Medical Forum / Diseases and Disorders / AIDS / December 2005
Blood Transfusions are real safe..yes they are
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vorlon359@gmail.com - 04 Dec 2005 18:35 GMT Chinese blood donor with HIV infected at least 21 others
BEIJING (AFP) - An HIV carrier in northeast China who gave blood 15 times before he was diagnosed with the virus unknowingly infected at least 21 people, state media have reported.
The infected donor, surnamed Song, from Dehui city in Jilin province tested positive for HIV on October 20, by which time 25 people had already received his blood, the China Youth Daily newspaper said.
The 41-year-old man gave blood 15 times to the central blood bank of Dehui between January 2003 and June 2004 without having been diagnosed as an HIV carrier, it said.
The case only came to light after a female farmer surnamed Wang died recently, having contracted a "mysterious disease" which was eventually diagnosed as AIDS.
She received the tainted blood during an operation in March 2003. Her case was reported to local authorities, who traced the blood back to Song.
An official investigation found that a total of 18 recipients of Song's blood have been infected with the HIV virus, of whom, three, including Wang, developed AIDS and died, Xinhua news agency said.
Song's two sex partners, as well as one of their spouses, were also diagnosed with HIV, it said.
Authorities have taken disciplinary action against six Dehui health officials and detained 11 staff at the blood bank.
China says there are about 840,000 HIV-positive people in China, although the United Nations says the figure could be much higher and has warned that the number of infected people could rise to 10 million by 2010.
Chinese government spending on AIDS prevention has risen to 800 million yuan (99 million US dollars) this year, up from 100 million yuan in 2002, according to official figures.
Health Minister Gao Qiang said Wednesday the government would be able to achieve its long-term goal of keeping the number of HIV patients to under 1.5 million by 2010.
SheBlewHimDidYouBlowHim - 04 Dec 2005 18:54 GMT amazing that a "loving, caring" supreme being can't stop murdering people with diseases he created in the first f.cking place
Cracklin' - 04 Dec 2005 19:14 GMT > amazing that a "loving, caring" supreme being can't stop murdering people > with diseases he created in the first f.cking place ==================== Maybe this god sees disease as some kind of natural birth-control for humans. The Jehovah's Witnesses call it Jehovah's "undeserved kindness."
:-(  Signature CR..... "Well, then, have I become YOUR enemy because I tell YOU the truth (about the WTS)? Galatians 4:16 NWT ~~~~~~~~~~~~~~~~~~~~~~~~~~~ }<(((({{o>
R. Pierce Butler - 07 Dec 2005 02:57 GMT >> amazing that a "loving, caring" supreme being can't stop murdering >> people with diseases he created in the first f.cking place [quoted text clipped - 3 lines] > kindness." >:-( Didn't "Mother Teresa" say that excruciating pain was Jesus kissing the victim?
Someone should figure out a way to retrieve the money that Teresa collected and do something good with it.
pierce
Ike - 05 Dec 2005 02:18 GMT > amazing that a "loving, caring" supreme being can't stop murdering people > with diseases he created in the first f.cking place What are you blathering about?
Death - 05 Dec 2005 02:47 GMT "SheBlewHimDidYouBlowHim" <killgod@killgod.com> wrote in message
> > amazing that a "loving, caring" supreme being can't stop murdering people > > with diseases he created in the first f.cking place What a hateful and intolorent thing to say about filthy disease spreading faggots. Supreme in the art of denial only.
Epidemiology April 2001
Auerbach, J. D. and Coates, T. J. (2000). HIV Prevention Research: Accomplishments and Challenges for the Third Decade of AIDS. American Journal of Public Health 90(7): 1029-32.
The past 2 decades have taught us that HIV prevention can work. We now have evidence from places as diverse as Senegal, Thailand, Uganda, and Australia that concerted HIV prevention efforts at the national level have resulted in the maintenance of low seroprevalence rates where they otherwise would have been expected to rise. We are beginning to observe declining rates of HIV prevalence and incidence in places and populations with historically high rates--for example, injection drug users in New York City. This trend points to the long-term impact of prevention efforts in those communities. The best of these efforts have been based on sound scientific research. As we move into the third decade of the AIDS epidemic, it is important to restate principles, acknowledge advances, and identify challenges and future directions in HIV prevention research.
Barrett, D. C., Hudes, E. S. and Paul, J. P. (1997). Reexamination of Intergenerational Linkage of HIV Infection [Letter; Comment]. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 15(4): 318-9.
Binson, D., Michaels, S., Stall, R., Coates, T. J., Gagnon, J. and Catania, J. (1995). Prevalence and Social Distribution of Men Who Have Sex with Men: United States and Its Urban Centers. Journal of Sex Research 32(3): 245-254.
Examined the prevalence data on the social distribution, and AIDS-related behavior of homosexual men, from 2 national probability surveys (the General Social Survey [GSS] and the National Health and Social Life Survey [NHSLS]), and a probability survey of urban centers in the US (the National AIDS Behavioral Surveys [NABS]). Six waves of the GSS were combined with the NHSLS into a single data set (1988-1994). A large number of Subjects (aged 18-49 yrs) were interviewed regarding their sexual behavior. Results show that Subjects residing in larger cities, the highly educated, and Whites were more likely to report sex with men. In the urban sample, one-third of Subjects reported sex with women. Minority men were more likely to report sex with men and women. More than half of the men with an HIV risk factor reported consistent condom use. ((c) 1999 APA/PsycINFO, all rights reserved)
Binson, D. and Catania, J. A. (1998). Respondents' Understanding of the Words Used in Sexual Behavior Questions. Public Opinion Quarterly 62(2): 190-208.
Assessed the difficulty 4,790 respondents (aged 18-49 yrs) have in understanding the vocabulary used in sexual behavior questions. We embedded several questions related to respondents' self-reported difficulty in understanding the terms "vaginal intercourse" and "anal intercourse" in a telephone survey of the general population. National AIDS Behavioral Survey II was administered. Most Subjects reported that these terms were easy to understand. However, men were more likely than women to report difficulty, and minority Subjects were more likely than white Subjects to indicate that "vaginal intercourse" and "anal intercourse" were difficult to understand. Most striking was the finding that 25% of those with less than 12 yrs of education reported comprehension difficulty with these terms. In addition, in the High Risk Cities sample, respondents who found the terms difficult to understand were more likely to report "zero" when asked the number of people they had vaginal or anal intercourse with. This has implications for STD/HIV prevention policy in that some demographic groups may appear less sexually active than they really are. Hence, they may be ignored as likely candidates for intervention programs. More research is needed to assess the various dimensions to this problem. ((c) 1999 APA/PsycINFO, all rights reserved)
Catania, J. A., Gibson, D. R., Chitwood, D. D. and Coates, T. J. (1990). Methodological Problems in AIDS Behavioral Research: Influences on Measurement Error and Participation Bias in Studies of Sexual Behavior. Psychological Bulletin 108(3): 339-62.
An unprecedented number of human sexuality studies have been initiated in response to the acquired immune deficiency syndrome (AIDS) epidemic. Unfortunately, methodological developments in the field of sex research have been slow in meeting the demands of AIDS investigations focusing on the diverse populations at risk for infection with the human immunodeficiency virus (e.g., adolescents, gay men, intravenous-drug users, ethnic minorities, elderly transfusees). In this article, we review and integrate current literature on measurement error and participation bias in sex research, with an emphasis on collecting sexual information in the context of AIDS. The relevance of these findings for AIDS-related sex research is discussed, and recommendations are made to guide future investigations.
Catania, J. A., Binson, D., Van Der Straten, A. and Stone, V. (1995). Methodological Research on Sexual Behavior in the AIDS Era. Annual Review of Sex Research(VI): 77-125.
Reviews recent methodological studies on the use of methods currently employed to assess adult sexual behavior, particularly AIDS-relevant sexual behaviors (P. Blumstein et al., 1990; J. A. Catania et al, 1993; Catania et al., 1990; Catania et al., 1990). The authors provide a brief overview of the recent surveys that have been conducted using probability sampling techniques, along with a discussion of sexual behavior issues endemic to AIDS-related surveys; reliability and validity of self-reported sexual behavior; validity of self-reported changes in sexual behavior; pretesting of survey instruments; indices of measurement error; and major influences on measurement error of sexual behaviors, including respondent factors, instrument and mode effects, and interviewer variables. It is concluded that although some excellent methodological studies have been conducted, much of this work is in need of replication across various ethnic, age, and AIDS-risk groups. ((c) 2000 APA/PsycINFO, all rights reserved)
Catania, J. A., Moskowitz, J. T., Ruiz, M. and Cleland, J. (1996). A Review of National AIDS-Related Behavioral Surveys. AIDS 10 Suppl A: S183-90.
