobacterium and CMV that
> occured before he started taking ARVs had absolutely nothing whatsoever
[quoted text clipped - 6 lines]
> instead.  Not that I think that would have done him any good, but it still
> would have been better than toxic ARV's.

So the PCP, anemia, thrush, meningitis, mycobacterium and CMV were just
some wild coincidence?

Who exactly are you trying to delude with this nonsense?

Chris Noble
wilyretrovirus - 23 Feb 2006 20:16 GMT
"So the PCP, anemia, thrush, meningitis, mycobacterium and CMV were just
some wild coincidence?"

Geez, Chris, is that all they could get on him?  I'm sure if they tried a
little harder they could have diagnosed him with a few more choices from
the "AIDS" smorgasbord.

I wonder how many illnesses they could pin on Christine Maggiore if they
got their dirty little mitts on her?

Not sorry really, if I don't think there's much, if any integrity involved
when it comes to "HIV/AIDS".  
Brian Mailman - 23 Feb 2006 21:58 GMT
> "So the PCP, anemia, thrush, meningitis, mycobacterium and CMV were just
> some wild coincidence?"
[quoted text clipped - 8 lines]
> Not sorry really, if I don't think there's much, if any integrity involved
> when it comes to "HIV/AIDS".  

and like the Bushistas, you say things just to say them.

B/
wilyretrovirus - 23 Feb 2006 21:18 GMT
Chris,
I thought you weren't going to respond to any of Iconoclaster's posts
anymore?

I don't want you to stop responding, though.  I knew you couldn't resist
for long.
Brian Mailman - 23 Feb 2006 21:59 GMT
> Chris,
> I thought you weren't going to respond to any of Iconoclaster's posts
> anymore?
>
> I don't want you to stop responding, though.  I knew you couldn't resist
> for long.

You-all are like a 20-car pileup.  You hate yourself for it, but you
just can't stop watching.

B/
Iconoclaster - 24 Feb 2006 00:00 GMT
>"So the PCP, anemia, thrush, meningitis, mycobacterium and CMV were just
some wild coincidence?"

No coincidence there.  But some people, among which gay men (certainly not
all of them) were engaging in a dangerous and irresponsible lifestyle.
And they had a whole babyboomer generation behind them, trying to tell
everybody that drugs are not bad for you.  They were wrong.  Drugs are bed
for you.  Not only heroin, cocaine, amphetamines and XRC, but also valium,
prozac, and all other kinds of mindfucking drugs.  And let's not forget
ARV's.
But this group would never admit they had been wrong and stupid (talk
about denialists!)  They would rather shirk their responsibility by
accepting a mystery killer virus that some greedy bastard had pulled out
of his hat, so they could blame their ill health on that virus, and go on
taking more drugs.

Just ask yourself this question: Now who's being delusional here?
Chris Noble - 24 Feb 2006 01:02 GMT
> >"So the PCP, anemia, thrush, meningitis, mycobacterium and CMV were just
> some wild coincidence?"
[quoted text clipped - 6 lines]
> prozac, and all other kinds of mindfucking drugs.  And let's not forget
> ARV's.

Are you trying to say that David Pasquarelli was on heroin or cocaine
or amphetamines etc?
Any evidence? Or are you so desperate to come up with an alternative
explanation that you will make up any crap about him that you want. Do
you want to email David's partner and ask him whether David was taking
drugs?

> But this group would never admit they had been wrong and stupid (talk
> about denialists!)  They would rather shirk their responsibility by
[quoted text clipped - 3 lines]
>
> Just ask yourself this question: Now who's being delusional here?

You.

Chris Noble
wilyretrovirus - 24 Feb 2006 02:21 GMT
"Are you trying to say that David Pasquarelli was on heroin or cocaine or
amphetamines etc?
Any evidence? Or are you so desperate to come up with an alternative
explanation that you will make up any crap about him that you want. Do
you want to email David's partner and ask him whether David was taking
drugs?"

