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Medical Forum / Diseases and Disorders / AIDS / October 2005HIV-p24 is a liver protein HIV-p41p17 are syphilis proteins
GMCarter wrote: > Duesbergia and Perthia! HIV doesn't exist. Yeah! But you and the other spamming trolls do exist. HIV-p17p41 are in reality syphilis and borrelia proteins. they are part of the chronic Th1 deseases http://www.researchd.com/viralag/viralag.htm or http://www.bionetinc.com/pdf/bigg.pdf and HIV-p24 is a liver protein from the golgi apparatus in liver cells against toxins, part of a healthy Th2 immune response. we have 2 totally different tests in 1 HIV-test! in other words: we have drug users, with or WITHOUT a TH1 problem. this is the only solution to the contradictions from both sides (Duesberg and Gallo) here some references from the new p24 sciences: Belden, W.J., and C. Barlowe. 1996. Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport. J Biol Chem. 271:26939-26946. Belden, W.J.u.B., C. 2001. Distinct Roles for the Cytoplasmic Tail Sequences of Emp24p and Erv25p in Transport between the Endoplasmatic Reticulum and Golgi Complex. JBC. in press. Blum, R., P. Feick, M. Puype, J. Vandekerckhove, R. Klengel, W. Nastainczyk, and I. Schulz. 1996. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. J Biol Chem. 271:17183-17189. Blum, R., F. Pfeiffer, P. Feick, W. Nastainczyk, B. Kohler, K.H. Schafer, and I. Schulz. 1999. Intracellular localization and in vivo trafficking of p24A and p23. J Cell Sci. 112:537-548. Denzel, A., F. Otto, A. Girod, R. Pepperkok, R. Watson, I. Rosewell, J.J. Bergeron, R.C. Solari, and M.J. Owen. 2000. The p24 family member p23 is required for early embryonic development. Curr Biol. 10:55-58. Dominguez, M., K. Dejgaard, J. Fullekrug, S. Dahan, A. Fazel, J.P. Paccaud, D.Y. Thomas, J.J. Bergeron, and T. Nilsson. 1998. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. J Cell Biol. 140:751-65. Emery, G., Grünberg, J. und Rojo, M. 1999. The p24 family of transmembrane proteins at the interface between endoplasmatic reticulum and Golgi apparatus. Protoplasma. 207:24-30. Emery, G., M. Rojo, and J. Gruenberg. 2000. Coupled transport of p24 family members. J Cell Sci. 113:2507-2516. Fiedler, K., M. Veit, M.A. Stamnes, and J.E. Rothman. 1996. Bimodal interaction of coatomer with the p24 family of putative cargo receptors. Science. 273:1396- 9. Füllekrug, J., T. Suganuma, B.L. Tang, W. Hong, B. Storrie, and T. Nilsson. 1999. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell. 10:1939-1955. Gommel, D., L. Orci, E.M. Emig, M.J. Hannah, M. Ravazzola, W. Nickel, J.B. Helms, F.T. Wieland, and K. Sohn. 1999. p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form heterooligomeric complexes and cycle between the organelles of the early secretory pathway. FEBS Lett. 447:179-185. Kaiser, C. 2000. Thinking about p24 proteins and how transport vesicles select their cargo. Proc Natl Acad Sci U S A. 97:3783-3785. Kuiper, R.P., G. Bouw, K.P. Janssen, J. Rotter, F. van Herp, and G.J. Martens. 2001. Localization of p24 putative cargo receptors in the early secretory pathway depends on the biosynthetic activity of the cell. Biochem J. 360:421-9. Marzioch, M., D.C. Henthorn, J.M. Herrmann, R. Wilson, D.Y. Thomas, J.J. Bergeron, R.C. Solari, and A. Rowley. 1999. Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell. 10:1923-1938. Muniz, M., C. Nuoffer, H.P. Hauri, and H. Riezman. 2000. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. J Cell Biol. 148:925-930. Schimmoller, F., B. Singer-Kruger, S. Schroder, U. Kruger, C. Barlowe, and H. Riezman. 1995. The absence of Emp24p, a component of ER-derived COPIIcoated vesicles, causes a defect in transport of selected proteins to the Golgi. Embo J. 14:1329-1339. Springer, S., E. Chen, R. Duden, M. Marzioch, A. Rowley, S. Hamamoto, S. Merchant, and R. Schekman. 2000. The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 97:4034-4039. >GMCarter wrote: >> Duesbergia and Perthia! HIV doesn't exist. [quoted text clipped - 9 lines] > >and HIV-p24 is a liver protein from the golgi apparatus Do you actually read any of the references you post? I can't imagine you do. Neither URL supports your ridiculous assertions even remotely. No matter how many times you post this nonsense. Are you like a secret anti-denialist whose trying to come off as such a complete idiot that it makes it easier to refute you? You don't really need to, generally speaking. They pretty much do that well on their own. Syphilis is not the same as HIV. Not even close. George M. Carter > Syphilis is not the same as HIV. Not even close. > > George M. Carter hey, our dear spamming GMGlaxo, do you know the difference between gag and p24? or do you think the readers are as silly as you? >> Syphilis is not the same as HIV. Not even close. >> >> George M. Carter > >hey, our dear spamming GMGlaxo, That's the best you can do. I disagree and so I side with pharma? Wrong polemic. A bit too facile, dear. >do you know the difference