Catania, J. A., Canchola, J. and Pollack, L. (1996). They Said It Couldn't Be Done - the National Health and Social Life Survey - Response. Public Opinion Quarterly V60(N4): 620-627.
Catania, J., Binson, D., Peterson, J. and Canchola, J. (1997). The Effects of Question Wording. Researching Sexual Behavior : Methodological Issues. Jenkins, A. C. and Bancroft, J. Bloomington :, Indiana University Press.
Catania, J. (1998). The Sexual Self-Disclosure Scale. Handbook of Sexuality-Related Measures. Davis, C. M. Thousand Oaks, Calif. :, Sage Publications.
Catania, J. (1998). The Dyadic Sexual Communication Scale. Handbook of Sexuality-Related Measures. Davis, C. M. Thousand Oaks, Calif. :, Sage Publications.
Catania, J. (1998). The Dyadic Sexual Regulation Scale. Handbook of Sexuality-Related Measures. Davis, C. M. Thousand Oaks, Calif. :, Sage Publications.
Catania, J. A. (1999). A Framework for Conceptualizing Reporting Bias and Its Antecedents in Interviews Assessing Human Sexuality. Journal of Sex Research 36(1): 25-38.
journal abstract The present paper reviews conceptual models of self-presentation bias in interview situations that focus on assessments of human sexuality. An heuristic framework is developed that synthesizes these models to focus on self-presentation/self-disclosure bias as a function of emotional distress and threat to self-esteem, both intermediate outcomes that are influenced by four general factors: Respondent, Interviewer, Task, and Contextual. Empirical research within each of these four general factors is discussed, and areas for further research are outlined. ((c) 1999 APA/PsycINFO, all rights reserved)
Catania, J. A. (1999). A Comment on Advancing the Frontiers of Sexological Methods. Journal of Sex Research V36(N1): 1-2.
Catania, J., Binson, D., Dolcini, M. M., Moskowitz, J. T. and van der Straten, A. (2001). Frontiers in the Behavioral Epidemiology of HIV/STDs. Handbook of Health Psychology. Baum, A., Revenson, T. A. and Singer, J. E. Mahwah, N.J. :, Lawrence Erlbaum Associates.
Cates, W., Jr., Chesney, M. A. and Cohen, M. S. (1997). Primary HIV Infection--a Public Health Opportunity? American Journal of Public Health 87(12): 1928-30.
Primary human immunodeficiency virus (HIV) infection should be considered a key target for HIV prevention activities. Mathematical models suggest that the primary HIV infection interval makes a disproportionate contribution to the HIV epidemic, perhaps accounting for as many as half of the existing infections at any point in time. If this is true, primary infection presents a special window of opportunity within which to exert a maximum impact on the spread of HIV. A combination of biological, behavioral, and social factors may account for the influence of primary infection on the HIV epidemic. HIV prevention measures can be focused on each of these factors. Biologically, detecting individuals early in the course of infection and offering treatment can reduce viral load and possibly an individual's infectiousness. Behaviorally, counseling newly infected persons about the importance of adopting safer practices may instill prevention behaviors at a critical time. Socially, using a network approach to notify persons exposed to those with primary infections can dampen the amplification effect of rapid HIV spread through high-risk environments. By focusing prevention efforts on the primary HIV infection interval, public health officials could increase their leverage in slowing the HIV epidemic.
Coates, T. J., Aggleton, P., Gutzwiller, F., Des Jarlais, D., Kihara, M., Kippax, S., Schechter, M. and van den Hoek, J. A. (1996). HIV Prevention in Developed Countries. Lancet 348(9035): 1143-8.
HIV prevention in developed countries is marked by impressive successes and dismal failures. The successes point the way to what works; the failures highlight obstacles that must be overcome. Successes include important behavioural changes among gay and bisexual men, antiviral use to prevent vertical transmission, and securing the safety of the blood supply. New strategies are needed to reach the residual of individuals continuing with unsafe practices (a special hazard in high-prevalence areas); to reach young people who are beginning to engage in sexual relations and injection drug use; and to overcome political opposition to prevention strategies.
Coates, T. J. and Feldman, M. D. (1997). An Overview of HIV Prevention in the United States. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 14 Suppl 2: S13-6.
Despite recent promising results with protease inhibitors and combinations of drugs in treating HIV-infected persons, a cure or vaccine for AIDS is unlikely within the next several years. Therefore, prevention remains the most realistic strategy for dealing with the HIV epidemic. However, HIV prevention efforts in the United States face enormous challenges. Translating knowledge about effective HIV prevention strategies into sound HIV prevention policy must be a priority. For example, AIDS prevention experts must dispel the myth that needle exchange programs for injection drug users encourage drug use. Such programs may, however, decrease the risk for HIV transmission. Another challenge is to implement effective sex education programs. It is well established that early sex education does not lead to promiscuity among young people; in fact, it may actually decrease overall sexual activity and decrease high-risk sexual activities. Finally, prevention programs must reach those most at risk. Surveillance data indicate that these include young gay men, Hispanic and African Americans, and the economically disadvantaged. Prevention policy too often is formed on the basis of opinion or anecdote rather than on the basis of science. Sound and strong science is needed to ensure that the best programs and policies can be put into place.
Colford, J. M., Jr., Ngo, L. and Tager, I. (1994). Factors Associated with Survival in Human Immunodeficiency Virus-Infected Patients with Very Low Cd4 Counts [See Comments]. American Journal of Epidemiology 139(2): 206-18.
The authors examined the survival experience of 289 human immunodeficiency virus (HIV)-infected men to identify factors independently associated with survival in patients with very low CD4 counts (< or = 100/mm3). All subjects were HIV-infected men cared for at the San Francisco Veterans' Affairs Medical Center between January 1988 and November 1991. Survival was measured from the date on which a patient was first known to have a CD4 count < or = 100/mm3 until death or censoring. Factors potentially associated with survival were examined initially using the product limit (Kaplan-Meier) method; a multivariate model of survival was constructed using a proportional hazards (Cox) regression. Four variables were identified as independently associated with survival (p < 0.05) in the Cox proportional hazards model: CD4 count, hematocrit, azidothymidine use, and clinical stage (prior history of acquired immunodeficiency syndrome vs. no prior history). All 16 possible combinations of these four (dichotomized) variables were examined; eight different patterns of survival were detected. Identification of survival patterns that can be described by data obtained as part of routine clinical care has implications for patient care, the design of clinical trials, the study of mechanisms of progression of HIV-related immunosuppression, and planning of health care resource needs for populations of patients with very low CD4 counts.
Collins, C. (1997). Dangerous Inhibitions: How American Is Letting AIDS Become an Epidemic of the Young. San Francisco, CA, Center for AIDS Prevention Studies.
Daley, C., Caceres, C. F., Choi, K. H., Hearst, N., Hironaka, K. and Osmond, D. H. (1999). International Epidemiology of HIV/AIDS. The AIDS Knowledge Base : A Textbook on HIV Disease from the University of California, San Francisco and San Francisco General Hospital. Sande, M. A., Volberding, P. and Cohen, P. T. Philadelphia, PA :, Lippincott, Williams and Wilkins: 23-41.
DeCarlo, P. and Grinstead, O. (1999). The 'Post-AIDS' Era and the Effect of Treatment Advances. Focus 14(11): 1-4.
DeCarlo, P. (1999). HIV among Women in Developing Countries. Harvard AIDS Review(Spring): 2-6.
Grandi, J. L., Goihman, S., Ueda, M. and Rutherford, G. W. (2000). HIV Infection, Syphilis, and Behavioral Risks in Brazilian Male Sex Workers. AIDS & Behavior 4(1): 129-135.
To describe the epidemiology of HIV and syphilis infection and sexual practices among male sex workers, the authors studied 434 transvestites and 96 "hustlers" (mean age 22 yrs) recruited by peers in the metropolitan area of Sao Paulo, Brazil, from 1992-1998. Participants were young adults with low education levels who had recently immigrated to Sao Paulo and supported themselves primarily through sex work. The prevalence of HIV infection among transvestites and hustlers was 40% and 22% respectively, and the prevalence of current or past syphilis was 43% and 27%, respectively. Infection was associated more with gender performance and duration of sex work than to recent unsafe sexual practices or recent condom use. As opposed to hustlers whose clients came primarily from Sao Paulo and were homosexual, transvestites were more likely to have foreign and heterosexual clients. HIV and syphilis among sex workers are urgent public health problems that require continuous prevention programs for male sex workers and their clients. (PsycINFO Database Record (c) 2000 APA, all rights reserved)
Hearst, N., Mandel, J. S. and Coates, T. J. (1995). Collaborative AIDS Prevention Research in the Developing World: The Caps Experience. AIDS 9(Suppl 1): S1-5.