Unfortunately, David's ACTUP brethren have been very tight-lipped about
what lead up to David's passing.  David reached a sort of warrior/hero
status amongst some dissidents.  I doubt that his cohorts would be willing
to come forward and let us all know what he was up to health-wise, lest he
fall from his pedestal.  They're not doing the rest of us any favors with
their silence.

I'm not worried about anybody being a "hero".  I just want the madness to
end.  So, despite how many times Georgy-poo invokes the name of his
favorite dead dissident, I'll remain unconvinced that Mr. Pasquarelli died
from the effects of a pretend retrovirus.  We're missing some pieces of
that puzzle, and I'd be willing to bet the folks at ACTUP have those
pieces.  
Chris Noble - 24 Feb 2006 03:18 GMT
> "Are you trying to say that David Pasquarelli was on heroin or cocaine or
> amphetamines etc?
[quoted text clipped - 9 lines]
> fall from his pedestal.  They're not doing the rest of us any favors with
> their silence.

After David died an explanation of the "true" cause of his death was
being promised to come out. That was almost 2 years ago. You can make
up any story you want but the only people you will convince are
yourself and others that don't want to consider the possibility that
HIV killed David Pasquarelli.

> I'm not worried about anybody being a "hero".  I just want the madness to
> end.  So, despite how many times Georgy-poo invokes the name of his
> favorite dead dissident, I'll remain unconvinced that Mr. Pasquarelli died
> from the effects of a pretend retrovirus.  We're missing some pieces of
> that puzzle, and I'd be willing to bet the folks at ACTUP have those
> pieces.

Why don't you pursue the truth? You claim to be interested in the truth
but there is this code of silence amongst Denialists that prevents them
from asking questions about HIV+ people that die with very rare
diseases like PCP and KS.

Chris Noble
wilyretrovirus - 24 Feb 2006 03:43 GMT
"After David died an explanation of the "true" cause of his death was being
promised to come out. That was almost 2 years ago."

Yes, probably for the reason I mentioned.  Don't know though as his
friends remain tight-lipped.

"You can make up any story you want but the only people you will convince
are yourself and others that don't want to consider the possibility that
HIV killed David Pasquarelli."

I'm not making up any stories about what killed him.  Like I said, I bet
the folks at ACTUP have more than a clue about this.  

Yeah, I do wonder how an ordinary retrovirus (didn't you call it that?)
can wreak so much profitable havoc.  I wonder even more how a pretend
retrovirus can do all the damage attributed to it.
wilyretrovirus - 24 Feb 2006 04:15 GMT
"Why don't you pursue the truth? You claim to be interested in the truth
but there is this code of silence amongst Denialists that prevents them
from asking questions about HIV+ people that die with very rare diseases
like PCP and KS."

Yes, I'm interested in knowing more about David Pasquarelli.  I doubt I'll
get very far with his friends at ACTUP.  I'm sure I've stepped on some
toes with my various posts about Pasquarelli here and there.  Time will
tell, I hope.

I must have missed the meeting about the "denialist code of
silence"...along with the secret handshake.  
Iconoclaster - 27 Feb 2006 00:25 GMT
>"but there is this code of silence amongst Denialists that prevents them
from asking questions about HIV+ people that die with very rare diseases
like PCP and KS."

On the contrary.  As you must have noticed, we love asking questions.
Wily already asked you how you figure a retrovirus manages to destroy
these immune cells and cause all those diseases.
PCP and KS very rare?  Hardly.  KS has been convincingly linked to the use
of poppers.  The incidence of KS has sharply decreased with the use of
poppers.  PCP is not all that rare.  It grabs its chance when all the
bacterial pathogens have been killed off.  Does prophylactive use of
antibiotics ring a bell?
GMCarter - 27 Feb 2006 11:54 GMT
>>"but there is this code of silence amongst Denialists that prevents them
>from asking questions about HIV+ people that die with very rare diseases
[quoted text clipped - 5 lines]
>PCP and KS very rare?  Hardly.  KS has been convincingly linked to the use
>of poppers.

