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Medical Forum / Diseases and Disorders / AIDS / October 2005

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HIV & FIV

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Alex - 13 Oct 2005 06:55 GMT
Janet K. Yamamoto, PhD, a professor of pathobiology at the
University of Florida College of Veterinary Medicine and member of
the board of directors of the Richard M. Brodsky Foundation has
discovered a link between the viruses that cause feline and human AIDS.

Yamamoto's groundbreaking research may predict that cats
with feline immunodeficiency virus, also known as FIV or feline AIDS,
could possibly be more effectively treated using some form of the
experimental human vaccine. Yamamoto theorizes that the apparent
relationships between the human and feline viruses can lead to a vaccine
for human AIDS.

From Nov. 29 to Dec. 6, 2005, the foundation will be bringing
to Gainesville the World AIDS Marathon, conference, Art for AIDS
exhibition, Noor H'mara: A Concert for AIDS, nightclub awareness nights,
and H'mara: A Night of Poetry, amongst many other events, in commemoration
of World AIDS Day on Dec. 1.

Yamamoto will be speaking at the conference. She will enlighten us all
with her expertise and inspire us to strive for a cure, which may be closer than
we think.

"As an AIDS researcher and professor at the University myself, I
know that the 2005 World AIDS Marathon is a great opportunity for the
University of Florida to further enhance its research efforts in the fight against
AIDS, and I strongly urge runners and non-runners to support this very worthy
event," Yamamoto said

Yamamoto, who received a doctorate in microbiology from the University
of Texas Medical Branch in 1981, developed a vaccine for feline immunodeficiency
virus (FIV). The vaccine, called Fel-O-Vax®, was approved by the USDA in March 2002.

In 1986, Yamamoto co-discovered the deadly FIV together with Niels
Pederson, D.V.M, of the University of California at Davis.

"Just because there are medications on the market to treat HIV/AIDS, does
not mean that there is a cure," Yamamoto said. "Awareness has dropped in
the United States and it's imperative that the public realizes that this is not a
foreign issue."
Tim Fitzmaurice - 13 Oct 2005 10:58 GMT
> Yamamoto's groundbreaking research may predict that cats
> with feline immunodeficiency virus, also known as FIV or feline AIDS,
> could possibly be more effectively treated using some form of the
> experimental human vaccine. Yamamoto theorizes that the apparent
> relationships between the human and feline viruses can lead to a vaccine
> for human AIDS.

That final statement in itself is not all that earthshattering, in fact
its pretty basic and not uncommonly stated for many comparative virus
biology projects.

Its the first bit that's important - ie the devil is in the details...now
specifics on how FIV and HIV might work together she pulled together
with others in this review

Uhl EW, Heaton-Jones TG, Pu R, Yamamoto JK
FIV vaccine development and its importance to veterinary and human
medicine: a review FIV vaccine 2002 update and review.
Vet Immunol Immunopathol. 2002 Dec;90(3-4):113-32. Review

The interesting bit (ie how you might use FIV as a model for HIV) is
pulled together from this sort of work...

Coleman JK, Pu R, Martin M, Sato E, Yamamoto JK.
HIV-1 p24 vaccine protects cats against feline immunodeficiency virus
infection.
AIDS. 2005 Sep 23;19(14):1457-66.

...where the FIV testing indicates human vaccine candidates.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
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