BACKGROUND: Prevention through behavior change is the only way to control the spread of HIV infection in the developing world. Success in prevention requires consistent and persistent intervention over time, a clear understanding of the realities of target populations and involvement of members of these populations in prevention efforts. Applied local research is urgently needed, especially in the developing world, to design interventions that meet these criteria and to test their effectiveness. CENTER FOR AIDS PREVENTION STUDIES (CAPS) MODEL OF INTERNATIONAL COLLABORATIVE RESEARCH: Each year, eight to 10 scientists from developing countries visit CAPS in San Francisco for 10 weeks of intensive learning and collaboration. The main emphasis is on designing a protocol for a research project related to AIDS prevention in the visiting scientist's home country. CAPS provides pilot study funding and technical assistance to implement the project. RESULTS: The quality of the resulting collaborative research is represented by the articles published in this volume and by the many alumni of the program who have undertaken additional research projects and/or assumed leadership positions in AIDS control efforts in their countries.
Kahn, J. G., Gurvey, J., Pollack, L. M., Binson, D. and Catania, J. A. (1997). How Many HIV Infections Cross the Bisexual Bridge? An Estimate from the United States. AIDS 11(8): 1031-7.
OBJECTIVE: Most heterosexual women with AIDS have been infected by male sex partners who acquired HIV via injecting drug use or sex with men. The contribution of bisexuality to heterosexual HIV however, has been poorly quantified. In this paper, we estimate the number of HIV infections that spread from the homosexual community to women who have sex with bisexual men. METHODS: We developed an HIV transmission model and assigned values to the model's parameters using data from a probability survey of US cities with a high risk of HIV. RESULTS: We estimated that these are about 400 HIV infections transmitted annually from HIV-infected bisexual men in high-risk cities to their female sex partners; two-thirds of these infections are transmitted to main female partners and one-third to casual partners. Uncertainties in the value of model parameters lead to variation in expected HIV infections mostly within the range 200 to 600, and for one parameter up to nearly 800. CONCLUSION: We conclude that transmission via bisexuality is a relatively minor component of the estimated 40,000 annual HIV infections in the USA.
Lacerda, R., Gravato, N., McFarland, W., Rutherford, G., Iskrant, K., Stall, R. and Hearst, N. (1997). Truck Drivers in Brazil: Prevalence of HIV and Other Sexually Transmitted Diseases, Risk Behavior and Potential for Spread of Infection. AIDS 11 Suppl 1: S15-9.
OBJECTIVES: To determine the prevalence of HIV and syphilis and related risk behavior in a sample of truck drivers in Santos, Brazil. SUBJECTS AND METHODS: A cross-sectional study was performed of 300 male truck drivers recruited in the port of Santos, Brazil, including a face-to-face interview and blood sampling for HIV and syphilis serology. RESULTS: Of 300 subjects, 4 (1.3%) were positive for HIV, 25 (8.3%) for syphilis by the Venereal Disease Research Laboratory (VDRL) test and 38 (13%) were positive for syphilis by the fluorescent treponemal antibody (absorbed) test (FTA-Abs). Seventy-one per cent had been employed as truck drivers for more than 10 years and 93% lived outside of Santos. Most participants were married (72%); 40% reported having more than one sex partner; 21% reported sex with commercial sex workers; 14% reported sex with girls that they met on the road; 16% had sex with other men's wives; and 3.3% reported sex with men during the past year. The use of rebite, an oral stimulant, was reported by 43% and was associated with being FTA-Abs-positive (P = 0.04). Being HIV-positive was associated with having sex with friends (P = 0.04), partners usually considered 'safe' by truck drivers. Being syphilis-positive (VDRL) was significantly associated with sex with partners also considered as 'safe', namely primary sex partners, steady partners and other men's wives. DISCUSSION: This is the first study to determine HIV and syphilis seroprevalence among truck drivers in South America. Findings confirm that this group has a high potential risk for HIV infection and other sexually transmitted diseases, and thus currently presents an opportunity for prevention.
Lifson, A. R., Allen, S., Wolf, W., Serufilira, A., Kantarama, G., Lindan, C. P., Hudes, E. S., Nsengumuremyi, F., Taelman, H. and Batungwanayo, J. (1995). Classification of HIV Infection and Disease in Women from Rwanda. Evaluation of the World Health Organization HIV Staging System and Recommended Modifications. Annals of Internal Medicine 122(4): 262-70.
OBJECTIVE: To develop a human immunodeficiency virus (HIV) staging system for sub-Saharan Africa on the basis of an evaluation of the World Health Organization (WHO) system and predictors of mortality. DESIGN: Prospective cohort study with 4 years of follow-up. SETTING: Kigali, Rwanda. PATIENTS: 412 HIV-infected women recruited from prenatal and pediatric clinics. MEASUREMENTS: Clinical signs and symptoms of HIV disease, laboratory assays (including complete blood count and erythrocyte sedimentation rate), and cumulative mortality. RESULTS: The WHO staging system includes a clinical and a laboratory axis. The clinical axis was revised by inclusion of oral candidiasis, chronic oral or genital ulcers, and pulmonary tuberculosis as "severe" disease (clinical stage IV); in addition, body mass index was substituted for weight loss in the definition for the wasting syndrome. The 36-month cumulative mortality was 7% for women in modified clinical stage I ("asymptomatic"), 15% for those in stage II, 19% for those in stage III, and 36% for those in stage IV (P < 0.001). The laboratory axis was revised by replacing lymphocyte count with hematocrit and erythrocyte sedimentation rate. The 36-month mortality was 10% for women in modified stage A ("normal" laboratory results) and 33% for those in stage B (erythrocyte sedimentation rate > 65 mm/h or hematocrit < 0.38) (P < 0.001). A single staging system combining clinical and laboratory criteria is proposed, with a 36-month mortality of 7% for women in combined stage I, 10% for those in stage II, 29% for those in stage III, and 62% for those in stage IV (P < 0.001). CONCLUSIONS: On the basis of this analysis, a staging system relevant for sub-Saharan Africa is proposed that reflects the range of HIV-related outcomes, has strong prognostic significance, includes inexpensive and available laboratory tests, and can be used by both clinicians and researchers.
Lindan, C. P., Lieu, T. X., Giang, L. T., Lap, V. D., Thuc, N. V., Thinh, T., Lurie, P. and Mandel, J. S. (1997). Rising HIV Infection Rates in Ho Chi Minh City Herald Emerging AIDS Epidemic in Vietnam. AIDS 11 Suppl 1: S5-13.
OBJECTIVE: To describe the epidemiology of HIV in Ho Chi Minh City in the context of current surveillance data from Vietnam. METHODS: Since the late 1980s, HIV surveillance data have been collected in Ho Chi Minh City from centers for the treatment of venereal disease and tuberculosis, centers for the rehabilitation of injecting drug users and sex workers, prenatal clinics, blood banks and other sites. RESULTS: The first case of HIV infection in Vietnam was identified in 1990 in Ho Chi Minh City. The cumulative number of reported HIV infections in this city at the end of 1996 was 2774, about half of the number of cases in the country; 86% of infections were among men, 86% among injecting drug users, 2.5% among patients with sexually transmitted diseases and 2.5% among sex workers. The first HIV infection among antenatal women was detected in 1994. The prevalence of HIV among injecting drug users rose dramatically from 1% in 1992 to 39% in 1996, compared with 1.2% among sex workers, 0.3% among blood donors and 1.3% among tuberculosis patients in 1996. The populations of injecting drug users and sex workers in Ho Chi Minh City are estimated to be 30000 and 80000, respectively, and rates of sexually transmitted diseases are 2-3 per 1000 persons per year. By the end of December 1996, 42 out of 53 provinces had reported HIV infections, and border areas near China and Cambodia began identifying large numbers of HIV-seropositive people. CONCLUSIONS: Ho Chi Minh City is at the forefront of a new HIV epidemic in Vietnam. This epidemic shows similarities to that in Thailand nearly a decade ago, with rapidly rising HIV rates among injecting drug users and infection already established among sex workers. Prevention efforts should include the targeting of injecting drug users and sex workers outside rehabilitation centers, the availability of sterile needles and condoms, the establishment of anonymous testing sites, the control of sexually transmitted diseases and the coordination of programs within southeast Asia.
Lurie, P., Lowe, R. A., Avins, A. L., Phillips, K. A., Kahn, J. G., Franks, P. E. and Ciccarone, D. H. (1992). Undiagnosed HIV Infection in Acute Care Hospitals [Letter; Comment] [See Comments]. New England Journal of Medicine 327(25): 1815-6.
Martin, J. N., Ganem, D. E., Osmond, D. H., Page-Shafer, K. A., Macrae, D. and Kedes, D. H. (1998). Sexual Transmission and the Natural History of Human Herpesvirus 8 Infection. New England Journal of Medicine 338(14): 948-54.