Bullshit. You have no data for that. No data to support the ludicrous
assertion that PCP is common.

> The incidence of KS has sharply decreased with the use of
>poppers.  

What the f.ck are you babbling about? Where did you get the idea
poppers use has decreased?

>PCP is not all that rare.  It grabs its chance when all the
>bacterial pathogens have been killed off.  Does prophylactive use of
>antibiotics ring a bell?

WHY would anyone need prophylaxis? Unless maybe HIV infection had
resulted in the CD4 count dropping below 200.

Do you enjoy being SO vastly f.cking stupid and displaying it nonstop?

        George M. Carter
Iconoclaster - 13 Mar 2006 02:59 GMT
>"Bullshit. You have no data for that. No data to support the ludicrous
assertion that PCP is common."

We've been through this before.  M.D.'s are not research scientists.  When
they get a patient with pneumonia, they start him on antibiotics.  Only
when none of the antibiotics work, does it occur to them that the cause
could be non-bacterial.  Unfortunately, some patients have already died in
the meantime.

>"What the f.ck are you babbling about? Where did you get the idea poppers
use has decreased?"

Maybe it has not decreased in New York.  I have not gotten any reports
from the bathhouses there. But I just heard from someone who was in San
Francisco.  He wrote me that poppers/alcohol has now been largely replaced
by crystal meth/alcohol.
Hardly an improvement, but I think the use of poppers has decreased, at
least on the West Coast.

>"WHY would anyone need prophylaxis? Unless maybe HIV infection had
resulted in the CD4 count dropping below 200."

You're missing the point entirely, as usual.  Forget "HIV infection".
That doesn't exist, so that's not what I meant.  A lot of people with
frequent sexual contacts (both gay and straight) got into the bad habit of
using antibiotics as prophylaxis, to ward off sexually transmissible
diseases (I mean the real ones, that actually exist).  This is pretty dumb
behavior.  The antibiotics may knock out the bacteria, but fungi get a
better chance that way.  So PCP becomes more prevalent.

I know I'll never get through your thick skull, but maybe this will get
the silent lurkers to start thinking.
GMCarter - 13 Mar 2006 11:01 GMT
>>"Bullshit. You have no data for that. No data to support the ludicrous
>assertion that PCP is common."
>
>We've been through this before.  M.D.'s are not research scientists.

Some are.

This is yet another massively brain hemorrhaged stupid argument.

f.ck, you are so goddamned stupid it is difficult to believe you have
the gall to ever open your mouth in public. You must be a repugnican.

        George M. Carter
Chris Noble - 13 Mar 2006 11:13 GMT
> >"Bullshit. You have no data for that. No data to support the ludicrous
> assertion that PCP is common."
[quoted text clipped - 4 lines]
> could be non-bacterial.  Unfortunately, some patients have already died in
> the meantime.

George was asking for data not something that the voices in your head
tell you.
You may be surprised but science doesn't work by saying "because I say
so".

If you are going to claim that PCP is in fact common then come up with
some evidence.

Bullshit^n =/= data

Chris Noble
Gary Stein - 13 Mar 2006 22:17 GMT
> >"Bullshit. You have no data for that. No data to support the ludicrous
> assertion that PCP is common."
[quoted text clipped - 4 lines]
> could be non-bacterial.  Unfortunately, some patients have already died in
> the meantime.

You can repeat this as many times as you feel the need however with out any
evidence to back it up it is still just your opinion which anyone who reads
your posts knows is worth about as much as the cost of posting a message to
a Usenet forum Zero cents.

>>"What the f.ck are you babbling about? Where did you get the idea poppers
> use has decreased?"
[quoted text clipped - 16 lines]
> behavior.  The antibiotics may knock out the bacteria, but fungi get a
> better chance that way.  So PCP becomes more prevalent.