between gag and p24? Yep. You know what pol is? rev? tat? nef? vpr? vpu? >or do you think the readers are as silly as you? Well, I trust some of them aren't as stupid as you. George M. Carter GMSpammer wrote >>do you know the difference between gag and p24? >Yep. and what is it? >Well, I trust some of them aren't as stupid as you. > George M. Spammer Ok., what is the difference between gag and p24? >GMSpammer wrote > [quoted text clipped - 3 lines] > >and what is it? I notice you snipped my reply. Yep. You know what pol is? rev? tat? nef? vpr? vpu? >Ok., what is the difference between gag and p24? p24, in the current discussion, refers to a core protein of HIV of the nucleocapsid. gag is the gene and/or gene product that is a polyprotein that after protease digestion produces p24, p17, p7 and p6. see http://www.avert.org/virus.htm http://ca.expasy.org/uniprot/P04593 http://jvi.asm.org/cgi/content/abstract/72/3/2208 So--your turn. Answer my question if you can. George M. Carter ** Eyeson J, King D, Boaz MJ, Sefia E, Tomkins S, Waters A, et al. Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjects. AIDS. 2003 Nov 7;17(16):2299-311. Department of Immunology, Guy's, King's and St Thomas' School of Medicine and Dentistry, King's College Hospital, London SE5 9NU, UK. AIM: To characterize HIV-1 Gag p24-specific CD4 cell responses in HIV-exposed-seronegative (ES) individuals. METHODOLOGY: Twelve ES individuals, of diverse ethnicity and wild type for the CCR5 Delta-32 mutation, were identified. Controls were HIV-negative blood donors. Gag p24-specific and total Vbeta+ CD4 cells that expressed MIP-1beta, IFN-gamma and IL-2 were enumerated by intracytoplasmic cytokine staining. beta-Chemokine expression was correlated with susceptibility to R5 HIV-1 infection, as measured by polymerase chain reaction for integrated HIV-1 and by p24 enzyme-linked immunosorbent assay. RESULTS: Similar numbers of mitogen-stimulated and Vbeta+ MIP-1beta+, IFN-gamma+ and IL-2+ T cells were found in ES and HIV-negative control subjects. However, all ES subjects tested had an HIV Gag p24-specific MIP-1beta+, IFN-gamma+ and IL-2+ CD4 T-cell response that was rare in controls. p24-Specific cells of all ES but no control subjects could be expanded by in-vitro Ag/IL-2 stimulation, and when re-stimulated with an overlapping peptide series showed evidence of a broad CD4 cell memory response directed against multiple regions of Gag p24. Mitogen-stimulated ES CD4 cells were as susceptible to HIV infection as those from control subjects, but p24-specific IFN-gamma+ CD4 cells of six out of seven ES subjects tested were less susceptible to R5 HIV-1 infection than the counterpart fraction depleted of p24-specific IFN-gamma+ cells. The addition of blocking anti-beta-chemokine antibodies did not promote R5 HIV-1 infection of p24-specific IFN-gamma+ cells. CONCLUSION: Specific CD4 cell immunity, characterized by a broadly directed memory Gag-p24 CD4 cell response and reduced susceptibility of specific CD4 cells to R5 HIV-1 infection, is a likely correlate of non-transmission. GMSpammer wrote >>>>do you know the difference between gag and p24? >>>Yep. >>and what is it? >p24, in the current discussion, refers to a core protein of HIV of the nucleocapsid. very good! Georgispammi! it refers to the disussion of the nucleo capsid firehouse of the firefighters; http://www.letsroll911.org/discussion_in_firehouse.mpg >gag is the gene and/or gene product very good, a synthetic NIH product >that is a >polyprotein no Georgispammi, gag is a dna sequence >that after protease digestion very good, our dear spamming Georgi, if you took no protease inhibitors, then: >produces p24 hurray, your liver is functioning! > p17 no, trolling Georgiboy, p17 is a protein of a Treponema and Borrelia infection, need more teaching from glaxo? http://aids-info.net/micha/hiv/aids/english.html >very good, a synthetic NIH product Where did you get that idea, Coprilalia? >>that is a >>polyprotein > >no Georgispammi, gag is a dna sequence No, Copriphagia, a dna sequence is translated into a protein! Gosh, golly gee! So trolling Copridingbat, what else ya got? Lucy GMSpammer wrote: >Gosh, >golly gee! >gag, that is a >polyprotein, is translated into a protein! Are you sure? And reverse transcriptase has nothing to do? >GMSpammer wrote: > [quoted text clipped - 4 lines] > >Are you sure? And reverse transcriptase has nothing to do? Hey! No fair! I asked you about a bunch of genes and gene products and you ran away! Go get some toilet paper and wipe your nose. GMSpammer wrote: > >GMSpammer wrote: > > > >>Gosh, > >>golly gee! > >>gag, that is a > >>polyprotein, is translated into a protein! no George, gag is no protein. but gag may be a variant! of what? of a GMSpammer glaxo troll, of course. >>> Syphilis is not the same as HIV. Not even close. >>> [quoted text clipped - 3 lines] > > That's the best you can do. Pitiful, isn't it? A blue-green alga has a better wit. B/
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