BACKGROUND: Although human herpesvirus 8 (HHV-8) has been suspected to be the etiologic agent of Kaposi's sarcoma, little is known about its seroprevalence in the population, its modes of transmission, and its natural history. METHODS: The San Francisco Men's Health Study, begun in 1984, is a study of a population-based sample of men in an area with a high incidence of human immunodeficiency virus (HIV) infection. We studied all 400 men infected at base line with HIV and a sample of 400 uninfected men. Base-line serum samples were assayed for antibodies to HHV-8 latency-associated nuclear antigen (anti-LANA). In addition to the seroprevalence and risk factors for anti-LANA seropositivity, we analyzed the time to the development of Kaposi's sarcoma. RESULTS: Anti-LANA antibodies were found in 223 of 593 men (37.6 percent) who reported any homosexual activity in the previous five years and in none of 195 exclusively heterosexual men. Anti-LANA seropositivity correlated with a history of sexually transmitted diseases and had a linear association with the number of male sexual-intercourse partners. Among the men who were infected with both HIV and HHV-8 at base line, the 10-year probability of Kaposi's sarcoma was 49.6 percent. Base-line anti-LANA seropositivity preceded and was independently associated with subsequent Kaposi's sarcoma, even after adjustment for CD4 cell counts and the number of homosexual partners. CONCLUSIONS: The prevalence of HHV-8 infection is high among homosexual men, correlates with the number of homosexual partners, and is temporally and independently associated with Kaposi's sarcoma. These observations are further evidence that HHV-8 has an etiologic role in Kaposi's sarcoma and is sexually transmitted among men.
Martin, J. N., Rose, D. A., Hadley, W. K., Perdreau-Remington, F., Lam, P. K. and Gerberding, J. L. (1999). Emergence of Trimethoprim-Sulfamethoxazole Resistance in the AIDS Era. Journal of Infectious Diseases 180(6): 1809-18.
Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used for Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus (HIV)-infected patients, but little is known about the effects of this practice on the emergence of TMP-SMX-resistant bacteria. A serial cross-sectional study of resistance to TMP-SMX among all clinical isolates of Staphylococcus aureus and 7 genera of Enterobacteriaceae was performed at San Francisco General Hospital. Resistance among all isolates was <5.5% from 1979 to 1986 but then markedly increased, reaching 20.4% in 1995. This was most prominent in HIV-infected patients: resistance increased from 6.3% in 1988 to 53% in 1995. The largest increases in resistance were in Escherichia coli (24% in 1988 to 74% in 1995) and S. aureus (0% to 48%) obtained from HIV-infected patients. A rapid increase in the use of prophylactic TMP-SMX in HIV disease was also observed during this time in San Francisco and is likely responsible for the increase in TMP-SMX resistance.
Martin, J. N. and Osmond, D. H. (2000). Determining Specific Sexual Practices Associated with Human Herpesvirus 8 Transmission [Invited Commentary]. American Journal of Epidemiology 151(3): 225-9; discussion 230.
Laboratory and epidemiologic studies have established human herpesvirus 8 (HHV8) as an etiologic agent of Kaposi's sarcoma. With strong evidence linking HHV8 infection with the number of sexual partners among homosexual men, the challenge now is to determine the specific sexual acts associated with HHV8 transmission. Initial studies of specific practices, however, have differed in their conclusions; the paper by Dukers et al. in this issue of the Journal is the first to associate penile-oral intercourse with HHV8 transmission. Many sources of bias may contribute to the conflicting findings of studies reported to date: HHV8 research still lacks an adequately specific and sensitive serologic assay; identification of relevant exposure periods and measurement of sexual practices are imperfect; and sufficient adjustment for confounding is problematic. These numerous potential biases may be particularly important when trying to detect underlying associations that may be of low-order magnitude. The study by Dukers et al. (Am J Epidemiol 2000;151:213-24) is an important contribution to research on HHV8 transmission, but we do not yet know enough about the possible sexual routes of transmission to recommend avoiding any single behavior. For now, the best prevention advice is to reinforce the more general safe sex practices that have been promoted to prevent human immunodeficiency virus and other sexually transmitted diseases.
Martin, J. N., Amad, Z., Cossen, C., Lam, P. K., Kedes, D. H., Page-Shafer, K. A., Osmond, D. H. and Forghani, B. (2000). Use of Epidemiologically Well-Defined Subjects and Existing Immunofluorescence Assays to Calibrate a New Enzyme Immunoassay for Human Herpesvirus 8 Antibodies. Journal of Clinical Microbiology 38(2): 696-701.
Agreement between assays for the detection of human herpesvirus 8 (HHV-8) antibodies has been limited. In part, this disagreement has been because assay calibration (i.e., differentiating positive from negative results) has not been done in a standardized fashion with reference to a wide spectrum of HHV-8-infected (true-positive) and HHV-8-uninfected (true-negative) persons. To describe the performance of an assay for HHV-8 antibodies more accurately, we used epidemiologically well-characterized subjects in conjunction with testing on two existing immunofluorescence assays for HHV-8 antibodies to define two groups: a group of 135 HHV-8-infected individuals (true positives), including Kaposi's sarcoma patients and those asymptomatically infected, and a group of 234 individuals with a high likelihood of being HHV-8 uninfected (true negatives). A new enzyme immunoassay (EIA), using lysed HHV-8 virion as the antigen target, was then developed. With the above true positives and true negatives as references, the sensitivity and specificity of the EIA associated with different cutoff values were determined. At the cutoff that maximized both sensitivity and specificity, sensitivity was 94% and specificity was 93%. When the EIA was used to test a separate validation group, a distribution of seropositivity that matched that predicted for the agent of Kaposi's sarcoma was observed: 55% of homosexual men were seropositive, versus 6% seropositivity in a group of children, women, and heterosexual men. It is proposed that the EIA has utility for large-scale use in a number of settings and that the calibration method described can be used for other assays, both to more accurately describe the performance of these assays and to permit more-valid interassay comparison.
Mbugua, G. G., Muthami, L. N., Mutura, C. W., Oogo, S. A., Waiyaki, P. G., Lindan, C. P. and Hearst, N. (1995). Epidemiology of HIV Infection among Long Distance Truck Drivers in Kenya. East African Medical Journal 72(8): 515-8.
A total number of two hundred eighty three long distance truck drivers and their assistants (loaders) who ferry goods between Kenya and Zaire were included in a cross-sectional study between September 1991 and April 1992. Twenty six percent of the study subjects were seropositive for HIV-1 and none were HIV-2 seropositive. Countries of birth and residence were significantly associated with HIV infection (X2 = 23.6, P = 0.0006). Significant associations were also found between HIV seropositivity and level of education from secondary school and above (OR = 3.4, 95% C.I. = 1.01-11.55); being circumcised was more protective, (OR = 0.38; 95% C.I. = 0.19-0.76), history of many years of driving (X2 = 9.3, p = 0.0254) and income (OR = 11.13, 95% C.I. = 1.35-91.95). When a stepwise multiple logistic regression model was fitted to all the variables observed to be significant in the univariate analysis, the following risk factors attained statistical significance: lack of circumcision (OR = 3.75); income greater than Ksh. 2000 (OR = 7.24); being employed in long distance driving more than 11 years (OR = 3.98); and secondary school education and above (OR = 4.06, 95% C.I. = 1.18-13.98). Reference for all the above Odds Ratios was 1.
McFarland, W., Mvere, D., Shandera, W. and Reingold, A. (1997). Epidemiology and Prevention of Transfusion-Associated Human Immunodeficiency Virus Transmission in Sub-Saharan Africa. Vox Sanguinis 72(2): 85-92.
BACKGROUND AND OBJECTIVES: Compared to industrialised nations, countries in sub-Saharan Africa experience a greater amount of transfusion-associated HIV transmission due to high rates of transfusion in some groups of patients, a higher incidence and prevalence of HIV infection in donor populations, a lack of HIV antibody screening in some areas, and a higher residual risk of contamination in blood supplies despite antibody screening. MATERIALS AND METHODS: Epidemiologic review. RESULTS: Epidemiologic evidence supports the effectiveness of three relatively inexpensive strategies to prevent transfusion-associated HIV transmission in sub-Saharan Africa: HIV antibody screening, avoidance of unnecessary use of blood products, and exclusion of donors at high risk of infection. Such prevention strategies have not been universally implemented. CONCLUSIONS: International aid to establish and maintain HIV antibody screening programmes, implementation of sound criteria for transfusion, and the search for HIV risk factors to use as donor exclusion criteria must be expanded in the region.
McFarland, W. and DeCarlo, P. (1998). New Epidemics: The Global Status of HIV. Focus 13(11): 5-7.