Again where's the beef, you make a bold statement and don't back it up with
any data. I challenge you to find a US physician who will prescribe
antibiotics to a healthy person for prophylaxis against STD's. You of course
will be unable to do so because it would be clearly outside of the 'standard
of care' consensus of the American medical community and would thus expose
the doctor to liability in the court system. As you are well aware in the
litigious climate of the US this is something no doctor is willing to do.

The knowledge that antibiotics where over used during the first few decades
of there existence has been plainly understood for 20 years and it is only
the growth in population that increases there sales. The Western Medical
community has made successful educational efforts in discouraging doctors
use of antibiotics unless there is a real need for there use.

Gary Stein
Iconoclaster - 17 Mar 2006 03:30 GMT
>"Again where's the beef, you make a bold statement and don't back it up
with any data."

That's what the HIV-pushers have done for more than 20 years.

>"I challenge you to find a US physician who will prescribe antibiotics to
a healthy person for prophylaxis against STD's."

Hate to break this news to you, but there's more world outside the borders
of the U.S.  Ever heard of Canada?  Mexico?

>"The Western Medical community has made successful educational efforts in
discouraging doctors use of antibiotics unless there is a real need for
there use."

Good!  It's about time.  Americans are fervent pill poppers.  This
overmedication must stop sometime.
Gary Stein - 18 Mar 2006 23:16 GMT
> >"Again where's the beef, you make a bold statement and don't back it up
> with any data."
[quoted text clipped - 6 lines]
> Hate to break this news to you, but there's more world outside the borders
> of the U.S.  Ever heard of Canada?  Mexico?

Even if what you say is true (which I doubt) it says nothing about AIDS in
the US which you have continuously implied is caused by the over use of
antibiotics. When I showed you that this statement is patiently false you
wander off and talk about Canada and Mexico.....

Gary Stein
Iconoclaster - 27 Feb 2006 00:35 GMT
>"but there is this code of silence amongst Denialists that prevents them
from asking questions about HIV+ people that die with very rare diseases
like PCP and KS."

On the contrary.  We love to ask questions.
Why do you call PCP and KS very rare diseases?  We've seen lots of KS when
poppers were in style.  And with the decrease in the use of poppers, also
the incidence of KS diminished.
PCP rare?  Not really.  Usually, a patient who is not in a "risk group for
HIV" does not even get tested for it.
But PCP sticks up its head whenever the bacterial pathogens have been
killed off.  Does prophylactic use of antibiotics ring a bell?
Iconoclaster - 26 Feb 2006 23:54 GMT
>"Are you trying to say that David Pasquarelli was on heroin or cocaine or
amphetamines etc?"

I wouldn't know; I never knew him.  All I know is that he got sick, fell
into the hands of the HIV mafia that assumes the only ailment a gay man
can ever have is AIDS.  And, instead of treating whatever he really had,
they finished him off with ARV's.

>"Do you want to email David's partner and ask him whether David was
taking drugs?"

No.  But maybe you want to email David's partner, to explain why you and
your crowd are still gloating over David's death.