McFarland, W., Kellogg, T. A., Louie, B., Murrill, C. and Katz, M. H. (2000). Low Estimates of HIV Seroconversions among Clients of a Drug Treatment Clinic in San Francisco, 1995 to 1998. Journal of Acquired Immune Deficiency Syndromes 23(5): 426-9.
We estimated HIV incidence among injection drug users attending a drug treatment clinic in San Francisco from 1995 to 1998 using two methods. An anonymous sequential testing method identified no seroconversions among clients seen more than once during the period (one-sided upper 95% confidence limit 1.02 per 100 person-years). A sensitive/less sensitive immunoassay testing strategy detected no early infections (one-sided upper 95% confidence limit 1.90% per year). Methods were concordant and feasible in the setting. Although detection of no new HIV infections in this population of injection drug users (IDUs) is encouraging, epidemiologic studies among IDUs not in treatment are needed to monitor the HIV epidemic effectively.
McQuitty, M., McFarland, W., Kellogg, T. A., White, E. and Katz, M. H. (1999). Home Collection Versus Publicly Funded HIV Testing in San Francisco: Who Tests Where? Journal of Acquired Immune Deficiency Syndromes 21(5): 417-22.
We examined records of all HIV antibody tests performed at anonymous publicly funded (PF) sites and by home collection (HC) testing for residents of San Francisco from August 1996 to December 1997. Although far fewer tests were performed by HC testing than at PF sites (715 versus 8712, respectively), a higher proportion of HC testers reported no prior history of HIV testing (33.1% versus 17.9%). HIV seroprevalence was higher among PF tests (1.8%) than among HC tests (0.9%). Compared with PF testers, HC testers were less likely to be gay men, lesbian or bisexual women, heterosexual women, African American, or Latino. HC testers were more likely to report sex with a known HIV-positive partner. HC testers were also more likely to reside in affluent neighborhoods. HC testing reaches some high-risk persons who may not otherwise seek PF testing, although, overall, the risk profile of HC testers appeared lower than that of PF testers. HC testing reaches some individuals who can financially afford HC testing, thus saving public prevention resources for hard-to-reach, high-risk populations.
Mills, T. C., Stall, R., Catania, J. A. and Coates, T. J. (1997). Interpreting HIV Prevalence and Incidence among Americans: Bridging Data and Public Policy. American Journal of Public Health 87(5): 864-6.
Page-Shafer, K., Delorenze, G. N., Satariano, W. A. and Winkelstein, W., Jr. (1996). Comorbidity and Survival in HIV-Infected Men in the San Francisco Men's Health Survey. Annals of Epidemiology 6(5): 420-30.
The course of disease associated with infection with the human immunodeficiency virus varies widely. Some patients deteriorate rapidly, while others live for years, even after an illness that defines the acquired immunodeficiency syndrome (AIDS). In this study, comorbidity, or the presence of concurrent health problems, was investigated prospectively as a possible co-factor for different rates of decline in 395 homosexual/bisexual men in the San Francisco Men's Health Study (SFMHS) who were infected with the human immunodeficiency virus (HIV). Comorbidity data obtained from baseline interviews included both chronic and infectious diseases as well as depression. Smoking, alcohol, and drug use were also examined. The most prevalent comorbid conditions were sexually transmitted diseases (90%) and hepatitis B infection (76%). Most chronic and acute concurrent health conditions were not significant discrete predictors of survival to AIDS or death after controlling for immune status and markers of disease progression. Significantly, other risk factors (e.g., depression and smoking) were found to be associated with more rapid progression. Men with symptoms of depression had a higher risk of progression of AIDS diagnosis; the relative hazard (RH) was 1.4 (95% confidence interval [CI], 1.00-2.08); smoking was associated with higher risk of death (RH, 1.6; 95% CI, 1.20-2.17). Older age was marginally associated with poorer survival to death. No associations were found between survival and alcohol and drug use.
Page-Shafer, K. A., McFarland, W. and Katz, M. (1997). 1997 HIV Consensus Report on HIV Prevalence and Incidence in San Francisco. Dept. of Public Health, AIDS Office, Epidemiology Unit,
Paul, J. P., Stall, R. and Bloomfield, K. A. (1991). Gay and Alcoholic: Epidemiologic and Clinical Issues. Alcohol Health & Research World 15(2): 151-160.
Examines whether elevated rates of alcoholism exist in the gay community (GC), whether the rates of alcohol abuse (ALA) are changing, and what are the risk factors for ALA in the GC. The authors also examine whether there is a need for gay-sensitive alcoholism treatment programs, how the existing treatment programs respond to the needs of gay alcoholics, and how gay alcoholics obtain the social support necessary to maintain sobriety. Early studies estimated that 1 out of every 3 gay men and lesbians was an abuser of alcohol or illegal drugs. Later work found lower rates of ALA among gay men. There is evidence of a decline of alcoholism among lesbians also. ((c) 1999 APA/PsycINFO, all rights reserved)
Paul, J., Hays, R. B. and Coates, T. J. (1995). The Impact of the HIV Epidemic on U.S. Gay Male Communities. Lesbian, Gay, and Bisexual Identities over the Lifespan : Psychological Perspectives. D'Augelli, A. R. and Patterson, C. New York :, Oxford University Press: 347-397.
Peterson, J. and DiClemente, R. (1994). Lessons Learned from Behavioral Interventions: Caveats, Gaps and Implications. Preventing AIDS : Theories and Methods of Behavioral Interventions. DiClemente, R. J. and Peterson, J. L. New York :, Plenum Press.
Ruiz, J. D., Molitor, F., McFarland, W., Klausner, J., Lemp, G., Page-Shafer, K., Parikh-Patel, A., Morrow, S. and Sun, R. K. (2000). Prevalence of HIV Infection, Sexually Transmitted Diseases, and Hepatitis and Related Risk Behavior in Young Women Living in Low-Income Neighborhoods of Northern California. Western Journal of Medicine 172(6): 368-73.
OBJECTIVE: To estimate the prevalence of human immunodeficiency virus (HIV) infection, sexually transmitted diseases, and hepatitis and the associated sexual and drug-using behavior among women residing in low-income neighborhoods in 5 northern California counties. METHODS: From April 4, 1996, to January 6, 1998, women aged 18 to 29 years were recruited door-to-door from randomly selected street blocks within 1990 census block groups below the 10th percentile for median household income for each county. RESULTS: Of 24,223 dwellings enumerated, contact was made with residents from 19,546 (80.7%). Within contacted dwellings, 3,560 eligible women were identified and 2,545 enrolled (71.5%). Weighted estimates for disease prevalence were HIV infection, 0.3% (95% confidence interval, 0.1%-0.4%); syphilis, 0.7% (0.3%-1.1%); gonorrhea, 0.8% (0.3%-1.3%); chlamydia, 3.3% (2.4%-4.8%); herpes simplex virus, type 1, 73.7% (71.6%-76.9%); herpes simplex virus, type 2, 34.4% (29.9%-39.0%); hepatitis A, 33.5% (28.3%-38.7%); chronic hepatitis B, 0.8% (0.3%-1.2%); and hepatitis C, 2.5% (1.4%-3. 6%). Condom use at last sexual intercourse with a new partner was reported by 44.0% (33.9%-54.1%). Injection drug use in the last 6 months was reported by 1.8% (1.0%-2.7%). CONCLUSIONS: The Young Women's Survey provided population-based estimates of the prevalence of 8 infectious diseases and related risk behavior within a population for whom data are often difficult to collect. Population-based data are needed for appropriate targeting and planning of primary and secondary disease prevention.
Seed, J., Allen, S., Mertens, T., Hudes, E., Serufilira, A., Carael, M., Karita, E., Van de Perre, P. and Nsengumuremyi, F. (1995). Male Circumcision, Sexually Transmitted Disease, and Risk of HIV. AIDS 8: 83-90.
Ssali, F. N., Kamya, M. R., Wabwire-Mangen, F., Kasasa, S., Joloba, M., Williams, D., Mugerwa, R. D., Ellner, J. J. and Johnson, J. L. (1998). A Prospective Study of Community-Acquired Bloodstream Infections among Febrile Adults Admitted to Mulago Hospital in Kampala, Uganda. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 19(5): 484-9.
Septicemia is a frequent cause of death in HIV-infected adults in developing countries. Additional prospective studies are needed to determine the etiology of bloodstream infections (BSI) in febrile HIV-infected adults and guide initial evaluation and treatment in this setting. We assessed the prevalence and etiology of community-acquired BSI among 299 consecutive febrile adult medical admissions to Mulago Hospital, Kampala, Uganda, over a 4-month period in 1997. The median age of our patients was 30 years, 159 (53%) were male, and 227 (76%) HIV-1-seropositive. Overall, prevalence of bacteremia or fungemia (1 patient) was 24%. Bacteremia was more frequent in HIV-infected than in uninfected patients (27% versus 15%, respectively; p = .04). Mycobacterium tuberculosis (n = 28), Streptococcus pneumoniae (n = 15) and Salmonella species (n = 13) were the most frequent isolates. All Salmonella and mycobacterial isolates were recovered from HIV-infected patients. Pneumococcal bacteremia was not associated with HIV seropositivity. M. avium complex and M. simiae were isolated from two HIV-infected patients. The rate of mycobacteremia among febrile HIV-infected adults presenting for hospitalization was 13%. Bacteremia and disseminated tuberculosis are frequent causes of morbidity in febrile HIV-infected Ugandan adults. Initial empiric antibiotic coverage in this setting should be targeted toward the pneumococcus and gram-negative enteric bacilli, especially nontyphi Salmonella species. All patients presenting with chronic cough should be evaluated for tuberculosis.
Stall, R. D., Greenwood, G. L., Acree, M., Paul, J. and Coates, T. J. (1999). Cigarette Smoking among Gay and Bisexual Men. American Journal of Public Health 89(12): 1875-8.
OBJECTIVES: This study measured the prevalence of cigarette smoking among gay men and identified associations with smoking. METHODS: Household-based (n = 696) and bar-based (n = 1897) sampling procedures yielded 2593 gay male participants from Portland, Ore, and Tucson, Ariz, in the spring of 1992. RESULTS: Forty-eight percent of the combined sample reported current smoking, a rate far above prevalence estimates for men in Arizona (z = 14.11, P < .001) or Oregon (z = 24.24, P < .001). Significant associations with smoking included heavy drinking, frequent gay bar attendance, greater AIDS-related losses, HIV seropositivity, lower health rating than members of same age cohort, lower educational attainment, and lower income. CONCLUSIONS: Rates of cigarette smoking are very high among gay men. Tobacco prevention and cessation campaigns should be designed to reach the gay male community.
Strathdee, S. A., Veugelers, P. J., Page-Shafer, K. A., McNulty, A., Moss, A. R., Schechter, M. T., van Griensven, G. J. and Coutinho, R. A. (1996). Lack of Consistency between Five Definitions of Nonprogression in Cohorts of HIV-Infected Seroconverters. AIDS 10(9): 959-65.
OBJECTIVE: To identify appropriate criteria for characterizing HIV-infected nonprogressors. DESIGN: Five definitions were compared as follows: (1) last CD4 count > 500 x 10(6)/l; (2) two most recent CD4 counts > 500 x 10(6)/l; (3) calculated CD4 count based on linear regression > 500 x 10(6)/l; (4) CD4 slope > or = 0 with no antiretroviral use; (5) all CD4 counts > 500 x 10(6)/l, decline in CD4 slope < 5 cells per year, no antiretroviral use. PARTICIPANTS: Five prospective cohorts of homosexual men with documented dates of HIV-1 seroconversion. MAIN OUTCOME MEASURES: Proportions of nonprogressors were calculated 7, 8, 9 and 10 years following seroconversion (n = 285). Definitions were evaluated with respect to consistency over time and across sites. Subjects lacking CD4 counts within 3 years preceding end of follow-up were excluded. RESULTS: Across sites, proportions of nonprogressors ranged from 1% (definition 5) to 17.5% (definition 1) 10 years after seroconversion. Definitions based on absolute CD4 counts (definitions 1-3) had higher proportions and were less consistent than those based on stable slopes (definitions 4 and 5). For each definition, proportions decreased as follow-up increased, but were most stable for definition 4 (3%). Site differences decreased as follow-up increased, but remained nearly threefold for definitions 1-3. None of the definitions classified the same subjects as nonprogressors at any timepoint. CONCLUSIONS: Observations regarding nonprogression are highly dependent on the definition and the duration of follow-up. Our findings highlight methodological challenges which will need to be overcome in natural history studies of nonprogression.
van Benthem, B. H., Veugelers, P. J., Cornelisse, P. G., Strathdee, S. A., Kaldor, J. M., Shafer, K. A., Coutinho, R. A. and van Griensven, G. J. (1998). Is AIDS a Floating Point between HIV Seroconversion and Death? Insights from the Tricontinental Seroconverter Study. AIDS 12(9): 1039-45.
OBJECTIVE: To investigate the significance of the time from seroconversion to AIDS (incubation time) and other covariates for survival from AIDS to death. METHODS: In survival analysis, survival from AIDS to death was compared for different categories of length of incubation time adjusted and unadjusted for other covariates, and significant predictors for survival from AIDS to death were investigated. RESULTS: Survival after AIDS was not affected by the incubation time in univariate as well as in multivariate analyses. Predictive factors for progression from AIDS to death were age at seroconversion, type of AIDS diagnosis, and CD4 cell count at AIDS. The relative hazard for age at seroconversion increased 1.38-fold over 10 years. Men with a CD4 cell count at AIDS of <130 x 10(6)/l had a twofold higher risk in progression to death than men with higher CD4 cell counts. Persons diagnosed with lymphoma had a sixfold higher risk of progression to death than persons with Kaposi's sarcoma or opportunistic infections. CONCLUSIONS: The incubation time as well as other factors before AIDS did not affect survival after AIDS. Survival from AIDS to death can be predicted by data obtained at the time of AIDS diagnosis, such as type of diagnosis, age and CD4 cell count. AIDS seems to be a significant point in progression to death, and not just a floating point between infection and death affected by prior factors for persons who did not receive effective therapy and did not have long incubation times.
Waldo, C. R. and Coates, T. (2000). Acquired Immune Deficiency Syndrome. Encyclopedia of Psychology. Kazdin, A. E. Washington, D.C. : Oxford [Oxfordshire] ; New York :, American Psychological Association ; Oxford University Press.
Waldo, C. R. and Coates, T. (2000). HIV/AIDS Prevention: Successes and Challenges. Promoting Human Wellness : New Frontiers for Research, Practice, and Policy. Jamner, M. S. and Stokols, D. Berkeley :, University of California Press.
Waldo, C. R., McFarland, W., Katz, M. H., MacKellar, D. and Valleroy, L. A. (2000). Very Young Gay and Bisexual Men Are at Risk for HIV Infection: The San Francisco Bay Area Young Men's Survey Ii. Journal of Acquired Immune Deficiency Syndromes 24(2): 168-74.
OBJECTIVES: To compare HIV seroprevalence and sexual risk behavior among very young gay and bisexual men (aged 15-17 years) and their older counterparts (aged 18-22 years). To examine drug-use patterns and correlates of sexual risk behavior in both of these age groups. DESIGN AND METHODS: An interviewer-administered cross-sectional survey of 719 gay and bisexual males between 15 and 22 years old was conducted through a venue-based sampling design. Blood specimens were collected and tested for HIV antibodies, hepatitis B, and syphilis. Interviews assessed sexual and drug-use behavior as well as psychosocial variables believed to be related to sexual risk-taking, including self-acceptance of gay or bisexual identity, perceptions of peer norms concerning safer sex, and perceptions of the ability to practice safer sex (safer sex self-efficacy). RESULTS: Of the 719 participants, 100 (16.2%) were aged between 15 and 17 years. HIV seroprevalence was somewhat lower among those aged 15 to 17 years (2.0%) compared with those aged 18 to 22 years (6.8%). Overall, the prevalence of hepatitis-B core antibody was significantly lower in the younger age group (5.0%) than in the older group (14.1%). The men aged 15 to 17 years used alcohol, ecstasy, and heroin less frequently than those aged 18 to 22 years. The age groups did not differ in the proportion of men who reported any unprotected anal intercourse in the previous 6 months (31.2%). In both age groups, use of amphetamines, ecstasy, and amyl nitrate was associated with unprotected anal intercourse. Self-acceptance of gay or bisexual identity was related to less sexual risk for those aged 15 to 17 years. In both age groups, greater safer sex self-efficacy was linked to less HIV sexual risk-taking. In the younger group, perceptions of peer norms that support safer sex were related to less risk behavior. CONCLUSIONS: Very young gay and bisexual men engage in unprotected anal sex at rates comparable with those for their somewhat older counterparts, raising serious concern over their risk of acquiring HIV infection. To prevent seroconversions, interventions must target those <18 years of age, and prevention programs should address the use of certain drugs in relation to sex and sexual risk-taking. To be most effective, programs should develop innovative communication strategies to take into account lack of self-acceptance of gay or bisexual identity and low self-efficacy for practicing safer sex.