I think you still don't get it.  I'm not saying all gay men were taking
drugs and lived an unhealthy life.  It was a minority, but they were the
first ones who succumbed.  And a whole "epidemic" was built on just the
first 5 cases by that a.shole Michael Gottlieb.
I'm also not saying the straights didn't do drugs or didn't live in an
irresponsible way.  I've known many of them too.  But the straights were
not targeted for extinction, as the gays were.
Without the invention of AIDS, the number of deaths would have been
limited to those few who drove their bodies faster than a human body can
endure.  And their grieving buddies would have seen the light (well, at
least most of them), and would have moderated their lifestyle.  End of
story.  But "AIDS" changed all that.  A hetero who got sick in the late
eighties would get treated for the very ailment he had.  Not so for a gay
man.  He would get tested for "HIV", and if found positive (from whatever
cause), he would be put to death with high doses of AZT.  And the Moronic
Majority said: "Gee, a lot of people are dying from AIDS".  And bingo!  An
epidemic that only strikes gay men and drug addicts (the hemophiliacs were
just dragged in on their coattails).
Now, isn't it ironic that you and the resident stooges on this forum are
desperately trying to keep the HIV/AIDS scam going, while I, a complete
outsider, have to stand up for a gay community that's too gullible to see
that their own buddies are aiding and abetting a bunch of extremely evil
people who are hellbent on eradicating them?
But that's me.  I'll always support the underdog.
Chris Noble - 27 Feb 2006 09:36 GMT
> >"Are you trying to say that David Pasquarelli was on heroin or cocaine or
> amphetamines etc?"
[quoted text clipped - 3 lines]
> can ever have is AIDS.  And, instead of treating whatever he really had,
> they finished him off with ARV's.

How do you know they didn't treat the opportunistic infections?

> >"Do you want to email David's partner and ask him whether David was
> taking drugs?"
>
> No.  But maybe you want to email David's partner, to explain why you and
> your crowd are still gloating over David's death.

Nobody is gloating over his death.

I am expressing disgust for the people that told David that HIV doesn't
cause AIDS and that everything will be OK.

Denialists like you are the ones showing disrespect for David by making
up stories about him being on drugs.

Paul King made up lots of stories about David and was corrected by
David's partner Steve Huggins

http://tinyurl.com/r4dum
------------------------------------------------------------------------------
PaulKing is wrong and has no knowledge of David's health choices.

David did not die of heart failure, or liver failure (as PaulKing has
posted
elsewhere), and he did not take HAART for many years before he was a
dissident.

David died from advancing CMV (Cytomegalovirus) infection in his CNS
(Central Nervous System - spine and brain).
He did take Viramune and Trizivir for a few months shortly before his
death.

I am David's partner of seven years and participated in every aspect of
his
health decisions.  Please feel free to email me with any questions or
questionable posts you may see about him.

Thanks,
Steve
---------------------------------------------------------------------------------

Chris Noble
Iconoclaster - 01 Mar 2006 00:40 GMT
>"How do you know they didn't treat the opportunistic infections?"

I have no direct knowledge of that.  But generally, they don't, if the
patient is a gay man.
Steve Huggins mentioned Dave was treated with Viramune and Trizivir for a
few months.  He also said Dave died of CMV infection.  Well, do you think
Viramune and Trizivir constitute the right treatment for CMV infections?
Peter Duesberg would call this "shooting at bunny rabbits with nuclear
warheads."  CMV is not exactly a deadly virus feared by everybody.  They
just slaughtered the poor guy because they hated him.

>"Denialists like you are the ones showing disrespect for David by making
up stories about him being on drugs."

I never made up those stories.  Everybody gets sick once in a while.  But
David Pasquarelli could have walked into that hospital with nothing worse
than a bad cold, and he wouldn't have gotten out  alive.  My disrespect is
not aimed at him, but at the quacks who treated him.
Chris Noble - 01 Mar 2006 03:56 GMT
> >"How do you know they didn't treat the opportunistic infections?"
>
> I have no direct knowledge of that.  But generally, they don't, if the
> patient is a gay man.

Bullshit.
http://www.cdc.gov/mmwr/PDF/rr/rr5315.pdf

> Steve Huggins mentioned Dave was treated with Viramune and Trizivir for a
> few months.  He also said Dave died of CMV infection.  Well, do you think
> Viramune and Trizivir constitute the right treatment for CMV infections?
> Peter Duesberg would call this "shooting at bunny rabbits with nuclear
> warheads."  CMV is not exactly a deadly virus feared by everybody.  They
> just slaughtered the poor guy because they hated him.

CMV is rarely serious if you are not immunosuppressed.