Waldo, C. R. and Coates, T. J. (2000). Multiple Levels of Analysis and Intervention in HIV Prevention Science: Examplars and Directions for New Research. AIDS 14(Supplement 2): 500.
posted in toto 12-4-05
Enkidu the Atheist - 04 Dec 2005 18:56 GMT > Chinese blood donor with HIV infected at least 21 others > > BEIJING (AFP) - An HIV carrier in northeast China who gave blood 15 > times > before he was diagnosed with the virus unknowingly infected at least > 21 people, state media have reported. Given the choice between certain and immediate death now from blood loss or an unlikely but possible death in the future from AIDS, I'd choose the latter.
 Signature Enkidu AA#2165 http://www.musings.leaddogs.org/ EAC Chaplain and ordained minister, ULC, Modesto, CA
PGP ID: 0xC4CE8CF0
"History teaches us that men and nations behave wisely once they have exhausted all other alternatives." * Abba Eban
Cracklin' - 04 Dec 2005 19:10 GMT > Chinese blood donor with HIV infected at least 21 others > > BEIJING (AFP) - An HIV carrier in northeast China who gave blood 15 > times > before he was diagnosed with the virus unknowingly infected at least 21 > people, state media have reported. ================= Now tell us how many millions of people were saved by getting transfusions and didn't get a disease. How many JWs, including children died refusing blood over the years? Why does the WTS hide these statistics?
 Signature CR........ Examples of FINE SPIRITUAL FOOD AT THE APPROPRIATE TIME FROM "THE SLAVE": "We need not here repeat the evidences that the 'seventh trump' began its sounding in A.D. 1840, and will continue until the end of the time of trouble" {WT Nov 1880 p1}; "masturbation is no mere innocent pastime but rather a practice that can lead to homosexual acts" {WT May 15 1970 p315; also WT Oct 1 1970 p604}; "If heaven were made the receptacle of the heathen, savages, barbarians, the idiotic, simple, insane and INFANTS, it would cease to be heaven to a considerable extent, and become a pandemonium .. billions of ignorant, imbecile and degraded .. never formed characters [not] fit companions for saints" {WT Oct 15 1896 p245} Fine JW Wisdom!! ------------------------------------------------------------------------
vorlon359@gmail.com - 04 Dec 2005 19:20 GMT > > Chinese blood donor with HIV infected at least 21 others > > [quoted text clipped - 5 lines] > Now tell us how many millions of people were saved by getting transfusions > and didn't get a disease. By all means if you really have the stats.. go ahead and post them.
> How many JWs, including children died refusing > blood over the years? Why does the WTS hide these statistics? > -- > CR........ First you have to prove that such statics exist.
However here are the stats of people who have died of a blood transfusions and it is in the millions:
http://www.wrongdiagnosis.com/d/diseases_contagious_from_blood_transfusion/death -types.htm
Now then where are your Stats..
Death Statistics for Types of Diseases contagious from blood transfusion Disease Death Rate Estimate US deaths estimate Statistic Used for Calculation Hepatitis B N/A N/A estimated 1.5 million HBV carriers in the U.S. (NWHIC); 417,000 people currently infected (CDC 2001) Chronic Hepatitis B N/A N/A 750,000 people in the United States (NIAID) Hepatitis C approx 1 in 136 or 0.74% or 2 million people in USA estimated 2 to 5 million HCV chronic carriers estimated 2 to 5 million HCV chronic carriers Chronic Hepatitis C approx 1 in 68 or 1.47% or 4 million people in USA Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK). Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK). HTLV-1 N/A N/A uncommon Malaria N/A N/A No information Tropical Spastic Paraparesis N/A N/A
Oh,,, and the Sheriff dept in your county have been notified of your abuse.
Aråchñe - 04 Dec 2005 20:02 GMT >>================= >>Now tell us how many millions of people were saved by getting transfusions [quoted text clipped - 13 lines] > > http://www.wrongdiagnosis.com/d/diseases_contagious_from_blood_transfusion/death -types.htm If we go by the stats of the website, it would indicate that more people died recieving a blood transfusion than Jw's refusing it. There are only 6 million JW's and not all of them die when the refuse a blood transfusion because of modern medical technology.
GMCarter - 04 Dec 2005 22:01 GMT >> Chinese blood donor with HIV infected at least 21 others >> [quoted text clipped - 6 lines] >and didn't get a disease. How many JWs, including children died refusing >blood over the years? Why does the WTS hide these statistics? One wonders why they don't have better blood supply monitoring in place. This is reminiscent of the scandals that shook various Red Cross outfits from the US and Canada to Europe: they were too cheap to test the blood for common pathogens, like HIV.
George M. Carter
Jesus H Christ - 05 Dec 2005 03:04 GMT vorlon359@gmail.com wrote in news:1133721305.492399.107970 @g44g2000cwa.googlegroups.com:
> Chinese blood donor with HIV infected at least 21 others
> Authorities have taken disciplinary action against six Dehui health > officials and detained 11 staff at the blood bank. Don't expect the technical and personnel standards of third-world countries to be that of first world.
This particular disaster was in China and was almost certainly the result of safety process failure due to poor management and/or corruption. Not unlike other civil disasters that occur in that particular country.
The risks of HIV infection in *western* countries blood supplies are less than one per two million; http://www.fda.gov/cber/gdlns/nathivhcv.htm
jesus
bg12345@apexmail.com - 05 Dec 2005 04:50 GMT Blood transfusions become unsafe for the same reason religion is unsafe: those infected end up mixing their tained blood into other people's and poisoning everybody leading to mass deaths.
If you want to blame someone, blame idiots who believe in exact right and wrong (ie. "if you disagree with me you're wrong") such as the PRC government, muslims, or xians.
> Chinese blood donor with HIV infected at least 21 others > > BEIJING (AFP) - An HIV carrier in northeast China who gave blood 15 > times > before he was diagnosed with the virus unknowingly infected at least 21 > people, state media have reported. <snip>
> The 41-year-old man gave blood 15 times to the central blood bank of > Dehui > between January 2003 and June 2004 without having been diagnosed as an > HIV > carrier, it said. It's worse elsewhere in China:
http://www.guardian.co.uk/china/story/0,7369,1070800,00.html
This is Xiongqiao village in Henan province, the ground zero of arguably the world's worst HIV/Aids epidemic, with up to a million people infected in this single province through a vast, largely unregulated blood-selling operation. [...] For an 800cc donation, villagers were paid 45 Renminbi (RMB, about £3.50), enough to feed a family for a week. Realising that they could get far more for milking their veins than for tending the land, they lined up day-in and day-out for years to make donations. By the peak - around 1995 - Henan had become the nation's blood farm. [...] The system had been adapted so that villagers could give such huge amounts of blood without suffering anaemia. After extracting plasma from each 800cc donation, the collectors would pump 400cc back into the arms of the donors. It is believed that people's blood often got mixed up in this way, spreading HIV to almost everyone involved. [...] Based on the proliferation of blood collection units in the mid 1990s, Aids activists estimate that more than a million people in Henan were contaminated.
"If you sold blood, there is a 90% chance of infection," said a local man. "But people don't want to know. My wife is now sick, but is afraid to take a test."
> China says there are about 840,000 HIV-positive people in China, > although > the United Nations says the figure could be much higher and has warned > that > the number of infected people could rise to 10 million by 2010. Doctors in China, speaking anonymously, have put the number at five to ten times the government's estimates.
Bob Dog Atheist #153 = 1^3 + 5^3 + 3^3 EAC's chief cook and brainwasher
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"Sooner or later the despairing Churches will try to get a world-alliance with something like Fascist tyranny to check the growth of Atheism. It is their one hope." - Joseph McCabe
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Hidden from the world, a village dies of Aids while China refuses to face a growing crisis
Jonathan Watts in Xiongqiao village, Henan province, the ground zero of an epidemic threatening millions
Saturday October 25, 2003 The Guardian
Chang Sun's wife is HIV positive. So is his mother. So is his aunt. So is his cousin and his cousin's wife. So is the woman next door and, probably, so is her husband. In fact, it is quite possible that almost every adult and many of the children in his small, remote village are infected.
And then, there are those who lie in the flat, brown vegetable fields, which are steadily filling with mossy green burial mounds.
Among them is Chang's father, who died of Aids last year, and his three-year-old daughter, who succumbed the year before that. His first wife is there too - she threw herself down the village well in 2000 after a doctor told her she was no longer worth treating because she had the virus.
Another plot will soon be needed. As we walk furtively to Chang's home under cover of darkness, the crackling of firewood in a neighbour's yard reminds him that a traditional wake is being held for the latest son to be lost to the disease, the 10th victim in the village this year.
"It is our custom for strong male adults to carry the coffin, but so many people are sick or dead that there aren't enough of us left," says the 35-year-old farmer. "So now it is the old people who are doing the burying."
This is Xiongqiao village in Henan province, the ground zero of arguably the world's worst HIV/Aids epidemic, with up to a million people infected in this single province through a vast, largely unregulated blood-selling operation.