If you are going to make claims about the doctors purposefully killing
David then take them to court. You might have to find proof for your
unsubstantiated claims though.

> >"Denialists like you are the ones showing disrespect for David by making
> up stories about him being on drugs."
[quoted text clipped - 3 lines]
> than a bad cold, and he wouldn't have gotten out  alive.  My disrespect is
> not aimed at him, but at the quacks who treated him.

You were the one who brought up the subject of heroin and cocaine when
we were talking about David Pasquarelli.

Chris Noble
Iconoclaster - 05 Mar 2006 01:20 GMT
>"If you are going to make claims about the doctors purposefully killing
David then take them to court."

I have no legal standing.  I have never even known him.  
GMCarter - 24 Feb 2006 12:08 GMT
>>"So the PCP, anemia, thrush, meningitis, mycobacterium and CMV were just
>some wild coincidence?"
[quoted text clipped - 3 lines]
>And they had a whole babyboomer generation behind them, trying to tell
>everybody that drugs are not bad for you.  

oh, what a COMPLETE f.cking load of crap.

A LOT of gay men I know that died of AIDS didn't do drugs. And a LOT
of straight people I know did LOTS of drugs.

This is the most f.cking homophobic, brain dead asinine, unsupported
bullshit theory to ever hit the universe. Duesberg is a f.cking quack.

Look, if ANY recreational drug caused AIDS, it would be meth. Meth
labs are everywhere and NOT limited to gay men by any stretch of the
imagination.

There is NO EVIDENCE that ANY recreational drug causes CD4 counts to
decline to zero.

They can definitely f.ck you up or kill you--especially drugs like
alcohol and tobacco. But they don't cause AIDS.

        George M. Carter
Iconoclaster - 26 Feb 2006 22:39 GMT
>"This is the most f.cking homophobic, brain dead asinine, unsupported
bullshit theory to ever hit the universe."

Whoa!  Wait a minute!  A homophobic theory?  Coming from me?  You must be
confusing me with 'Death'.
I am the guy who has been trying to tell gay men that the whole AIDS (or
GRID) scam started out as a direct attack on the gay community.  The
greedy pharma companies only got into the act later, when Africa was
dangled before their noses.  Of course there are stupid people in every
social group, but someone who is gay and, after 21 years of being cheated
and duped, still doesn't know that the AIDS orthodoxy is up to no good,
must be exceptionally stupid.  And then to think that there are folks like
you, Mr. Carter, who have sold out to the enemy, and continue this fraud
by driving buddies into the claws of the HIV mob, and to their deaths by
poisoning.

>"A LOT of gay men I know that died of AIDS didn't do drugs. And a LOT of
straight people I know did LOTS of drugs."

Yeah, I used to know a lot of gay men who said they didn't use drugs.
Also a lot of straights who used drugs, and wrecked their bodies.
I mentioned people who would rather blame some occult virus for their
ailments than admit it were the drugs that did them in.  And YOU are
exactly that type, Mr. Carter.  Always blaming outside forces when you
screw up.

>"Look, if ANY recreational drug caused AIDS, it would be meth. Meth labs
are everywhere and NOT limited to gay men by any stretch of the
imagination."

You're absolutely right about this.  And I heard from somebody who just
came back from San Francisco that crystal meth is now the most used drug
in combination with alcohol there.  Hardly an improvement over poppers and
alcohol.

>"There is NO EVIDENCE that ANY recreational drug causes CD4 counts to
decline to zero."

This whole CD4 counting business is a load of crap.  CD4+ T-cells exist,
of course, but the immunologists don't know yet what the hell's going on.
There is NO EVIDENCE that CD4-levels are in any way related to any kind of
disease.
And you can take your CD4 cells and stick 'em...
Oh well, you know where to stick things.
GMCarter - 27 Feb 2006 11:56 GMT
>>"This is the most f.cking homophobic, brain dead asinine, unsupported
>bullshit theory to ever hit the universe."
>
>Whoa!  Wait a minute!  A homophobic theory?  Coming from me?  You must be
>confusing me with 'Death'.

Not in the slightest. Everything you write screams "BIGOT" much tho
you might try to hide it. Or--being a denialist par
excellence--unaware of your own abiding prejudices and ignorance.

        George M. Carter
GMCarter - 23 Feb 2006 10:22 GMT
>>"And they wind up dead, like David Pasquarelli, if they buy your sibilant
>lies and your abject
>ignorance"
>
>We've been through this before.  Pasquarelli didn't die until het had
>decided to take the toxic drugs after all.

Wow. That's compassionate. So the PCP and cryptococcal meningitis are
normal diseases in young male adults in the US? Huh.

I'm sure you have all the cites and references to back that theory up,
don't you?
Gary Stein - 21 Feb 2006 04:59 GMT
> And dying from ARV's is
> more terrifying than dying from any of the AIDS diseases.  Get treated for
> what ailment you *really* have.  Forget about AIDS."
> Now if everybody would frame those words and hang them over his bed...

Now that's about the biggest load of crap you've posted here to date
Claster. As someone who almost died 3 times before I started ARV I can tell
you first hand that your full of sh.t. I will take the side effects of ARV
(which I have been taking daily for a decade) over laying in a hospital bed
wondering if this breath will be my last any day.

Gary Stein
Iconoclaster - 22 Feb 2006 23:17 GMT
>"As someone who almost died 3 times before I started ARV I can tell you
first hand that your full of sh.t. I will take the side effects of ARV
(which I have been taking daily for a decade) over laying in a hospital
bed wondering if this breath will be my last any day."

I'm sory to hear that.  As I said before, I wish you well.  You must be a
very strong, healthy  individual, being able to take that crap for so long
and still be alive.  But I'm convinced you would be doing better yet if
you quit the ARV's.  I know somebody here who quit the drugs, and she's
doing much better now than when she was still taking them.
These poisons are the same stuff they're using for cancer chemotherapy.
I've seen people die with dignity from cancer, and I've seen people die
like poisoned rats from cancer chemotherapy, stripped of anything that
even remotely reminded me of a human being.
I may get cancer some day (who can tell?), but my choice is already made -
no chemotherapy.  AIDS is out of the question, of course.  I'll never get
that, because it's a fraud.
Gary Stein - 18 Feb 2006 21:02 GMT
> "Have you read "Intelligent Design" websites. You will also find comments
> there saying that Darwinists spend so much time attempting to
[quoted text clipped - 8 lines]
> but you've really spent a good deal of time and energy debating/discussing
> with him.  There must be a reason or two for that.

Yes honest people have a hard time ignoring liars, thus when someone like
Iconclaster shows up here and consistently lies, misrepresents, obfuscates,
and overall attempts to use disinformation to convince people of his wild
eyed theories about HIV honest intelligent people push back at him.

> "Iconoclaster asserts that HIV does not exist without providing any
> justifiable reasons for this belief. When he does provide reasons such
[quoted text clipped - 13 lines]
> Iconoclaster "wins", I doubt that I'll suddenly become convinced that HIV
> causes AIDS.

Just for grins what would convince you?

Gary Stein
wilyretrovirus - 18 Feb 2006 23:41 GMT
"Yes honest people have a hard time ignoring liars, thus when someone like
Iconclaster shows up here and consistently lies, misrepresents,
obfuscates, and overall attempts to use disinformation to convince people
of his wild
eyed theories about HIV honest intelligent people push back at him."

Gary, thank you, you made me laugh.

>You two can debate the point about mutation all >you like.  Whether you
or Iconoclaster "wins", I >doubt that I'll suddenly become convinced that
>HIV causes AIDS.

"Just for grins what would convince you?"