The situation is already a catastrophe, but the risks are growing. The medical treatment is inadequate and the authorities are trying to cover up the truth with a lethal mix of censorship and police intimidation.
The Guardian has gained rare access to the village and has spoken to HIV-positive villagers who have been arrested and beaten for trying to draw attention to their plight; to health officials who have been harassed, sued and kept under surveillance for speaking out; and to local newspaper reporters who have been fired for trying to publish the truth.
It has also heard from Aids experts, charity organisations and foreign diplomats who have either been refused access to Henan or only allowed to enter under heavy restrictions.
Outside journalists fare little better: two cameramen from China's state-run television channel, CCTV, were kicked out this week.
The problem and response are side-effects of modern China's peculiar blend of profit-at-all-costs capitalism and hide-and- control communism. Even more than the Sars scare this year, the HIV crisis in Henan underlines the growing gulf between the urban rich and rural poor and the state's overarching emphasis on social stability at the expense of individual rights and free speech.
Impoverished
It was almost inevitable that the outbreak occurred in Henan. Here in the most populous and impoverished of China's provinces, life is cheaper than almost anywhere else in the world. The average Henan farmer survives on 46 pence per day.
When local health authorities were suddenly told to start making profits in the late 1980s, as part of the country's drive towards capitalism, Henan's officials turned to almost their only untapped resource: the blood of the province's 90 million population. Vans were converted into mini-clinics and driven out into the countryside. Ambitious peasants established themselves as "bloodheads" (brokers) to meet the demand among both buyers and sellers.
For an 800cc donation, villagers were paid 45 Renminbi (RMB, about £3.50), enough to feed a family for a week. Realising that they could get far more for milking their veins than for tending the land, they lined up day-in and day-out for years to make donations. By the peak - around 1995 - Henan had become the nation's blood farm.
"Almost everybody did it," said Chang's cousin, Ming.
"We would sell extra if there was a marriage ceremony coming up or if we wanted to build a house. The most I ever did was four donations in a single day."
The system had been adapted so that villagers could give such huge amounts of blood without suffering anaemia. After extracting plasma from each 800cc donation, the collectors would pump 400cc back into the arms of the donors. It is believed that people's blood often got mixed up in this way, spreading HIV to almost everyone involved.
Ming started to show symptoms of Aids in February and now spends most of his time lying on a bed held together by string, watching snowy black-and-white TV images on an old television set. Under a single naked light that illuminates the fading newsprint that serves as wallpaper, he says he has only lasted so long because the central government began providing free retroviral drugs this year.
After years of denial, the health ministry in Beijing has recently started to face up to the problem in Henan. Officials cautiously acknowledge that tens of thousands of people may have been infected. Although the government dodges the question of responsibility, steps are being taken to ease the suffering of the victims.
As well as the free medicine, money has been provided for HIV clinics and plans are mooted for free education and tax breaks for the growing number of Aids orphans and widows in Henan. But villagers say the authorities are still covering up the enormous scale of the outbreak. Based on the proliferation of blood collection units in the mid 1990s, Aids activists estimate that more than a million people in Henan were contaminated.
"If you sold blood, there is a 90% chance of infection," said a local man. "But people don't want to know. My wife is now sick, but is afraid to take a test."
The disease is also spreading across generations. At a nursery school for orphans in Houyang, all the 38 children have at least one parent who is HIV positive, many of whom are likely to have passed on the disease during birth. Only three of the five and six-year-olds have been tested, but all three were positive.
The founder of the school, Chen Xiangyang, said one girl is now sick. "Her mother died of Aids and her father ran away after he tested positive. We don't tell the children even if they have the disease; we try to make them as happy as possible."
In remote villages like Xiongqiao, which has no road and only one telephone, residents say they are being neglected because corrupt local officials want to play down their own accountability.
"The headman told us that he doesn't want us to get the reputation as an 'Aids village' but it is a fact that almost everyone here has the disease," said Chang. Other villagers said their claims for the benefits due to HIV sufferers have been turned down.
Tempers snapped in June, after four villagers died of Aids in less than a week and two residents were detained by police on their way to petition the provincial government for help. The arrests sparked China's most violent Aids-related confrontation. Almost 100 villagers overturned an official's car and marched on the village headman's office to protest against their lack of health care. The authorities' response was swift and bloody: two days after the demonstration, 600 baton-wielding police stormed the village, battering down doors, smashing windows and beating residents, including HIV-sufferers, children and Chang's 56-year- old mother, who says she still feels pain in the arm they broke.
Death and darkness fill Chang's house, which was built with money he made from selling blood. The mood is set by the black-framed picture of his father who died last year, and in the funeral poems - "The wide land weeps for those we have loved and lost" - to his first wife and child which are pasted to the walls. It also seems to have taken liquid form in a murky bottle of traditional medicine that is all he and his mother have to ward off Aids.
Negative
Astonishingly, Chang tested negative for HIV. He does not believe the results, nor has he changed his lifestyle despite being remarried to a HIV-positive wife from a neighbouring and equally infected village.
"Everyone in my family has HIV. Why should I be different?" he says.
It is a view shared by many - not least because they cannot afford the 3Rmb price of a condom, equivalent to half a day's wages. Also to blame is a lack of Aids education in the villages by Henan officials who would rather ignore the problem than teach people how to deal with it.
The consequences for China will be devastating as many infected villagers are migrating to work in Beijing and other big cities. "It is now too late to stop the spread of the disease," said Gao Yaojie, the most outspoken advocate of a rethink of China's policy on Aids.
Overseas, Ms Gao has won awards for her efforts to raise the problems of Henan. In China, she has been denied a passport, had her phone bugged and been placed temporarily under house arrest. Numerous others who have tried to raise the problem have encountered similar problems. Last year, a local doctor - Wan Yanhai - was detained for allegedly passing out information about the scale of the epidemic. A journalist, who asked not to be named, said he had been fired by three different newspapers in Henan for trying to get the story published.
On the way from the city, a few hours drive from Xiongquiao, I asked a taxi driver if she was aware of any HIV cases in the province.
"No, no, definitely not", she replied. "That is just wicked rumour mongering. We have no Aids here. You don't have to worry. Trust me. A taxi driver knows these things."
Secrets, lies and damning statistics
· China refused to accept that it had a major HIV problem until 2002. Then in a single day, it pushed up its estimate for infected people from 30,000 to 1 million. Aids activists believe the real number could be more than twice as high
· Last month, Human Rights Watch issued a report condemning China's policy on HIV/Aids. Few Chinese people saw it because the government blocked the group's website
· In international forums and English language media, Chinese officials acknowledge that the country could have 10m HIV cases by 2010. In the domestic Chinese language media, however, officials cite infection figures as low as 40,000
· Asked why the cover-up is necessary, an official in Henan told doctors: "Who will invest in our province if they believe we have a huge number of HIV cases"
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AkreM - 05 Dec 2005 08:08 GMT to bad our life blood will be accounted for as it states. I can see why things happen like this. It's not meant to have someone elses blood. We are trying to play God when we are not God in the first place. Egotistic-Power trips at work. Whos really helping who here? The devil has just about everyone confused is seems.
Michael http://www.geocities.com/mikeakrem/ ...and what about God?
Jon Stoll - 05 Dec 2005 14:58 GMT > to bad our life blood will be accounted for as it states. I can see why > things happen like this. It's not meant to have someone elses blood. We [quoted text clipped - 3 lines] > > Michael You really are a f.cking idiot. It it weren't for a blood transfusion I would have died as an infant. People like you are incredibly sickening.
Jon
Cracklin' - 05 Dec 2005 15:38 GMT > to bad our life blood will be accounted for as it states. I can see why > things happen like this. It's not meant to have someone elses blood. We > are trying to play God when we are not God in the first place. So you're saying your god wants us to die when can be saved? What a cruel god that is! :-(
> Egotistic-Power trips at work. Whos really helping who here? The devil > has just about everyone confused is seems. So the devil wants us to LIVE (take a transfusion) while your god wants us to die if we hemorrhage? Do you realize that's what you just claimed?
CR....... / o{}xxxxx[]::::::::::::::::::::::::::::::::::::::::::::> \ Fight for FREEDOM from religious tyranny! ~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Skeptic - 05 Dec 2005 20:39 GMT First, learn to type and spell. Second, if you really believe that horsecrap about "playing god" you surely realize that that line of thinking results in the internet being an evil tool who's users will go straight to hell, right? I hear it's toasty down there, so bring some Bermuda's when you pass on.
> to bad our life blood will be accounted for as it states. I can see why > things happen like this. It's not meant to have someone elses blood. We [quoted text clipped - 5 lines] > http://www.geocities.com/mikeakrem/ > ...and what about God?
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