Well, Gary,
your "team" has had almost 22 years now to convince/brainwash me that HIV
causes AIDS.  I  may have an answer to your question, though.  I think if
I sustained some sort of horrific, irreparable head injury that left me
practically retarded, you might be able to convince me that HIV causes
AIDS.  I'd have to lose much of my ability to reason and think critically
before I was able to swallow all of the tripe that comes from the orthodox
view on "AIDS".  

Just for grins, Gary, kiss my hairy a.s.  
Iconoclaster - 19 Feb 2006 00:51 GMT
>"I think if I sustained some sort of horrific, irreparable head
injury..."

Or, maybe, a co-infection with the .357Magnum Virus?
Brian Mailman - 19 Feb 2006 01:49 GMT
> ...   I  may have an answer to your question, though.  I think if
> I sustained some sort of horrific, irreparable head injury that left me
> practically retarded, you might be able to convince me that HIV causes
> AIDS.

See, Gary, that's the difference between that mindset and ours.  If
someone came along with properly documented and convincing evidence that
the denialist POV actually had been accurate... we'd be accepting it.

B/
Gary Stein - 21 Feb 2006 04:51 GMT
I was thinking the same thing. Odd how the denialists claim it is the
mainstream who's minds are closed but when their honest it is actually they
who have the closed minds..................

Gary Stein

>> ...   I  may have an answer to your question, though.  I think if
>> I sustained some sort of horrific, irreparable head injury that left me
[quoted text clipped - 6 lines]
>
> B/
wilyretrovirus - 21 Feb 2006 20:20 GMT
"I was thinking the same thing. Odd how the denialists claim it is the
mainstream who's minds are closed but when their honest it is actually
they
who have the closed minds.................."

Gary Stein

<yawn>
Gary Stein - 22 Feb 2006 00:39 GMT
> "I was thinking the same thing. Odd how the denialists claim it is the
> mainstream who's minds are closed but when their honest it is actually
[quoted text clipped - 4 lines]
>
> <yawn>

You must go through life half asleep, that being the only excuse for such
lazy reasoning....................

Gary Stein
GMCarter - 19 Feb 2006 12:35 GMT
snip
>Just for grins, Gary, kiss my hairy a.s.  

LOL....this is about what one might expect from someone who relies
utterly on faith to make his decisions.

Dearest, if that hairy a.s is HIV+, you will be dead in short order
and not need to worry about your brain.

Wonder what ever happened to Paul Whiting? I hope he is OK!

        George M. Carter
wilyretrovirus - 19 Feb 2006 14:47 GMT
"Dearest, if that hairy a.s is HIV+, you will be dead in short order and
not need to worry about your brain."

Short order?  Don't I have to wait ten years or more for "HIV's" timer to
go off, signaling it to start wreaking havoc on my t-cells, or however the
f.ck it's supposed to lower my t-cell count?

Sorry, witchypoo, I can't be hexed by you and your imaginary retrovirus.

"Wonder what ever happened to Paul Whiting? I hope he is OK!"

Sure, George, I "believe" you.  Salivating at the mere thought of a sick
or dead dissident?  As far as I know, Paul's fine, sorry to disappoint
you.
Brian Mailman - 19 Feb 2006 17:26 GMT
> Wonder what ever happened to Paul Whiting? I hope he is OK!

He disappeared right after I posted a long screed talking about how the
traditional medicine he so blasts (confusing pharmabiz with the practice
of medicine) does and is incorporating 'alternative' medicine.

B/
GMCarter - 20 Feb 2006 11:12 GMT
>> Wonder what ever happened to Paul Whiting? I hope he is OK!
>
>He disappeared right after I posted a long screed talking about how the
>traditional medicine he so blasts (confusing pharmabiz with the practice
>of medicine) does and is incorporating 'alternative' medicine.

And long has been. The good part is finding out what works/helps.

The bad part is the "biz" side that takes discoveries and does not
reward discoverers nearly as much (sometimes not at all) as CEOs and
stockholders. A clear and complete perve